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Your search keyword '"Shao, Zengwu"' showing total 747 results
Start Over Author "Shao, Zengwu" Publication Type Academic Journals
747 results on '"Shao, Zengwu"'

22. Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation

Author

Feng, Yong, Liao, Yunfei, Zhang, Jianming, Shen, Jacson, Shao, Zengwu, Hornicek, Francis, and Duan, Zhenfeng

Subjects
Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Genetics, Cancer, Underpinning research, 2.1 Biological and endogenous factors, Aetiology, 1.1 Normal biological development and functioning, Cell Line, Tumor, Cell Movement, Cell Proliferation, Core Binding Factor beta Subunit, Cyclin-Dependent Kinases, Gene Expression Regulation, Neoplastic, Humans, Osteosarcoma, Promoter Regions, Genetic, Protein Transport, Transcriptional Activation, CDK11, CBF beta, Transcription, CBFβ, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

BACKGROUND:Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 transcriptionally regulated genes are largely unknown. METHODS:In this study, we performed a global transcriptional analysis using gene array technology to investigate the transcriptional role of CDK11 in osteosarcoma. The promoter luciferase assay, chromatin immunoprecipitation assay, and Gel Shift assay were used to identify direct transcriptional targets of CDK11. Clinical relevance and function of core-binding factor subunit beta (CBFβ) were further accessed in osteosarcoma. RESULTS:We identified a transcriptional role of protein-DNA interaction for CDK11p110, but not CDK11p58, in the regulation of CBFβ expression in osteosarcoma cells. The CBFβ promoter luciferase assay, chromatin immunoprecipitation assay, and Gel Shift assay confirmed that CBFβ is a direct transcriptional target of CDK11. High expression of CBFβ is associated with poor outcome in osteosarcoma patients. Expression of CBFβ contributes to the proliferation and metastatic behavior of osteosarcoma cells. CONCLUSIONS:These data establish CBFβ as a mediator of CDK11p110 dependent oncogenesis and suggest that targeting the CDK11- CBFβ pathway may be a promising therapeutic strategy for osteosarcoma treatment.

Published
2019

23. Correction to: Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation

Author

Feng, Yong, Liao, Yunfei, Zhang, Jianming, Shen, Jacson, Shao, Zengwu, Hornicek, Francis, and Duan, Zhenfeng

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

Following publication of the original article [1], it was reported that Figs. 4 and 5 were not updated during the production process.

Published
2019

24. Current Status and Prospects of Immunotherapy for Osteosarcoma

Author

WU Wei, JING Doudou, CAO Li, PU Feifei, and SHAO Zengwu

Subjects
osteosarcoma, tumor immune escape, immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Osteosarcoma is a malignant tumor with extreme invasiveness and metastasis as well as dismal prognosis. It is critical to rapidly find a unique therapy strategy capable of significantly improving the prognosis of osteosarcoma. Tumor immunotherapy has the potential to reawaken the immune system, restart and sustain the tumor-immune cycle in the body, resulting in the death of tumor cells. CD8+ CTL, CD4+ T cells, NK cells and NKT cells all play critical roles in tumor immunity, while humoral immunity may not only inhibit tumor growth but also enhance it. Researchers have devised various strategies to boost the immune system in recent years based on tumor immune response studies. This paper highlights and examines osteosarcoma immunotherapy from two perspectives: (1) boosting the response of patient's own immune system to the tumor; (2) exogenously improving the patient's immunological function.

Published
2022
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30. Graphene derivative based hydrogels in biomedical applications.

Author

Ni, Feifei, Chen, Yangyang, Wang, Ze, Zhang, Xin, Gao, Fei, Shao, Zengwu, and Wang, Hong

Subjects
GRAPHENE oxide, ELECTRIC conductivity, QUANTUM dots, THREE-dimensional printing, GRAPHENE
Abstract

Graphene and its derivatives are widely used in tissue-engineering scaffolds, especially in the form of hydrogels. This is due to their biocompatibility, electrical conductivity, high surface area, and physicochemical versatility. They are also used in tissue engineering. Tissue engineering is suitable for 3D printing applications, and 3D printing makes it possible to construct 3D structures from 2D graphene, which is a revolutionary technology with promising applications in tissue and organ engineering. In this review, the recent literature in which graphene and its derivatives have been used as the major components of hydrogels is summarized. The application of graphene and its derivative-based hydrogels in tissue engineering is described in detail from different perspectives. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Primary intradural extramedullary extraosseous Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (PIEES/PNET) of the thoracolumbar spine: A case report and literature review

