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694 results on '"Sahin, Ugur"'

1. Expression of the tumor antigens NY-ESO-1, tyrosinase, MAGE-A3, and TPTE in pediatric and adult melanoma: a retrospective case control study

Author

Forchhammer, Stephan, Pop, Oltin Tiberiu, Hahn, Matthias, Aebischer, Valentin, Seitz, Christian M., Schroeder, Christopher, Liebmann, Alexandra, Abele, Michael, Wild, Hannah, Bien, Ewa, Kunc, Michal, Schneider, Dominik T., Cuk, Katarina, Büttel, Isabel, Flemmig, Carina, Peters, Magdalena, Laible, Mark, Brück, Patrick, Türeci, Özlem, Sahin, Ugur, Flatz, Lukas, and Brecht, Ines B.

Published
2024
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7. Prediction of response to neoadjuvant chemotherapy by MammaTyper® across breast cancer subtypes: A retrospective cross-sectional study

Author

Schettini, Francesco, Saracchini, Silvana, Bassini, Anna, Marus, Wally, Corsetti, Serena, Specogna, Ilaria, Bertola, Manuela, Micheli, Elvia, Wirtz, Ralph M., Laible, Mark, Şahin, Uğur, Strina, Carla, Milani, Manuela, Aguggini, Sergio, Tancredi, Richard, Fiorio, Elena, Sulfaro, Sandro, and Generali, Daniele

Published
2024
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9. More than a Virus: How COVID 19 Infected Education in Turkey?

Author

Akbulut, Melisa, Sahin, Ugur, and Esen, Ali Can

Abstract

Purpose: We aim with this report to provide information on how the Covid-19 pandemic affected education and citizenship education in Turkey. Design: The report is based on literature review, the analysis of social media, and the observations of the authors. We provide a general framework of Turkish education after the pandemic using sources such as official statements from government offices; social media entries were analyzed to provide different perspectives. Finally, observations of the authors based on their experiences with distance learning were included in the report. Findings: We argue that despite the efforts of the state, there are still problems in the distance learning process, mainly relating to the access to online classes and the very limited room given to Covid-19 as a topic in social studies courses. In addition, we find that social media have played a significant role in increasing citizen participation as a consequence of the pandemic.

Published
2020

11. Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer

Author

De Sanctis, Francesco, Dusi, Silvia, Caligola, Simone, Anselmi, Cristina, Petrova, Varvara, Rossi, Barbara, Angelini, Gabriele, Erdeljan, Michael, Wöll, Stefan, Schlitter, Anna Melissa, Metzler, Thomas, Steiger, Katja, Borok, Zea, Bailey, Peter, Bauer, Aline, Halin, Cornelia, Boschi, Federico, Giugno, Rosalba, Canè, Stefania, Lawlor, Rita, Corbo, Vincenzo, Scarpa, Aldo, Constantin, Gabriela, Ugel, Stefano, Vascotto, Fulvia, Sahin, Ugur, Türeci, Özlem, and Bronte, Vincenzo

Published
2024
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13. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Author

Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., and Balachandran, Vinod P.

Published
2023
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20. Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity

Author

Muik, Alexander, Lui, Bonny Gaby, Quandt, Jasmin, Diao, Huitian, Fu, Yunguan, Bacher, Maren, Gordon, Jessica, Toker, Aras, Grosser, Jessica, Ozhelvaci, Orkun, Grikscheit, Katharina, Hoehl, Sebastian, Kohmer, Niko, Lustig, Yaniv, Regev-Yochay, Gili, Ciesek, Sandra, Beguir, Karim, Poran, Asaf, Vogler, Isabel, Türeci, Özlem, and Sahin, Ugur

Published
2023
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22. The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection

Author

Arieta, Christina M., Xie, Yushu Joy, Rothenberg, Daniel A., Diao, Huitian, Harjanto, Dewi, Meda, Shirisha, Marquart, Krisann, Koenitzer, Byron, Sciuto, Tracey E., Lobo, Alexander, Zuiani, Adam, Krumm, Stefanie A., Cadima Couto, Carla Iris, Hein, Stephanie, Heinen, André P., Ziegenhals, Thomas, Liu-Lupo, Yunpeng, Vogel, Annette B., Srouji, John R., Fesser, Stephanie, Thanki, Kaushik, Walzer, Kerstin, Addona, Theresa A., Türeci, Özlem, Şahin, Uğur, Gaynor, Richard B., and Poran, Asaf

