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Introdução: A doença periodontal, quando não controlada pode gerar resposta inflamatória sistêmica, além de ser foco de infecção por meio de bacteremias. O tratamento da doença periodontal realizado através de raspagem e alisamento radicular (RAP) gera bacteremias transitórias, porém é eficaz em reduzir a atividade da doença. Na literatura, não há dados que apontam a segurança de realizar RAP em pacientes que realizaram transplante de células tronco hematopoiéticas alogênico (alo-TCTH). Objetivo: O objetivo desse estudo foi avaliar a segurança do procedimento de RAP entre os dias D+90 e D+130 em pacientes que realizaram alo-TCTH. Pacientes e métodos: Foi realizado um estudo multicêntrico, longitudinal, prospectivo, intervencional e randomizado que alocou os pacientes em dois grupos: controle e grupo de estudo. O grupo de estudo recebeu intervenção periodontal (RAP). Todos os pacientes, de ambos os grupos, foram submetidos a coleta de sinais vitais, hemocultura em sangue periférico e cateter e acompanhamento para ocorrência de complicações infecciosas (bacteremia, sepse, pneumonia) e uso de antibiótico, por 10 dias após o procedimento (grupo estudo), ou randomização (controle). O grupo controle fez uma única coleta (T0) de hemocultura, enquanto o grupo de estudo realizou 3 coletas em T0-pré RAP; T1-2 horas após a RAP e T2- 24 horas após a RAP. Resultados: Foram incluídos 216 pacientes, sendo 108 (50%) pacientes no grupo controle e 108 (50%) no grupo de estudo. Um total de 8 (7,4%) hemoculturas foram positivas no T0 do grupo controle, sendo 4 (3,7%) de sangue periférico e 4 (3,7%) de cateter. O grupo estudo apresentou 18 (14,8%) hemoculturas positivas nos 3 tempos de coletas: em T0 foram 4 (3,7%) de sangue periférico e 4 (3,7%) em cateter, em T1 foi 1 (0,1%) em sangue periférico e 1 (0,1%) em cateter e em T2 foram 4 (3,7%) de sangue periférico e 4 (3,7%) em cateter. Um total de 38 (17,8%) pacientes apresentaram complicações infecciosas nos primeiros 10 dias após RAP e coletas de hemocultura, desse número 30 pacientes tiveram hemocultura negativa em T0, sendo 13 do grupo controle e 17 do grupo de estudo. Não foram encontradas diferenças entre os grupos para hemocultura em T0 de sangue periférico (p = 1,00), hemocultura em T0 de cateter (p = 1,00), infecção nos primeiros 10 dias após RAP e coleta de hemoculturas (p = 0,47), pneumonia (p = 0,5) e uso de antibióticos (p = 1,00). Nenhum dos grupos apresentou bacteremia, nem sepse. Foi encontrada correlação entre hemocultura em T0 de sangue periférico e infecção (p < 0,001) nos 10 dias de acompanhamento do estudo e entre hemocultura em T0 de cateter e infecção em (p < 0,001) em ambos os grupos, bem como ocorreu correlação entre hemocultura em T2 de sangue periférico e cateter com infecção. Foi encontrada associação total entre hemocultura de sangue periférico de cateter (p < 0,001) em ambos os grupos. Conclusão: A realização de RAP em pacientes entre D+90 e D+130 pós alo-TCTH se mostrou segura adotando medidas preventivas como profilaxia antibiótica e monitoramento dos pacientes.

