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1. Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study

Author

Castro-Espin, Carlota, Cairat, Manon, Navionis, Anne-Sophie, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Mellemkjær, Lene, Mancini, Francesca Romana, Hajji-Louati, Mariem, Severi, Gianluca, Le Cornet, Charlotte, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Sacerdote, Carlotta, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Smith-Byrne, Karl, Heath, Alicia K., Christakoudi, Sofia, Gunter, Marc J., Rinaldi, Sabina, Agudo, Antonio, and Dossus, Laure

Published
2024
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3. Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Heymer, Emma J., Hawkins, Michael M., Winter, David L., Teepen, Jop C., Sunguc, Ceren, Ronckers, Cécile M., Allodji, Rodrigue S., Alessi, Daniela, Sugden, Elaine, Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Garwicz, Stanislaw, Grabow, Desiree, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Michel, Gisela, Schindera, Christina, Haddy, Nadia, Journy, Neige, Česen Mazić, Maja, Skinner, Roderick, Kok, Judith L., Gunnes, Maria W., Wiebe, Thomas, Sacerdote, Carlotta, Maule, Milena M., Terenziani, Monica, Jakab, Zsuzsanna, Winther, Jeanette F., Lähteenmäki, Päivi M., Zadravec Zaletel, Lorna, Haupt, Riccardo, Kuehni, Claudia E., Kremer, Leontien C., de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2024
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4. HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation.

Author

Grigoryan, Hasmik, Imani, Partow, Sacerdote, Carlotta, Masala, Giovanna, Grioni, Sara, Tumino, Rosario, Chiodini, Paolo, Dudoit, Sandrine, Vineis, Paolo, and Rappaport, Stephen M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Lymphoma, Hematology, Cancer, Aetiology, 2.2 Factors relating to the physical environment, Humans, Male, Female, Serum Albumin, Human, Reactive Oxygen Species, Sex Characteristics, Incidence, Prospective Studies, Cysteine, Lymphoma, Non-Hodgkin, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe higher incidence of non-Hodgkin lymphoma (NHL) in males is not well understood. Although reactive oxygen species (ROS) have been implicated as causes of NHL, they cannot be measured directly in archived blood.MethodsWe performed untargeted adductomics of stable ROS adducts in human serum albumin (HSA) from 67 incident NHL cases and 82 matched controls from the European Prospective Investigation into Cancer and Nutrition-Italy cohort. Regression and classification methods were employed to select features associated with NHL in all subjects and in males and females separately.ResultsSixty seven HSA-adduct features were quantified by liquid chromatography-high-resolution mass spectrometry at Cys34 (n = 55) and Lys525 (n = 12). Three features were selected for association with NHL in all subjects, while seven were selected for males and five for females with minimal overlap. Two selected features were more abundant in cases and seven in controls, suggesting that altered homeostasis of ROS may affect NHL incidence. Heat maps revealed differential clustering of features between sexes, suggesting differences in operative pathways.ConclusionsAdduct clusters dominated by Cys34 oxidation products and disulfides further implicate ROS and redox biology in the etiology of NHL. Sex differences in dietary and alcohol consumption also help to explain the limited overlap of feature selection between sexes. Intriguingly, a disulfide of methanethiol from enteric microbial metabolism was more abundant in male cases, thereby implicating microbial translocation as a potential contributor to NHL in males.ImpactOnly two of the ROS adducts associated with NHL overlapped between sexes and one adduct implicates microbial translocation as a risk factor.

Published
2023

5. PORTARIA DE CONSOLIDAÇÃO N5/2017 E AS FAIXAS DE TEMPERATURA ESTABELECIDAS PARA TRANSPORTE DE SANGUE TOTAL: DESAFIO PARA CAMPANHAS DE DOAÇÃO REALIZADAS FORA DOS HEMOCENTROS

Author

JP Cogo, PG Schimites, WB Weber, IR Schimites, GF Peres, MA Froener, and MD Sacerdote

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Objetivos: Analisar as faixas de temperatura de transporte de sangue total definidas na Portaria de Consolidação N°5/2017 no contexto de campanhas externas de doação de sangue. Material e métodos: Avaliou-se a Portaria de Consolidação N°5/2017, em seu artigo 269, §2°e 3°(Origem: PRT MS/GM 158/2016, Art. 270, §2°e 3°, respectivamente), relativos às temperaturas de transporte de sangue total para a manutenção das propriedades biológicas dos hemocomponentes a serem produzidos. Discussão: O Art. 269, §2°, estipula que o sangue total nas coletas externas deve ser transportado na faixa de temperatura de 20 a 24°C, uma vez que para se processar concentrado de plaquetas a temperatura não deve ser inferior a 20°C. No §3°é informado que em casos que não seja desejado o fracionamento de plaquetas, o sangue total poderá ser transportado na faixa de 1 a 10°C. Assim, a faixa de temperatura entre 10 e 20°C não é permitida para o transporte do sangue total, segundo a portaria, mas não são encontrados na literatura científica estudos demonstrando porque esta faixa não é permitida. As coletas externas são situações em que os profissionais podem não encontrar as condições ideais, como aquelas dos hemocentros, para a realização das atividades, uma vez que as coletas podem ocorrer em unidades básicas de saúde, hospitais ou mesmo em ônibus próprios para este fim, o que demanda adaptações desses espaços para garantir a qualidade do sangue coletado e dos hemocomponentes a serem produzidos. Uma dificuldade encontrada pelos autores em coletas externas é o transporte de sangue total na faixa de 1 a 10°C (quando não serão processadas plaquetas), situação que exigiria sempre a disponibilidade de refrigeradores para esta finalidade, o que não acontece. Mesmo quando há refrigeradores disponíveis, o tempo necessário para o resfriamento acaba sendo longo. Com isso, validamos e estabelecemos em nosso POP que a faixa de temperatura ideal para o transporte do sangue total em coletas externas é a de 20 a 24°C, independentemente do fracionamento ou não de concentrado de plaquetas, uma vez que o concentrado de hemácias pode ser processado em qualquer das duas faixas de temperatura consideradas. Em razão do tempo entre a coleta e o processamento, não fracionamos plasma devido a possível perda de atividade de fatores de coagulação caso o plasma não seja congelado em até 8 horas. Uma publicação de 2020 da International Society of Blood Transfusion (ISBT), que trata do transporte e armazenamento de sangue, traz a informação de que o sangue recém coletado deve ser armazenado em caixa térmica com gelo reciclável para que a temperatura seja reduzida de 37°C para 22±2°C em até 4 horas após a coleta, mas para isso, considera que o gelo reciclável deve conter material com ponto de fusão de 18°C a ser congelado entre 1 e 10°C. O gelo reciclável que temos disponível tem como recomendação a sua manutenção em -22°C por 72 horas antes do uso. Conclusão: A adequação dos processos em coletas externas visando à manutenção da qualidade dos hemocomponentes nos fez estabelecer a temperatura de 22±2°C no transporte de sangue total, para que este não corresse o risco de atingir temperaturas inferiores a 20°C durante o transporte, o que inviabilizaria o processamento de plaquetas e implicaria no desprezo do sangue. Ainda, o tempo necessário para o sangue total chegar ao hemocentro para ser processado foi reduzido por não ser necessário esperar atingir temperatura inferior a 10°C.

Published
2024
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6. Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analysesResearch in context

Author

Sabrina E. Wang, Vivian Viallon, Matthew Lee, Niki Dimou, Fergus Hamilton, Carine Biessy, Tracy O'Mara, Maria Kyrgiou, Emma J. Crosbie, Therese Truong, Gianluca Severi, Rudolf Kaaks, Renée Turzanski Fortner, Matthias B. Schulze, Benedetta Bendinelli, Sieri Sabina, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Marta Crous-Bou, Maria-Jose Sánchez, Amaia Aizpurua, Daniel Rodriguez Palacios, Marcela Guevara, Ruth C. Travis, Konstantinos K. Tsilidis, Alicia Heath, James Yarmolinsky, Sabina Rinaldi, Marc J. Gunter, and Laure Dossus

Subjects
Endometrial cancer, Proteomics, Interleukin-6, HSD11B1, Mendelian randomisation, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: Inflammation and immune dysregulation are hypothesized contributors to endometrial carcinogenesis; however, the precise underlying mechanisms remain unclear. Methods: We measured pre-diagnostically 152 plasma protein biomarkers in 624 endometrial cancer case-control pairs nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Odds ratios (ORs) were estimated using conditional logistic regression, accounting for confounding and multiple comparisons. Proteins considered as associated with endometrial cancer risk were further tested in a two-sample Mendelian randomization (MR) analysis using summary data from the UK Biobank (n = 52,363) and the Endometrial Cancer Association Consortium (12,270 cases and 46,126 controls). Findings: In the EPIC nested case-control study, IL-6 [OR per NPX (doubling of concentration) = 1.28 (95% confidence interval (CI) 1.03–1.57)], HGF [1.48 (1.06–2.07)], PIK3AP1 [1.22 (1.00–1.50)] and CLEC4G [1.52 (1.00–2.32)] were positively associated; HSD11B1 [0.67 (0.49–0.91)], SCF [0.68 (0.49–0.94)], and CCL25 [0.80 (0.65–0.99)] were inversely associated with endometrial cancer risk; all estimates had multiple comparisons adjusted P-value > 0.05. In complementary MR analysis, IL-6 [OR per inverse-rank normalized NPX = 1.19 (95% CI 1.04–1.36)] and HSD11B1 [0.91 (0.84–0.99)] were associated with endometrial cancer risk. Interpretation: Altered IL-6 signalling and reduced glucocorticoid activity via HSD11B1 might play important roles in endometrial carcinogenesis. Funding: Funding for IIG_FULL_2021_008 was obtained from Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme; Funding for INCA_15849 was obtained from Institut National du Cancer (INCa).

