Search

Your search keyword '"Ramnarayan, Padmanabhan"' showing total 335 results
Start Over Author "Ramnarayan, Padmanabhan" Publication Type Academic Journals

Refine your results

more »

more »

more »

more »

more »
335 results on '"Ramnarayan, Padmanabhan"'

1. Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Author

Patel, Harsita, Carter, Michael J., Jackson, Heather, Powell, Oliver, Fish, Matthew, Terranova-Barberio, Manuela, Spada, Filomena, Petrov, Nedyalko, Wellman, Paul, Darnell, Sarah, Mustafa, Sobia, Todd, Katrina, Bishop, Cynthia, Cohen, Jonathan M., Kenny, Julia, van den Berg, Sarah, Sun, Thomas, Davis, Francesca, Jennings, Aislinn, Timms, Emma, Thomas, Jessica, Nyirendra, Maggie, Nichols, Samuel, Estamiana Elorieta, Leire, D’Souza, Giselle, Wright, Victoria, De, Tisham, Habgood-Coote, Dominic, Ramnarayan, Padmanabhan, Tissières, Pierre, Whittaker, Elizabeth, Herberg, Jethro, Cunnington, Aubrey, Kaforou, Myrsini, Ellis, Richard, Malim, Michael H., Tibby, Shane M., Shankar-Hari, Manu, and Levin, Michael

Published
2024
Full Text
View/download PDF

4. Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children

Author

Zhang, Zhenguang, Kean, Iain R. L., Dratva, Lisa M., Clark, John A., Syrimi, Eleni, Khan, Naeem, Daubney, Esther, White, Deborah, O’Neill, Lauran, Chisholm, Catherine, Payne, Caroline, Benkenstein, Sarah, Kupiec, Klaudia, Galassini, Rachel, Wright, Victoria, Winmill, Helen, Robbins, Ceri, Brown, Katherine, Ramnarayan, Padmanabhan, Scholefield, Barnaby, Peters, Mark, Klein, Nigel, Montgomery, Hugh, Meyer, Kerstin B., Teichmann, Sarah A., Bryant, Clare, Taylor, Graham, and Pathan, Nazima

Published
2024
Full Text
View/download PDF

7. Operational Definitions Related to Pediatric Ventilator Liberation

Author

Abu-Sultaneh, Samer, Iyer, Narayan Prabhu, Fernández, Analía, Gaies, Michael, González-Dambrauskas, Sebastián, Hotz, Justin Christian, Kneyber, Martin CJ, López-Fernández, Yolanda M, Rotta, Alexandre T, Werho, David K, Baranwal, Arun Kumar, Blackwood, Bronagh, Craven, Hannah J, Curley, Martha AQ, Essouri, Sandrine, Fioretto, Jose Roberto, Hartmann, Silvia MM, Jouvet, Philippe, Korang, Steven Kwasi, Rafferty, Gerrard F, Ramnarayan, Padmanabhan, Rose, Louise, Tume, Lyvonne N, Whipple, Elizabeth C, Wong, Judith Ju Ming, Emeriaud, Guillaume, Mastropietro, Christopher W, Napolitano, Natalie, Newth, Christopher JL, Khemani, Robinder G, and Network, Pediatric Acute Lung Injury and Sepsis Investigators

Subjects
Lung, Bioengineering, Pediatric, Assistive Technology, Patient Safety, Humans, Child, Respiration, Artificial, Ventilator Weaning, Ventilators, Mechanical, Research Design, Airway Extubation, airway extubation, extubation failure, high-flow nasal cannula, mechanical ventilation, noninvasive ventilation, pediatric ICU, ventilator weaning, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Clinical Sciences, Respiratory System
Abstract

