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A systematic review and meta-analysis of brain hyperscanning research suggests that interbrain synchrony (IBS) can be used as an objective measure of teamwork. The study found that factors like familiarity and stress levels among team members facilitate IBS. It also showed that IBS is correlated with teamwork behaviors and affective states, and predicts team performance to some extent. While there are limitations to the technology used, the researchers concluded that brain hyperscanning is a promising tool for studying teamwork. Additionally, a collection of articles explores topics related to physical activity and exercise, including factors influencing physical activity in adults with overweight or obesity, the impact of mindfulness-based activities during high-intensity interval training, negative messages directed at athletes on social media, the effects of fitness center closures on physical activity in older adults during the COVID-19 pandemic, and the impact of fitfluencer captions on body image and exercise intentions in adolescents. These articles provide valuable insights and emphasize the need for further research and support in promoting physical activity and well-being. [Extracted from the article]

Context: Current lower-extremity return to sport testing primarily considers the physical status of an athlete; however, sport participation requires continuous cognitive dual-task engagement. Therefore, the purpose was to develop and evaluate the reliability of a visual-cognitive reactive (VCR) triple hop test that simulates the typical sport demand of combined online visual-cognitive processing and neuromuscular control to improve return to sport testing after lower-extremity injury. Design: Test–retest reliability. Methods: Twenty-one healthy college students (11 females, 23.5 [3.7] y, 1.73 [0.12] m, 73.0 [16.8] kg, Tegner Activity Scale 5.5 [1.1] points) participated. Participants performed a single-leg triple hop with and without a VCR dual task. The VCR task incorporated the FitLight system to challenge peripheral response inhibition and central working memory. Maximum hop distance, reaction time, cognitive errors, and physical errors were measured. Two identical testing visits were separated by 12 to 17 days (14 [1] d). Results: Traditional triple hop (intraclass correlation coefficients: ICC(3,1) =.96 [.91–.99]; standard error of the measurement = 16.99 cm) and the VCR triple hop (intraclass correlation coefficients(3,1) =.92 [.82–.97]; standard error of the measurement = 24.10 cm) both demonstrated excellent reliability for the maximum hop distance, and moderate reliability for the VCR triple hop reaction time (intraclass correlation coefficients(3,1) =.62 [.09–.84]; standard error of the measurement = 0.09 s). On average, the VCR triple hop resulted in a hop distance deficit of 8.17% (36.4 [5.1] cm; P <.05, d = 0.55) relative to the traditional triple hop. Conclusions: Hop distance on the VCR triple hop had excellent test–retest reliability and induced a significant physical performance deficit when compared with the traditional triple hop assessment. The VCR triple hop reaction time also demonstrated moderate reliability. [ABSTRACT FROM AUTHOR]

Background: Current treatment of major depressive disorder is facing challenges, including a low remission rate, late onset of efficacy, and worsening severity due to comorbid symptoms such as psychosis and cognitive dysfunction. Serotonin (5-HT) neurotransmission is involved in a wide variety of psychiatric diseases and its potential as a drug target continues to attract attention. Objectives: The present study elucidates the effects of a novel 5-HT modulator, DSP-6745, on depression and its comorbid symptoms. Results: In vitro radioligand binding and functional assays showed that DSP-6745 is a potent inhibitor of 5-HT transporter and 5-HT2A, 5-HT2C, and 5-HT7 receptors. In vivo, DSP-6745 (6.4 and 19.1 mg/kg as free base, p.o.) increased the release of not only 5-HT, norepinephrine, and dopamine, but also glutamate in the medial prefrontal cortex. The results of in vivo mouse phenotypic screening by SmartCube® suggested that DSP-6745 has a behavioral signature combined with antidepressant-, anxiolytic-, and antipsychotic-like signals. A single oral dose of DSP-6745 (6.4 and 19.1 mg/kg) showed rapid antidepressant-like efficacy in the rat forced swim test, even at 24 h post-dosing, and anxiolytic activity in the rat social interaction test. Moreover, DSP-6745 (12.7 mg/kg, p.o.) led to an improvement in the apomorphine-induced prepulse inhibition deficit in rats. In the marmoset object retrieval with detour task, which is used to assess cognitive functions such as attention and behavioral inhibition, DSP-6745 (7.8 mg/kg, p.o.) enhanced cognition. Conclusions: These data suggest that DSP-6745 is a multimodal 5-HT receptor antagonist and a 5-HT transporter inhibitor and has the potential to be a rapid acting antidepressant with efficacies in mitigating the comorbid symptoms of depression. [ABSTRACT FROM AUTHOR]

