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555 results on '"Radbruch, Alexander"'

2. Rasmussen’s encephalitis: structural, functional, and clinical correlates of contralesional epileptiform activity

Author

Bauer, Tobias, von Wrede, Randi D., Pujar, Suresh, Rácz, Attila, Hoppe, Christian, Baumgartner, Tobias, Varadkar, Sophia, Held, Nina R., Reiter, Johannes T., Enders, Selma, David, Bastian, Prillwitz, Conrad C., Brugues, Mar, Keil, Vera C. W., Jeub, Monika, Borger, Valeri, Sander, Josemir W., Kunz, Wolfram S., Radbruch, Alexander, Weber, Bernd, Helmstaedter, Christoph, Vatter, Hartmut, Baldeweg, Torsten, Becker, Albert J., Cross, J. Helen, Surges, Rainer, and Rüber, Theodor

Published
2024
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3. Contrast media for hysterosalpingography: systematic search and review providing new guidelines by the Contrast Media Safety Committee of the European Society of Urogenital Radiology

Author

Geenen, Remy W. F., van der Molen, Aart J., Dekkers, Ilona A., Bellin, Marie-France, Bertolotto, Michele, Correas, Jean-Michel, Heinz-Peer, Gertraud, Mahnken, Andreas H., Quattrocchi, Carlo C., Radbruch, Alexander, Reimer, Peter, Roditi, Giles, Sebastià, Carmen, Stacul, Fulvio, Romanini, Laura, Clément, Olivier, and Brismar, Torkel B

Published
2024
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6. Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the EFLM Science Committee

Author

van der Molen, Aart J., Krabbe, Johannes G., Dekkers, Ilona A., Geenen, Remy W. F., Bellin, Marie-France, Bertolotto, Michele, Brismar, Torkel B., Cadamuro, Janne, Correas, Jean-Michel, Heinz-Peer, Gertraud, Langlois, Michel R., Mahnken, Andreas H., Ozben, Tomris, Quattrocchi, Carlo C., Radbruch, Alexander, Reimer, Peter, Roditi, Giles, Romanini, Laura, Sebastià, Carmen, Simundic, Ana-Maria, Stacul, Fulvio, and Clement, Olivier

Published
2024
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11. Waiting times between examinations with intravascularly administered contrast media: a review of contrast media pharmacokinetics and updated ESUR Contrast Media Safety Committee guidelines

Author

van der Molen, Aart J., Dekkers, Ilona A., Geenen, Remy W. F., Bellin, Marie-France, Bertolotto, Michele, Brismar, Torkel B., Correas, Jean-Michel, Heinz-Peer, Gertraud, Mahnken, Andreas H., Quattrocchi, Carlo C., Radbruch, Alexander, Reimer, Peter, Roditi, Giles, Romanini, Laura, Sebastià, Carmen, Stacul, Fulvio, and Clement, Olivier

Published
2024
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13. Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment

Author

Banat, Mohammed, Potthoff, Anna-Laura, Hamed, Motaz, Borger, Valeri, Scorzin, Jasmin E., Lampmann, Tim, Asoglu, Harun, Khalafov, Logman, Schmeel, Frederic C., Paech, Daniel, Radbruch, Alexander, Nitsch, Louisa, Weller, Johannes, Herrlinger, Ulrich, Toma, Marieta, Gielen, Gerrit H., Vatter, Hartmut, and Schneider, Matthias

Published
2024
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14. Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses

Author

Zeyen, Thomas, Paech, Daniel, Weller, Johannes, Schäfer, Niklas, Tzaridis, Theophilos, Duffy, Cathrina, Nitsch, Louisa, Schneider, Matthias, Potthoff, Anna-Laura, Steinbach, Joachim Peter, Hau, Peter, Schlegel, Uwe, Seidel, Clemens, Krex, Dietmar, Grauer, Oliver, Goldbrunner, Roland, Zeiner, Pia Susan, Tabatabai, Ghazaleh, Galldiks, Norbert, Stummer, Walter, Hattingen, Elke, Glas, Martin, Radbruch, Alexander, Herrlinger, Ulrich, and Schaub, Christina