Published
2024
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7. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author

Tong, Tammy Y. N., Clarke, Robert, Schmidt, Julie A., Huybrechts, Inge, Noor, Urwah, Forouhi, Nita G., Imamura, Fumiaki, Travis, Ruth C., Weiderpass, Elisabete, Aleksandrova, Krasimira, Dahm, Christina C., van der Schouw, Yvonne T., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Kaaks, Rudolf, Katzke, Verena, Schiborn, Catarina, Schulze, Matthias B., Mayen-Chacon, Ana-Lucia, Masala, Giovanna, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda M. A., Verschuren, W. M. Monique, Brustad, Magritt, Nøst, Therese Haugdahl, Crous-Bou, Marta, Petrova, Dafina, Amiano, Pilar, Huerta, José María, Moreno-Iribas, Conchi, Engström, Gunnar, Melander, Olle, Johansson, Kristina, Lindvall, Kristina, Aglago, Elom K., Heath, Alicia K., Butterworth, Adam S., Danesh, John, and Key, Timothy J.

Published
2024
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8. Financial Aid Nudges: A National Experiment with Informational Interventions

Author

Page, Lindsay C., Sacerdote, Bruce I., Goldrick-Rab, Sara, and Castleman, Benjamin L.

Abstract

Despite high prices, many college students do not re-file the Free Application for Federal Student Aid (FAFSA) or file late, making college less affordable. Low-cost technological interventions delivering personalized information and/or advising may improve refiling and academic outcomes, but questions remain regarding the efficacy of this approach at scale. This multi-pronged randomized experiment tested informational and framing text message interventions for a national sample of approximately 10,000 undergraduates. The text outreach caused earlier FAFSA re-filing for some students. However, gains in re-filing during the active intervention period were not sustained after the intervention concluded and did not translate into additional federal financial aid or improved postsecondary persistence or attainment. Implications for the scaling and targeting of nudging are discussed.

Published
2023
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9. Physical activity modification over time according to socioeconomic position: results from the EPIC-Italy cohort study

Author

Valeria Pala, Giovanna Masala, Fulvio Ricceri, Carlotta Sacerdote, Lucia Dansero, Matteo Franco, Luigi Facchini, Luca Manfredi, Benedetta Bendinelli, Melania Assedi, Valentina Vitale, and Saverio Caini

Subjects
Medicine (General), R5-920
Abstract

Objectives Our study aimed to investigate how physical activity (PA) changes over an 11-year follow-up among adults from different socioeconomic positions (SEP) near retirement age. Moreover, an analysis of different PA types is considered.Methods We used data from the EPIC-Italy cohort. We evaluated PA using the Cambridge Physical Activity Index (CPAI) and the metabolic equivalent of tasks (MET) per hour of activity for recreational PA and household PA. Educational level was assessed using the Relative Index of Inequality (RII). Occupational classes were classified according to LIFEPATH Consortium knowledge. Logistic regression was used to analyse PA among SEP and changes during follow-up. Analyses were also conducted separately for sex.Results The higher educated were more prevalent in the higher quartile of recreational PA than the lower educated both at baseline and follow-up (37% vs 28% and 37% vs 27%, respectively). At the baseline, the lower educated had a higher risk of being physically inactive than the higher educated based on recreational PA (overall OR: 1.50, 95% CI 1.40 to 1.60). Manual workers did not show a higher risk of less PA than professionals/managers (overall OR: 1.03, 95% CI 0.91 to 1.16).At follow-up, the lower educated and manual workers showed a higher risk of being physically inactive (lower educated OR: 1.46, 95% CI 1.37 to 1.56; manual worker OR: 1.33, 95% CI 1.18 to 1.50). The analyses of changes in PA showed that those who were less educated or manual workers had a higher risk of worsening their PA during the follow-up period, particularly women in recreational PA and men in CPAI measurement.Conclusion Individuals who had a disadvantaged SEP showed a higher risk of performing less PA over time.

Published
2024
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11. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.

Author

Gaziano, Liam, Sun, Luanluan, Arnold, Matthew, Bell, Steven, Cho, Kelly, Kaptoge, Stephen, Song, Rebecca, Burgess, Stephen, Posner, Daniel, Mosconi, Katja, Robinson-Cohen, Cassianne, Mason, Amy, Bolton, Thomas, Tao, Ran, Allara, Elias, Schubert, Petra, Chen, Lingyan, Staley, James, Staplin, Natalie, Altay, Servet, Amiano, Pilar, Arndt, Volker, Ärnlöv, Johan, Barr, Elizabeth, Björkelund, Cecilia, Boer, Jolanda, Brenner, Hermann, Casiglia, Edoardo, Chiodini, Paolo, Cooper, Jackie, Coresh, Josef, Cushman, Mary, Dankner, Rachel, Davidson, Karina, de Jongh, Renate, Donfrancesco, Chiara, Engström, Gunnar, Freisling, Heinz, de la Cámara, Agustín, Gudnason, Vilmundur, Hankey, Graeme, Hansson, Per-Olof, Heath, Alicia, Hoorn, Ewout, Imano, Hironori, Jassal, Simerjot, Kaaks, Rudolf, Katzke, Verena, Kauhanen, Jussi, Kiechl, Stefan, Koenig, Wolfgang, Kronmal, Richard, Kyrø, Cecilie, Lawlor, Deborah, Ljungberg, Börje, MacDonald, Conor, Masala, Giovanna, Meisinger, Christa, Melander, Olle, Moreno Iribas, Conchi, Ninomiya, Toshiharu, Nitsch, Dorothea, Nordestgaard, Børge, Onland-Moret, Charlotte, Palmieri, Luigi, Petrova, Dafina, Garcia, Jose, Rosengren, Annika, Sacerdote, Carlotta, Sakurai, Masaru, Santiuste, Carmen, Schulze, Matthias, Sieri, Sabina, Sundström, Johan, Tikhonoff, Valérie, Tjønneland, Anne, Tong, Tammy, Tumino, Rosario, Tzoulaki, Ioanna, van der Schouw, Yvonne, Monique Verschuren, W, Völzke, Henry, Wallace, Robert, Wannamethee, S, Weiderpass, Elisabete, Willeit, Peter, Woodward, Mark, Yamagishi, Kazumasa, Zamora-Ros, Raul, Akwo, Elvis, Pyarajan, Saiju, Gagnon, David, Tsao, Philip, Muralidhar, Sumitra, Edwards, Todd, Damrauer, Scott, Joseph, Jacob, Pennells, Lisa, Wilson, Peter, and Harrison, Seamus

Subjects
cardiovascular diseases, coronary disease, kidney diseases, stroke, Humans, Mendelian Randomization Analysis, Prospective Studies, Cardiovascular Diseases, Coronary Disease, Risk Factors, Diabetes Mellitus, Stroke, Kidney
Abstract

BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values 105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR 105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.

Published
2022

12. Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analyses

Author

Wang, Sabrina E., Viallon, Vivian, Lee, Matthew, Dimou, Niki, Hamilton, Fergus, Biessy, Carine, O'Mara, Tracy, Kyrgiou, Maria, Crosbie, Emma J., Truong, Therese, Severi, Gianluca, Kaaks, Rudolf, Fortner, Renée Turzanski, Schulze, Matthias B., Bendinelli, Benedetta, Sabina, Sieri, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Crous-Bou, Marta, Sánchez, Maria-Jose, Aizpurua, Amaia, Palacios, Daniel Rodriguez, Guevara, Marcela, Travis, Ruth C., Tsilidis, Konstantinos K., Heath, Alicia, Yarmolinsky, James, Rinaldi, Sabina, Gunter, Marc J., and Dossus, Laure

Published
2024
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13. Food biodiversity and gastrointestinal cancer risk in nine European countries: Analysis within a prospective cohort study

Author

Huybrechts, Inge, Chimera, Bernadette, Hanley-Cook, Giles T., Biessy, Carine, Deschasaux-Tanguy, Mélanie, Touvier, Mathilde, Kesse-Guyot, Emmanuelle, Srour, Bernard, Baudry, Julia, Berlivet, Justine, Casagrande, Corinne, Nicolas, Geneviève, Lopez, Jessica Blanco, Millett, Christopher J., Cakmak, Emine Koc, Robinson, Oliver J.K., Murray, Kris A., Schulze, Matthias B., Masala, Giovanna, Guevara, Marcela, Bodén, Stina, Cross, Amanda J., Tsilidis, Kostas, Heath, Alicia K., Panico, Salvatore, Amiano, Pilar, Huerta, José Ma, Key, Tim, Ericson, Ulrika, Stocks, Tanja, Lundblad, Marie Wasmuth, Skeie, Guri, Sacerdote, Carlotta, Katzke, Verena, Playdon, Mary C., Ferrari, Pietro, Vineis, Paolo, Lachat, Carl, and Gunter, Marc J.

