Search

In this paper, the potential of Sentinel-1A and Sentinel-2A satellite images for land cover mapping is evaluated at three levels of spatial detail; exploratory, reconnaissance, and semi-detailed. To do so, two different image classification approaches are compared: (i) a traditional pixel-wise approach; and (ii) an object–oriented approach. In both cases, the classification task was conducted using the “RandomForest” algorithm. The case study was also intended to identify a set of radar channels, optical bands, and indices that are relevant for classification. The thematic accuracy of the classifications displays the best results for the object-oriented approach to exploratory and recognition levels. The results show that the integration of multispectral and radar data as explanatory variables for classification provides better results than the use of a single data source.

Copyright of Dyna is the property of Universidad Nacional de Colombia, Medellin, Facultad de Minas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We have determined the effects that tightly bound water molecules have on the de novo design of cyclin-dependent kinase-2 (CDK2) ligands. In particular, we have analyzed the impact of a specific structural water molecule on the chemical diversity and binding mode of ligands generated through a de novo structure-based ligand generation method in the binding site of CDK2. The tightly bound water molecule modifies the size and shape of the binding site and we have found that it also imposed constraints on the observed binding modes of the generated ligands. This in turn had the indirect effect of reducing the chemical diversity of the underlying molecular scaffolds that were able to bind to the enzyme satisfactorily. [ABSTRACT FROM AUTHOR]