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[FeFe]-hydrogenases function as both H2 catalysts and sensors. While catalysis is well investigated, details regarding the H2 sensing mechanism are limited. Here, we relate protein structure changes to H2 sensing, similar to light-driven bio-sensors. Our results highlight how identical cofactors incorporated in alternative protein scaffolds serve different functions in nature. [ABSTRACT FROM AUTHOR]

Hydrogen is considered one of the key enablers of the transition towards a sustainable and net-zero carbon economy. When produced from renewable sources, hydrogen can be used as a clean and carbon-free energy carrier, as well as improve the sustainability of a wide range of industrial processes. Photobiological hydrogen production is considered one of the most promising technologies, avoiding the need for renewable electricity and rare earth metal elements, the demands for which are greatly increasing due to the current simultaneous electrification and decarbonization goals. Photobiological hydrogen production employs photosynthetic microorganisms to harvest solar energy and split water into molecular oxygen and hydrogen gas, unlocking the long-pursued target of solar energy storage. However, photobiological hydrogen production has to-date been constrained by several limitations. This review aims to discuss the current state-of-the art regarding hydrogenase-driven photobiological hydrogen production. Emphasis is placed on engineering strategies for the expression of improved, non-native, hydrogenases or photosynthesis re-engineering, as well as their combination as one of the most promising pathways to develop viable large-scale hydrogen green cell factories. Herein we provide an overview of the current knowledge and technological gaps curbing the development of photobiological hydrogenase-driven hydrogen production, as well as summarizing the recent advances and future prospects regarding the expression of non-native hydrogenases in cyanobacteria and green algae with an emphasis on [FeFe] hydrogenases. [ABSTRACT FROM AUTHOR]

Baseball players have demonstrated greater thoracolumbar rotation (TLR) range of motion (ROM) toward their nonthrowing arm sides. This imbalance is thought to be compensatory to ROM deficiencies at the throwing arm's shoulder. The purpose of this study was to examine the relationship between TLR and glenohumeral (GH) ROM measures (internal rotation, external rotation, horizontal adduction) among collegiate baseball players. Findings demonstrated limited and no relationships between TLR and GH ROM. Future research should advance these findings by examining symptomatic participants and hip ROM as additional variables. Doing so may enhance clinicians' abilities to comprehensively predict, prevent, detect, and treat movement deficiencies, and subsequent injuries, suffered by competitive baseball players. [ABSTRACT FROM AUTHOR]