This article represents a systematical investigation on the structures of silver(i) dicarboxylate incorporating secondary ligands, revealing that the secondary interactions could play an important role in interlinking low-dimensional entities to high-dimensional supramolecular frameworks. A new 2D silver(i) crystalline dicarboxylate, {[Ag6(ADC)3(H2O)1.5]2·5.18H2O}n(1) (H2ADC = 1,3-adamantanedicarboxylic acid), has been obtained by slow diffusion of corresponding precursors. To investigate the influence of the properties of pyridylic neutral ligands on the complex structures based on compound 1, five kinds of neutral ligands (bipy = 4,4′-bipyridine; bpa = 1,2-bis(4-pyridyl)ethane; bpe = 1,2-bis(4-pyridyl)ethene; bpp = 1,3-bis(4-pyridyl)propane; bpdap = N,N′-bis(3-pyridyl)-2,6-diaminopyridine) were selected, and a series of new silver(i) dicarboxylate have been synthesized: {[Ag(bpa)(HADC)]}n(2), {[Ag(bpp)(HADC)]·CH3OH}n(3), {[Ag4(bpe)3(ADC)2]·2H2O}n(4), {[Ag(bipy)(HADC)]·H2O}n(5), {[Ag2(bipy)2(ADC)]·6H2O}n(6), and [Ag8(bpdap)4(ADC)4]·2C2H5OH·6H2O (7). Single-crystal X-ray structural analysis shows that complexes 1and 4are formed by hexanuclear and tetranuclear Ag(i) clusters with weak Ag–Ag interactions. Complexes 2and 3are dinuclear structures, 5and 6exhibit an infinite 1D chain structure, whereas 7is a discrete octanuclear Ag(i) unit. The structures of 1–7span from dinuclear, tetranuclear, hexanuclear, to octanuclear Ag(i) complexes, which indicates that secondary ligands do play important roles in the formation of such coordination architectures. Thermal stability, X-ray powder diffraction and luminescent properties of the compounds are also discussed. [ABSTRACT FROM AUTHOR]

Abstract  Benzoic acid esterification and ethyl benzoate transesterification with subcritical methanol were carried out at 220 °C without any catalyst. A procedure for biodiesel production from vegetable oil under indicated conditions was proposed. [ABSTRACT FROM AUTHOR]

Abstract  A new procedure for the preparation of amino complexes of silicon tetrafluoride was proposed. For this purpose, silica gel is dissolved in a fluoroanhydride—methanol system at room temperature followed by the precipitation of SiF4 solvate that was formed with tertiary amine (pyridine, 1,10-phenanthroline, 2,2′-bipyridyl). The yields of the formed complexes are 69–83%. [ABSTRACT FROM AUTHOR]

The Lee Chronic Graft-versus-Host Disease (GVHD) Symptom Scale is a patient-reported instrument developed and validated in English to measure the symptoms and functional impact of cGVHD. This tool has not yet been validated in a Latin American population, however. The Brazil-Seattle Chronic GVHD Consortium conducted a multicenter study at 5 Brazilian institutions to validate the Lee cGVHD Symptom Scale in adults with cGVHD. Study objectives included the translation and validation of the instrument in Brazilian Portuguese and evaluation of the correlation with other quality of life (QoL) tools, including the Medical Outcomes Study Short Form 36 (SF-36) and Functional Assessment of Chronic Illness Therapy with Bone Marrow Transplant subscale (FACT-BMT). Translation and validation were done according to the American Association of Orthopedic Surgeons Outcome Committee guidelines. Spearman's correlation coefficient was used to measure construct validity. Reliability was assessed using Cronbach's α and intraclass correlation coefficients. Between April 2011 and August 2012, 47 patients with cGVHD based on the 2005 National Institutes of Health criteria (29 males [62%], 18 females [38%]; median age, 48 years; range, 23 to 69 years) were enrolled in this study. The reliability of the Lee cGVHD Symptom Scale was adequate (Cronbach's α = 0.62 to 0.83). The correlations between similar domains of the Lee cGVHD Symptom Scale, SF-36, and FACT-BMT were moderate to high. Our data indicate that the Brazilian Portuguese version of the Lee cGVHD Symptom Scale is valid and reliable and can be used in clinical trials of cGVHD in Brazil., (Copyright © 2016 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)

Objective: To assess the safety and efficiency of cell therapy for pseudarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemporaneously using the Sepax(®) equipment., Methods: Six patients with nonunion of the tibia or femur were treated. Four received a percutaneous infusion of autologous bone marrow aspirated from the iliac crest, and two received autologous bone marrow mononuclear cells separated from the aspirate with the Sepax(®). The primary fixation method was unchanged, and the nonunion focus was not exposed. Physical examination and radiographies were performed 2, 4 and 6 months after the treatment by the same physician. After consolidation of the fracture the satisfaction of the patients was estimated using the adapted QALY scale., Results: No complications occurred as a result of the referred procedures. Bone consolidation was obtained in all cases within 3 to 24 weeks. The degree of patient satisfaction before and after bone consolidation was assessed, with the average value increasing from two to nine (p=0.0156)., Conclusion: We conclude that the proposed method is effective and safe for the treatment of nonunion of long bones regardless of the stabilization method used. Level of Evidence II, Prospective Comparative Study.