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Your search keyword '"Shao, Qian"' showing total 842 results
Start Over Author "Shao, Qian" Publication Type Academic Journals
842 results on '"Shao, Qian"'

11. Two C-terminal isoforms of Aplysia tachykinin–related peptide receptors exhibit phosphorylation-dependent and phosphorylation-independent desensitization mechanisms

Author

Mao, Rui-ting, Guo, Shi-qi, Zhang, Guo, Li, Ya-dong, Xu, Ju-ping, Wang, Hui-ying, Fu, Ping, Liu, Cui-ping, Wu, Shao-qian, Chen, Ping, Mei, Yu-shuo, Jin, Qing-chun, Liu, Cheng-yi, Zhang, Yan-chu-fei, Ding, Xue-ying, Liu, Wei-jia, Romanova, Elena V., Zhou, Hai-bo, Cropper, Elizabeth C., Checco, James W., Sweedler, Jonathan V., and Jing, Jian

Published
2024
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16. Prevention of STAT3-related pathway in SK-N-SH cells by natural product astaxanthin

Author

Shao-Qian Sun, Feng-Xiang Du, Li-Hua Zhang, Hao-Shi, Fu-Ying Gu, Yu-Lin Deng, and Yi-Zhi Ji

Subjects
Neuroblastoma, Astaxanthin, STAT3, Cell proliferation, Apoptosis, Cell migration inhibition, Other systems of medicine, RZ201-999
Abstract

Abstract Purpose Neuroblastoma (NB) is the most common solid malignancy in children. Despite current intensive treatment, the long-term event-free survival rate is less than 50% in these patients. Thus, patients with NB urgently need more valid treatment strategies. Previous research has shown that STAT3 may be an effective target in high-risk NB patients. However, there are no effective inhibitors in clinical evaluation with low toxicity and few side effects. Astaxanthin is a safe and natural anticancer product. In this study, we investigated whether astaxanthin could exert antitumor effects in the SK-N-SH neuroblastoma cancer cell line. Method MTT and colony formation assays were used to determine the effect of astaxanthin on the proliferation and colony formation of SK-N-SH cells. Flow cytometry assays were used to detect the apoptosis of SK-N-SH cells. The migration and invasion ability of SK-N-SH cells were detected by migration and invasion assays. Western blot and RT-PCR were used to detect the protein and mRNA levels. Animal experiments were carried out and cell apoptosis in tissues were assessed using a TUNEL assay. Result We confirmed that astaxanthin repressed proliferation, clone formation ability, migration and invasion and induced apoptosis in SK-N-SH cells through the STAT3 pathway. Furthermore, the highest inhibitory effect was observed when astaxanthin was combined with si-STAT3. The reason for this may be that the combination of astaxanthin and si-STAT3 can lower STAT3 expression further than astaxanthin or si-STAT3 alone. Conclusion Astaxanthin can exert anti-tumor effect on SK-N-SH cells. The inhibitory effect was the higher when astaxanthin was combined with si-STAT3.

Published
2023
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25. Case Report: CD19 and CD20 monoclonal antibodies with sequential chemotherapy for refractory acute B-lymphocytic leukemia in children

Author

Jia-Nan Li, Yu Li, Ji-Xun Lin, Li-Na Wang, Xiao-Li Zhang, Juan Ouyang, Du-Bo Chen, Shao-Qian Chen, Jun-Xun Li, Xue-Qun Luo, Yan-Lai Tang, and Li-Bin Huang

Subjects
blinatumomab, refractory acute B-lymphocytic leukemia, allo hematopoietic stem cell transplantation, rituximab, minimal residual disease, Immunologic diseases. Allergy, RC581-607
Abstract

ObjectiveThis paper observes the efficacy of chemotherapy combined with CD19 and CD20 monoclonal antibodies in clearing minimal residual disease (MRD) and bridging transplantation for refractory acute B-lymphoblastic leukemia (B-ALL) in children and reviews the literature.MethodsA 4-year-old boy diagnosed with B-ALL in our hospital was treated with the SCCLG-ALL-2016 protocol. MRD and gene quantification decreased after induction but remained persistently positive, with poor efficacy. After this patient received three cycles of consolidation chemotherapy combined with blinatumomab and rituximab, MRD and fusion gene quantification became negative, and he received allogeneic hematopoietic stem cell transplantation (allo-HSCT).ResultsDuring the use of monoclonal antibodies, neurotoxicity, CRS, or other side effects did not occur. Before transplantation, MRD became negative, and the bone marrow had been in complete remission since transplantation (13 months).ConclusionChemotherapy combined with blinatumomab for refractory B-ALL in children can bring a better remission rate for patients and is a means of bridging transplantation. Nevertheless, sequential CD20 monoclonal antibody therapy is the first report , and no adverse effects were observed in our case. It is well tolerated and can be used as one of the treatments for refractory B-ALL.

Published
2023
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34. Four cases of localized plaque psoriasis successfully treated by intense pulsed light: A case series

Author

Cai-Xia Hu, Yu Cui, Yi Cheng, Shun-Qiang Gao, Wen-Qing Wang, Shao-Qian Jiang, and Yan Zhang

Subjects
Medicine
Abstract

Four patients with localized plaque psoriasis had used various systemic drugs along with topical cream. However, their skin lesions recurred, and the disease was refractory. After 2 weeks of discontinuation of oral and external medication, they were given three consecutive irradiation treatments with intense pulsed light once every 2 weeks for a 6-week period. After treating for 6 weeks, the erythema colors of the patients were evidently darkened, the scales were evidently reduced, and the skin lesions were significantly thinner or even flattened. The treatment was satisfactory, without occurrence of severe adverse reactions.

Published
2023
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36. Modifying Polyvinylidene Chloride Resin with Fluorine Monomer and Cross‐Linking Monomers.

Author

Gao, Fengjun, Zhang, Zhifeng, Song, Qianqian, Abo‐Dief, Hala M., Alzahrani, Eman, Wang, Shouyang, Liu, Yan, Shao, Qian, Yang, Jing, Guo, Zhanhu, El‐Bahy, Zeinhom M., and Ge, Ruixiang

Abstract

Modified polyvinylidene chloride (PVDC) resin was prepared using octafluoropentyl methacrylate and trimethylolpropane trimethacrylate as modifying monomers through seeded emulsion polymerization. The successful incorporation of octafluoropentyl methacrylate into the PVDC resin was confirmed by Fourier transform infrared spectroscopy (FTIR) and X‐ray photoelectron spectroscopy (XPS) analyses. Scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and XPS were utilized to investigate the element distribution in the modified monomer emulsion and the mechanism of monomer modification. The results demonstrated that the fluorine monomer was reacted in the resin, and mainly concentrated on the surface of the resin. The addition of octafluoropentyl methacrylate and trimethylolpropane trimethacrylate improved the water resistance of the resin. Compared to unmodified PVDC resin, the contact angle of the modified PVDC resin increased from 89.46° to 109.51°, and the water resistance at room temperature increased from 120 to 500 h. Furthermore, the modified resin exhibited excellent mechanical properties, thermal stability, and storage stability. [ABSTRACT FROM AUTHOR]

Published
2024
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