Young children's lie‐telling behavior is associated with their theory of mind (ToM) development. However, current evidence is primarily based on cross‐sectional studies, with very little longitudinal evidence on the causal relation between the two constructs. The current study provided much‐needed cross‐lagged longitudinal evidence on the association between ToM and lying in young children. Adopting a short‐term longitudinal design, we tested 104 normally developing children's (64 boys, M = 54.0 months) false belief understanding and lie‐telling behaviors three times at 4‐month intervals. Results showed the cross‐lagged model fit the data well. Lie‐telling behaviors exhibited moderate stability across the three time points, while ToM exhibited moderate stability between the first two time points but not between Time 2 and Time 3. Earlier false belief understanding significantly predicted children's later lie‐telling behavior, controlling for family socioeconomic status, child age, gender, only child status, and Time 1 verbal ability and inhibitory control. On the contrary, earlier lie‐telling did not predict later false beliefs understanding. We concluded that earlier false belief understanding predicts later lie‐telling behavior in preschool children, but not vice versa. [ABSTRACT FROM AUTHOR]

Understanding what others think and feel, an essential ingredient of social functioning, develops early on, allowing children to understand and evaluate other people's actions. To assess whether those actions break or uphold moral rules (moral judgments), children must consider the agent's intentions and whether the action harms or helps others. The present study investigated longitudinally the changes and interrelations between cognitive and affective perspective‐taking and moral evaluations in 3‐ to 5‐year‐old preschoolers (N = 92, 43 girls). We assessed children's first‐order theory of mind and their ability to understand other people's emotions. Next, we presented them with two moral stories which measured how children evaluated the "good" or "bad" nature of the character's intention, and whether the character deserved to be punished. Controlling for inhibitory control—which is thought to help individuals integrate information about intention—and for time across development, our main findings showed that moral judgment was positively associated with theory of mind and that both moral judgment and punishment were positively associated with the ability to understand other people's emotions. There were developmental effects for each of the measured variables, improvements being visible 15 months later, especially in the case of the theory of mind and punishment attributions. We discuss our findings in light of recent models of moral judgment regarding the processes involved in children's moral judgments and put forward future methodological directions. [ABSTRACT FROM AUTHOR]