Published
2024
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14. Radiation Doses Received by Major Organs at Risk in Children and Young Adolescents Treated for Cancer with External Beam Radiation Therapy: A Large-scale Study from 12 European Countries

Author

Diallo, Ibrahima, Allodji, Rodrigue S., Veres, Cristina, Bolle, Stéphanie, Llanas, Damien, Ezzouhri, Safaa, Zrafi, Wael, Debiche, Ghazi, Souchard, Vincent, Fauchery, Romain, Haddy, Nadia, Journy, Neige, Demoor-Goldschmidt, Charlotte, Winter, David L., Hjorth, Lars, Wiebe, Thomas, Haupt, Riccardo, Robert, Charlotte, Kremer, Leontien, Bardi, Edit, Sacerdote, Carlotta, Terenziani, Monica, Kuehni, Claudia E., Schindera, Christina, Skinner, Roderick, Winther, Jeanette Falck, Lähteenmäki, Päivi, Byrn, Julianne, Jakab, Zsuzsanna, Cardis, Elisabeth, Pasqual, Elisa, Tapio, Soile, Baatout, Sarah, Atkinson, Mike, Benotmane, Mohammed Abderrafi, Sugden, Elaine, Zaletel, Lorna Zadravec, Ronckers, Cecile, Reulen, Raoul C., Hawkins, Mike M., and de Vathaire, Florent

Published
2024
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16. Child rearing or childbearing? Risk of cardiovascular diseases associated to parity and number of children

Author

Angelo d’Errico, Dario Fontana, Carlotta Sacerdote, and Chiara Ardito

Subjects
Cardiovascular diseases, Children, Childrearing, Childbearing, Socioeconomic disadvantage, Double burden, Public aspects of medicine, RA1-1270
Abstract

Abstract Background An increased risk of cardiovascular diseases (CVD) has been associated with women’s parity, but whether or not this association reflects a direct pregnancy effect, or exposure to factors related to childrearing, still appears unclear. We assessed the CVD risk associated with number of children separately by gender and tested effect modification by socioeconomic position (SEP) and employment status, in order to elucidate the possible mechanisms underlying this association. Methods The study population was composed of 20,904 men and 25,246 women who were interviewed in one of two National Health Surveys conducted in 2000 and 2005 in Italy. These subjects were followed for CVD incidence up to 2014 through record-linkage with national archives of mortality and hospitalisations. CVD risk was estimated by Cox regression models that were adjusted for socio-demographics, perceived health, lifestyles, biological CVD risk factors and for other potential confounders. Results CVD incidence was significantly increased among men with 3 or more children (HR = 1.26, 95% CI: 1.02–1.56) and among women with 2 and with 3 or more children (HR = 1.42, 95% CI: 1.10–1.83; and HR = 1.39, 95% CI: 1.03–1.87, respectively) compared to subjects without children and no significant gender differences were observed. Subjects with lower SEP displayed stronger associations with parity and a higher number of children for both genders; by contrast, no modifying effect of employment status was observed. Conclusions Taken together, the significant association between higher parity and CVD risk in both genders, and the higher risk of CVD associated with higher parity among lower SEP parents, suggests that childrearing has a potential effect on the development of CVD that is more pronounced among disadvantaged families, although a concurrent effect of childbearing cannot be completely excluded.

Published
2024
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18. The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease

Author

Špacírová, Zuzana, Kaptoge, Stephen, García-Mochón, Leticia, Rodríguez Barranco, Miguel, Sánchez Pérez, María José, Bondonno, Nicola P., Tjønneland, Anne, Weiderpass, Elisabete, Grioni, Sara, Espín, Jaime, Sacerdote, Carlotta, Schiborn, Catarina, Masala, Giovanna, Colorado-Yohar, Sandra M., Kim, Lois, Moons, Karel G. M., Engström, Gunnar, Schulze, Matthias B., Bresson, Léa, Moreno-Iribas, Concepción, and Epstein, David

Published
2023
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19. Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study

Author

Zheng, Ju-Sheng, Steur, Marinka, Imamura, Fumiaki, Freisling, Heinz, Johnson, Laura, van der Schouw, Yvonne T, Tong, Tammy YN, Weiderpass, Elisabete, Bajracharya, Rashmita, Crous-Bou, Marta, Dahm, Christina C, Heath, Alicia K, Ibsen, Daniel B, Jannasch, Franziska, Katzke, Verena, Masala, Giovanna, Moreno-Iribas, Conchi, Sacerdote, Carlotta, Schulze, Matthias B, Sieri, Sabina, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, and Forouhi, Nita G

Published
2024
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21. Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Harewood, Rhea, Rothwell, Joseph A., Bešević, Jelena, Viallon, Vivian, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Wedekind, Roland, Prehn, Cornelia, Adamski, Jerzy, Schmidt, Julie A., Jacobs, Inarie, Tjønneland, Anne, Olsen, Anja, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Prada, Marcela, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Sacerdote, Carlotta, Jakszyn, Paula Gabriela, Sánchez, Maria-Jose, Castilla, Jesús, Chirlaque, María-Dolores, Atxega, Amaia Aizpurua, van Guelpen, Bethany, Heath, Alicia K., Papier, Keren, Tong, Tammy Y.N., Summers, Scott A., Playdon, Mary, Cross, Amanda J., Keski-Rahkonen, Pekka, Chajès, Véronique, Murphy, Neil, and Gunter, Marc J.

Published
2024
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22. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, Sánchez, María José, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, Wm Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, LineL, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen

Published
2024
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23. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries

Author

Fiolet, Thibault, Nicolas, Geneviève, Casagrande, Corinne, Horvath, Zsuzsanna, Frenoy, Pauline, Weiderpass, Elisabete, Gunter, Marc J., Manjer, Jonas, Sonestedt, Emily, Palli, Domenico, Simeon, Vittorio, Tumino, Rosario, Bueno-de-Mesquita, Bas, Huerta, José María, Rodriguez-Barranco, Miguel, Abilleira, Eunate, Sacerdote, Carlotta, Schulze, Matthias B., Heath, Alicia K., Rylander, Charlotta, Skeie, Guri, Nøst, Therese Haugdahl, Tjønneland, Anne, Olsen, Anja, Pala, Valeria, Kvaskoff, Marina, Huybrechts, Inge, and Mancini, Francesca Romana

Published
2024
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24. The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study

Author

Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K., Gunter, Marc J., Kaaks, Rudolf, Schulze, Matthias B., Fortner, Renée T., Antoniussen, Christian S., Dahm, Christina C., Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M., Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M., Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, and Agudo, Antonio

Published
2023
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25. Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)Research in context

Author

Rhea Harewood, Joseph A. Rothwell, Jelena Bešević, Vivian Viallon, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Roland Wedekind, Cornelia Prehn, Jerzy Adamski, Julie A. Schmidt, Inarie Jacobs, Anne Tjønneland, Anja Olsen, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Marcela Prada, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Carlotta Sacerdote, Paula Gabriela Jakszyn, Maria-Jose Sánchez, Jesús Castilla, María-Dolores Chirlaque, Amaia Aizpurua Atxega, Bethany van Guelpen, Alicia K. Heath, Keren Papier, Tammy Y.N. Tong, Scott A. Summers, Mary Playdon, Amanda J. Cross, Pekka Keski-Rahkonen, Véronique Chajès, Neil Murphy, and Marc J. Gunter

Subjects
Colorectal cancer, Metabolomics, Lipids, Glycerophospholipids, Sphingolipids, Acylcarnitines, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. Findings: Of the 97 assayed lipids, 24 were inversely associated (nominally p

Published
2024
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26. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Author

Christakoudi, Sofia, Tsilidis, Konstantinos K., Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S., Dahm, Christina C., Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., Monninkhof, Evelyn M., Quirós, J. Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H., Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K., Aglago, Elom K., Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio

Published
2023
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27. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

Yammine, S. G., Huybrechts, I., Biessy, C., Dossus, L., Panico, S., Sánchez, M. J., Benetou, V., Turzanski-Fortner, R., Katzke, V., Idahl, A., Skeie, G., Olsen, K. Standahl, Tjønneland, A., Halkjaer, J., Colorado-Yohar, S., Heath, A. K., Sonestedt, E., Sartor, H., Schulze, M. B., Palli, D., Crous-Bou, M., Dorronsoro, A., Overvad, K., Gurrea, A. Barricarte, Severi, G., Vermeulen, R. C.H., Sandanger, T. M., Travis, R. C., Key, T., Amiano, P., Van Guelpen, B., Johansson, M., Sund, M., Tumino, R., Wareham, N., Sacerdote, C., Krogh, V., Brennan, P., Riboli, E., Weiderpass, E., Gunter, M. J., and Chajès, V.

