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Start Over Author "Shirley Cruz" Publication Type Academic Journals
3 results on '"Shirley Cruz"'

3. Novel 2-(substituted phenyl)benzimidazole derivatives with potent activity against IgE, cytokines, and CD23 for the treatment of allergy and asthma.

Author

Richards ML, Lio SC, Sinha A, Tieu KK, and Sircar JC

Subjects
Administration, Oral, Animals, Anti-Allergic Agents chemistry, Anti-Allergic Agents pharmacology, Asthma drug therapy, Asthma immunology, Benzimidazoles chemistry, Benzimidazoles pharmacology, Biological Availability, Cells, Cultured, Female, Hypersensitivity immunology, Mice, Mice, Inbred BALB C, Spleen cytology, Spleen drug effects, Spleen immunology, Structure-Activity Relationship, Th2 Cells immunology, Anti-Allergic Agents chemical synthesis, Benzimidazoles chemical synthesis, Cytokines antagonists & inhibitors, Hypersensitivity drug therapy, Immunoglobulin E biosynthesis, Receptors, IgE antagonists & inhibitors
Abstract

The effectiveness of the injectable anti-IgE antibody omalizumab has validated IgE as an important target for allergic diseases, thus spawning the development of small-molecule IgE inhibitors. Herein, a brief SAR is described for novel phenylbenzimidazole compounds that potently suppress IgE responses. In addition to IgE, these agents inhibit other targets critical for allergic response. The profile of orally active AVP-13358, the lead compound of this series currently in clinical trials, is described.

Published
2004
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