Response inhibition is a crucial component of executive control. Although mainly studied in upper limb tasks, it is fully implicated in gait initiation. Here, we assessed the influence of proactive and reactive inhibitory control during gait initiation in healthy adult participants. For this purpose, we measured kinematics and electroencephalography (EEG) activity (event‐related potential [ERP] and time‐frequency data) during a modified Go/NoGo gait initiation task in 23 healthy adults. The task comprised Go‐certain, Go‐uncertain, and NoGo conditions. Each trial included preparatory and imperative stimuli. Our results showed that go‐uncertainty resulted in delayed reaction time, without any difference for the other parameters of gait initiation. Proactive inhibition, that is, Go uncertain versus Go certain conditions, influenced EEG activity as soon as the preparatory stimulus. Moreover, both proactive and reactive inhibition influenced the amplitude of the ERPs (central P1, occipito‐parietal N1, and N2/P3) and theta and alpha/low beta band activities in response to the imperative—Go‐uncertain versus Go‐certain and NoGo versus Go‐uncertain—stimuli. These findings demonstrate that the uncertainty context; induced proactive inhibition, as reflected in delayed gait initiation. Proactive and reactive inhibition elicited extended and overlapping modulations of ERP and time‐frequency activities. This study shows the protracted influence of inhibitory control in gait initiation. We studied proactive and reactive inhibition in a Go/NoGo gait initiation task manipulating the uncertainty context of Go trials. Proactive inhibition (Go‐uncertain vs. ‐certain) induced delayed onset of anticipatory postural adjustments of gait. We showed intricated and extended electroencephalography signatures of proactive and reactive inhibition in both the event‐related potentials and time‐frequency domains, uncovering a tight interplay between the release of proactive inhibition, the setting of reactive inhibition, action selection, and gait initiation. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine how malingered PTSD behavior affects the performance of a continuous performance task (CPT). An analog trauma group, two malingering groups (with or without educational intervention), and a control group were organized according to simulation design. During the CPT, the numbers of errors and response time indicators along with post-error slowing (PES) and recovery (PER) process were measured. Results are as follows: First, the analog trauma group showed deficits of response inhibition and a higher level of PES compared to the control group. Second, malingered PTSD caused a significant number of errors, inconsistent performance, and no PES. Third, there was a significantly more impaired and inconsistent performance in the low level of knowledge of disability. Finally, a discriminant accuracy of more than 90% appeared in the discriminant analysis of all group comparison conditions. Taken together, the results of this study show that post-error behavior indicators are affected by malingered PTSD, and differences according to the degree of knowledge of PTSD can also be confirmed. These results are expected to be used as basic data for the development of tasks for the detection of malingerers in clinical scenes in the future. [ABSTRACT FROM AUTHOR]

This paper aims to examine the key factors influencing young drivers' hazard avoidance in Iran. In this study, a hazard avoidance index is defined and calculated for investigating the effect of impulsiveness, behavioral, and psychological characteristics on driving hazard avoidance. A questionnaire and go-no-go and flanker computer tests as well as a driving simulator are used for collecting data from 173 Iranian drivers under the age of 30. For this purpose, different scenarios were used, such as pedestrian crossing, the presence of fixed obstacles, and animals crossing the road, whose various characteristics are also changed. Structural equation modeling and the partial least squares method are applied for investigating the relationship between different variables and the hazard avoidance index. The results show that the driver hazard avoidance index is mostly affected by variables such as inhibitory control, opposite directional response, attentional impulsiveness, motion impulsiveness, non-planning impulsiveness, disregarding the law, and lapses and error. The results could help policymakers to assess diving hazard avoidance and improve training programs related to traffic safety based on the variables that are more effective on inexperienced and novice drivers' hazard avoidance [ABSTRACT FROM AUTHOR]

• LPA promotes the migration of skeletal muscle-isolated FAPs through LPA 1 signaling. • YAP activity is required for LPA-induced migration of FAPs. • FAPs isolated from dystrophic muscle possess an enhanced migration response to LPA, behavior which can be blocked by inhibiting LPA 1/3 or YAP activity. Skeletal muscle fibrosis is defined as the excessive accumulation of extracellular matrix (ECM) components and is a hallmark of muscular dystrophies. Fibro-adipogenic progenitors (FAPs) are the main source of ECM, and thus have been strongly implicated in fibrogenesis. In skeletal muscle fibrotic models, including muscular dystrophies, FAPs undergo dysregulations in terms of proliferation, differentiation, and apoptosis, however few studies have explored the impact of FAPs migration. Here, we studied fibroblast and FAPs migration and identified lysophosphatidic acid (LPA), a signaling lipid central to skeletal muscle fibrogenesis, as a significant migration inductor. We identified LPA receptor 1 (LPA 1) mediated signaling as crucial for this effect through a mechanism dependent on the Hippo pathway, another pathway implicated in fibrosis across diverse tissues. This cross-talk favors the activation of the Yes-associated protein 1 (YAP) and Transcriptional coactivator with PDZ-binding motif (TAZ), leading to increased expression of fibrosis-associated genes. This study reveals the role of YAP in LPA-mediated fibrotic responses as inhibition of YAP transcriptional coactivator activity hinders LPA-induced migration in fibroblasts and FAPs. Moreover, we found that FAPs derived from the mdx 4cv mice, a murine model of Duchenne muscular dystrophy, display a heightened migratory phenotype due to enhanced LPA signaling compared to wild-type FAPs. Remarkably, we found that the inhibition of LPA 1 or YAP transcriptional coactivator activity in mdx 4cv FAPs reverts this phenotype. In summary, the identified LPA-LPA 1 -YAP pathway emerges as a critical driver of skeletal muscle FAPs migration and provides insights into potential novel targets to mitigate fibrosis in muscular dystrophies. [ABSTRACT FROM AUTHOR]