Published
2023
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28. Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study)

Author

Green, Jennifer B., Everett, Brendan M., Ghosh, Alokananda, Younes, Naji, Krause-Steinrauf, Heidi, Barzilay, Joshua, Desouza, Cyrus, Inzucchi, Silvio E., Pokharel, Yashashwi, Schade, David, Scrymgeour, Alexandra, Tan, Meng H., Utzschneider, Kristina M., Mudaliar, Sunder, Crandall, J.P., McKee, M.D., Behringer-Massera, S., Brown-Friday, J., Xhori, E., Ballentine-Cargill, K., Duran, S., Estrella, H., Gonzalez de la Torre, S., Lukin, J., Phillips, L.S., Burgess, E., Olson, D., Rhee, M., Wilson, P., Raines, T.S., Boers, J., Costello, J., Maher-Albertelli, M., Mungara, R., Savoye, L., White, C.A., Gullett, C., Holloway, L., Morehead, F., Person, S., Sibymon, M., Tanukonda, S., Adams, C., Ross, A., Balasubramanyam, A., Gaba, R., Gonzalez Hattery, E., Ideozu, A., Jimenez, J., Montes, G., Wright, C., Hollander, P., Roe, E., Jackson, A., Smiley, A., Burt, P., Estrada, L., Chionh, K., Ismail-Beigi, F., Falck-Ytter, C., Sayyed Kassem, L., Sood, A., Tiktin, M., Kulow, T., Newman, C., Stancil, K.A., Cramer, B., Iacoboni, J., Kononets, M.V., Sanders, C., Tucker, L., Werner, A., Maxwell, A., McPhee, G., Patel, C., Colosimo, L., Krol, A., Goland, R., Pring, J., Alfano, L., Kringas, P., Hausheer, C., Tejada, J., Gumpel, K., Kirpitch, A., Schneier, H., AbouAssi, H., Chatterjee, R., Feinglos, M.N., English Jones, J., Khan, S.A., Kimpel, J.B., Zimmer, R.P., Furst, M., Satterwhite, B.M., Thacker, C.R., Evans Kreider, K., Mariash, C.N., Mather, K.J., Ismail, H.M., Lteif, A., Mullen, M., Hamilton, T., Patel, N., Riera, G., Jackson, M., Pirics, V., Aguillar, D., Howard, D., Hurt, S., Bergenstal, R., Carlson, A., Martens, T., Johnson, M., Hill, R., Hyatt, J., Jensen, C., Madden, M., Martin, D., Willis, H., Konerza, W., Yang, S., Kleeberger, K., Passi, R., Fortmann, S., Herson, M., Mularski, K., Glauber, H., Prihoda, J., Ash, B., Carlson, C., Ramey, P.A., Schield, E., Torgrimson-Ojerio, B., Arnold, K., Kauffman, B., Panos, E., Sahnow, S., Bays, K., Berame, K., Cook, J., Ghioni, D., Gluth, J., Schell, K., Criscola, J., Friason, C., Jones, S., Nazarov, S., Rassouli, N., Puttnam, R., Ojoawo, B., Nelson, R., Curtis, M., Hollis, B., Sanders-Jones, C., Stokes, K., El-Haqq, Z., Kolli, A., Tran, T., Wexler, D., Larkin, M.E., Meigs, J., Chambers, B., Dushkin, A., Rocchio, G., Yepes, M., Steiner, B., Dulin, H., Cayford, M., Chu, K., DeManbey, A., Hillard, M., Martin, K., Thangthaeng, N., Gurry, L., Kochis, R., Raymond, E., Ripley, V., Stevens, C., Park, J., Aroda, V., Ghazi, A., Magee, M., Ressing, A., Loveland, A., Hamm, M., Hurtado, M., Kuhn, A., Leger, J., Manandhar, L., Mwicigi, F., Sanchez, O., Young, T., Garg, R., Lagari-Libhaber, V., Florez, H.J., Valencia, W.M., Marks, J., Casula, S., Oropesa-Gonzalez, L., Hue, L., Cuadot, A., Nieto-Martinez, R., Riccio Veliz, A.K., Gutt, M., Kendal, Y.J., Veciana, B., Ahmann, A., Aby-Daniel, D., Joarder, F., Morimoto, V., Sprague, C., Yamashita, D., Cady, N., Rivera-Eschright, N., Kirchhoff, P., Morales Gomez, B., Adducci, J., Goncharova, A., Hox, S.H., Petrovitch, H., Matwichyna, M., Jenkins, V., Broadwater, L., Ishii, R.R., Bermudez, N.O., Hsia, D.S., Cefalu, W.T., Greenway, F.L., Waguespack, C., King, E., Fry, G., Dragg, A., Gildersleeve, B., Arceneaux, J., Haynes, N., Thomassie, A., Pavlionis, M., Bourgeois, B., Hazlett, C., Henry, R., Boeder, S., Pettus, J., Diaz, E., Garcia-Acosta, D., Maggs, S., DeLue, C., Stallings, A., Castro, E., Hernandez, S., Krakoff, J., Curtis, J.M., Killean, T., Khalid, M., Joshevama, E., Diaz, E., Martin, D., Tsingine, K., Karshner, T., Albu, J., Pi-Sunyer, F.X., Frances, S., Maggio, C., Ellis, E., Bastawrose, J., Gong, X., Banerji, M.A., August, P., Lee, M., Lorber, D., Brown, N.M., Josephson, D.H., Thomas, L.L., Tsovian, M., Cherian, A., Jacobson, M.H., Mishko, M.M., Kirkman, M.S., Buse, J.B., Diner, J., Dostou, J., Machineni, S., Young, L., Bergamo, K., Goley, A., Kerr, J., Largay, J.F., Guarda, S., Cuffee, J., Culmer, D., Fraser, R., Almeida, H., Coffer, S., Debnam, E., Kiker, L., Morton, S., Josey, K., Fuller, G., Garvey, W.T., Cherrington, A.L., Dyer, D., Lawson, M.C.R., Griffith, O., Agne, A., McCullars, S., Cohen, R.M., Craig, J., Rogge, M.C., Burton, K., Kersey, K., Wilson, C., Lipp, S., Vonder Meulen, M.B., Adkins, C., Onadeko, T., Rasouli, N., Baker, C., Schroeder, E., Razzaghi, M., Lyon, C., Penaloza, R., Underkofler, C., Lorch, R., Douglass, S., Steiner, S., Sivitz, W.I., Cline, E., Knosp, L.K., McConnell, J., Lowe, T., Herman, W.H., Pop-Busui, R., Martin, C., Waltje, A., Katona, A., Goodhall, L., Eggleston, R., Kuo, S., Bojescu, S., Bule, S., Kessler, N., LaSalle, E., Whitley, K., Seaquist, E.R., Bantle, A., Harindhanavudhi, T., Kumar, A., Redmon, B., Bantle, J., Coe, M., Mech, M., Taddese, A., Lesne, L., Smith, S., Kuechenmeister, L., Shivaswamy, V., Burbach, S., Rodriguez, M.G., Seipel, K., Alfred, A., Morales, A.L., Eggert, J., Lord, G., Taylor, W., Tillson, R., Adolphe, A., Burge, M., Duran-Valdez, E., Martinez, J., Bancroft, A., Kunkel, S., Ali Jamaleddin Ahmad, F., Hernandez McGinnis, D., Pucchetti, B., Scripsick, E., Zamorano, A., DeFronzo, R.A., Cersosimo, E., Abdul-Ghani, M., Triplitt, C., Juarez, D., Mullen, M., Garza, R.I., Verastiqui, H., Wright, K., Puckett, C., Raskin, P., Rhee, C., Abraham, S., Jordan, L.F., Sao, S., Morton, L., Smith, O., Osornio Walker, L., Schnurr-Breen, L., Ayala, R., Kreymer, R.B., Sturgess, D., Kahn, S.E., Alarcon-Casas Wright, L., Boyko, E.J., Tsai, E.C., Trence, D.L., Trikudanathan, S., Fattaleh, B.N., Montgomery, B.K., Atkinson, K.M., Kozedub, A., Concepcion, T., Moak, C., Prikhodko, N., Rhothisen, S., Elasy, T.A., Martin, S., Shackelford, L., Goidel, R., Hinkle, N., Lovell, C., Myers, J., Lipps Hogan, J., McGill, J.B., Salam, M., Schweiger, T., Kissel, S., Recklein, C., Clifton, M.J., Tamborlane, W., Camp, A., Gulanski, B., Pham, K., Alguard, M., Gatcomb, P., Lessard, K., Perez, M., Iannone, L., Magenheimer, E., Montosa, A., Cefalu, W.T., Fradkin, J., Burch, H.B., Bremer, A.A., Nathan, D.M., Lachin, J.M., Buse, J.B., Kahn, S.E., Larkin, M.E., Tiktin, M., Wexler, D., Burch, H.B., Bremer, A.A., Lachin, J.M., Bebu, I., Butera, N., Buys, C.J., Fagan, A., Gao, Y., Gramzinski, M.R., Hall, S.D., Kazemi, E., Legowski, E., Liu, H., Suratt, C., Tripputi, M., Arey, A., Backman, M., Bethepu, J., Lund, C., Mangat Dhaliwal, P., McGee, P., Mesimer, E., Ngo, L., Steffes, M., Seegmiller, J., Saenger, A., Arends, V., Gabrielson, D., Conner, T., Warren, S., Day, J., Huminik, J., Soliman, E.Z., Zhang, Z.M., Campbell, C., Hu, J., Keasler, L., Hensley, S., Li, Y., Herman, W.H., Kuo, S., Martin, C., Waltje, A., Mihalcea, R., Min, D.J., Perez-Rosas, V., Prosser, L., Resnicow, K., Ye, W., Shao, H., Zhang, P., Luchsinger, J., Sanchez, D., Assuras, S., Groessl, E., Sakha, F., Chong, H., Hillery, N., Abdouch, I., Bahtiyar, G., Brantley, P., Broyles, F.E., Canaris, G., Copeland, P., Craine, J.J., Fein, W.L., Gliwa, A., Hope, L., Lee, M.S., Meiners, R., Meiners, V., O’Neal, H., Park, J.E., Sacerdote, A., Sledge Jr, E., Soni, L., Steppel-Reznik, J., and Turchin, A.

