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A series of acyclic selenopurine nucleosides 3a–f and 4a–g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 µM) and HSV-2 (EC50 = 6.34 µM) activities without cytotoxicity up to 100 µM, while 2,6-diaminopurine derivatives 4e–g exhibited significant anti-human cytomegalovirus (HCMV) activity, which is slightly more potent than the guanine derivative 4d, indicating that they might act as prodrugs of seleno-ganciclovir (4d).

Objective: Contactless monitoring of instantaneous heart rate and respiration rate has a significant clinical relevance. This work aims to use Speckle Vibrometry (i.e., based on the secondary laser speckle effect) to contactlessly measure these two vital signs in an intensive care unit. Methods: In this work, we propose an algorithm for the estimation of instantaneous heart rate and respiration rate from mechanically ventilated patients. The algorithm uses multiple regions, principal component analysis, and dominant angle analysis. A semi-automated peak detection method is implemented to precisely label the aortic valve opening peak within the cardiac waveform. Results: Compared with electrocardiography, the present work achieves limits of agreement of [−2.19, 1.73] beats per minute of instantaneous heart rate. The measurement spot is on the chest covered with two to three layers of duvet blankets. Compared with the airway flow signal measured by the mechanical ventilator, the present work achieves limits of agreement of [−0.68, 0.46] respirations per minute of instantaneous respiration rate. Conclusions: These results showcased Speckle Vibrometry’s potential in vital sign monitoring in a clinical setting. Significance: This is the first human clinical study for Speckle Vibrometry.

To overcome the metabolic instability brought by the highly reactive and polar iminium moiety (C=N+) of sanguinarine, a series of novel 2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium salts was designed and synthesized with a vital step of the cyclization between isoquinolin-1-amine and 1,2-dibromoethane, followed by evaluation of the antitumor and antibacterial activity. 2c presented good antitumor activity against NB4 cells (IC50 = 30.00 μM), and 2b showed the best antibacterial activity in most cases among 2a-2c, especially against E. coli and Salmonella, with a MIC value of 241.4 μM. Despite all  compounds 2a-2c showed decreased bioactivity, the results might support the significance of maintaining  a sufficient positive charge on quaternary ammonium ion to exert potential bioactivity. Compared with  2a, the introduction of methyl (2b) or ethyl (2c) could significantly enhance the bioactivity in a possible  manner of stabilizing the positive charge as electron-donating groups. This study provides guidance on the structural design of isoquinoline as an antitumor or antibacterial agent. [ABSTRACT FROM AUTHOR]

Instantaneous heart rate (IHR) has been investigated for sleep applications, such as sleep apnea detection and sleep staging. To ensure the comfort of the patient during sleep, it is desirable for IHR to be measured in a contact-free fashion. In this work, we use speckle vibrometry (SV) to perform on-skin and on-textile IHR monitoring in a sleep setting. Minute motions on the laser-illuminated surface can be captured by a defocused camera, enabling the detection of cardiac motions even on textiles. We investigate supine, lateral, and prone sleeping positions. Based on Bland–Altman analysis between SV cardiac measurements and electrocardiogram (ECG), with respect to each position, we achieve the best limits of agreement with ECG values of [−8.65, 7.79] bpm, [−9.79, 9.25] bpm, and [−10.81, 10.23] bpm, respectively. The results indicate the potential of using speckle vibrometry as a contact-free monitoring method for instantaneous heart rate in a setting where the participant is allowed to rest in a spontaneous position while covered by textile layers.

A series of acyclic selenopurine nucleosides 3a-f and 4a-g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 μM) and HSV-2 (EC50 = 6.34 μM) activities without cytotoxicity up to 100 μM, while 2,6-diaminopurine derivatives 4e-g exhibited significant anti-human cytomegalovirus (HCMV) activity, which is slightly more potent than the guanine derivative 4d, indicating that they might act as prodrugs of seleno-ganciclovir (4d). [ABSTRACT FROM AUTHOR]

This work presents an overview of the main strategies that have been proposed for non-invasive monitoring of heart rate (HR) in extramural and home settings. We discuss three categories of sensing according to what physiological effect is used to measure the pulsatile activity of the heart, and we focus on an illustrative sensing modality for each of them. Therefore, electrocardiography, photoplethysmography, and mechanocardiography are presented as illustrative modalities to sense electrical activity, mechanical activity, and the peripheral effect of heart activity. In this paper, we describe the physical principles underlying the three categories and the characteristics of the different types of sensors that belong to each class, and we touch upon the most used software strategies that are currently adopted to effectively and reliably extract HR. In addition, we investigate the strengths and weaknesses of each category linked to the different applications in order to provide the reader with guidelines for selecting the most suitable solution according to the requirements and constraints of the application.