Research Findings: Executive Function (EF) and Early Math (EM) are foundational skills for children's school success. Interventions have shown to foster these skills, but their effectiveness in less developed countries remains unknown. This study examined the initial efficacy of an eight-week EF and an EM skills program for young Iranian children at risk for mathematical difficulties. Participants included 88 five- to six-year-old children who were randomly assigned into three conditions: Business-As-Usual (BAU) control group, EF training group, or an EM training group. The experimental groups received 24 sessions over two months. In the EF group, children had significantly higher working memory and planning scores at posttest, which were stable five months later. No significant group difference was found on inhibitory control. In the EM group, children demonstrated stronger math performance compared to BAU children at the posttest and follow-up, suggesting stable math improvement. There was no significant effect of EF training on math performance or significant effect of math training on EF skills. Practice or Policy: Findings suggest that the EF training was related to stronger EF and EM training was related to better math performance. However, there were no significant transfer effects of EF on math and vice versa. [ABSTRACT FROM AUTHOR]

Background: White noise stimulation has demonstrated efficacy in enhancing working memory in children with ADHD. However, its impact on other executive functions commonly affected by ADHD, such as inhibitory control, remains largely unexplored. This research aims to explore the effects of two types of white noise stimulation on oculomotor inhibitory control in children with ADHD. Method: Memory guided saccade (MGS) and prolonged fixation (PF) performance was compared between children with ADHD (N = 52) and typically developing controls (TDC, N = 45), during auditory and visual white noise stimulation as well as in a no noise condition. Results: Neither the auditory nor the visual white noise had any beneficial effects on performance for either group. Conclusions: White noise stimulation does not appear to be beneficial for children with ADHD in tasks that target oculomotor inhibitory control. Potential explanations for this lack of noise benefit will be discussed. [ABSTRACT FROM AUTHOR]

There is growing interest in identifying the mechanisms underpinning the effects of physical activity on executive functions (e.g. inhibitory control, cognitive flexibility) in children. Our study examined cardiorespiratory fitness, muscular fitness, and motor competence as potential mediators of this relationship. The study used baseline data from the Learning to Lead (L2L) cluster randomised controlled trial. In total, 675 children (7–11 years, 49.5% girls) completed measures of moderate-to-vigorous physical activity (MVPA), cardiorespiratory fitness, muscular fitness, motor competence, and executive functions. Structural equation modelling was used to examine the potential mediating roles of cardiorespiratory fitness, muscular fitness, and motor competence in the cross-sectional association between MVPA and executive functions. Cardiorespiratory fitness (β = 0.06, SE = 0.021, p = 0.004) partially mediated the association between MVPA and cognitive flexibility. Muscular fitness was a significant mediator of the association between MVPA and both inhibitory control (β = 0.03, SE = 0.014, p = 0.027) and cognitive flexibility (β = 0.06, SE = 0.021, p = 0.005). No significant mediated effects were found for motor competence. Our findings suggest cardiorespiratory and muscular fitness (but not motor competence) mediate the association between physical activity and executive functions in children. [ABSTRACT FROM AUTHOR]