Published
2023
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16. Deep-learning based detection of vessel occlusions on CT-angiography in patients with suspected acute ischemic stroke

Author

Brugnara, Gianluca, Baumgartner, Michael, Scholze, Edwin David, Deike-Hofmann, Katerina, Kades, Klaus, Scherer, Jonas, Denner, Stefan, Meredig, Hagen, Rastogi, Aditya, Mahmutoglu, Mustafa Ahmed, Ulfert, Christian, Neuberger, Ulf, Schönenberger, Silvia, Schlamp, Kai, Bendella, Zeynep, Pinetz, Thomas, Schmeel, Carsten, Wick, Wolfgang, Ringleb, Peter A., Floca, Ralf, Möhlenbruch, Markus, Radbruch, Alexander, Bendszus, Martin, Maier-Hein, Klaus, and Vollmuth, Philipp

Published
2023
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17. An open presurgery MRI dataset of people with epilepsy and focal cortical dysplasia type II

Author

Schuch, Fabiane, Walger, Lennart, Schmitz, Matthias, David, Bastian, Bauer, Tobias, Harms, Antonia, Fischbach, Laura, Schulte, Freya, Schidlowski, Martin, Reiter, Johannes, Bitzer, Felix, von Wrede, Randi, Rácz, Atilla, Baumgartner, Tobias, Borger, Valeri, Schneider, Matthias, Flender, Achim, Becker, Albert, Vatter, Hartmut, Weber, Bernd, Specht-Riemenschneider, Louisa, Radbruch, Alexander, Surges, Rainer, and Rüber, Theodor

Published
2023
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23. Deep-learning-based reconstruction of undersampled MRI to reduce scan times: a multicentre, retrospective, cohort study

Author

Rastogi, Aditya, Brugnara, Gianluca, Foltyn-Dumitru, Martha, Mahmutoglu, Mustafa Ahmed, Preetha, Chandrakanth J, Kobler, Erich, Pflüger, Irada, Schell, Marianne, Deike-Hofmann, Katerina, Kessler, Tobias, van den Bent, Martin J, Idbaih, Ahmed, Platten, Michael, Brandes, Alba A, Nabors, Burt, Stupp, Roger, Bernhardt, Denise, Debus, Jürgen, Abdollahi, Amir, Gorlia, Thierry, Tonn, Jörg-Christian, Weller, Michael, Maier-Hein, Klaus H, Radbruch, Alexander, Wick, Wolfgang, Bendszus, Martin, Meredig, Hagen, Kurz, Felix T, and Vollmuth, Philipp

Published
2024
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29. Correction to: Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses

Author

Zeyen, Thomas, Paech, Daniel, Weller, Johannes, Schäfer, Niklas, Tzaridis, Theophilos, Duffy, Cathrina, Nitsch, Louisa, Schneider, Matthias, Potthoff, Anna-Laura, Steinbach, Joachim Peter, Hau, Peter, Schlegel, Uwe, Seidel, Clemens, Krex, Dietmar, Grauer, Oliver, Goldbrunner, Roland, Zeiner, Pia Susan, Tabatabai, Ghazaleh, Galldiks, Norbert, Stummer, Walter, Hattingen, Elke, Glas, Martin, Radbruch, Alexander, Herrlinger, Ulrich, and Schaub, Christina

Published
2023
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30. Intravenous contrast medium extravasation: systematic review and updated ESUR Contrast Media Safety Committee Guidelines

Author

Roditi, Giles, Khan, Nadir, van der Molen, Aart J., Bellin, Marie-France, Bertolotto, Michele, Brismar, Torkel, Correas, Jean-Michel, Dekkers, Ilona A., Geenen, Remy W. F., Heinz-Peer, Gertraud, Mahnken, Andreas H., Quattrocchi, Carlo C., Radbruch, Alexander, Reimer, Peter, Romanini, Laura, Stacul, Fulvio, Thomsen, Henrik S., and Clément, Olivier