Published
2024
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29. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Author

Sofia Christakoudi, Konstantinos K. Tsilidis, Laure Dossus, Sabina Rinaldi, Elisabete Weiderpass, Christian S. Antoniussen, Christina C. Dahm, Anne Tjønneland, Lene Mellemkjær, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Anne M. May, Evelyn M. Monninkhof, J. Ramón Quirós, Catalina Bonet, Maria-Jose Sánchez, Pilar Amiano, María-Dolores Chirlaque, Marcela Guevara, Ann H. Rosendahl, Tanja Stocks, Aurora Perez-Cornago, Sandar Tin Tin, Alicia K. Heath, Elom K. Aglago, Laia Peruchet-Noray, Heinz Freisling, and Elio Riboli

Subjects
Obesity, Body shape, Waist size, ABSI, Hip size, Breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.

Published
2023
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31. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study

Author

Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio

Published
2023
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32. Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study

Author

Sedlmeier, Anja M., Viallon, Vivian, Ferrari, Pietro, Peruchet-Noray, Laia, Fontvieille, Emma, Amadou, Amina, Seyed Khoei, Nazlisadat, Weber, Andrea, Baurecht, Hansjörg, Heath, Alicia K., Tsilidis, Kostas, Kaaks, Rudolf, Katzke, Verena, Inan-Eroglu, Elif, Schulze, Matthias B., Overvad, Kim, Bonet, Catalina, Ubago-Guisado, Esther, Chirlaque, María-Dolores, Ardanaz, Eva, Perez-Cornago, Aurora, Pala, Valeria, Tumino, Rosario, Sacerdote, Carlotta, Pasanisi, Fabrizio, Borch, Kristin B., Rylander, Charlotta, Weiderpass, Elisabete, Gunter, Marc J., Fervers, Béatrice, Leitzmann, Michael F., and Freisling, Heinz

Published
2023
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33. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, Hawkins, Michael M., Winter, David L., Dudley, Isabelle M., Heymer, Emma J., Teepen, Jop C., Allodji, Rodrigue S., Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Ronckers, Cécile M., Haddy, Nadia, Gudmundsdottir, Thorgerdur, Garwicz, Stanislaw, Jankovic, Momcilo, van der Pal, Helena J. H., Mazić, Maja Česen, Schindera, Christina, Grabow, Desiree, Maule, Milena M., Kaatsch, Peter, Kaiser, Melanie, Fresneau, Brice, Michel, Gisela, Skinner, Roderick, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Gunnes, Maria Winther, Terenziani, Monica, Winther, Jeanette F., Lähteenmäki, Päivi M., Zaletel, Lorna Zadravec, Kuehni, Claudia E., Kremer, Leontien C., Haupt, Riccardo, de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2023
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34. The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients

Author

Amedeo Gagliardi, Giulia Francescato, Giulio Ferrero, Giovanni Birolo, Sonia Tarallo, Antonio Francavilla, Giulia Piaggeschi, Carla Di Battista, Gaetano Gallo, Alberto Realis Luc, Carlotta Sacerdote, Giuseppe Matullo, Paolo Vineis, Alessio Naccarati, and Barbara Pardini

Subjects
8q24 genomic region, bladder cancer, colorectal cancer, microRNAs, stool, urine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The 8q24 locus is enriched in cancer‐associated polymorphisms and, despite containing relatively few protein‐coding genes, it hosts the MYC oncogene and other genetic elements connected to tumorigenesis, including microRNAs (miRNAs). Research on miRNAs may provide insights into the transcriptomic regulation of this multiple cancer‐associated region. Material and methods We profiled all miRNAs located in the 8q24 region in 120 colorectal cancer (CRC) patients and 80 controls. miRNA profiling was performed on cancer/non‐malignant adjacent mucosa, stool, and plasma extracellular vesicles (EVs), and the results validated with The Cancer Genome Atlas (TCGA) data. To verify if the 8q24‐annotated miRNAs altered in CRC were dysregulated in other cancers and biofluids, we evaluated their levels in bladder cancer (BC) cases from the TCGA dataset and in urine and plasma EVs from a set of BC cases and healthy controls. Results Among the detected mature miRNAs in the region, 12 were altered between CRC and adjacent mucosa (adj. p

Published
2023
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35. Protein and amino acid intakes in relation to prostate cancer risk and mortality—A prospective study in the European Prospective Investigation into Cancer and Nutrition

Author

Julie A. Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjønneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Bas Bueno‐de‐Mesquita, Maria‐Jose Sánchez, José M. Huerta, Aurelio Barricarte, Pilar Amiano, Antonio Agudo, Anders Bjartell, Tanja Stocks, Elin Thysell, Maria Wennberg, Elisabete Weiderpass, Ruth C. Travis, Timothy J. Key, and Aurora Perez‐Cornago

Subjects
dietary amino acid intakes, dietary protein intakes, prostate cancer incidence, prostate cancer mortality, tumour subtypes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The association between protein intake and prostate cancer risk remains unclear. Aims To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable‐adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results During a mean follow‐up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HRQ3=1.14 (95% CI 1.05–1.23); HRQ4=1.09 (1.01–1.18); HRQ5=1.10 (1.02–1.19)); similar results were observed for yogurt protein (HRQ3=1.14 (1.05–1.24); HRQ4=1.09 (1.01–1.18); HRQ5=1.12 (1.04–1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes. Discussion Considering the weak associations and many tests, the results must be interpreted with caution. Conclusion This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large‐scale, pooled analyses of prospective data.

Published
2023
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36. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Author

S. G. Yammine, I. Huybrechts, C. Biessy, L. Dossus, S. Panico, M. J. Sánchez, V. Benetou, R. Turzanski-Fortner, V. Katzke, A. Idahl, G. Skeie, K. Standahl Olsen, A. Tjønneland, J. Halkjaer, S. Colorado-Yohar, A. K. Heath, E. Sonestedt, H. Sartor, M. B. Schulze, D. Palli, M. Crous-Bou, A. Dorronsoro, K. Overvad, A. Barricarte Gurrea, G. Severi, R. C.H. Vermeulen, T. M. Sandanger, R. C. Travis, T. Key, P. Amiano, B. Van Guelpen, M. Johansson, M. Sund, R. Tumino, N. Wareham, C. Sacerdote, V. Krogh, P. Brennan, E. Riboli, E. Weiderpass, M. J. Gunter, and V. Chajès

Subjects
Fatty acids, Endometrial cancer, Epidemiology, Diet, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Results Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. Conclusion Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

Published
2023
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37. Food Processing and Risk of Crohn’s Disease and Ulcerative Colitis: A European Prospective Cohort Study

Author

Meyer, Antoine, Dong, Catherine, Casagrande, Corinne, Chan, Simon S.M., Huybrechts, Inge, Nicolas, Geneviève, Rauber, Fernanda, Levy, Renata Bertazzi, Millett, Christopher, Oldenburg, Bas, Weiderpass, Elisabete, Heath, Alicia K., Tong, Tammy Y.N., Tjønneland, Anne, Kyrø, Cecilie, Kaaks, Rudolf, Katzke, Verena A., Bergman, Manuela M., Palli, Domenico, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Colorado-Yohar, Sandra M., Sánchez, Maria-Jose, Grip, Olof, Lindgren, Stefan, Luben, Robert, Gunter, Marc J., Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, and Carbonnel, Franck

Published
2023
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39. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Karina Standahl Olsen, Torkjel Manning Sandanger, Therese Haugdahl Nøst, J. Ramón Quirós, Catalina Bonet, Miguel Rodríguez Barranco, María-Dolores Chirlaque, Eva Ardanaz, Malte Sandsveden, Jonas Manjer, Linda Vidman, Matilda Rentoft, David Muller, Kostas Tsilidis, Alicia K. Heath, Hector Keun, Jerzy Adamski, Pekka Keski-Rahkonen, Augustin Scalbert, Marc J. Gunter, and Vivian Viallon

Subjects
Metabolomics, Cancer, Breast, Colorectal, Endometrial, Kidney, Medicine
Abstract

Abstract Background Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty. Results Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk. Conclusions These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.