Self-control allows animals to resist instant gratification and invest more time and/or energy in better outcomes. However, widespread temporal self-control tasks lack ecological validity for many species, and few studies have explored whether self-control can be measured in the wild. We used a spatial discounting task resembling natural foraging decisions to measure self-control in wild toutouwai (Petroica longipes), a songbird endemic to New Zealand. Birds chose between a near, low-quality food item and a high-quality food item further away. Toutouwai showed striking individual variation in their self-control abilities. Validation tests suggested that our task reliably measured self-control in a spatial foraging context. However, individual-level performance was confounded by food preferences and the satiation and/or learning effects associated with increasing trial number, limiting the applicability of this task as a measure of individual variation in self-control. Nonetheless, we found no correlation between an individual's self-control and their inhibitory control measured using a detour task, suggesting that self-control is a distinct ability from the suppression of impulsive motor actions in toutouwai. This study demonstrates for the first time that a bird is capable of self-control in a spatial context and provides suggestions for how future researchers may robustly quantify individual differences in self-control in the wild. [ABSTRACT FROM AUTHOR]

Mathematics, along with reading and writing, is a core academic subject in the school curriculum. The development of mathematical skills is influenced by various cognitive factors, with executive functions (EF) playing a central role. EF, which encompasses working memory, inhibitory control, and cognitive flexibility, is critical for supporting complex cognitive processes required for problem-solving and mathematical reasoning. Research consistently shows that children with stronger EF tend to achieve better academic outcomes, including in mathematics. The goal of the present study was to examine the relationships between the global EF and its three core components – working memory, inhibitory control, and cognitive flexibility – and their impact on mathematics achievement. The sample for this study consisted of 180 children, aged 8–11 years (mean age: 9.6, SD: 1.0 year; 83 girls, 97 boys). EF was assessed using the Yellow-Red test, while mathematics achievement was evaluated based on teachers’ evaluations of the child’s mathematics performance. The results indicated a statistically significant effect of global EF and its three components on mathematics achievement. Given the potential malleability of EFs, we conclude with recommendations for strategies to enhance EF development at an early school age. [ABSTRACT FROM AUTHOR]

Background: A growing body of literature links prenatal mood and substance use to children's cognitive and behavioral development. The relative contribution of these risk factors on children's executive function (EF) in the context of socioeconomic adversities needs further evaluation. To address this gap, we investigated the role of prenatal maternal anxiety and depression on childhood EF, specifically inhibitory control and working memory, within the context of socioeconomic adversities and prenatal substance use. We hypothesized that higher maternal mood symptoms, higher persistent prenatal drinking and smoking, and lower socioeconomic status would be associated with lower EF skills during early childhood. Methods: We used data from 334 mother–child dyads followed prospectively through pregnancy and the offspring's childhood. Prenatal maternal depression and anxiety were assessed via standardized questionnaires. Prenatal alcohol and tobacco consumption were assessed via a timeline follow-back interview. The EF touch battery assessed child inhibitory control and working memory at 3–5 years of age (4.76 ± 0.58 years, 171 females). Separate linear regression models were used to estimate the association of prenatal tobacco, alcohol, anxiety, and depression exposure with our two components of child EF, inhibitory control and working memory, while adjusting for gestational age, sex, and age at assessment. The following variables were also included as covariates: maternal educational achievement, employment status, parity, and household crowding index. Results: Children of mothers with high trait anxiety scores had reduced inhibitory control compared to children of mothers without trait anxiety or depression (β = -0.12, 95% CI:-0.22,-0.01). Children of mothers in the moderate to high continuous smoking group showed lower inhibitory control (β = − 0.19, 95% CI:-0.38,-0.01) compared to children of mothers in the none smoking group. Additionally, lower maternal education and higher household crowding were each associated with reduced inhibitory control. We found no significant association between prenatal maternal depression, anxiety, or socioeconomic factors with working memory. Conclusions: These results underscore the need for comprehensive context-specific intervention packages, including mental health support for women to promote healthy inhibitory control development in children. [ABSTRACT FROM AUTHOR]