Published
2022
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31. Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy—the MecMeth/NOA-24 trial

Author

Zeyen, Thomas, Potthoff, Anna-Laura, Nemeth, Robert, Heiland, Dieter H., Burger, Michael C., Steinbach, Joachim P., Hau, Peter, Tabatabai, Ghazaleh, Glas, Martin, Schlegel, Uwe, Grauer, Oliver, Krex, Dietmar, Schnell, Oliver, Goldbrunner, Roland, Sabel, Michael, Thon, Niklas, Delev, Daniel, Clusmann, Hans, Seidel, Clemens, Güresir, Erdem, Schmid, Matthias, Schuss, Patrick, Giordano, Frank A., Radbruch, Alexander, Becker, Albert, Weller, Johannes, Schaub, Christina, Vatter, Hartmut, Schilling, Judith, Winkler, Frank, Herrlinger, Ulrich, and Schneider, Matthias

Published
2022
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34. Interictal blood–brain barrier dysfunction in piriform cortex of people with epilepsy.

Author

Schulte, Freya, Reiter, Johannes T., Bauer, Tobias, Taube, Julia, Bitzer, Felix, Witt, Juri‐Alexander, Piper, Rory, Thanabalasingam, Anoja, von Wrede, Randi, Racz, Attila, Baumgartner, Tobias, Borger, Valeri, Specht‐Riemenschneider, Louisa, Vatter, Hartmut, Hattingen, Elke, Deichmann, Ralf, Helmstaedter, Christoph, Radbruch, Alexander, Friedman, Alon, and Surges, Rainer

Abstract

Objective: The piriform cortex is considered to be highly epileptogenic. Its resection during epilepsy surgery is a predictor for postoperative seizure freedom in temporal lobe epilepsy. Epilepsy is associated with a dysfunction of the blood–brain barrier. We investigated blood–brain barrier dysfunction in the piriform cortex of people with temporal lobe epilepsy using quantitative T1‐relaxometry. Methods: Gadolinium‐based contrast agent was administered ictally and interictally in 37 individuals before undergoing quantitative T1‐relaxometry. Postictal and interictal images were co‐registered, and subtraction maps were created as biomarkers for peri‐ictal (∆qT1interictal‐postictal) and interictal (∆qT1noncontrast‐interictal) blood–brain barrier dysfunction. Values were extracted for the piriform cortex, hippocampus, amygdala, and the whole cortex. Results: In temporal lobe epilepsy (n = 14), ∆qT1noncontrast‐interictal was significantly higher in the piriform cortex than in the whole cortex (p = 0.02). In extratemporal lobe epilepsy (n = 23), ∆qT1noncontrast‐interictal was higher in the hippocampus than in the whole cortex (p = 0.05). Across all individuals (n = 37), duration of epilepsy was correlated with ∆qT1noncontrast‐interictal (ß = 0.001, p < 0.001) in all regions, while the association was strongest in the piriform cortex. Impaired verbal memory was associated with ∆qT1noncontrast‐interictal only in the piriform cortex (p = 0.04). ∆qT1interictal‐postictal did not show differences in any region. Interpretation: Interictal blood–brain barrier dysfunction occurs in the piriform cortex in temporal lobe epilepsy. This dysfunction is linked to longer disease duration and worse cognitive deficits, emphasizing the central role of the piriform cortex in the epileptogenic network of temporal lobe epilepsy. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Clinical significance and prevalence of subarachnoid hyperdensities on flat detector CT after mechanical thrombectomy: does it really matter?

