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Start Over Author "Ritchie, C." Publication Type Academic Journals
878 results on '"Ritchie, C."'

8. GWAS for executive function and processing speed suggests involvement of the CADM2 gene

Author

Ibrahim-Verbaas, CA, Bressler, J, Debette, S, Schuur, M, Smith, AV, Bis, JC, Davies, G, Trompet, S, Smith, JA, Wolf, C, Chibnik, LB, Liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, DJ, Schmidt, CO, Mather, KA, Chouraki, V, Sun, Q, Resnick, SM, Rose, LM, Oldmeadow, C, Stewart, M, Smith, BH, Gudnason, V, Yang, Q, Mirza, SS, Jukema, JW, deJager, PL, Harris, TB, Liewald, DC, Amin, N, Coker, LH, Stegle, O, Lopez, OL, Schmidt, R, Teumer, A, Ford, I, Karbalai, N, Becker, JT, Jonsdottir, MK, Au, R, Fehrmann, RSN, Herms, S, Nalls, M, Zhao, W, Turner, ST, Yaffe, K, Lohman, K, van Swieten, JC, Kardia, SLR, Knopman, DS, Meeks, WM, Heiss, G, Holliday, EG, Schofield, PW, Tanaka, T, Stott, DJ, Wang, J, Ridker, P, Gow, AJ, Pattie, A, Starr, JM, Hocking, LJ, Armstrong, NJ, McLachlan, S, Shulman, JM, Pilling, LC, Eiriksdottir, G, Scott, RJ, Kochan, NA, Palotie, A, Hsieh, Y-C, Eriksson, JG, Penman, A, Gottesman, RF, Oostra, BA, Yu, L, DeStefano, AL, Beiser, A, Garcia, M, Rotter, JI, Nöthen, MM, Hofman, A, Slagboom, PE, Westendorp, RGJ, Buckley, BM, Wolf, PA, Uitterlinden, AG, Psaty, BM, Grabe, HJ, Bandinelli, S, and Chasman, DI

Subjects
Biological Psychology, Clinical and Health Psychology, Psychology, Genetics, Basic Behavioral and Social Science, Aging, Human Genome, Brain Disorders, Behavioral and Social Science, Mental Health, Neurosciences, Aged, Aged, 80 and over, Cell Adhesion Molecules, Cognition, Cohort Studies, Executive Function, Female, Genetic Association Studies, Genetic Variation, Genome-Wide Association Study, Genomics, Humans, Introns, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, White People, gamma-Aminobutyric Acid, Generation Scotland, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.

Published
2016

10. Differences in composition of symptom clusters between older and younger oncology patients

Author

Yates, P, Miaskowski, C, Cataldo, JK, Paul, SM, Cooper, BA, Alexander, K, Aouizerat, B, Dunn, L, Ritchie, C, McCarthy, A, and Skerman, H

Subjects
Medical and Health Sciences, Anesthesiology
Abstract

Context Older oncology patients have unique needs associated with the many physical, psychological, and social changes associated with the aging process. The mechanisms underpinning and the impact of these changes are not well understood. Identification of clusters of symptoms is one approach that has been used to elicit hypotheses about the biological and/or psychological basis for variations in symptom experiences. Objectives The purposes of this study were to identify and compare symptom clusters in younger (

