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Your search keyword '"Rowland, Laura M."' showing total 373 results
Start Over Author "Rowland, Laura M." Publication Type Academic Journals
373 results on '"Rowland, Laura M."'

2. Relations Among Anhedonia, Reinforcement Learning, and Global Functioning in Help-seeking Youth.

Author

Akouri-Shan, LeeAnn, Schiffman, Jason, Millman, Zachary B, Demro, Caroline, Fitzgerald, John, Rakhshan Rouhakhtar, Pamela J, Redman, Samantha, Reeves, Gloria M, Chen, Shuo, Gold, James M, Martin, Elizabeth A, Corcoran, Cheryl, Roiser, Jonathan P, Buchanan, Robert W, Rowland, Laura M, and Waltz, James A

Subjects
Serious Mental Illness, Clinical Research, Behavioral and Social Science, Basic Behavioral and Social Science, Pediatric, Neurosciences, Mental Health, Brain Disorders, Mental health, Adolescent, Anhedonia, Depression, Female, Humans, Male, Patient Acceptance of Health Care, Psychosocial Functioning, Psychotic Disorders, Reinforcement, Psychology, Risk, psychosis risk, salience, negative symptoms, depression, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Dysfunction in the neural circuits underlying salience signaling is implicated in symptoms of psychosis and may predict conversion to a psychotic disorder in youth at clinical high risk (CHR) for psychosis. Additionally, negative symptom severity, including consummatory and anticipatory aspects of anhedonia, may predict functional outcome in individuals with schizophrenia-spectrum disorders. However, it is unclear whether anhedonia is related to the ability to attribute incentive salience to stimuli (through reinforcement learning [RL]) and whether measures of anhedonia and RL predict functional outcome in a younger, help-seeking population. We administered the Salience Attribution Test (SAT) to 33 participants who met criteria for either CHR or a recent-onset psychotic disorder and 29 help-seeking youth with nonpsychotic disorders. In the SAT, participants must identify relevant and irrelevant stimulus dimensions and be sensitive to different reinforcement probabilities for the 2 levels of the relevant dimension ("adaptive salience"). Adaptive salience attribution was positively related to both consummatory pleasure and functioning in the full sample. Analyses also revealed an indirect effect of adaptive salience on the relation between consummatory pleasure and both role (αβ = .22, 95% CI = 0.02, 0.48) and social functioning (αβ = .14, 95% CI = 0.02, 0.30). These findings suggest a distinct pathway to poor global functioning in help-seeking youth, via impaired reward sensitivity and RL.

Published
2021

10. Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★

Author

Huang, Junchao, Zhu, Yu, Fan, Fengmei, Chen, Song, Hong, Yuan, Cui, Yimin, Luo, Xingguang, Tan, Shuping, Wang, Zhiren, Shang, Lan, Yuan, Ying, Zhang, Jianxin, Yang, Fude, Li, Chiang-Shan R., Rowland, Laura M., Kochunov, Peter, Zhang, Fengyu, Hong, L. Elliot, and Tan, Yunlong

Published
2020
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13. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia.

Author

Wright, Susan N, Hong, L Elliot, Winkler, Anderson M, Chiappelli, Joshua, Nugent, Katie, Muellerklein, Florian, Du, Xioming, Rowland, Laura M, Wang, Danny JJ, and Kochunov, Peter

Subjects
Humans, Spin Labels, Perfusion, Smoking, Memory, Short-Term, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Cerebrovascular Circulation, Algorithms, Adult, Middle Aged, Female, Male, Diffusion Tensor Imaging, White Matter, Gray Matter, DTI-FA, acute change, attention, cognition, nicotine, processing speed, white matter, Memory, Short-Term, Experimental Psychology, Neurosciences, Cognitive Sciences
Abstract

Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal information processing speed (PS) requires intact white matter (WM) physiology to support information transfer. In a cohort of 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which is measured using diffusion tensor imaging, mediated by the mismatch in WM/gray matter blood perfusion, and measured using arterial spin labeling. Our findings are specific to PS, and testing this hypothesis for patient-control differences in working memory produces no explanation. We demonstrate that PS deficits in schizophrenia can be explained by neurophysiological alterations in cerebral WM. Whether the disproportionately low WM integrity in schizophrenia is due to illness or secondary due to this disorder deserves further examination.