BackgroundCommon, operational definitions are crucial to assess interventions and outcomes related to pediatric mechanical ventilation. These definitions can reduce unnecessary variability among research and quality improvement efforts, to ensure findings are generalizable, and can be pooled to establish best practices.Research questionCan we establish operational definitions for key elements related to pediatric ventilator liberation using a combination of detailed literature review and consensus-based approaches?Study design and methodsA panel of 26 international experts in pediatric ventilator liberation, two methodologists, and two librarians conducted systematic reviews on eight topic areas related to pediatric ventilator liberation. Through a series of virtual meetings, we established draft definitions that were voted upon using an anonymous web-based process. Definitions were revised by incorporating extracted data gathered during the systematic review and discussed in another consensus meeting. A second round of voting was conducted to confirm the final definitions.ResultsIn eight topic areas identified by the experts, 16 preliminary definitions were established. Based on initial discussion and the first round of voting, modifications were suggested for 11 of the 16 definitions. There was significant variability in how these items were defined in the literature reviewed. The final round of voting achieved ≥ 80% agreement for all 16 definitions in the following areas: what constitutes respiratory support (invasive mechanical ventilation and noninvasive respiratory support), liberation and failed attempts to liberate from invasive mechanical ventilation, liberation from respiratory support, duration of noninvasive respiratory support, total duration of invasive mechanical ventilation, spontaneous breathing trials, extubation readiness testing, 28 ventilator-free days, and planned vs rescue use of post-extubation noninvasive respiratory support.InterpretationWe propose that these consensus-based definitions for elements of pediatric ventilator liberation, informed by evidence, be used for future quality improvement initiatives and research studies to improve generalizability and facilitate comparison.

Published
2023

8. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Patel, Harsita, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Tremoulet, Adriana, Munblit, Daniel, Ulloa-Gutierrez, Rolando, Carter, Michael J, Ramnarayan, Padmanabhan, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, Levin, Michael, consortium, Best Available Treatment Study, Chouli, Mohamed, Hamadouche, Nacera, Ladj, Mohamed Samir, Vázquez, Jorge Agrimbau, Carmona, Rodrigo, Collia, Adrian Gustavo, Ellis, Alejandro, Natta, Diego, Pérez, Laura, Rubiños, Mayra, Veliz, Natalia, Yori, Silvana, Britton, Philip N, Burgner, David P, Carey, Emma, Crawford, Nigel W, Giuliano, Hayley, McMinn, Alissa, Wong, Shirley, Wood, Nicholas, Holter, Wolfgang, Krainz, Matthias, Ulreich, Raphael, Zurl, Christoph, Dehoorne, Joke, Haerynck, Filomeen, Hoste, Levi, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Farias, Camila Giuliana Almeida, Almeida, Flávia Jacqueline, Leal, Izabel Alves, da Silva, André Ricardo Araujo, Araujo e Silva, Anna Esther, Barreiro, Sabrina TA, da Silva, Daniella Gregória Bomfim Prado, Cervi, Maria Celia, dos Santos Naja Cardoso, Mirian Viviane, Teixeira, Cristiane Henriques, Jarovsky, Daniel, Araujo, Julienne Martins, Berezin, Eitan Naaman, Sáfadi, Marco Aurélio Palazzi, la Ossa, Rolando Andres Paternina-de, Vieira, Cristina Souza, Dimitrova, Anna, Ganeva, Margarita, Stefanov, Stefan, Telcharova-Mihaylovska, Albena, Biggs, Catherine M, Lopez, Alison, Scuccimarri, Rosie, Tan, Ryan, Wasserman, Sam, Withington, Davinia, Ampuero, Camila, Aravena, Javiera, B, Raul Bustos, Casanova, Daniel, Cruces, Pablo, Diaz, Franco, García-Salum, Tamara, Godoy, Loreto, Medina, Rafael A, Galaz, Gonzalo Valenzuela, Camacho-Moreno, Germán, Avila-Aguero, María L, Brenes-Chacón, Helena, Camacho-Badilla, Kattia, Ivankovich-Escoto, Gabriela, Naranjo-Zuniga, Gabriela, and Soriano-Fallas, Alejandra

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Comparative Effectiveness Research, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Best Available Treatment Study (BATS) consortium, Clinical sciences
Abstract

BackgroundMultisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments.MethodsThe Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370.FindingsWe enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2-11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75-1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58-1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91-1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70-1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11-0·20]; p

Published
2023

9. Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document.

