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Your search keyword '"Singh, Amrita"' showing total 543 results
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543 results on '"Singh, Amrita"'

5. Geospatial assessment of agroforestry land use systems using very high-resolution satellite images and artificial intelligence

Author

Trivedi, Shivam, Vinod, P. V., Chandrasekaran, B., Nagashree, M. K., Rama Subramoniam, S., Manjula, V. B., Singh, Amrita, Mani, J. K., Suryavanshi, Arun S., Rehpade, Sushilkumar B., Goyal, Akash, Shankar Ram, N. R., Das, P. K., Kumar, Tanumi, Paul, Arati, Verma, M. K., Sharma, Shashikant, Varghese, A. O., Rao, S. H., Aravinda Kumar, P., Shah, Divya, Chandrasekar, K., Nagajothi, K., Bera, A. K., Hebbar, R., Jha, C. S., Srivastav, S. K., Sinha, R. B., and Chauhan, Prakash

Published
2024
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20. Configuration for a grounded lossy impedance simulator employing CC-CFAs and grounded passive elements

Author

Jain Manoj Kumar, Singh Amrita, and Wairya Subodh

Subjects
frequency-dependent negative-resistance (fdnr), current controlled-cfa (cc-cfa), capacitance multiplier, elliptic filter, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

This article presents a configuration that can simulate both a resistor in series with a frequency-dependent negative-resistance (R-D) and a resistor in series with a capacitor (R-C), with a different selection of passive elements. The proposed circuit employs only two current-controlled-current-feedback- amplifiers (CC-CFAs) and grounded passive elements. This configuration does not require passive element matching, and the simulated equivalent element values can be tuned electronically by applying a biasing current to the CC-CFAs. To demonstrate the application of the proposed grounded series R-D impedance simulator, it is applied to a second-order notch filter and a fifth-order elliptic lowpass filter, whereas the series R-C impedance simulator is applied to a secondorder resonance circuit to find the band-pass response of the input current. Our theoretical analysis is confirmed by the results of a PSPICE simulation.

Published
2023
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22. Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

Author

Abdelfattah, Ahmed S., Zheng, Jihong, Singh, Amrita, Huang, Yi-Chieh, Reep, Daniel, Tsegaye, Getahun, Tsang, Arthur, Arthur, Benjamin J., Rehorova, Monika, Olson, Carl V.L., Shuai, Yichun, Zhang, Lixia, Fu, Tian-Ming, Milkie, Daniel E., Moya, Maria V., Weber, Timothy D., Lemire, Andrew L., Baker, Christopher A., Falco, Natalie, Zheng, Qinsi, Grimm, Jonathan B., Yip, Mighten C., Walpita, Deepika, Chase, Martin, Campagnola, Luke, Murphy, Gabe J., Wong, Allan M., Forest, Craig R., Mertz, Jerome, Economo, Michael N., Turner, Glenn C., Koyama, Minoru, Lin, Bei-Jung, Betzig, Eric, Novak, Ondrej, Lavis, Luke D., Svoboda, Karel, Korff, Wyatt, Chen, Tsai-Wen, Schreiter, Eric R., Hasseman, Jeremy P., and Kolb, Ilya

Published
2023
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27. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus

Author

Duy, Phan Q., Weise, Stefan C., Marini, Claudia, Li, Xiao-Jun, Liang, Dan, Dahl, Peter J., Ma, Shaojie, Spajic, Ana, Dong, Weilai, Juusola, Jane, Kiziltug, Emre, Kundishora, Adam J., Koundal, Sunil, Pedram, Maysam Z., Torres-Fernández, Lucia A., Händler, Kristian, De Domenico, Elena, Becker, Matthias, Ulas, Thomas, Juranek, Stefan A., Cuevas, Elisa, Hao, Le Thi, Jux, Bettina, Sousa, André M. M., Liu, Fuchen, Kim, Suel-Kee, Li, Mingfeng, Yang, Yiying, Takeo, Yutaka, Duque, Alvaro, Nelson-Williams, Carol, Ha, Yonghyun, Selvaganesan, Kartiga, Robert, Stephanie M., Singh, Amrita K., Allington, Garrett, Furey, Charuta G., Timberlake, Andrew T., Reeves, Benjamin C., Smith, Hannah, Dunbar, Ashley, DeSpenza, Jr., Tyrone, Goto, June, Marlier, Arnaud, Moreno-De-Luca, Andres, Yu, Xin, Butler, William E., Carter, Bob S., Lake, Evelyn M. R., Constable, R. Todd, Rakic, Pasko, Lin, Haifan, Deniz, Engin, Benveniste, Helene, Malvankar, Nikhil S., Estrada-Veras, Juvianee I., Walsh, Christopher A., Alper, Seth L., Schultze, Joachim L., Paeschke, Katrin, Doetzlhofer, Angelika, Wulczyn, F. Gregory, Jin, Sheng Chih, Lifton, Richard P., Sestan, Nenad, Kolanus, Waldemar, and Kahle, Kristopher T.