Published
2023
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27. Hybrid core-shell particles for mRNA systemic delivery

Author

Andretto, Valentina, Repellin, Mathieu, Pujol, Marine, Almouazen, Eyad, Sidi-Boumedine, Jacqueline, Granjon, Thierry, Zhang, Heyang, Remaut, Katrien, Jordheim, Lars Petter, Briançon, Stéphanie, Keil, Isabell Sofia, Vascotto, Fulvia, Walzer, Kerstin C., Sahin, Ugur, Haas, Heinrich, Kryza, David, and Lollo, Giovanna

Published
2023
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29. Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial

Author

Hui, Ai-Min, Li, Jingxin, Zhu, Li, Tang, Rong, Ye, Huayue, Lin, Mei, Ge, Lei, Wang, Xiyuan, Peng, Fuzhong, Wu, Zhenggang, Guo, Xiling, Shi, Yunfeng, Pan, Hongxing, Zhu, Jiahong, Song, Zhizhou, Qiu, Jingjun, Wang, Wei, Zheng, Jianfei, Ozhelvaci, Orkun, Shpyro, Svetlana, Bushway, Meghan, Derhovanessian, Evelyna, Kühnle, Marie-Cristine, Luxemburger, Ulrich, Muik, Alexander, Shishkova, Yoana, Khondker, Zakaria, Hu, Simin, Lagkadinou, Eleni, Şahin, Uğur, Türeci, Özlem, and Zhu, Fengcai

Published
2022
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30. Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma* [S]

Author

Shraibman, Bracha, Barnea, Eilon, Kadosh, Dganit Melamed, Haimovich, Yael, Slobodin, Gleb, Rosner, Itzhak, López-Larrea, Carlos, Hilf, Norbert, Kuttruff, Sabrina, Song, Colette, Britten, Cedrik, Castle, John, Kreiter, Sebastian, Frenzel, Katrin, Tatagiba, Marcos, Tabatabai, Ghazaleh, Dietrich, Pierre-Yves, Dutoit, Valérie, Wick, Wolfgang, Platten, Michael, Winkler, Frank, von Deimling, Andreas, Kroep, Judith, Sahuquillo, Juan, Martinez-Ricarte, Francisco, Rodon, Jordi, Lassen, Ulrik, Ottensmeier, Christian, van der Burg, Sjoerd H, Thor Straten, Per, Poulsen, Hans Skovgaard, Ponsati, Berta, Okada, Hideho, Rammensee, Hans-Georg, Sahin, Ugur, Singh, Harpreet, and Admon, Arie

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Rare Diseases, Brain Disorders, Neurosciences, Brain Cancer, Cancer, Good Health and Well Being, Alleles, Antigens, Neoplasm, Biomarkers, Tumor, Brain Neoplasms, Glioblastoma, Histocompatibility Antigens Class I, Humans, Peptides, Proteome, CTA, Cancer Biomarker(s), Cancer Therapeutics, HLA, Immunoaffinity, Immunotherapy, MHC, Peptidomics, Plasma or Serum Analysis, Biochemistry & Molecular Biology
Abstract

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. Further, early detection of GBM, such as by a routine blood test, may improve survival, even with the current treatment modalities. This study includes large-scale analyses of the HLA peptidome (immunopeptidome) of the plasma-soluble HLA molecules (sHLA) of 142 plasma samples, and the membranal HLA of GBM tumors of 10 of these patients' tumor samples. Tumor samples were fresh-frozen immediately after surgery and the plasma samples were collected before, and at multiple visits after surgery. In total, this HLA peptidome analysis involved 52 different HLA allotypes and resulted in the identification of more than 35,000 different HLA peptides. Strong correlations were observed in the signal intensities and in the repertoires of identified peptides between the tumors and plasma-soluble HLA peptidomes of the individual patients, whereas low correlations were observed between these HLA peptidomes and the tumors' proteomes. HLA peptides derived from Cancer/Testis Antigens (CTAs) were selected based on their presence among the HLA peptidomes of the patients and absence of expression of their source genes from any healthy and essential human tissues, except from immune-privileged sites. Additionally, peptides were selected as potential biomarkers if their levels in the plasma-sHLA peptidome were significantly reduced after the removal of tumor mass. The CTAs identified among the analyzed HLA peptidomes provide new opportunities for personalized immunotherapy and for early diagnosis of GBM.

