271 results on '"Shen, Jingkang"'
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2. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors
3. Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction
4. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
5. Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
6. Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site
7. Designing of novel ERRγ inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives
8. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
9. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
10. Stereoselective addition of Grignard reagents to (2-methyl-5-tert-butyl)phenyl 1-thio-β-D-ribopentodialdo-1,4-furanoside derivative
11. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity
12. Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic
13. Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design
14. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors
15. Synthesis and biological evaluation of 6H-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization
16. Discovery of 1H‑Imidazo[4,5‑b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
17. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
18. Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors
19. Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors
20. (N,N-Diisopropylcarbamoyloxy)-methyl p-tolyl sulfone: preparation and application for the syntheses of 1,2-diols
21. Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists
22. Discovery of benzhydrylpiperazine derivatives as CB 1 receptor inverse agonists via privileged structure-based approach
23. Aromatic β-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists
24. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
25. Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
26. Discovery of Novel 2‑Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
27. Illudalic acid as a potential LAR inhibitor: Synthesis, SAR, and preliminary studies on the mechanism of action
28. MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules
29. Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates
30. Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis.
31. One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation
32. Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors
33. MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation
34. Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor
35. DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks
36. Molecular modeling studies of [4-(3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine-based CDK4 inhibitors.
37. Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L
38. Preparation of 5′-deoxy-5′-amino-5′-C-methyl adenosine derivatives and their activity against DOT1L
39. BSSF: a fingerprint based ultrafast binding site similarity search and function analysis server
40. Design and synthesis of benzylpiperidine inhibitors targeting the menin–MLL1 interface
41. Rational Design and Evaluation of 6‑(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)‑ones as Polypharmacological Inhibitors of BET and Kinases.
42. Formation of 1,3-diazocine by palladium catalyzed C–H arylation
43. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
44. Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors
45. Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.
46. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
47. Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study.
48. 1,2-trans-1-Dihydroxyboryl benzyl S-glycoside as glycosyl donor
49. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization
50. Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors.
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