Author

Abu-Sultaneh, Samer, Iyer, Narayan, Fernández, Analía, Gaies, Michael, González-Dambrauskas, Sebastián, Hotz, Justin, Kneyber, Martin, López-Fernández, Yolanda, Rotta, Alexandre, Werho, David, Baranwal, Arun, Blackwood, Bronagh, Craven, Hannah, Curley, Martha, Essouri, Sandrine, Fioretto, Jose, Hartmann, Silvia, Jouvet, Philippe, Korang, Steven, Rafferty, Gerrard, Ramnarayan, Padmanabhan, Rose, Louise, Tume, Lyvonne, Whipple, Elizabeth, Wong, Judith, Emeriaud, Guillaume, Mastropietro, Christopher, Napolitano, Natalie, Newth, Christopher, and Khemani, Robinder

Subjects
airway extubation, clinical protocols, mechanical ventilators, pediatric intensive care units, ventilator weaning, Humans, Child, Respiration, Artificial, Ventilator Weaning, Ventilators, Mechanical, Airway Extubation, Sepsis
Abstract

Rationale: Pediatric-specific ventilator liberation guidelines are lacking despite the many studies exploring elements of extubation readiness testing. The lack of clinical practice guidelines has led to significant and unnecessary variation in methods used to assess pediatric patients readiness for extubation. Methods: Twenty-six international experts comprised a multiprofessional panel to establish pediatrics-specific ventilator liberation clinical practice guidelines, focusing on acutely hospitalized children receiving invasive mechanical ventilation for more than 24 hours. Eleven key questions were identified and first prioritized using the Modified Convergence of Opinion on Recommendations and Evidence. A systematic review was conducted for questions that did not meet an a priori threshold of ⩾80% agreement, with Grading of Recommendations, Assessment, Development, and Evaluation methodologies applied to develop the guidelines. The panel evaluated the evidence and drafted and voted on the recommendations. Measurements and Main Results: Three questions related to systematic screening using an extubation readiness testing bundle and a spontaneous breathing trial as part of the bundle met Modified Convergence of Opinion on Recommendations criteria of ⩾80% agreement. For the remaining eight questions, five systematic reviews yielded 12 recommendations related to the methods and duration of spontaneous breathing trials, measures of respiratory muscle strength, assessment of risk of postextubation upper airway obstruction and its prevention, use of postextubation noninvasive respiratory support, and sedation. Most recommendations were conditional and based on low to very low certainty of evidence. Conclusions: This clinical practice guideline provides a conceptual framework with evidence-based recommendations for best practices related to pediatric ventilator liberation.

Published
2023

10. Framework for Research Gaps in Pediatric Ventilator Liberation

Author

Abu-Sultaneh, Samer, Baranwal, Arun Kumar, Blackwood, Bronagh, Craven, Hannah J., Curley, Martha A.Q., Emeriaud, Guillaume, Essouri, Sandrine, Fernández, Analía, Fioretto, Jose Roberto, Gaies, Michael, González-Dambrauskas, Sebastián, Hartmann, Silvia M.M., Hotz, Justin Christian, Iyer, Narayan Prabhu, Jouvet, Philippe, Kneyber, Martin C.J., Korang, Steven Kwasi, López-Fernández, Yolanda M., Mastropietro, Christopher W., Napolitano, Natalie, Newth, Christopher J.L., Rafferty, Gerrard F., Ramnarayan, Padmanabhan, Rose, Louise, Rotta, Alexandre T., Tume, Lyvonne N., Werho, David K., Whipple, Elizabeth C., Ming Wong, Judith Ju, and Khemani, Robinder G.

Published
2024
Full Text
View/download PDF

12. Protocol for a Randomized Controlled Trial to Evaluate a Permissive Blood Pressure Target Versus Usual Care in Critically Ill Children with Hypotension (PRESSURE)

Author

Darnell, Robert, Brown, Alanna, Laing, Emma, Edwards, Julia, Harrison, David A., Manning, Joseph C., Peters, Mark J., Ramnarayan, Padmanabhan, Ray, Samiran, Sadique, Zia, Scholefield, Barnaby R., Shortt, Dermot, Lampro, Lamprini, Au, Carly, Rowan, Kathy M., Mouncey, Paul, and Inwald, David P.