Published
2019

38. BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Author

Sahin, Ugur, Muik, Alexander, Vogler, Isabel, Derhovanessian, Evelyna, Kranz, Lena M., Vormehr, Mathias, Quandt, Jasmin, Bidmon, Nicole, Ulges, Alexander, Baum, Alina, Pascal, Kristen E., Maurus, Daniel, Brachtendorf, Sebastian, Lorks, Verena, Sikorski, Julian, Koch, Peter, and Hilker, Rolf

Subjects
T cells -- Health aspects, Viral antibodies -- Health aspects, Antibodies -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

BNT162b2, a nucleoside-modified mRNA formulated in lipid nanoparticles that encodes the SARS-CoV-2 spike glycoprotein (S) stabilized in its prefusion conformation, has demonstrated 95% efficacy in preventing COVID-19.sup.1. Here we extend a previous phase-I/II trial report.sup.2 by presenting data on the immune response induced by BNT162b2 prime-boost vaccination from an additional phase-I/II trial in healthy adults (18-55 years old). BNT162b2 elicited strong antibody responses: at one week after the boost, SARS-CoV-2 serum geometric mean 50% neutralizing titres were up to 3.3-fold above those observed in samples from individuals who had recovered from COVID-19. Sera elicited by BNT162b2 neutralized 22 pseudoviruses bearing the S of different SARS-CoV-2 variants. Most participants had a strong response of IFN[gamma].sup.+ or IL-2.sup.+ CD8.sup.+ and CD4.sup.+ T helper type 1 cells, which was detectable throughout the full observation period of nine weeks following the boost. Using peptide-MHC multimer technology, we identified several BNT162b2-induced epitopes that were presented by frequent MHC alleles and conserved in mutant strains. One week after the boost, epitope-specific CD8.sup.+ T cells of the early-differentiated effector-memory phenotype comprised 0.02-2.92% of total circulating CD8.sup.+ T cells and were detectable (0.01-0.28%) eight weeks later. In summary, BNT162b2 elicits an adaptive humoral and poly-specific cellular immune response against epitopes that are conserved in a broad range of variants, at well-tolerated doses. In a phase-I/II trial in healthy adults, the BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells against SARS-CoV-2 epitopes that are conserved in a wide range of currently circulating variants., Author(s): Ugur Sahin [sup.1] [sup.2] , Alexander Muik [sup.1] , Isabel Vogler [sup.1] , Evelyna Derhovanessian [sup.1] , Lena M. Kranz [sup.1] , Mathias Vormehr [sup.1] , Jasmin Quandt [sup.1] [...]

Published
2021
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42. BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Author

Vogel, Annette B., Kanevsky, Isis, Che, Ye, Swanson, Kena A., Muik, Alexander, Vormehr, Mathias, Kranz, Lena M., Walzer, Kerstin C., Hein, Stephanie, Güler, Alptekin, Loschko, Jakob, Maddur, Mohan S., Ota-Setlik, Ayuko, Tompkins, Kristin, Cole, Journey, Lui, Bonny G., Ziegenhals, Thomas, Plaschke, Arianne, Eisel, David, Dany, Sarah C., Fesser, Stephanie, Erbar, Stephanie, Bates, Ferdia, Schneider, Diana, Jesionek, Bernadette, Sänger, Bianca, Wallisch, Ann-Kathrin, Feuchter, Yvonne, Junginger, Hanna, Krumm, Stefanie A., Heinen, André P., Adams-Quack, Petra, Schlereth, Julia, Schille, Stefan, Kröner, Christoph, de la Caridad Güimil Garcia, Ramón, Hiller, Thomas, Fischer, Leyla, Sellers, Rani S., Choudhary, Shambhunath, Gonzalez, Olga, Vascotto, Fulvia, Gutman, Matthew R., Fontenot, Jane A., Hall-Ursone, Shannan, Brasky, Kathleen, Griffor, Matthew C., Han, Seungil, Su, Andreas A. H., Lees, Joshua A., Nedoma, Nicole L., Mashalidis, Ellene H., Sahasrabudhe, Parag V., Tan, Charles Y., Pavliakova, Danka, Singh, Guy, Fontes-Garfias, Camila, Pride, Michael, Scully, Ingrid L., Ciolino, Tara, Obregon, Jennifer, Gazi, Michal, Carrion, Jr, Ricardo, Alfson, Kendra J., Kalina, Warren V., Kaushal, Deepak, Shi, Pei-Yong, Klamp, Thorsten, Rosenbaum, Corinna, Kuhn, Andreas N., Türeci, Özlem, Dormitzer, Philip R., Jansen, Kathrin U., and Sahin, Ugur