Theory of Mind (ToM), the ability to understand others' thoughts and emotions, is crucial for social interaction. However, few longitudinal studies have explored ToM development within different social domains, particularly among rural populations. To address this gap, we conducted a study with 113 preschoolers aged 3–5 years from rural China. We assessed ToM development in different social domains using false belief tasks at three different time points with semester intervals, and we evaluated their performance on the Peabody Picture Vocabulary Test and inhibitory control (IC). Results showed that ToM development trajectories differ across domains, with moral and social‐conventional domains developing earlier than the personal domain. Additionally, while general cognitive skills such as language and IC are associated with ToM development across these domains, they do not significantly predict it. This study enhances our understanding of ToM development by emphasizing the importance of including rural samples in developmental research. [ABSTRACT FROM AUTHOR]

AbstractObjective: This proof-of-concept study aimed to characterize semantic memory profiles in individuals with human immunodeficiency virus (HIV) and mild neurocognitive impairment. Method: Using a semantic relatedness task, we explored conceptual association and word selection patterns in people living with HIV (PLWH; n = 50) relative to people living without HIV (n = 46). We also studied whether word selection patterns in the PLWH group were associated with working memory capacity, cognitive flexibility and inhibitory control. Results: While accuracy did not differ between groups, PLWH produced significantly longer responses than controls (r = .32), with fewer hypernyms (d = .47), more troponyms (r = .37), and words that were more frequent (r = .39) and had more phonological neighbors (r = .22). These patterns survived covariation with participants’ cognitive status. None of these patterns correlated with measures of working memory, cognitive flexibility, inhibitory control or viral load (all correlation coefficients < .36). Conclusions: Together, these results suggest that PLWH might use alternative word finding strategies during semantic memory navigation, irrespective of the severity of other cognitive symptoms. Such findings contribute to the characterization of cognitive deficits in HIV and to the search for novel markers of the condition. [ABSTRACT FROM AUTHOR]

Numerous studies have reported that long-term sports training can affect inhibitory control and induce brain functional alterations. However, the influence of environmental dynamics in sports training on inter-cortical connectivity has not been well studied. In the current study, we used twin-coil transcranial magnetic stimulation to investigate the functional connectivity between dorsolateral prefrontal cortex (DLPFC) and ipsilateral primary motor cortex (M1) during proactive and reactive inhibition in participants with sports skills in dynamic environment (open-skill experts), stable environment (closed-skill experts), and no sports skills (controls). Using a modified stop signal task, proactive inhibition was measured by the response delay effect (RDE), and reactive inhibition was measured by the stop-signal reaction time (SSRT). Intra-hemispheric DLPFC-M1 interactions and single pulse motor-evoked potentials (MEPs) were measured during the task. A stronger inhibitory effect of the DLPFC over M1 was observed during early reactive control stages compared to baseline levels. In addition, this inhibitory effect was pronounced when comparing open-skill experts to non-athlete controls, a relationship that was significantly correlated with superior reactive control performance. Furthermore, DLPFC to M1 influencing direction shifted from late proactive control to reactive control. Behavioral results also demonstrated enhanced proactive control abilities in open-skill experts relative to controls. Such enhancement may be due to the combination of environmental complexity and physical fitness in long-term skill training. [ABSTRACT FROM AUTHOR]