Published
2024
Full Text
View/download PDF

16. Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial

Author

Thomas, Carla, Jirasek, Petr, Jones, Dawn, Dore, Rachael, O'Malley, Laura, Kanthimatinathan, Hari Krishnan, Winmill, Helen, Ashton, Lydia, Owen, Samantha, Davis, Peter, Marley-Munn, Helen, Moody, Francesca, Haskins, Ellen, Dodge, Laura, Jones, Andrew, Thomas, Joan, Murphy, Gail, Lillie, Jon, Williams, Aleks, Wellman, Paul, Aougah, Esther, Payne, Caroline, Belfield, Holly, Akpan, Joshua, Benkenstein, Sarah, Beech, Emily, Manjra, Ilham I, Hulme, Sara-Louise, Sarfatti, Avishay, Beadon, Kirsten, Harmer, Rebecca, Deep, Akash, Balnta, Christina, D'Silva, Pamela, Hylton, Asha, Saikia, Bedangshu, Nichani, Sanjiv, Patel, Rekha, Davies, Patrick, Anderson, Laura, Lawless, Laura, Dewar, Alex, Reynolds, David, Levin, Richard, Bowman, Fiona, Pujazon, Andrea-Rosa, Davidson, Mark, Szulik, Katarzyna, Bunni, Lara, Jennings, Claire, Marshall, Rebecca, Griksaitis, Michael, Thomas, Philippa, Postlethwaite, Catherine, Cook, Amber, Dwarakanathan, Buvana, Gomes de Queiroz, Joana, Ros Foguet, Montserrat, Ali, Hawakiin, Bycroft, Thomas, Darnell, Sarah, Mustafa, Sobia, Bridges, Katy, Mulgrew, Kirsty, Heenan, Nadine, Bell, Lynne, Davies, Andrew, Peters, Mark J, Gould, Doug W, Ray, Samiran, Thomas, Karen, Chang, Irene, Orzol, Marzena, O'Neill, Lauran, Agbeko, Rachel, Au, Carly, Draper, Elizabeth, Elliot-Major, Lee, Giallongo, Elisa, Jones, Gareth A L, Lampro, Lamprini, Pappachan, Jon, Peters, Sam, Ramnarayan, Padmanabhan, Sadique, Zia, Rowan, Kathryn M, Harrison, David A, and Mouncey, Paul R