Published
2015

12. Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

Author

Audrain, C., Auffret, A., Bakardjian, H., Baldacci, F., Batrancourt, B., Benakki, I., Benali, H., Bertin, H., Bertrand, A., Boukadida, L., Cacciamani, F., Causse, V., Cavedo, E., Cherif Touil, S., Chiesa, P.A., Colliot, O., Dalla Barba, G., Depaulis, M., Dos Santos, A., Dubois, B., Dubois, M., Epelbaum, S., Fontaine, B., Francisque, H., Gagliardi, G., Genin, A., Genthon, R., Glasman, P., Gombert, F., Habert, M.O., Hampel, H., Hewa, H., Houot, M., Jungalee, N., Kas, A., Kilani, M., La Corte, V., Le Roy, F., Lehericy, S., Letondor, C., Levy, M., Lista, S., Lowrey, M., Ly, J., Makiese, O., Masetti, I., Mendes, A., Metzinger, C., Michon, A., Mochel, F., Nait Arab, R., Nyasse, F., Perrin, C., Poirier, F., Poisson, C., Potier, M.C., Ratovohery, S., Revillon, M., Rojkova, K., Santos-Andrade, K., Schindler, R., Servera, M.C., Seux, L., Simon, V., Skovronsky, D., Thiebaut, M., Uspenskaya, O., Vlaincu, M., Aguilar, L.F., Babiloni, C., Benda, N., Black, K.L., Bokde, A.L.W., Bonuccelli, U., Broich, K., Bun, R.S., Cacciola, F., Castrillo, J., Ceravolo, R., Coman, C.M., Corvol, J.C., Cuello, A.C., Cummings, J.L., Depypere, H., Duggento, A., Durrleman, S., Escott-Price, V., Federoff, H., Ferretti, M.T., Fiandaca, M., Frank, R.A., Garaci, F., George, N., Giorgi, F.S., Graziani, M., Haberkamp, M., Herholz, K., Karran, E., Kim, S.H., Koronyo, Y., Koronyo-Hamaoui, M., Lamari, F., Langevin, T., Lehéricy, S., Lorenceau, J., Mapstone, M., Neri, C., Nisticò, R., Nyasse-Messene, F., O'Bryant, S.E., Perry, G., Ritchie, C., Rossi, S., Santarnecchi, E., Schneider, L.S., Sporns, O., Toschi, N., Verdooner, S.R., Vergallo, A., Villain, N., Welikovitch, L., Woodcock, J., Younesi, E., Vergallo, Andrea, Bun, René-Sosata, Toschi, Nicola, Baldacci, Filippo, Zetterberg, Henrik, Blennow, Kaj, Cavedo, Enrica, Lamari, Foudil, Habert, Marie-Odile, Dubois, Bruno, Floris, Roberto, Garaci, Francesco, Lista, Simone, and Hampel, Harald

Published
2018
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13. Differences in the symptom experience of older versus younger oncology outpatients: A cross-sectional study

Author

Cataldo, Janine, Cataldo, JK, Paul, S, Cooper, B, Skerman, H, Alexander, K, Aouizerat, B, Blackman, V, Merriman, J, Dunn, L, and Ritchie, C

Abstract

Background: Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received subs

Published
2013

14. Differences in the symptom experience of older versus younger oncology outpatients: A cross-sectional study

Author

Cataldo, JK, Paul, S, Cooper, B, Skerman, H, Alexander, K, Aouizerat, B, Blackman, V, Merriman, J, Dunn, L, Ritchie, C, Yates, P, and Miaskowski, C

Abstract

Background: Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received substandard treatment because of concerns about adverse effects. Given the paucity of research on the multiple dimensions of the symptom experience in older oncology patients, the purpose of this study was to evaluate for differences in ratings of symptom occurrence, severity, frequency, and distress between younger (< 60 years) and older ( ≥ 60 years) adults undergoing cancer treatment. We hypothesized that older patients would have significantly lower ratings on four symptom dimensions.Methods: Data from two studies in the United States and one study in Australia were combined to conduct this analysis. All three studies used the MSAS to evaluate the occurrence, severity, frequency, and distress of 32 symptoms.Results: Data from 593 oncology outpatients receiving active treatment for their cancer (i.e., 44.4% were < 60 years and 55.6% were ≥ 60 years of age) were evaluated. Of the 32 MSAS symptoms, after controlling for significant covariates, older patients reported significantly lower occurrence rates for 15 (46.9%) symptoms, lower severity ratings for 6 (18.9%) symptoms, lower frequency ratings for 4 (12.5%) symptoms, and lower distress ratings for 14 (43.8%) symptoms.Conclusions: This study is the first to evaluate for differences in multiple dimensions of symptom experience in older oncology patients. For almost 50% of the MSAS symptoms, older patients reported significantly lower occurrence rates. While fewer age-related differences were found in ratings of symptom severity, frequency, and distress, a similar pattern was found across all three dimensions. Future research needs to focus on a detailed evaluation of patient and clinical characteristics (i.e., type and dose of treatment) that explain the differences in symptom experience identified in this study. © 2013 Cataldo et al.; licensee BioMed Central Ltd.