Author

Zidan, Mousa, Shiwa Ghaei, Bode, Felix J., Weller, Johannes M., Krueger, Nadine, Lehnen, Nils Christian, Petzold, Gabor C., Radbruch, Alexander, Dorn, Franziska, and Paech, Daniel

Subjects
NIH Stroke Scale, T-test (Statistics), LOGISTIC regression analysis, KRUSKAL-Wallis Test, BRAIN diseases, TREATMENT effectiveness, DESCRIPTIVE statistics, CHI-squared test, MULTIVARIATE analysis, MANN Whitney U Test, RETROSPECTIVE studies, ODDS ratio, STROKE, THROMBECTOMY, DATA analysis software, CONFIDENCE intervals, DISEASE risk factors, DISEASE complications
Abstract

Background Subarachnoid hyperdensities after mechanical thrombectomy (MT) are a common finding. However, it is often regarded as clinically insignificant. Objective With this single-center investigation, to identify the prevalence of subarachnoid hyperdensities following MT, associated predictors, and the impact on the clinical outcome of the patients. Methods 383 patients from the stroke registry were analyzed for the presence of subarachnoid hyperdensities on flat detector CT (FDCT) directly after the completion of MT, and on follow-up dual-energy CT, then classified according to a visual grading scale. 178 patients were included with anterior circulation occlusions. Regression analysis was performed to identify significant predictors, and Kruskal-Wallis analysis and X² test were performed to test the variables among the different groups. The primary outcome was the modified Rankin Scale (mRS) score at 90 days and was analyzed with the Wilcoxon-Mann-Whitney rank-sum test. Results The prevalence of subarachnoid hyperdensities on FDCT was (66/178, 37.1%) with patients experiencing a significant unfavorable outcome (P=0.035). Significantly fewer patients with subarachnoid hyperdensities achieved a mRS score of ≤3 at 90 days 25/66 (37.9%) vs 60/1 12 (53.6%), P=0.043). In addition, mortality was significantly higher in the subarachnoid hyperdensities group (34.8% vs 19.6%, P=0.024). Distal occlusions and a higher number of device passes were significantly associated with subarachnoid hyperdensities (P=0.026) and (P=0.001), respectively. Patients who received intravenous tissue plasminogen activator had significantly fewer subarachnoid hyperdensities (P=0.029). Conclusions Postinterventional subarachnoid hyperdensities are a frequent finding after MT and are associated with neurological decline and worse functional outcome. They are more common with distal occlusions and multiple device passes. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood.

Author

van Osch, Matthias J. P., Wåhlin, Anders, Scheyhing, Paul, Mossige, Ingrid, Hirschler, Lydiane, Eklund, Anders, Mogensen, Klara, Gomolka, Ryszard, Radbruch, Alexander, Qvarlander, Sara, Decker, Andreas, Nedergaard, Maiken, Mori, Yuki, Eide, Per Kristian, Deike, Katerina, and Ringstad, Geir

Subjects
MAGNETIC resonance imaging, INTRAVENOUS injections, INTRATHECAL injections, CONTRAST media, CEREBROSPINAL fluid
Abstract

Over the last decade, it has become evident that cerebrospinal fluid (CSF) plays a pivotal role in brain solute clearance through perivascular pathways and interactions between the brain and meningeal lymphatic vessels. Whereas most of this fundamental knowledge was gained from rodent models, human brain clearance imaging has provided important insights into the human system and highlighted the existence of important interspecies differences. Current gold standard techniques for human brain clearance imaging involve the injection of gadolinium‐based contrast agents and monitoring their distribution and clearance over a period from a few hours up to 2 days. With both intrathecal and intravenous injections being used, which each have their own specific routes of distribution and thus clearance of contrast agent, a clear understanding of the kinetics associated with both approaches, and especially the differences between them, is needed to properly interpret the results. Because it is known that intrathecally injected contrast agent reaches the blood, albeit in small concentrations, and that similarly some of the intravenously injected agent can be detected in CSF, both pathways are connected and will, in theory, reach the same compartments. However, because of clear differences in relative enhancement patterns, both injection approaches will result in varying sensitivities for assessment of different subparts of the brain clearance system. In this opinion review article, the "EU Joint Programme – Neurodegenerative Disease Research (JPND)" consortium on human brain clearance imaging provides an overview of contrast agent pharmacokinetics in vivo following intrathecal and intravenous injections and what typical concentrations and concentration–time curves should be expected. This can be the basis for optimizing and interpreting contrast‐enhanced MRI for brain clearance imaging. Furthermore, this can shed light on how molecules may exchange between blood, brain, and CSF. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Tumor-associated epilepsy in patients with brain metastases: necrosis-to-tumor ratio forecasts postoperative seizure freedom