Published
2024
Full Text
View/download PDF

21. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Chouli, Mohamed, Hamadouche, Nacera, Ladj, Mohamed Samir, Agrimbau Vázquez, Jorge, Carmona, Rodrigo, Collia, Adrian Gustavo, Ellis, Alejandro, Natta, Diego, Pérez, Laura, Rubiños, Mayra, Veliz, Natalia, Yori, Silvana, Britton, Philip N., Burgner, David P., Carey, Emma, Crawford, Nigel W., Giuliano, Hayley, McMinn, Alissa, Wong, Shirley, Wood, Nicholas, Holter, Wolfgang, Krainz, Matthias, Ulreich, Raphael, Zurl, Christoph, Dehoorne, Joke, Haerynck, Filomeen, Hoste, Levi, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Almeida Farias, Camila Giuliana, Almeida, Flávia Jacqueline, Alves Leal, Izabel, Araujo da Silva, André Ricardo, Araujo e Silva, Anna Esther, Barreiro, Sabrina T.A., Bomfim Prado da Silva, Daniella Gregória, Cervi, Maria Celia, dos Santos Naja Cardoso, Mirian Viviane, Henriques Teixeira, Cristiane, Jarovsky, Daniel, Martins Araujo, Julienne, Naaman Berezin, Eitan, Palazzi Sáfadi, Marco Aurélio, Paternina-de la Ossa, Rolando Andres, Souza Vieira, Cristina, Dimitrova, Anna, Ganeva, Margarita, Stefanov, Stefan, Telcharova-Mihaylovska, Albena, Biggs, Catherine M., Lopez, Alison, Scuccimarri, Rosie, Tan, Ryan, Wasserman, Sam, Withington, Davinia, Ampuero, Camila, Aravena, Javiera, Bustos B, Raul, Casanova, Daniel, Cruces, Pablo, Diaz, Franco, García-Salum, Tamara, Godoy, Loreto, Medina, Rafael A., Valenzuela Galaz, Gonzalo, Camacho-Moreno, Germán, Avila-Aguero, María L., Brenes-Chacón, Helena, Camacho-Badilla, Kattia, Ivankovich-Escoto, Gabriela, Naranjo-Zuniga, Gabriela, Soriano-Fallas, Alejandra, Ulloa-Gutierrez, Rolando, Yock-Corrales, Adriana, Amer, Maysa Abbas, Abdelmeguid, Yasmine, Ahmed, Yomna H.H.Z., Badib, Adham, Badreldin, Karim, Elkhashab, Yara, Heshmat, Hassan, Hussein, Amna, Mohamed Hussein, Amna Hussein, Ibrahim, Sandra, Shoman, Walaa, Yakout, Radwa M, Heinonen, Santtu, Angoulvant, François, Belot, Alexandre, Ouldali, Naïm, Beske, Florian, Heep, Axel, Masjosthusmann, Katja, Reiter, Karl, van den Heuvel, Ingeborg, von Both, Ulrich, Agrafiotou, Aikaterini, Antachopoulos, Charalampos, Charisi, Konstantina, Eleftheriou, Irini, Farmaki, Evangelia, Fotis, Lampros, Kafetzis, Dimitrios, Koletsi, Patra, Kourtesi, Katerina, Lampidi, Stavroula, Liakopoulou, Theodota, Maritsi, Despoina, Michailidou, Elisa, Milioudi, Maria, Mparmpounaki, Ioanna, Papadimitriou, Eleni, Papaevangelou, Vassiliki, Roilides, Emmanuel, Tsiatsiou, Olga, Tsolas, Georgios, Tsolia, Maria, Vantsi, Petrina, Banegas Pineda, Linda Yajeira, Borjas Aguilar, Karla Leversia, Cantillano Quintero, Edwin Mauricio, Ip, Patrick, Kwan, Mike Yat Wah, Kwok, Janette, Lau, Yu Lung, To, Kelvin, Wong, Joshua Sung Chih, David, Mate, Farkas, David, Kalcakosz, Szofia, Szekeres, Klaudia, Zsigmond, Borbala, Aslam, Nadeem, Luder, Anthony, Andreozzi, Laura, Bianco, Francesco, Bucciarelli, Valentina, Buonsenso, Danilo, Cimaz, Rolando, De Luca, Maia, Dellepiane, Rosa Maria, Fabi, Marianna, Filice, Emanuele, Lanari, Marcello, Lo Vecchio, Andrea, Mastrolia, Maria Vincenza, Mauro, Angela, Mazza, Angelo, Papa, Mario Virgilio, Romani, Lorenza, Scarano, Sara Maria, Simonini, Gabriele, Tipo, Vincenzo, Verdoni, Lucio, Macharia, Anne-Marie, Musiime, Grace, Reel, Bhupi, Wangai, Frederick, Pace, David, Torpiano, Paul, Anaya-Enriquez, Nancy, Carreon-Guerrero, Juan Manuel, Chacon-Cruz, Enrique, Cheung López, Mariana, Faugier Fuentes, Enrique, Fonseca Flores, Marisol, García-Domínguez, Miguel, Giron Vargas, Ana Luisa, Lopez-Delgado, Ivan, Lopez Hernández, Liliana, Menchaca Aguayo, Hector F., Montaño-Duron, Jesus Gilberto, Pérez-Gaxiola, Giordano, Ramos Tiñini, Pamela, Tostado-Morales, Edgardo, Valadez, Julio, Inchley, Christopher, Klevberg, Sjur, Knudsen, Per Kristian, Måseide, Per Helge, Carrera, Jose Manuel, Castaño, Elizabeth, Daza Timana, Carlos Alberto, De Leon, Tirza, Estripeaut, Dora, Levy, Jacqueline, Norero, Ximena, Record, Javier, Rojas-Bonilla, Magda, Wong, Mayra, Iramain, Ricardo, Hernandez, Roger, Huamán, Gian, Munaico, Manuel, Peralta, Carlos, Seminario, Diego, Zapata Yarlequé, Elmer Hans, Gadzinska, Justyna, Ludwikowska, Kamila, Mandziuk, Joanna, Okarska-Napierała, Magdalena, Alacheva, Zalina A., Alexeeva, Ekaterina, Ananin, Petr V., Antsupova, Margarita, Bakradze, Maya D., Berbenyuk, Anna, Bobkova, Polina, Borzakova, Svetlana, Chashchina, Irina L., El-Taravi, Yasmin, Fisenko, Andrey P., Gautier, Marina