Published
2013

22. Comprehensive geriatric assessment in the emergency department

Author

Ellis G, Marshall T, and Ritchie C

Subjects
Geriatric, Frailty, Emergency Department, Assessment, Geriatrics, RC952-954.6
Abstract

Graham Ellis,1 Trudi Marshall,2 Claire Ritchie2 1Medicine for the Elderly, Monklands Hospital, Airdrie, Scotland, UK; 2Kirklands Hospital, Bothwell, Scotland, UK Abstract: Changing global demography is resulting in older people presenting to emergency departments (EDs) in greater numbers than ever before. They present with greater urgency and are more likely to be admitted to hospital or re-attend and utilize greater resources. They experience longer waits for care and are less likely to be satisfied with their experiences. Not only that, but older people suffer poorer health outcomes after ED attendance, with higher mortality rates and greater dependence in activities of daily living or rates of admission to nursing homes. Older people’s assessment and management in the ED can be complex, time consuming, and require specialist skills. The interplay of multiple comorbidities and functional decline result in the complex state of frailty that can predispose to poor health outcomes and greater care needs. Older people with frailty may present to services in an atypical fashion requiring detailed, multidimensional, and increasingly multidisciplinary care to provide the correct diagnosis and management as well as appropriate placement for ongoing care or admission avoidance. ­Specific challenges such as delirium, functional decline, or carer strain need to be screened for and managed appropriately. Identifying patients with specific frailty syndromes can be critical to identifying those at highest risk of poor outcomes and most likely to benefit from further specialist interventions. Models of care are evolving that aim to deliver multidimensional assessment and management by multidisciplinary specialist care teams (comprehensive geriatric assessment). Increasingly, these models are demonstrating improved outcomes, including admission avoidance or reduced death and dependence. Delivering this in the ED is an evolving area of practice that adapts the principles of geriatric medicine for the urgent-care environment. Keywords: ED, frailty, models of care