Published
2021
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49. COVID-19 vaccine BNT162b1 elicits human antibody and T.sub.H1 T cell responses

Author

Sahin, Ugur, Muik, Alexander, Derhovanessian, Evelyna, Vogler, Isabel, Kranz, Lena M., Vormehr, Mathias, and Baum, Alina

Subjects
T cells -- Analysis -- Health aspects -- Physiological aspects, Immune response -- Analysis -- Physiological aspects -- Health aspects, Viral antibodies -- Analysis -- Physiological aspects -- Health aspects, Antibodies -- Analysis -- Physiological aspects -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Comirnaty (Vaccine) -- Dosage and administration -- Health aspects
Abstract

An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, tolerability and antibody response data from an ongoing placebo-controlled, observer-blinded phase I/II coronavirus disease 2019 (COVID-19) vaccine trial with BNT162b1, a lipid nanoparticle-formulated nucleoside-modified mRNA that encodes the receptor binding domain (RBD) of the SARS-CoV-2 spike protein.sup.1. Here we present antibody and T cell responses after vaccination with BNT162b1 from a second, non-randomized open-label phase I/II trial in healthy adults, 18-55 years of age. Two doses of 1-50 [mu]g of BNT162b1 elicited robust CD4.sup.+ and CD8.sup.+ T cell responses and strong antibody responses, with RBD-binding IgG concentrations clearly above those seen in serum from a cohort of individuals who had recovered from COVID-19. Geometric mean titres of SARS-CoV-2 serum-neutralizing antibodies on day 43 were 0.7-fold (1-[mu]g dose) to 3.5-fold (50-[mu]g dose) those of the recovered individuals. Immune sera broadly neutralized pseudoviruses with diverse SARS-CoV-2 spike variants. Most participants had T helper type 1 (T.sub.H1)-skewed T cell immune responses with RBD-specific CD8.sup.+ and CD4.sup.+ T cell expansion. Interferon-[gamma] was produced by a large fraction of RBD-specific CD8.sup.+ and CD4.sup.+ T cells. The robust RBD-specific antibody, T cell and favourable cytokine responses induced by the BNT162b1 mRNA vaccine suggest that it has the potential to protect against COVID-19 through multiple beneficial mechanisms. In a phase I/II dose-escalation clinical trial, the mRNA COVID-19 vaccine BNT162b1 elicits specific T cell and antibody responses that suggest it has protective potential., Author(s): Ugur Sahin [sup.1] [sup.2] , Alexander Muik [sup.1] , Evelyna Derhovanessian [sup.1] , Isabel Vogler [sup.1] , Lena M. Kranz [sup.1] , Mathias Vormehr [sup.1] , Alina Baum [sup.3] [...]

Published
2020
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50. An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Author

Sahin, Ugur, Oehm, Petra, Derhovanessian, Evelyna, Jabulowsky, Robert A., Vormehr, Mathias, Gold, Maike, Maurus, Daniel, Schwarck-Kokarakis, Doreen, Kuhn, Andreas N., Omokoko, Tana, Kranz, Lena M., Diken, Mustafa, Kreiter, Sebastian, Haas, Heinrich, Attig, Sebastian, Rae, Richard, Cuk, Katarina, Kemmer-Brück, Alexandra, Breitkreuz, Andrea, Tolliver, Claudia, Caspar, Janina, Quinkhardt, Juliane, Hebich, Lisa, Stein, Malte, Hohberger, Alexander, Vogler, Isabel, Liebig, Inga, Renken, Stephanie, Sikorski, Julian, Leierer, Melanie, Müller, Verena, Mitzel-Rink, Heidrun, Miederer, Matthias, Huber, Christoph, Grabbe, Stephan, Utikal, Jochen, Pinter, Andreas, Kaufmann, Roland, Hassel, Jessica C., Loquai, Carmen, and Türeci, Özlem

Published
2020
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