S., Glazyrina, Anastasia, Gorlenko, Cyrill, Grosheva, Mariia, Kiselev, Herman, Kondrikova, Elena, Korobyants, Evgeniya, Korsunskiy, Anatoliy A., Kovygina, Karina, Krasnaya, Ekaterina, Kurbanova, Seda, Kurdup, Maria K., Mamutova, Anna V., Mazankova, Lyudmila, Mitushin, Ilya L., Munblit, Daniel, Nargizyan, Anzhelika, Orlova, Yanina O., Osmanov, Ismail M., Polyakova, Anastasia S., Pushkareva, Anna, Romanova, Olga, Samitova, Elmira, Shvedova, Anastasia, Sologub, Anna, Iakovleva, Ekaterina, Tepaev, Rustem F., Tkacheva, Anna A., Yegiyan, Margarita, Yusupova, Valeriya, Zholobova, Elena, Grasa, Carlos Daniel, Epalza, Cristina, Lopez Segura, Nuria, Martinon-Torres, Federico, Melendo, Susana, Mendez-Echevarria, Ana, Mesa Guzmán, Juan Miguel, Palacios Argueta, Jorge Roberto, Rivero-Calle, Irene, Rivière, Jacques, Rodríguez-González, Moisés, Rojo, Pablo, Sanchez Manubens, Judith, Soler-Palacin, Pere, Soriano-Arandes, Antoni, Tagarro, Alfredo, Villaverde, Serena, Altman, Maria, Brodin, Petter, Horne, AnnaCarin, Palmblad, Karin, Brotschi, Barbara, Meyer Sauteur, Patrick, Pachlopnik Schmid, Jana, Prader, Seraina, Relly, Christa, Schlapbach, Luregn J., Seiler, Michelle, Strasser, Sophie, Trück, Johannes, Weber, Kathrin, Wütz, Daniela, Hamdan, Alaa, Melhem, Ibrahim, Moussa, Ahmed, Dunk, Joke, Ketharanathan, Naomi, Vermont, Clementien, Akyüz Özkan, Esra, Cetin, Benhur Sirvan, Erdeniz, Emine Hafize, Şahin, Irfan Oğuz, Borisova, Galina, Boyarchuk, Oksana, Boychenko, Lidiya, Boyko, Yaryna, Diudenko, Nadiia, Dyvonyak, Olha, Kasiyan, Olexandr, Katerynych, Kostiantyn, Kostyuchenko, Larysa, Mamenko, Marina, Melnyk, Kateryna, Miagka, Nelia, Nazarenko, Liliya, Nezgoda, Iryna, Rykova, Stanislava, Svyst, Olga, Teslenko, Maria, Trykosh, Mykola, Vasilenko, Nataliya, Volokha, Alla, Adams, Charlotte, Akomolafe, Toju, Al-Abadi, Eslam, Alders, Nele, Alifieraki, Styliani, Ansumanu, Hareef, Aston, Emily, Avram, Paula, Bamford, Alasdair, Banks, Millie, Basu Roy, Robin, Beattie, Thomas, Boleti, Olga, Bracken, Abbey, Broad, Jonathan, Cai, James, Carrol, Enitan D., Carter, Michael, Chandran, Anchit, Charlesworth, James, Chawla, Jaya, Cooper, Hannah, Cooray, Samantha, Davies, Patrick, Davis, Francesca, Drysdale, Simon B., Dzora, Ella, Emonts, Marieke, Evans, Ceri, Fidler, Katy, Foster, Caroline, Gong, Chen, Gongrun, Berin, Gonzalez, Carmen, Gorgun, Berin, Grandjean, Louis, Grant, Karlie, Guo, Jonathan, Hacohen, Yael, Hall, Jack, Hamid, Hytham K.S., Hassell, Jane, Hesketh, Christine, Hewlett, Jessica, Hnieno, Ahmad, Holt-Davis, Hannah, Hossain, Aleena, Hu, Shiying, Hudson, Lee D., Jheeta, Sharon, Johnson, Mae, Johnson, Sarah, Jyothish, Deepthi, Kampmann, Beate, Kavirayani, Akhila, Kelly, Deborah, Kirubakaran, Arangan, Kucera, Filip, Langer, Daniel, Lawson, George, Lees, Emily A, Lenihan, Rebecca, Lillie, Jon, Longbottom, Katherine, Lyall, Hermione, Mackdermott, Niamh, Maltby, Sarah, Mclelland, Thomas, McMahon, Anne-Marie, Miller, Danielle, Miranda, Mariana, Mirza, Luwaiza, Morrison, Zoe, Moshal, Karyn, Muller, Jennifer, Musuka, Phoebe, Myttaraki, Evangelia, Nadel, Simon, Nair, Sreedevi, Nuttall, Luke, Oremakinde, Oyinkansola, Osaghae, Daniella, Osman, Fatima, Ostrzewska, Anna, Paccagnella, Davide, Panthula, Mrinalini, Papachatzi, Eleni, Papadopoulou, Charalampia, Patel, Fahim, Patel, Harsita, Payne, Helen, Penner, Justin, Polandi, Shervin, Prendergast, Andrew J., Ramnarayan, Padmanabhan, Ranasinghe, Lasith, Ravichandran, Muthukumaran, Rhys-Evans, Sophie, Riordan, Andrew, Rodrigues, Charlene M.C., Roe, Lauren, Romaine, Sam, Schobi, Nina, Seddon, James, Shingadia, Delane, Sikdar, Oishi, Srivastava, Anand, Struik, Siske, Sun, Thomas, Tan, Rachel Wei, Taylor, Alice, Taylor, Amanda, Taylor, Andrew, Tran, Steven, Tsagkaris, Stavros, Tudor-Williams, Gareth, van den Berg, Sarah, van der Velden, Fabian, Ventilacion, Lyn, Wellman, Paul A., Withers Green, Joseph, Yanney, Michael P., Yeung, Shunmay, Badheka, Aditya, Badran, Sarah, Bailey, Dwight M., Burch, Anna Kathryn, Burns, Jane C., Cichon, Catherine, Cirks, Blake, Dallman, Michael D., Delany, Dennis R., Fairchok, Mary, Friedman, Samantha, Geracht, Jennifer, Langs-Barlow, Allison, Mann, Kelly, Padhye, Amruta, Quade, Alexis, Ramirez, Kacy Alyne, Rockett, John, Sayed, Imran Ali, Santos, Roberto P., Shahin, Amr A., Tremoulet, Adriana, Umaru, Samuel, Widener, Rebecca, Mujuru, Hilda Angela, Kandawasvika, Gwendoline, Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Carter, Michael J, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, and Levin, Michael