Published
2022
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40. Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage

Author

Angela Lopez-Cortes, Fabio Didonè, Laura Botta, Lisa L. Hjalgrim, Zsuzsanna Jakab, Adela Cañete Nieto, Charles Stiller, Bernward Zeller, Gemma Gatta, Kathy Pritchard-Jones, The BENCHISTA Project Working Group, Joanne Aitken, Leisa O’Neil, Monika Hack, Ruth Ladenstein, Elizabeth Van Eycken, Nancy Van Damme, Lindsay Frazier, Beatriz De Camargo, Marceli de Oliveira Santos, Zdravka Valerianova, Dobrin Konstantinov, Sumit Gupta, Jason D Pole, Mario Sekerija, Jan Stary, Jaroslav Sterba, Jeanette F Winther, Keiu Paapsi, Brigitte Lacour, Emmanuel Desandes, Jacqueline Clavel, Claire Poulalhon, Friederike Erdmann, Eleni T Petridou, Evdoxia Bouka, Michael Mian, Rocco Galasso, Giuseppe Sampietro, Francesco Vetrano, Milena M Maule, Carlotta Sacerdote, Paola Ballotari, Emilia De Santis, Margherita Ferrante, Rosalia Ragusa, Luca Boni, Magda Rognoni, Rosalba Amodio, Lorenza Boschetti, Francesco Cuccaro, Danila Bruno, Antonio G Russo, Federico Gervasi, Maria L Gambino, Elisabetta Borciani, Maria Michiara, Lucia Mangone, Gianbattista Spagnoli, Stefano Ferretti, Fabio Falcini, Eugenia Spata, Sonia Manasse, Paola Coccia, Francesca Bella, Adele Caldarella, Teresa Intrieri, Tiziana Scuderi, Roberto V Rizzello, Massimo Rugge, Stefano Guzzinati, Deirdre Murray, Tomohiro Matsuda, Kayo Nakata, Miriam J Azzopardi, Aina H Dahlen, Johannesen Tom Børge, Jerzy Kowalczyk, Monika Jedrzejczyk, Gabriela Caldas, Mihaela Bucurenci, Dana Coza, Vesna Zadnik, Arantza Lopez de Munain, Fernando Almela-Vich, Nieves Fuster-Camarena, Ra f a e l Marcos-Gragera, Maria José Sanchez, Nuria Aragones, Raquel Lopez, Maria Dolores Chirlaque, Marcela Guevara, Elena Pardo, Rafael Peris-Bonet, Marià Carulla, Päivi Lähteenmäki, Claudia E Kuehni, Shelagh M Redmond, Henrike Karim-Kos, Paul Stacey, Lucy Irvine, Anna Gavin, Deirdre Fitzpatrick, David S Morrison, Karen Smith, Dyfed Wyn Huws, Janet Warlow, Sandra Strauss, Simon Bailey, Adela Canete Nieto, Nathalie Gaspar, Filippo Spreafico, Angela Polanco, Riccardo Capocaccia, Andrea Di Cataldo, and Meric Klein

Subjects
childhood cancer, population-based, cancer registry, Toronto staging, diagnosis, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionVariation in stage at diagnosis of childhood cancers (CC) may explain differences in survival rates observed across geographical regions. The BENCHISTA project aims to understand these differences and to encourage the application of the Toronto Staging Guidelines (TG) by Population-Based Cancer Registries (PBCRs) to the most common solid paediatric cancers.MethodsPBCRs within and outside Europe were invited to participate and identify all cases of Neuroblastoma, Wilms Tumour, Medulloblastoma, Ewing Sarcoma, Rhabdomyosarcoma and Osteosarcoma diagnosed in a consecutive three-year period (2014-2017) and apply TG at diagnosis. Other non-stage prognostic factors, treatment, progression/recurrence, and cause of death information were collected as optional variables. A minimum of three-year follow-up was required. To standardise TG application by PBCRs, on-line workshops led by six tumour-specific clinical experts were held. To understand the role of data availability and quality, a survey focused on data collection/sharing processes and a quality assurance exercise were generated. To support data harmonization and query resolution a dedicated email and a question-and-answers bank were created.Results67 PBCRs from 28 countries participated and provided a maximally de-personalized, patient-level dataset. For 26 PBCRs, data format and ethical approval obtained by the two sponsoring institutions (UCL and INT) was sufficient for data sharing. 41 participating PBCRs required a Data Transfer Agreement (DTA) to comply with data protection regulations. Due to heterogeneity found in legal aspects, 18 months were spent on finalizing the DTA. The data collection survey was answered by 68 respondents from 63 PBCRs; 44% of them confirmed the ability to re-consult a clinician in cases where stage ascertainment was difficult/uncertain. Of the total participating PBCRs, 75% completed the staging quality assurance exercise, with a median correct answer proportion of 92% [range: 70% (rhabdomyosarcoma) to 100% (Wilms tumour)].ConclusionDifferences in interpretation and processes required to harmonize general data protection regulations across countries were encountered causing delays in data transfer. Despite challenges, the BENCHISTA Project has established a large collaboration between PBCRs and clinicians to collect detailed and standardised TG at a population-level enhancing the understanding of the reasons for variation in overall survival rates for CC, stimulate research and improve national/regional child health plans.

Published
2023
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43. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Author

Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula

Published
2022
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44. Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease

Author

Agha, Golareh, Mendelson, Michael M, Ward-Caviness, Cavin K, Joehanes, Roby, Huan, TianXiao, Gondalia, Rahul, Salfati, Elias, Brody, Jennifer A, Fiorito, Giovanni, Bressler, Jan, Chen, Brian H, Ligthart, Symen, Guarrera, Simonetta, Colicino, Elena, Just, Allan C, Wahl, Simone, Gieger, Christian, Vandiver, Amy R, Tanaka, Toshiko, Hernandez, Dena G, Pilling, Luke C, Singleton, Andrew B, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Li, Yun, Zhang, Guosheng, Stewart, James D, Floyd, James S, Wiggins, Kerri L, Rotter, Jerome I, Multhaup, Michael, Bakulski, Kelly, Horvath, Steven, Tsao, Philip S, Absher, Devin M, Vokonas, Pantel, Hirschhorn, Joel, Fallin, M Daniele, Liu, Chunyu, Bandinelli, Stefania, Boerwinkle, Eric, Dehghan, Abbas, Schwartz, Joel D, Psaty, Bruce M, Feinberg, Andrew P, Hou, Lifang, Ferrucci, Luigi, Sotoodehnia, Nona, Matullo, Giuseppe, Peters, Annette, Fornage, Myriam, Assimes, Themistocles L, Whitsel, Eric A, Levy, Daniel, and Baccarelli, Andrea A

Subjects
Human Genome, Heart Disease, Clinical Research, Prevention, Heart Disease - Coronary Heart Disease, Atherosclerosis, Cardiovascular, Genetics, Adult, Aged, Cohort Studies, Coronary Disease, CpG Islands, DNA Methylation, Europe, Female, Genome-Wide Association Study, Humans, Incidence, Leukocytes, Male, Middle Aged, Myocardial Infarction, Population Groups, Prognosis, Prospective Studies, Risk, United States, coronary artery disease, coronary heart disease, epigenetics, genomics, gene expression regulation, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundDNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts.MethodsNine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effect meta-analyses across cohorts.ResultsAmong 11 461 individuals (mean age 64 years, 67% women, 35% African American) free of CHD at baseline, 1895 developed CHD during a mean follow-up of 11.2 years. Methylation levels at 52 CpG (cytosine-phosphate-guanine) sites were associated with incident CHD or myocardial infarction (false discovery rate

Published
2019

45. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Author

Pellegrini, Cristina, Botta, Francesca, Massi, Daniela, Martorelli, Claudia, Facchetti, Fabio, Gandini, Sara, Maisonneuve, Patrick, Avril, Marie-Françoise, Demenais, Florence, Paillerets, Brigitte Bressac-de, Hoiom, Veronica, Cust, Anne E, Anton-Culver, Hoda, Gruber, Stephen B, Gallagher, Richard P, Marrett, Loraine, Zanetti, Roberto, Dwyer, Terence, Thomas, Nancy E, Begg, Colin B, Berwick, Marianne, Puig, Susana, Potrony, Miriam, Nagore, Eduardo, Ghiorzo, Paola, Menin, Chiara, Manganoni, Ausilia Maria, Rodolfo, Monica, Brugnara, Sonia, Passoni, Emanuela, Sekulovic, Lidija Kandolf, Baldini, Federica, Guida, Gabriella, Stratigos, Alexandros, Ozdemir, Fezal, Ayala, Fabrizio, Fernandez-de-Misa, Ricardo, Quaglino, Pietro, Ribas, Gloria, Romanini, Antonella, Migliano, Emilia, Stanganelli, Ignazio, Kanetsky, Peter A, Pizzichetta, Maria Antonietta, García-Borrón, Jose Carlos, Nan, Hongmei, Landi, Maria Teresa, Little, Julian, Newton-Bishop, Julia, Sera, Francesco, Fargnoli, Maria Concetta, Raimondi, Sara, Group, IMI Study, Alaibac, Mauro, Ferrari, Andrea, Valeri, Barbara, Sicher, Mariacristina, Mangiola, Daniela, Nazzaro, Gianluca, Tosti, Giulio, Mazzarol, Giovanni, Giudice, Giuseppe, Ribero, Simone, Astrua, Chiara, Mazzoni, Laura, Group, GEM Study, Orlow, Irene, Mujumdar, Urvi, Hummer, Amanda, Busam, Klaus, Roy, Pampa, Canchola, Rebecca, Clas, Brian, Cotignola, Javiar, Monroe, Yvette, Armstrong, Bruce, Kricker, Anne, Litchfield, Melisa, Tucker, Paul, Stephens, Nicola, Switzer, Teresa, Theis, Beth, From, Lynn, Chowdhury, Noori, Vanasse, Louise, Purdue, Mark, Northrup, David, Rosso, Stefano, Sacerdote, Carlotta, Leighton, Nancy, Gildea, Maureen, Bonner, Joe, Jeter, Joanne, Klotz, Judith, Wilcox, Homer, Weiss, Helen, Millikan, Robert, Mattingly, Dianne, and Player, Jon

Subjects
Clinical Research, Pediatric, Genetics, Prevention, Cancer, Adolescent, Adult, Aged, Biomarkers, Tumor, Case-Control Studies, Child, Female, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Logistic Models, Male, Melanoma, Middle Aged, Odds Ratio, Polymorphism, Genetic, Receptor, Melanocortin, Type 1, Retrospective Studies, Skin Neoplasms, IMI Study Group, GEM Study Group, M-SKIP Study Group
Abstract

BackgroundGermline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.MethodsIn this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger.FindingsWe analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02-2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06-3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05-2·44; p=0·04) and Asp294His (2·15, 1·05-4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants.InterpretationOur pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies.FundingSPD-Pilot/Project-Award-2015; AIRC-MFAG-11831.

