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Your search keyword '"Rigler, M. Y."' showing total 2 results
Start Over Author "Rigler, M. Y." Publication Type Academic Journals
2 results on '"Rigler, M. Y."'

2. [Cardiac manifestations of Lyme borreliosis with special reference to contractile dysfunction].

Author

Seinost G, Gasser R, Reisinger E, Rigler MY, Fischer L, Keplinger A, Dattwyler RJ, Dunn JJ, and Klein W

Subjects
Adolescent, Adult, Aged, Cardiac Catheterization, Cardiomyopathy, Dilated drug therapy, Cardiomyopathy, Dilated physiopathology, Cardiovascular Agents therapeutic use, Ceftriaxone administration & dosage, Drug Therapy, Combination, Echocardiography, Female, Humans, Infusions, Intravenous, Lyme Disease drug therapy, Lyme Disease physiopathology, Male, Middle Aged, Myocardial Contraction drug effects, Stroke Volume drug effects, Stroke Volume physiology, Treatment Outcome, Ventricular Function, Left drug effects, Ventricular Function, Left physiology, Cardiomyopathy, Dilated diagnosis, Lyme Disease diagnosis, Myocardial Contraction physiology
Abstract

Borrelia burgdorferi infection (BBI) is suggested to be associated with dilated cardiomyopathy (IDC). Stanek et al. were able to cultivate Borrelia burgdorferi (BB) from myocardial biopsy tissue of a patient with longstanding dilated cardiomyopathy. Here we present a study in which we examined the effect of standard antibiotic treatment on the left ventricular ejection fraction (LV-EF) in patients with dilated cardiomyopathy associated with BBI. In this study we assessed the serum (IgG, IgM ELISA; Western Blot) and the history of 46 IDC-patients with specific respect spect to BBI (mean LV-EF: 30.4 +/- 1.3%; measured by cardiac catheterisation and echocardiography--length-area-volume method). All 46 patients received standard treatment for dilated cardiomyopathy: ACE-inhibitors, digitalis and diuretics. 11 (24%) patients showed positive serology and a history of BBI; 9 of these also had a typical history of tick bite and erythema chronicum migrans (ECM) and/or other organ involvement, 2 had no recollection of tick bite or EMC, but showed other BB-associated disorders (neuropathy, oligoarthritis). These 11 patients with BBI received standard antibiotic treatment with intravenous ceftriaxone 2 g bid for 14 days. 6 (55%) recovered completely and showed a normal LV-EF after 6 months, 3 (27%) improved their LV-EF and 2 (18%) did not improve at all. This amounts to 9 (82%) recovery/improvement in the BB-group. The 35 patients who did not show positive serology or a history of BBI did not receive antibiotic treatment. In this group without BBI 12 (26%) showed recovery/improvement following the standard treatment of dilated cardiomyopathy (see above). Our results indicate that BBI could play a decisive role in the development of dilated cardiomyopathy, especially in a geographical region as Graz, where BB is endemic. While aware of the small number of BB-patients in this study, we nevertheless conclude that, in a remarkable number of patients with signs of BBI, dilated cardiomyopathy could be reversed and LV-EF improved upon standard antibiotic treatment.

Published
1998

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