Published
2023
Full Text
View/download PDF

22. Emergency Inter-Hospital Transfer of Children to PICUs in the United Kingdom: Qualitative Exploration of Parents’ Experiences of Retrieval Teams*

Author

Evans, Ruth E. C., Barber, Vicky, Ramnarayan, Padmanabhan, Davies, Patrick, Wray, Jo, Barber, Victoria, Darnell, Robert, Draper, Elizabeth S., Drikite, Laura, Entwistle, Matthew, Hudson, Emma, Kung, Enoch, Marriage, Will, Morris, Stephen, Mouncey, Paul, Pagel, Christina, Pearce, Anna, Polke, Eithne, Rajah, Fatemah, and Seaton, Sarah E.

Published
2023
Full Text
View/download PDF

25. Ethnicity and Observed Oxygen Saturations, Fraction of Inspired Oxygen, and Clinical Outcomes: A Post-Hoc Analysis of the Oxy-PICU Trial of Conservative Oxygenation.

Author

Jones, Gareth A. L., Wiegand, Martin, Ray, Samiran, Gould, Doug W., Agbeko, Rachel, Giallongo, Elisa, Charles, Walton N., Orzol, Marzena, O'Neill, Lauran, Lampro, Lamprini, Lillie, Jon, Pappachan, John, Ramnarayan, Padmanabhan, Harrison, David A., Mouncey, Paul R., and Peters, Mark J.

Published
2024
Full Text
View/download PDF

31. Protocol for a Randomized Multiple Center Trial of Conservative Versus Liberal Oxygenation Targets in Critically Ill Children (Oxy-PICU): Oxygen in Pediatric Intensive Care

Author

Chang, Irene, Thomas, Karen, OʼNeill Gutierrez, Lauran, Peters, Sam, Agbeko, Rachel, Au, Carly, Draper, Elizabeth, Jones, Gareth A. L., Major, Lee Elliot, Orzol, Marzena, Pappachan, John, Ramnarayan, Padmanabhan, Ray, Samiran, Sadique, Zia, Gould, Doug W., Harrison, David A., Rowan, Kathryn M., Mouncey, Paul R., and Peters, Mark J.