Author

Pu Feifei, Liu Jianxiang, Zhang Zhicai, Guo Tao, and Shao Zengwu

Subjects
chemotherapy, piees/pnet, radiotherapy, surgical resection, thoracolumbar, Medicine
Abstract

We present a rare case of a primary intradural extramedullary Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (PIEES/PNET) in the thoracolumbar spine and review the current literature. We describe the imaging manifestations, pathological features, surgical methods, and patient survival to shed light on the clinical management of this rare tumor. A 32-year-old man experienced progressive low back pain for more than 1 month. An intradural extramedullary tumor from T12 to L2 was detected on magnetic resonance imaging. He underwent a thoracolumbar laminotomy for decompression, complete excision of the intradural extramedullary tumor, and internal fixation with pedicle screws. A histopathological examination confirmed that the tumor was a PIEES/PNET via an immunohistochemical study of the surgically resected tissues. Postoperatively, the patient received chemotherapy and radiotherapy. No recurrence, metastasis, or failure of internal fixation were noted at a 17-month post-surgery radiographic examination. PIEES/PNET of the thoracolumbar spine is extremely rare. Treatment is difficult because the current literature is sparse and cases are rare. Complete resection combined with chemotherapy and radiotherapy effectively reduces recurrence and metastasis.

Published
2021
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39. Trends of epidemiological characteristics of traumatic spinal cord injury in China, 2009–2018

Author

Hao, Dingjun, Du, Jinpeng, Yan, Liang, He, Baorong, Qi, Xiao, Yu, Shicheng, Zhang, Jiaojiao, Zheng, Wenjing, Zhang, Rongqiang, Huang, Da-Geng, Yang, Junsong, Zhu, Ming, Ouyang, Jiawei, Zhao, He, Ding, Keyuan, Shi, Haodong, Cao, Yang, Zhang, Ying, Tang, Qinghua, Liu, Yuan, Zhang, Zilong, Wang, Yuhang, Tian, Ye, Chen, Hao, Bai, Lulu, Li, Heng, Mu, Chenchen, Wang, Youhan, Wang, Xiaohui, Jiang, Chao, Lin, Jianhua, Lin, Bin, Fan, Shunwu, Nie, Lin, Song, Jiefu, Ma, Xun, Shao, Zengwu, Gao, Yanzheng, Guan, Zhong, Song, Yueming, Ma, Weihu, and Chen, Qixin

Published
2021
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48. SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration.

Author

Chen, Xuanzuo, Li, Kanglu, Xiao, Yan, Wu, Wei, Lin, Hui, Qing, Xiangcheng, Tian, Shuo, Liu, Sheng, Feng, Shiqing, Wang, Baichuan, Shao, Zengwu, and Peng, Yizhong

Subjects
APOPTOSIS, CELL death inhibition, NUCLEUS pulposus, INTERVERTEBRAL disk, LUMBAR pain
Abstract

Intervertebral disc degeneration (IDD) is an age‐related disease and is responsible for low back pain. Oxidative stress‐induced cell death plays a fundamental role in IDD pathogenesis. Cuproptosis is a recently discovered form of programmed cell death dependent on copper availability. Whether cuproptosis is involved in IDD progression remains unknown. Herein, we established in vitro and in vivo models to investigate cuproptosis in IDD and the mechanisms by which oxidative stress interacts with copper sensitivity in nucleus pulposus cells (NPCs). We found that ferredoxin‐1 (FDX1) content increased in both rat and human degenerated discs. Sublethal oxidative stress on NPCs led to increased FDX1 expression, tricarboxylic acid (TCA) cycle‐related proteins lipoylation and aggregation, and cell death in the presence of Cu2+ at physiological concentrations, while FDX1 knockdown inhibited cell death. Since copper homeostasis is involved in copper‐induced cytotoxicity, we investigated the role of copper transport‐related proteins, including importer (CTR1) and efflux pumps (ATPase transporter, ATP7A, and ATP7B). CTR1 and ATP7A content increased under oxidative stress, and blocking CTR1 reduced oxidative stress/copper‐induced TCA‐related protein aggregation and cell death. Moreover, oxidative stress promoted the expression of specific protein 1 (SP1) and SP1‐mediated CTR1 transcription. SP1 inhibition decreased cell death rates, preserved disc hydration, and alleviated tissue degeneration. This suggests that oxidative stress upregulates FDX1 expression and copper flux through promoting SP1‐mediated CTR1 transcription, leading to increased TCA cycle‐related protein aggregation and cuproptosis. This study highlights the importance of cuproptosis in IDD progression and provides a promising therapeutic target for IDD treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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