Published
2022
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31. Inflammatory hydrocephalus

Author

Robert, Stephanie M., Reeves, Benjamin C., Marlier, Arnaud, Duy, Phan Q., DeSpenza, Tyrone, Kundishora, Adam, Kiziltug, Emre, Singh, Amrita, Allington, Garrett, Alper, Seth L., and Kahle, Kristopher T.

Published
2021
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37. First-in-Human Phase I Clinical Trial of an SFV-Based RNA Replicon Cancer Vaccine against HPV-Induced Cancers

Author

Komdeur, Fenne L., Singh, Amrita, van de Wall, Stephanie, Meulenberg, Janneke J.M., Boerma, Annemarie, Hoogeboom, Baukje Nynke, Paijens, Sterre T., Oyarce, Cesar, de Bruyn, Marco, Schuuring, Ed, Regts, Joke, Marra, Ruben, Werner, Naomi, Sluis, Jessica, van der Zee, Ate G.J., Wilschut, Jan C., Allersma, Derk P., van Zanten, Coba J., Kosterink, Jos G.W., Jorritsma-Smit, Annelies, Yigit, Refika, Nijman, Hans W., and Daemen, Toos

Published
2021
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39. Mediator complex: an important regulator of root system architecture.

Author

Agrawal, Rekha, Thakur, Pallabi, Singh, Amrita, Panchal, Poonam, and Thakur, Jitendra Kumar

Subjects
GENETIC transcription, RNA polymerases, FLOWER development, TRANSCRIPTION factors, ROOT growth
Abstract

Mediator, a multiprotein complex, is an important component of the transcription machinery. In plants, the latest studies have established that it functions as a signal processor that conveys transcriptional signals from transcription factors to RNA polymerase II. Mediator has been found to be involved in different developmental and stress-adaptation conditions, ranging from embryo, root, and shoot development to flowering and senescence, and also in responses to different biotic and abiotic stresses. In the last decade, significant progress has been made in understanding the role of Mediator subunits in root development. They have been shown to transcriptionally regulate development of almost all the components of the root system architecture—primary root, lateral roots, and root hairs. They also have a role in nutrient acquisition by the root. In this review, we discuss all the known functions of Mediator subunits during root development. We also highlight the role of Mediator as a nodal point for processing different hormone signals that regulate root morphogenesis and growth. [ABSTRACT FROM AUTHOR]

Published
2024
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41. mRNA-1273 vaccination induces polyfunctional memory CD4 and CD8 T cell responses in patients with solid cancers undergoing immunotherapy or/and chemotherapy.

Author

Gangaev, Anastasia, van Sleen, Yannick, Brandhorst, Nicole, Hoefakker, Kelly, Prajapati, Bimal, Singh, Amrita, Boerma, Annemarie, van der Heiden, Marieke, Oosting, Sjoukje F., van der Veldt, Astrid A. M., Hiltermann, T. Jeroen N., GeurtsvanKessel, Corine H., Dingemans, Anne-Marie C., Smit, Egbert F., de Vries, Elisabeth G. E., Haanen, John B. A. G., Kvistborg, Pia, and van Baarle, Debbie

Subjects
T cells, CANCER chemotherapy, COVID-19 vaccines, CANCER cells, FLOW cytometry
Abstract

Introduction: Research has confirmed the safety and comparable seroconversion rates following SARS-CoV-2 vaccination in patients with solid cancers. However, the impact of cancer treatment on vaccine-induced T cell responses remains poorly understood. Methods: In this study, we expand on previous findings within the VOICE trial by evaluating the functional and phenotypic composition of mRNA-1273-induced T cell responses in patients with solid tumors undergoing immunotherapy, chemotherapy, or both, compared to individuals without cancer. We conducted an ELISpot analysis on 386 participants to assess spike-specific T cell responses 28 days after full vaccination. Further in-depth characterization of using flow cytometry was performed on a subset of 63 participants to analyze the functional phenotype and differentiation state of spike-specific T cell responses. Results: ELISpot analysis showed robust induction of spike-specific T cell responses across all treatment groups, with response rates ranging from 75% to 80%. Flow cytometry analysis revealed a distinctive cytokine production pattern across cohorts, with CD4 T cells producing IFNγ, TNF, and IL-2, and CD8 T cells producing IFNγ, TNF, and CCL4. Variations were observed in the proportion of monofunctional CD4 T cells producing TNF, particularly higher in individuals without cancer and patients treated with chemotherapy alone, while those treated with immunotherapy or chemoimmunotherapy predominantly produced IFNγ. Despite these differences, polyfunctional spike-specific memory CD4 and CD8 T cell responses were comparable across cohorts. Notably, immunotherapy-treated patients exhibited an expansion of spike-specific CD4 T cells with a terminally differentiated effector memory phenotype. Discussion: These findings demonstrate that systemic treatment in patients with solid tumors does not compromise the quality of polyfunctional mRNA-1273-induced T cell responses. This underscores the importance of COVID-19 vaccination in patients with solid cancers undergoing systemic treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics.

