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The purpose of this study was to investigate the reproducibility of findings derived from a new iso-inertial dynamometer during bench press (BP) and squat (SQ) and to provide descriptive data for recreational athletes. A position transducer and accelerometer were combined to assess velocity and power during free weight lifting exercises. Simulated movement with a pulley system revealed the excellent technical consistency of the dynamometer. Sixteen male subjects participated in the study. Iso-inertial tests consisted of lifting as fast as possible four different relative loads (35, 50, 70, 90% 1RM in BP and 45, 60, 75, 90% 1RM in SQ). The test was repeated one week later. Analysis of variance revealed no significant variation between sessions or trials. Reproducibility was better in velocity than in power, although it remained fairly good in both exercises (coefficients of variation [CV] never exceeding 10%) except for the time to peak power parameter. Descriptive data confirmed the classical force-velocity and force-power relationships for BP and SQ. In conclusion, this study demonstrated reliable measurements in BP and SQ iso-inertial exercises. Monitoring force-velocity and force-power relationships offers an original functional approach in strength training supervision. [ABSTRACT FROM AUTHOR]

A series of 2,5-disubstituted-benzoxazole derivatives (1-13) were evaluated as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results demonstrated that the compounds exhibited a broad spectrum of AChE and BChE inhibitory activity ranging between 6.80% and 90.21% except one compound which showed no activity against AChE at the specified molar concentration. Another derivative displayed a similar activity to that of reference drug (galanthamine) for inhibition of AChE and BChE. In addition, molecular docking of the compounds into active site of AChE was performed using recombinant human AChE (PDB ID: 4ey6) in order to understand ligand-protein interactions.

A series of 2-(p-substituted phenyl)-5-[(4-substituted phenyl) sulfonylamido]-benzoxazoles were synthesized and tested for their antimicrobial activities. The structures of the new derivatives were elucidated by spectral techniques. The minimum inhibitory concentrations (MIC) of the new benzoxazoles were determined against standard bacterial and fungal strains and drug-resistant isolates and compared to those of several reference drugs.