Author

Bahna, Majd, Heimann, Muriel, Bode, Christian, Borger, Valeri, Eichhorn, Lars, Güresir, Erdem, Hamed, Motaz, Herrlinger, Ulrich, Ko, Yon-Dschun, Lehmann, Felix, Potthoff, Anna-Laura, Radbruch, Alexander, Schaub, Christina, Surges, Rainer, Weller, Johannes, Vatter, Hartmut, Schäfer, Niklas, Schneider, Matthias, and Schuss, Patrick

Published
2022
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39. Radiologic progression of glioblastoma under therapy—an exploratory analysis of AVAglio

Author

Nowosielski, Martha, Ellingson, Benjamin M, Chinot, Olivier L, Garcia, Josep, Revil, Cedric, Radbruch, Alexander, Nishikawa, Ryo, Mason, Warren P, Henriksson, Roger, Saran, Frank, Kickingereder, Philipp, Platten, Michael, Sandmann, Thomas, Abrey, Lauren E, Cloughesy, Timothy F, Bendszus, Martin, and Wick, Wolfgang

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Brain Disorders, Cancer, Clinical Research, Neurosciences, Brain Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Bevacizumab, Biomarkers, Tumor, Brain Neoplasms, Chemoradiotherapy, DNA Methylation, Disease Progression, Double-Blind Method, Female, Follow-Up Studies, Glioblastoma, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Promoter Regions, Genetic, Retrospective Studies, Survival Rate, Temozolomide, bevacizumab, MRI, radiologic phenotypes, treatment resistance, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundIn this exploratory analysis of AVAglio, a randomized phase III clinical study that investigated the addition of bevacizumab (Bev) to radiotherapy/temozolomide in newly diagnosed glioblastoma, we aim to radiologically characterize glioblastoma on therapy until progression and investigate whether the type of radiologic progression differs between treatment arms and is related to survival and molecular data.MethodsFive progression types (PTs) were categorized using an adapted algorithm according to MRI contrast enhancement behavior in T1- and T2-weighted images in 621 patients (Bev, n = 299; placebo, n = 322). Frequencies of PTs (designated as classic T1, cT1 relapse, T2 diffuse, T2 circumscribed, and primary nonresponder), time to progression (PFS), and overall survival (OS) were assessed within each treatment arm and compared with molecular subtypes and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation status.ResultsPT frequencies differed between the Bev and placebo arms, except for "T2 diffuse" (12.4% and 7.1%, respectively). PTs showed differences in PFS and OS; with "T2 diffuse" being associated with longest survival. Complete disappearance of contrast enhancement during treatment ("cT1 relapse") showed longer survival than only partial contrast enhancement decrease ("classic T1"). "T2 diffuse" was more commonly MGMT hypermethylated. Only weak correlations to molecular subtypes from primary tissue were detected.ConclusionsProgression of glioblastoma under therapy can be characterized radiologically. These radiologic phenotypes are influenced by treatment and develop differently over time with differential outcomes. Complete resolution of contrast enhancement during treatment is a favorable factor for outcome.