Published
2019

46. Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies

Author

Pierre-Antoine Dugué, Clara Bodelon, Felicia F. Chung, Hannah R. Brewer, Srikant Ambatipudi, Joshua N. Sampson, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Giovanni Fiorito, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Paolo Vineis, Silvia Polidoro, Laura Baglietto, Dallas English, Gianluca Severi, Graham G. Giles, Roger L. Milne, Zdenko Herceg, Montserrat Garcia-Closas, James M. Flanagan, and Melissa C. Southey

Subjects
Prospective study, DNA methylation, Epigenetic aging, Lifestyle, Breast cancer risk, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background DNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in the prediction of cancer risk. A substantial body of research has shown associations between epigenetic aging and risk of disease, including cancer. Here we aimed to study epigenetic measures of aging and lifestyle-related factors in association with risk of breast cancer. Methods Using data from four prospective case–control studies nested in three cohorts of European ancestry participants, including a total of 1,655 breast cancer cases, we calculated three methylation-based measures of lifestyle factors (body mass index [BMI], tobacco smoking and alcohol consumption) and seven measures of epigenetic aging (Horvath-based, Hannum-based, PhenoAge and GrimAge). All measures were regression-adjusted for their respective risk factors and expressed per standard deviation (SD). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional or unconditional logistic regression and pooled using fixed-effects meta-analysis. Subgroup analyses were conducted by age at blood draw, time from blood sample to diagnosis, oestrogen receptor-positivity status and tumour stage. Results None of the measures of epigenetic aging were associated with risk of breast cancer in the pooled analysis: Horvath ‘age acceleration’ (AA): OR per SD = 1.02, 95%CI: 0.95–1.10; AA-Hannum: OR = 1.03, 95%CI:0.95–1.12; PhenoAge: OR = 1.01, 95%CI: 0.94–1.09 and GrimAge: OR = 1.03, 95%CI: 0.94–1.12, in models adjusting for white blood cell proportions, body mass index, smoking and alcohol consumption. The BMI-adjusted predictor of BMI was associated with breast cancer risk, OR per SD = 1.09, 95%CI: 1.01–1.17. The results for the alcohol and smoking methylation-based predictors were consistent with a null association. Risk did not appear to substantially vary by age at blood draw, time to diagnosis or tumour characteristics. Conclusion We found no evidence that methylation-based measures of aging, smoking or alcohol consumption were associated with risk of breast cancer. A methylation-based marker of BMI was associated with risk and may provide insights into the underlying associations between BMI and breast cancer.

Published
2022
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47. Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejci, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Paapsi, Keiu, Malila, Nea, Pitkäniemi, Janne, Jooste, Valerie, Clavel, Jacqueline, Poulalhon, Claire, Lacour, Brigitte, Desandes, Emmanuel, Monnereau, Alain, Erdmann, Friederike, Spix, Claudia, Katalinic, Alexander, Petridou, Eleni, Markozannes, Georgios, Garami, Miklos, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M, Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotto, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Torrisi, Antonina, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Del Monego, Giulia, Buratti, Lucia, Serraino, Diego, Taborelli, Martina, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Vitale, Francesco, Michiara, Maria, Chiranda, Giorgio, Sacerdote, Carlotta, Maule, Milena, Cascone, Giuseppe, Spata, Eugenia, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Dinaro, Ylenia, Castaing, Marine, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Ferreira, Ana Maria, Bento, Maria José, Miranda, Ana, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, Marìa Dolores, Aleman, Araceli, Vizcaino, Ana, Almela, Fernando, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Cañete-Nieto, Adela, Peris-Bonet, Rafael, Galceran, Jaume, Carulla, Maria, Kuehni, Claudia, Redmond, Shelagh, Visser, Otto, Karim-Kos, Henrike, Stevens, Sarah, Stiller, Charles, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Cañete, Adela, Dal Maso, Luigino, and Mihor, Ana

Published
2022
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48. Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Author

Crous-Bou, Marta, Du, Mengmeng, Gunter, Marc J, Setiawan, Veronica W, Schouten, Leo J, Shu, Xiao-ou, Wentzensen, Nicolas, Bertrand, Kimberly A, Cook, Linda S, Friedenreich, Christine M, Gapstur, Susan M, Goodman, Marc T, Ibiebele, Torukiri I, La Vecchia, Carlo, Levi, Fabio, Liao, Linda M, Negri, Eva, McCann, Susan E, O’Connell, Kelly, Palmer, Julie R, Patel, Alpa V, Ponte, Jeanette, Reynolds, Peggy, Sacerdote, Carlotta, Sinha, Rashmi, Spurdle, Amanda B, Trabert, Britton, van den Brandt, Piet A, Webb, Penelope M, Petruzella, Stacey, Olson, Sara H, and De Vivo, Immaculata

Published
2022
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49. A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study.

Author

Jakub G Sobiecki, Fumiaki Imamura, Courtney R Davis, Stephen J Sharp, Albert Koulman, Jonathan M Hodgson, Marcela Guevara, Matthias B Schulze, Ju-Sheng Zheng, Claudia Agnoli, Catalina Bonet, Sandra M Colorado-Yohar, Guy Fagherazzi, Paul W Franks, Thomas E Gundersen, Franziska Jannasch, Rudolf Kaaks, Verena Katzke, Esther Molina-Montes, Peter M Nilsson, Domenico Palli, Salvatore Panico, Keren Papier, Olov Rolandsson, Carlotta Sacerdote, Anne Tjønneland, Tammy Y N Tong, Yvonne T van der Schouw, John Danesh, Adam S Butterworth, Elio Riboli, Karen J Murphy, Nicholas J Wareham, and Nita G Forouhi

Subjects
Medicine
Abstract

BackgroundSelf-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet.Methods and findingsWe derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants out of 166 randomised). We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). We included 22,202 participants, of whom 9,453 were T2D cases, with relevant biomarkers from an original case-cohort of 27,779 participants sampled from a cohort of 340,234 people. As a secondary measure of the Mediterranean diet, we used a score estimated from dietary-self report. Within the trial, the biomarker score discriminated well between the 2 arms; the cross-validated C-statistic was 0.88 (95% confidence interval (CI) 0.82 to 0.94). The score was inversely associated with incident T2D in EPIC-InterAct: the hazard ratio (HR) per standard deviation of the score was 0.71 (95% CI: 0.65 to 0.77) following adjustment for sociodemographic, lifestyle and medical factors, and adiposity. In comparison, the HR per standard deviation of the self-reported Mediterranean diet was 0.90 (95% CI: 0.86 to 0.95). Assuming the score was causally associated with T2D, higher adherence to the Mediterranean diet in Western European adults by 10 percentiles of the score was estimated to reduce the incidence of T2D by 11% (95% CI: 7% to 14%). The study limitations included potential measurement error in nutritional biomarkers, unclear specificity of the biomarker score to the Mediterranean diet, and possible residual confounding.ConclusionsThese findings suggest that objectively assessed adherence to the Mediterranean diet is associated with lower risk of T2D and that even modestly higher adherence may have the potential to reduce the population burden of T2D meaningfully.Trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12613000602729 https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=363860.