Published
2022
Full Text
View/download PDF

37. Acute Kidney Injury in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus-2 Pandemic: Experience From PICUs Across United Kingdom*

Author

Deep, Akash, Upadhyay, Gaurang, du Pré, Pascale, Lillie, Jon, Pan, Daniel, Mudalige, Nadeesha, Kanthimathinathan, Hari Krishnan, Johnson, Mae, Riphagen, Shelley, Dwarakanathan, Buvana, Raffaj, Dusan, Sundararajan, Santosh, Davies, Patrick, Mohammad, Zoha, Shetty, Nayan, Playfor, Stephen, Jardine, Michelle, Ross, Oliver, Levin, Richard, Waters, Gareth, Sinha, Ruchi, Scholefield, Barnaby R., Boot, Elizabeth, Koul, Ashwani, Freire-Gomez, Xabier, and Ramnarayan, Padmanabhan

Published
2020
Full Text
View/download PDF

38. Impact on 30-day survival of time taken by a critical care transport team to reach the bedside of critically ill children

Author

Seaton, Sarah E., Ramnarayan, Padmanabhan, Pagel, Christina, Davies, Patrick, Draper, Elizabeth S., Barber, Victoria, and Darnell, Robert

Subjects
Pediatric intensive care, Health care industry
Abstract

Author(s): Sarah E. Seaton [sup.1], Padmanabhan Ramnarayan [sup.2], Christina Pagel [sup.3], Patrick Davies [sup.4], Elizabeth S. Draper [sup.1], Victoria Barber, Robert Darnell, Patrick Davies, Elizabeth S. Draper, Laura Drikite, Matthew [...]

Published
2020
Full Text
View/download PDF

44. Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child

Author

Wijeyesekera, Anisha, Wagner, Josef, De Goffau, Marcus, Thurston, Sarah, Rodrigues Sabino, Adilson, Zaher, Sara, White, Deborah, Ridout, Jenna, Peters, Mark J., Ramnarayan, Padmanabhan, Branco, Ricardo G., Torok, M. Estee, Valla, Frederic, Meyer, Rosan, Klein, Nigel, Frost, Gary, Parkhill, Julian, Holmes, Elaine, and Pathan, Nazima

Published
2019
Full Text
View/download PDF

46. Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial

Author

Peters, Mark J., Jones, Gareth A. L., Wiley, Daisy, Wulff, Jerome, Ramnarayan, Padmanabhan, Ray, Samiran, and Inwald, David

Subjects
Children -- Comparative analysis, Clinical trials -- Comparative analysis, Health care industry
Abstract

Background Oxygen saturation monitoring for children receiving respiratory support is standard worldwide. No randomised clinical trials have compared peripheral oxygen saturation (SpO.sub.2) targets for critically ill children. The harm of interventions to raise SpO.sub.2 to > 94% may exceed their benefits. Methods We undertook an open, parallel-group randomised trial of children > 38 weeks completed gestation and 94%) or a conservative oxygenation group (SpO.sub.2 = 88-92% inclusive). Outcomes were measures of feasibility: recruitment rate, protocol adherence and acceptability, between-group separation of SpO.sub.2 and safety. The Oxy-PICU trial was registered before recruitment: ClinicalTrials.gov identifier NCT03040570. Results A total of 159 children met the inclusion criteria, of whom 119 (75%) were randomised between April and July 2017, representing a rate of 10 patients per month per site. The mean time to randomisation from first contact with an intensive care team was 1.9 (SD 2.2) h. Consent to continue in the study was obtained in 107 cases (90%); the children's parents/legal representatives were supportive of the consent process. The median (interquartile range, IQR) of time-weighted individual mean SpO.sub.2 was 94.9% (92.6-97.1) in the conservative oxygenation group and 97.5% (96.2-98.4) in the liberal group [difference 2.7%, 95% confidence interval (95% CI) 1.3-4.0%, p < 0.001]. Median (IQR) time-weighted individual mean FiO.sub.2 was 0.28 (0.24-0.37) in the conservative group and 0.37 (0.30-0.42) in the liberal group (difference 0.08, 95% CI 0.03-0.13, p < 0.001). There were no significant between-group differences in length of stay, duration of organ support or mortality. Two prespecified serious adverse events (cardiac arrests) occurred, both in the liberal oxygenation group. Conclusion A definitive clinical trial of peripheral oxygen saturation targets is feasible in critically ill children., Author(s): Mark J. Peters [sup.1] [sup.2], Gareth A. L. Jones [sup.1] [sup.2], Daisy Wiley [sup.3], Jerome Wulff [sup.3], Padmanabhan Ramnarayan [sup.4] [sup.5], Samiran Ray [sup.2], David Inwald [sup.5], Michael Grocott [...]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results