Author

DeSpenza Jr, Tyrone, Singh, Amrita, Allington, Garrett, Shujuan Zhao, Junghoon Lee, Kiziltug, Emre, Prina, Mackenzi L., Desmet, Nicole, Dang, Huy Q., Fields, Jennifer, Nelson-Williams, Carol, Junhui Zhang, Mekbib, Kedous Y., Dennis, Evan, Mehta, Neel H., Duy, Phan Q., Shimelis, Hermela, Walsh, Lauren K., Marlier, Arnaud, and Deniz, Engin

Subjects
*AUTISM spectrum disorders, *CEREBRAL ventricles, *GENETIC variation, *HYDROCEPHALUS, *MICROTUBULES, *CHILDREN with autism spectrum disorders
Abstract

Enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles (cerebral ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly recognized among patients with autism spectrum disorders (ASD). KATNAL2, a member of Katanin family microtubule-severing ATPases, is a known ASD risk gene, but its roles in human brain development remain unclear. Here, we show that nonsense truncation of Katnal2 (Katnal2Δ17) in mice results in classic ciliopathy phenotypes, including impaired spermatogenesis and cerebral ventriculomegaly. In both humans and mice, KATNAL2 is highly expressed in ciliated radial glia of the fetal ventricular-subventricular zone as well as in their postnatal ependymal and neuronal progeny. The ventriculomegaly observed in Katnal2Δ17 mice is associated with disrupted primary cilia and ependymal planar cell polarity that results in impaired cilia-generated CSF flow. Further, prefrontal pyramidal neurons in ventriculomegalic Katnal2Δ17 mice exhibit decreased excitatory drive and reduced high-frequency firing. Consistent with these findings in mice, we identified rare, damaging heterozygous germline variants in KATNAL2 in five unrelated patients with neurosurgically treated CH and comorbid ASD or other neurodevelopmental disorders. Mice engineered with the orthologous ASD-associated KATNAL2 F244L missense variant recapitulated the ventriculomegaly found in human patients. Together, these data suggest KATNAL2 pathogenic variants alter intraventricular CSF homeostasis and parenchymal neuronal connectivity by disrupting microtubule dynamics in fetal radial glia and their postnatal ependymal and neuronal descendants. The results identify a molecular mechanism underlying the development of ventriculomegaly in a genetic subset of patients with ASD and may explain persistence of neurodevelopmental phenotypes in some patients with CH despite neurosurgical CSF shunting. [ABSTRACT FROM AUTHOR]

Published
2024
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43. DEMOGRAPHIC PROFILE OF THE DIABETIC PERSONS IN JHANSI AND JALAUN DISTRICTS OF UTTAR PRADESH, INDIA.

Author

Kumar, Hemant, Singh, Anshika, Singh, Amrita, Sahu, Jyoti, and Rajak, Pooja

Subjects
QUALITY of life, DIABETES complications, MARITAL status, PEOPLE with diabetes, CHRONIC diseases, RATS
Abstract

Diabetes mellitus is one of the most prevalent chronic diseases in the world and the incidence of diabetes has increased dramatically in developing countries such as India. Health-related quality of life (HRQOL) is an important factor for self-management behaviours of diabetic patients. These behaviours have special importance in preventing complications of diabetes. Health-related quality of life (HRQOL) has become an important measure for evaluating patient treatment with noncurable chronic disease. In the present paper demographic profile of 200 men and women in which 118 were suffering from diabetes in which 68 were men 50 were women from two districts of Uttar Pradesh. The demographic profile of respondents depicted age, gender, religion, educational status, marital status, occupation of respondents. These are the important contributing factors to access the quality of life of diabetic subjects. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Emergency Mental Health Services for Children After the Terrorist Attacks of September 11, 2001

Author

Bruckner, Tim A, Kim, Yonsu, Lubens, Pauline, Singh, Amrita, Snowden, Lonnie, and Chakravarthy, Bharath

Subjects
Behavioral and Social Science, Brain Disorders, Clinical Research, Health Services, Pediatric, Mental Health, Emergency Care, Health and social care services research, 8.1 Organisation and delivery of services, Mental health, Good Health and Well Being, Adolescent, Black or African American, Asian, California, Child, Child, Preschool, Emergency Services, Psychiatric, Ethnicity, Female, Healthcare Disparities, Hispanic or Latino, Humans, Interrupted Time Series Analysis, Male, Medicaid, Mental Disorders, Mental Health Services, September 11 Terrorist Attacks, United States, White People, Young Adult, Emergency, Children, 9/11, Racial disparities, Clinical Sciences, Public Health and Health Services, Psychology, Psychiatry
Abstract

Much literature documents elevated psychiatric symptoms among adults after the terrorist attacks of September 11, 2001 (9/11). We, however, know of no research in children that examines emergency mental health services following 9/11. We test whether children's emergency services for crisis mental health care rose above expected values in September 2001. We applied time-series methods to California Medicaid claims (1999-2003; N = 127,200 visits). Findings in California indicate an 8.7% increase of children's emergency mental health visits statistically attributable to 9/11. Non-Hispanic white more than African American children account for this acute rise in emergency services.

Published
2016

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