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Cerebrospinal fluid drainage is recommended for high-risk patients to prevent spinal cord ischemia during aortic surgery; however, it is associated with complications. We report a case of a late-onset spinal subdural hematoma that developed after removal of the cerebrospinal fluid drainage tube from a patient who undergon thoracic endovascular aortic repair. Spinal hematoma usually develop 2 to 3 days after tube removal; however, in our patient's case, it developed after 7 days. Therefore, a spinal subdural hematoma can occur ≤1 week after drainage tube removal, necessitating prompt magnetic resonance imaging for patients with lower limb weakness or back pain., (© 2022 The Author(s).)