Published
2023
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50. Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort

Author

C Wright, C Sanders, C Wilson, L Tucker, S Jones, S Douglass, C Patel, A Kumar, S Smith, A Ghosh, C Adams, R Hill, D Martin, J Hu, M Lee, N Patel, O Smith, J Cook, J Day, M Jackson, G Riera, P McGee, J Park, J Jiménez, S Yang, A Carlson, C Martin, H Liu, Y Li, A Krol, K Wright, S Golden, A Sood, J Martinez, D Sanchez, K Burton, Y Gao, S Martin, O Sanchez, C DeSouza, M Johnson, L Estrada, A Jackson, J Higgins, K Martin, J Craig, A Kuhn, L Ngo, Deborah J Wexler, R Chatterjee, E Walker, J Kerr, W Taylor, J Lim, M Perez, R Henry, Vanita R Aroda, R Fraser, Cyrus Desouza, E King, C Campbell, J González, E Diaz, P Zhang, J Marks, S Abraham, A Ross, M Khalid, T Young, J Myers, J Barzilay, B Chambers, G Montes, C Jensen, J McConnell, R Nelson, L Prosser, S Morton, M Curtis, P Wilson, L Young, M Fürst, S Warren, C Newman, S Kuo, N Rasouli, A Werner, L Morton, A Ghazi, M Salam, F Ismail-Beigi, P Kringas, C Baker, E Ellis, A Cherian, L Holloway, M Madden, B Hollis, G Fuller, B Steiner, K Stokes, R Ayala, T Lowe, K Chu, S Durán, D Dyer, A Alfred, J Leger, Nicole M Butera, T Hamilton, J Costello, E Burgess, R Garg, A Maxwell, C Stevens, W Ye, T Tran, L Fischer, M Hurtado, H Schneier, C Lund, R Lorch, M Mullen, J Bantle, K Arnold, D Wexler, A TURCHIN, MS Lee, D Howard, J Tejada, S Hernandez, Tasma Harindhanavudhi, E Schroeder, K Pham, S Kunkel, A Fagan, G Lord, H CHONG, A Smiley, E Debnam, H Petrovitch, M Bäckman, B Kauffman, V Jenkins, B Cramer, JP Crandall, MD McKee, S Behringer-Massera, J Brown-Friday, E Xhori, K Ballentine-Cargill, H Estrella, S Gonzalez de la torre, J Lukin, LS Phillips, D Olson, M Rhee, TS Raines, J Boers, C Gullett, M Maher-Albertelli, R Mungara, L Savoye, CA White, F Morehead, S Person, M Sibymon, S Tanukonda, A Balasubramanyam, R Gaba, P Hollander, E Roe, P Burt, K Chionh, C Falck-Ytter, L Sayyed Kassem, M Tiktin, T Kulow, KA Stancil, J Iacoboni, MV Kononets, L Colosimo, R Goland, J Pring, L Alfano, C Hausheer, K Gumpel, A Kirpitch, JB Green, H AbouAssi, MN Feinglos, J English Jones, RP Zimmer, BM Satterwhite, K Evans Kreider, CR Thacker, CN Mariash, KJ Mather, A Lteif, V Pirics, D Aguillar, S Hurt, R Bergenstal, T Martens, J Hyatt, H Willis, W Konerza, K Kleeberger, R Passi, S Fortmann, M Herson, K Mularski, H Glauber, J Prihoda, B Ash, C Carlson, PA Ramey, E Schield, B Torgrimson-Ojerio, E Panos, S Sahnow, K Bays, K Berame, D Ghioni, J Gluth, K Schell, J Criscola, C Friason, S Nazarov, N Rassouli, R Puttnam, B Ojoawo, C Sanders-Jones, Z El-Haqq, A Kolli, J Meigs, A Dushkin, G Rocchio, M Yepes, H Dulin, M Cayford, A DeManbey, M Hillard, N Thangthaeng, L Gurry, R Kochis, E Raymond, V Ripley, V Aroda, A Loveland, M Hamm, HJ Florez, WM Valencia, S Casula, L Oropesa-Gonzalez, L Hue, AK Riccio Veliz, R Nieto-Martinez, M Gutt, A Ahmann, D Aby-Daniel, F Joarder, V Morimoto, C Sprague, D Yamashita, N Cady, N Rivera-Eschright, P Kirchhoff, B Morales Gomez, J Adducci, A Goncharova, SH Hox, M Matwichyna, NO Bermudez, L Broadwater, RR Ishii, DS Hsia, WT Cefalu, FL Greenway, C Waguespack, N Haynes, A Thomassie, B Bourgeois, C Hazlett, S Mudaliar, S Boeder, J Pettus, D Garcia-Acosta, S Maggs, C DeLue, E Castro, J Krakoff, JM Curtis, T Killean, E Joshevama, K Tsingine, T Karshner, J Albu, FX Pi-Sunyer, S Frances, C Maggio, J Bastawrose, X Gong, MA Banerji, D Lorber, NM Brown, DH Josephson, LL Thomas, M Tsovian, MH Jacobson, MM Mishko, MS Kirkman, JB Buse, J Dostou, K Bergamo, A Goley, JF Largay, S Guarda, J Cuffee, D Culmer, H Almeida, S Coffer, L Kiker, K Josey, WT Garvey, A Agne, S McCullars, RM Cohen, MC Rogge, K Kersey, S Lipp, MB Vonder Meulen, C Underkofler, S Steiner, E Cline, WH Herman, R Pop-Busui, MH Tan, A Waltje, A Katona, L Goodhall, R Eggleston, K Whitley, S Bule, N Kessler, E LaSalle, ER Seaquist, A Bantle, T Harindhanavudhi, B Redmon, M Coe, M Mech, A Taddese, L Lesne, L Kuechenmeister, V Shivaswamy, AL Morales, K Seipel, J Eggert, R Tillson, DS Schade, A Adolphe, M Burge, E Duran-Valdez, P August, MG Rodriguez, O Griffith, A Naik, Barbara I Gulanski, Heidi Krause-Steinrauf, Judith H Lichtman, Jennifer B Green, Colleen E Suratt, Hiba AbouAssi, Andrew J Ahmann, E Gonzalez Hattery, A Ideozu, G McPhee, SA Khan, JB Kimpel, HM Ismail, ME Larkin, M Magee, A Ressing, L Manandhar, F Mwicigi, V Lagari-Libhaber, A Cuadot, YJ Kendal, B Veciana, G Fry, A Dragg, B Gildersleeve, J Arceneaux, M Pavlionis, A Stallings, S Machineni, AL Cherrington, MCR Lawson, C Adkins, T Onadeko, M Razzaghi, C Lyon, R Penaloza, WI Sivitz, LK Knosp, S Bojescu, S Burbach, A Bancroft, FA Jamaleddin Ahmad, D Hernandez McGinnis, B Pucchetti, E Scripsick, A Zamorano, RA DeFronzo, E Cersosimo, M Abdul-Ghani, C Triplitt, D Juarez, RI Garza, H Verastiqui, C Puckett, P Raskin, C Rhee, LF Jordan, S Sao, L Osornio Walker, L Schnurr-Breen, RB Kreymer, D Sturgess, KM Utzschneider, SE Kahn, L Alarcon-Casas Wright, EJ Boyko, EC Tsai, DL Trence, S Trikudanathan, BN Fattaleh, BK Montgomery, KM Atkinson, A Kozedub, T Concepcion, C Moak, N Prikhodko, S Rhothisen, TA Elasy, L Shackelford, R Goidel, N Hinkle, C Lovell, J Lipps Hogan, JB McGill, T Schweiger, S Kissel, C Recklein, MJ Clifton, W Tamborlane, A Camp, B Gulanski, SE Inzucchi, M Alguard, P Gatcomb, K Lessard, L Iannone, A Montosa, E Magenheimer, J Fradkin, HB Burch, AA Bremer, DM Nathan, JM Lachin, H Krause-Steinrauf, N Younes, I Bebu, N Butera, CJ Buys, MR Gramzinski, SD Hall, E Kazemi, E Legowski, C Suratt, M Tripputi, A Arey, J Bethepu, P Mangat Dhaliwal, E Mesimer, M Steffes, J Seegmiller, A Saenger, V Arends, D Gabrielson, T Conner, J Huminik, A Scrymgeour, EZ Soliman, Y Pokharel, ZM Zhang, L Keasler, S Hensley, R Mihalcea, DJ Min, V Perez-Rosas, K Resnicow, H Shao, J Luchsinger, S Assuras, E Groessl, F Sakha, N Hillery, BM Everett, I Abdouch, G Bahtiyar, P Brantley, FE Broyles, G Canaris, P Copeland, JJ Craine, WL Fein, A Gliwa, L Hope, R Meiners, V Meiners, H O’Neal, JE Park, A Sacerdote, E Sledge, L Soni, J Steppel-Reznik, B Brooks-Worrell, CS Hampe, JP Palmer, A Shojaie, L Doner Lotenberg, JM Gallivan, and DM Tuncer

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction Type 2 diabetes mellitus (T2DM) is a powerful risk factor for cardiovascular disease (CVD), conferring a greater relative risk in women than men. We sought to examine sex differences in cardiometabolic risk factors and management in the contemporary cohort represented by the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Research design and methods GRADE enrolled 5047 participants (1837 women, 3210 men) with T2DM on metformin monotherapy at baseline. The current report is a cross-sectional analysis of baseline data collected July 2013 to August 2017.Results Compared with men, women had a higher mean body mass index (BMI), greater prevalence of severe obesity (BMI≥40 kg/m2), higher mean LDL cholesterol, greater prevalence of low HDL cholesterol, and were less likely to receive statin treatment and achieve target LDL, with a generally greater prevalence of these risk factors in younger women. Women with hypertension were equally likely to achieve blood pressure targets as men; however, women were less likely to receive ACE inhibitors or angiotensin receptor blockers. Women were more likely to be divorced, separated or widowed, and had fewer years of education and lower incomes.Conclusions This contemporary cohort demonstrates that women with T2DM continue to have a greater burden of cardiometabolic and socioeconomic risk factors than men, particularly younger women. Attention to these persisting disparities is needed to reduce the burden of CVD in women.Trial registration number ClinicalTrials.gov (NCT01794143)

Published
2023
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