Published
2014

45. Irish society of gastroenterology: Proceedings of Winter Meeting held Friday 21st and Saturday 22nd November, 1997

Author

Clarke, G., Ryan, E., O’Keane, J. C., Crowe, J., McMathuna, P., Moriarty, D., Ettarh, R., Sheahan, K., Hyland, J., O’Donoghue, D. P., Baird, A. W., Clarke, G., Ryan, E., Gormley, G., Keane, J. C. O., Crowe, J., MacMathuna, P., Wang, J. H., Wu, Q. D., Redmond, H. P., Condron, C., Bouchier-Hayes, D., Nally, K., Newton, F., O’Connell, J., O’Sullivan, G. C., Morgan, J., Collins, J. K., Shanahan, F., Goode, C., O’Connell, J., O’Sullivan, G. C., Collins, J. K., Shanahan, F., Winter, D. C., Taylor, C. T., Skelly, M. M., O’Donoghue, D. P., O’Sullivan, G. C., Baird, A. W., Harvey, B. J., Varghese, J. C., Farrell, M. A., McGrath, F. P., Murray, F. E., Osborne, H., Lee, M. J., Ryan, E., Sullivan, A., O’Keane, J. C., Crowe, J., Ryan, A. E., O’Keane, J. C., Crowe, J., Donovan, A. N., McCormick, P. A., Kenny, B., Somers, S., Bohan, A., Gibney, R. G., Marcaccio, M., Malone, D. E., Doyle, M., Delaney, C. P., Gorey, T. F., McEntee, G. P., O’Sullivan, G. C., Clarke, A., Stuart, R., Kelly, J., Kiely, M. D., Collins, J. K., Shanahan, F., O’Sullivan, M., Lovett, E., Mahmud, N., Kelleher, D., O’Morain, C. A., Larkin, C. J., Watson, R. G. P., Sloan, J. M., Ardill, J. E. S., Johnston, C. F., Buchanan, K. D., Heaney, A., Collins, J. S. A., Watson, G. R. P., Kalin, R. M., Heaney, A., Collins, J. S. A., Tham, T. C. K., Watson, R. G. P., McFarland, R. J., Bamford, K. B., Cróinín, T. Ó, Clyne, M., Drumm, B., Rowland, M., Kumar, D., O’Connor, P., Daly, L. E., Drumm, B., O’Toole, D. L., Long, A., Murphy, A. M., O’Neill, L., Weir, D. G., Kelleher, D., Heaney, A., Collins, J. S. A., Watson, R. G. P., Hopkins, A. M., Moynagh, P., O’Donoghue, D. P., Baird, A. W., Brennan, C., Harmey, J., Stapleton, P. P., Redmond, H. P., Bouchier-Hayes, D., Rasheed, A. M., Chen, G., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Gallagher, M., Grace, A., Xin, Y., Leader, M., Kay, E., Whelan, A., Pattison, U., Willoughby, R., Wallace, E., Weir, D., Feighery, C., Bennett, M. W., O’Connell, J., O’Sullivan, G. C., Brady, C., Roche, D., Collins, J. K., Shanahan, F., Mahmud, N., Molloy, A., McPartlin, J., Scott, J. M., Weir, D. G., Acheson, A. G., Lee, J., Khosraviani, K., Irwin, S. T., McDaid, J., McCormick, P. A., Docherty, J. R., O’Grady, A., Kay, E., Mabruk, M., Grace, A., Leader, M., Lee, J., Acheson, A. G., Irwin, S. T., Larkin, C. J., Johnston, C., Curry, W., Ardill, J., Cunningham, R., Buchanan, K. D., Watson, R. G. P., McDougall, N. I., Coyle, P. V., Callender, M. E., Ouinn, A. M., Warner, R., Stevens, F. M., Chakravarthi, P. I. S., Kearns, M., Bourke, M., Hassan, A., McWeeney, J., Stevens, F. M., McCarthy, C. F., Casey, M., O’Donoghue, J., Eustace-Ryan, A. M., O’Regan, P., Feighery, L., Jackson, J., Cronin, N., Shanahan, F., Quane, K., Feighery, C., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., Mulligan, E. D., Purcell, T., Dunne, B., Griffin, M., Noonan, N., Hollywood, D., Keeling, N., Reynolds, J. V., Hennessy, T. P. J., O’Sulhvan, M., Harman, I., Breslin, N. P., Clayton, N., O’Morain, C. A., Hogan, S., Donovan, B., Hayes, D., Kiely, M., Eustace-Ryan, A. M., O’Regan, P., Goulding, C. A., Albloushi, S. S., O’Connor, J., Courtney, M. G., Murray, F. E., Albloushi, S. S., Goulding, C. A., Kay, E., Royston, D., Leader, M., Courtney, M. G., Murray, F. E., Albloushi, S. S., Kay, E., Goulding, C. A., Grace, A., O’Connor, J., Shattock, A. G., Courtney, M. G., Murray, F. E., Albloushi, S. S., Stack, A., Kay, E., Goulding, C. A., Carmody, M., Murray, F. E., Courtney, M. G., Barrett, S., Ryan, E., O’Keane, J. C., Crowe, J., Hennigan, A., Delaney, C. P., Young, L., Shields, C. J., O’Keane, C., Gorey, T. F., Fitzpatrick, J. M., Rasheed, A. M., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Doyle, M. M., Stephens, R. B., Daly, P. A., Bennett, M. W., O’Connell, J., O’Sullivan, G. C., Brady, C., Roche, D., Collins, J. K., Shanahan, F., Briggs, G. M., McCrory, D., Briggs, G. M., McCrory, D., O’Neill, S., O’Grady, H., Grant, D. C., Barry, K., Traynor, O., Hyland, J. M. P., O’Toole, G. C., Grant, D. C., Barry, M. K., Hyland, J. M. P., Johnston, S. D., Ritchie, C. M., Robinson, T. J., Johnston, S. D., Kirby, J. M., Mackle, E. M., Robinson, T. J., Haider, N., Aherne, N., McNichol, F., Hamilton, D., Neary, P., Hegarty, S., Connor, J. O., Watson, R. G. K., Drudy, D., Alwan, A., Fenelon, L., O’Farrelly, C., Hyland, J., Byrne, B., Madrigal, L., Carton, J., Collins, C., O’Donoghue, D., O’Farrelly, C., Gannon, N., Hickey, A., O’Boyle, C. A., Byrne, R., Albloushi, S., and Murray, F.

Published
1998
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