Published
2018

42. Estimation of radiation exposure of children undergoing superselective intra-arterial chemotherapy for retinoblastoma treatment: assessment of local diagnostic reference levels as a function of age, sex, and interventional success

Author

Opitz, Marcel, Bos, Denise, Deuschl, Cornelius, Radbruch, Alexander, Zensen, Sebastian, Sirin, Selma, Forsting, Michael, Bechrakis, Nikolaos, Biewald, Eva, Bornfeld, Norbert, Ketteler, Petra, Timmermann, Beate, Stuschke, Martin, Guberina, Maja, Wetter, Axel, Göricke, Sophia, and Guberina, Nika

Published
2021
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43. Brain and Ventricle Volume Alterations in Idiopathic Normal Pressure Hydrocephalus Determined by Artificial Intelligence-Based MRI Volumetry.

Author

Bendella, Zeynep, Purrer, Veronika, Haase, Robert, Zülow, Stefan, Kindler, Christine, Borger, Valerie, Banat, Mohammed, Dorn, Franziska, Wüllner, Ullrich, Radbruch, Alexander, and Schmeel, Frederic Carsten

Subjects
ARTIFICIAL intelligence, CEREBRAL ventricles, GRAY matter (Nerve tissue), MAGNETIC resonance imaging, ALZHEIMER'S disease
Abstract

The aim of this study was to employ artificial intelligence (AI)-based magnetic resonance imaging (MRI) brain volumetry to potentially distinguish between idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD), and age- and sex-matched healthy controls (CG) by evaluating cortical, subcortical, and ventricular volumes. Additionally, correlations between the measured brain and ventricle volumes and two established semi-quantitative radiologic markers for iNPH were examined. An IRB-approved retrospective analysis was conducted on 123 age- and sex-matched subjects (41 iNPH, 41 AD, and 41 controls), with all of the iNPH patients undergoing routine clinical brain MRI prior to ventriculoperitoneal shunt implantation. Automated AI-based determination of different cortical and subcortical brain and ventricular volumes in mL, as well as calculation of population-based normalized percentiles according to an embedded database, was performed; the CE-certified software mdbrain v4.4.1 or above was used with a standardized T1-weighted 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence. Measured brain volumes and percentiles were analyzed for between-group differences and correlated with semi-quantitative measurements of the Evans' index and corpus callosal angle: iNPH patients exhibited ventricular enlargement and changes in gray and white matter compared to AD patients and controls, with the most significant differences observed in total ventricular volume (+67%) and the lateral (+68%), third (+38%), and fourth (+31%) ventricles compared to controls. Global ventriculomegaly and marked white matter reduction with concomitant preservation of gray matter compared to AD and CG were characteristic of iNPH, whereas global and frontoparietally accentuated gray matter reductions were characteristic of AD. Evans' index and corpus callosal angle differed significantly between the three groups and moderately correlated with the lateral ventricular volumes in iNPH patients [Evans' index (r > 0.83, p ≤ 0.001), corpus callosal angle (r < −0.74, p ≤ 0.001)]. AI-based MRI volumetry in iNPH patients revealed global ventricular enlargement and focal brain atrophy, which, in contrast to healthy controls and AD patients, primarily involved the supratentorial white matter and was marked temporomesially and in the midbrain, while largely preserving gray matter. Integrating AI volumetry in conjunction with traditional radiologic measures could enhance iNPH identification and differentiation, potentially improving patient management and therapy response assessment. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Contrast media safety: update on recent ESUR-Contrast Media Safety Committee publications.

Author

Clement, Olivier, Romanini, Laura, van der Molen, Aart J., Bellin, Marie-France, Bertolotto, Michele, Brismar, Torkel, Correas, Jean-Michel, Deike-Hofmann, Katerina, Dekkers, Ilona A., Geenen, Remy W. F., Heinz-Peer, Gertraud, Mallio, Carlo A., Mahnken, Andreas H., Quattrocchi, Carlo C., Radbruch, Alexander, Reimer, Peter, Roditi, Giles, Sebastià, Carmen, and Stacul, Fulvio

Published
2024
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