Published
2015

17. Anterior cingulate GABA levels predict whole-brain cerebral blood flow

Author

Krause, Benjamin W, Wijtenburg, S Andrea, Holcomb, Henry H, Kochunov, Peter, Wang, Danny JJ, Hong, L Elliot, and Rowland, Laura M

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Adolescent, Adult, Brain, Cerebrovascular Circulation, Female, Glutamic Acid, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Reference Values, Young Adult, gamma-Aminobutyric Acid, Arterial spin labeling, Cerebral blood flow, GABA, Magnetic resonance spectroscopy, Anterior cingulate, Cognitive Sciences, Biochemistry and cell biology, Biological psychology
Abstract

This study examined the relationship of γ-aminobutyric acid (GABA) and glutamate levels from the anterior and posterior cingulates (AC and PC) with cerebral blood flow (CBF) at rest. (1)H magnetic resonance spectroscopy measurements in the AC and PC and pseudo-continuous arterial spin labeling data were acquired from 10 healthy controls. GABA levels from the AC were strongly inversely correlated with global (whole-brain) CBF (r=-0.91, p=0.0015). GABA levels from the PC and glutamate levels from both regions were not significantly correlated with CBF. We hypothesize that GABA-mediated inhibition of AC activation of the locus coeruleus-norepinephrine pathway may influence global CBF.

Published
2014

18. Key Findings from Mental Health Research During the Menopause Transition for Racially and Ethnically Minoritized Women Living in the United States: A Scoping Review.

Author

Lewis Johnson, Tamara, Rowland, Laura M., Ashraf, Mahela S., Clark, Crystal T., Dotson, Vonetta M., Livinski, Alicia A., and Simon, Melissa

Subjects
*SCHIZOPHRENIA risk factors, *MENTAL depression risk factors, *MENTAL illness risk factors, *PSYCHIATRY, *MINORITIES, *SYSTEMATIC reviews, *PSYCHOSES, *RACE, *POST-traumatic stress disorder, *TREATMENT effectiveness, *RESEARCH funding, *INTERSECTIONALITY, *MENOPAUSE, *LITERATURE reviews, *HEALTH equity, *WOMEN'S health
Abstract

Background: Racially and ethnically minoritized (REM) women experience social and structural factors that may affect their response to mental health treatment and menopausal symptoms during the menopause transition (MT). This scoping review on mental health during the MT for REM women in the United States was conducted to characterize factors associated with mental health challenges. Materials and Methods: Five databases were searched. Articles were included if focused on MT in REM women in the United States and its territories with specific mental illnesses and published in English from 2005 to 2021. Titles and abstracts and full text were screened. Screening and data collection were completed in duplicate by two reviewers in Covidence. Results: Sixty-five articles were included and indicate that REM women experience a disproportionate burden of depressive symptoms during the MT. Less evidence is reported about anxiety, Post-Traumatic Stress Disorder, psychosis, schizophrenia, and other mental illnesses. The risk factors associated with mental illness during MT are social, structural, and biological. Treatment response to therapeutic interventions is often underpowered to explain REM differences. Conclusion: Depression during the MT is associated with negative outcomes that may impact REM women differentially. Incorporating theoretical frameworks (e.g., intersectionality, weathering) into mental health research will reduce the likelihood that scientists mislabel race as the cause of these inequities, when racism and intersecting systems of oppression are the root causes of differential expression of mental illness among REM women during the MT. There is a need for interdisciplinary research to advance the mental health of REM women. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Clinical and genetic validity of quantitative bipolarity

Author

Bruce, Heather A., Kochunov, Peter, Mitchell, Braxton, Strauss, Kevin A., Ament, Seth A., Rowland, Laura M., Du, Xiaoming, Fisseha, Feven, Kavita, Thangavelu, Chiappelli, Joshua, Wisner, Krista, Sampath, Hemalatha, Chen, Shuo, Kvarta, Mark D., Seneviratne, Chamindi, Postolache, Teodor T., Bellon, Alfredo, McMahon, Francis J., Shuldiner, Alan, and Elliot Hong, L.

Published
2019
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45. Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia

Author

Kochunov, Peter, Coyle, Thomas R., Rowland, Laura M., Jahanshad, Neda, Thompson, Paul M., Kelly, Sinead, Du, Xiaoming, Sampath, Hemalatha, Bruce, Heather, Chiappelli, Joshua, Ryan, Meghann, Fisseha, Feven, Savransky, Anya, Adhikari, Bhim, Chen, Shuo, Paciga, Sara A., Whelan, Christopher D., Xie, Zhiyong, Hyde, Craig L., Chen, Xing, Schubert, Christian R., O’Donnell, Patricio, and Hong, L. Elliot

Published
2017
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