There is robust evidence implicating inhibitory deficits as a fundamental behavioural phenotype in children with attention‐deficit/hyperactivity disorder (ADHD). However, prior studies have not directly investigated the role in which white matter properties within the fronto‐basal‐ganglia circuit may play in the development of inhibitory control deficits in this group. Combining recent advancements in brain‐behavioural modelling, we mapped the development of stop‐signal task (SST) performance and fronto‐basal‐ganglia maturation in a longitudinal sample of children aged 9–14 with and without ADHD. In a large sample of 135 ADHD and 138 non‐ADHD children, we found that the ADHD group had poorer inhibitory control (i.e., longer stop‐signal reaction times) across age compared to non‐ADHD controls. When applying the novel parametric race model, this group effect was driven by higher within‐subject variability (sigma) and higher number of extreme responses (tau) on stop trials. The ADHD group also displayed higher within‐subject variability on correct responses to go stimuli. Moreover, we observed the ADHD group committing more task‐based failures such as responding on stop trials (trigger failures) and omissions on go trials (go failures) compared to non‐ADHD controls, suggesting the contribution of attentional lapses to poorer response inhibition performance. In contrast, longitudinal modelling of fixel‐based analysis measures revealed no significant group differences in the maturation of fronto‐basal‐ganglia fibre cross‐section in a subsample (74 ADHD and 73 non‐ADHD children). Finally, brain‐behavioural models revealed that age‐related changes in fronto‐basal‐ganglia morphology (fibre cross‐section) were significantly associated with reductions in the variability of the correct go‐trial responses (sigma.true) and skew of the stop‐trial distribution (tauS). However, this effect did not differ between ADHD and typically developing children. Overall, our findings support the growing consensus suggesting that attentional deficits subserve ADHD‐related inhibitory dysfunction. Furthermore, we show novel evidence suggesting that while children with ADHD are consistently performing worse on the SST than their non‐affected peers, they appear to have comparable rates of neurocognitive maturation across this period. [ABSTRACT FROM AUTHOR]

Deception, a complex aspect of human behavior, is inherently difficult to detect directly. A valid alternative involves memory detection, particularly through methods such as the Reaction-Time based Concealed Information Test (RT-CIT). The RT-CIT assesses whether an individual possesses specific knowledge by presenting various probe (familiar) items amidst irrelevant (unfamiliar) items. The task-required "unfamiliar" response to probes may induce a response conflict. Resolving this conflict, by inhibiting the automatic "familiar" response, takes time and slows probe RTs–a phenomenon known as the RT-CIT effect. Notably, secondary psychopathy is characterized by disinhibition and impulsivity, traits which may hinder the ability to effectively manage experienced conflict. Therefore, we hypothesized that secondary psychopathy would be associated with an elevated RT-CIT effect. To investigate this hypothesized relation, we conducted a pre-registered study (n = 86, student sample), employing a novel CIT paradigm that incorporates no-go trials to assess response inhibition capacity. Psychopathic traits were measured using the Levenson Self-Report Psychopathy (LSRP) scale, while the Barratt Impulsiveness Scale (BIS-11) assessed impulsivity. The novel CIT paradigm revealed impressive detection efficiency. However, contrary to our expectations, we observed no significant correlation between the RT-CIT effect and secondary psychopathic traits (BF01 = 6.98). This cautiously suggests that while secondary psychopathic tendencies do not improve RT-CIT validity, they also do not compromise it. Although future investigations should explore more diverse contexts and populations, this tentative finding is reassuring and underscores the robustness of the CIT paradigm. [ABSTRACT FROM AUTHOR]

Background: Adolescents may have anxiety due to a series of events such as school work and social interaction. Improper handling of anxiety often leads to some negative consequences, such as Internet addiction. Therefore, this study further explored the relationship between anxiety and Internet addiction, as well as the mediating role of inhibitory control between the two, and also considered the moderating role of physical activity between anxiety and inhibitory control. Methods: A total of 1607 adolescents, comprising 664 boys and 943 girls with an average age of 15.86 years (SD = 0.73), from Shandong, Shanxi, Hebei, and Hunan provinces completed a self-report survey on physical activity, anxiety, inhibitory control, and Internet addiction. Descriptive analysis, correlation analysis, and mediation test were conducted. Results: The results revealed a significant positive correlation between anxiety and adolescent internet addiction (r = 0.413, p < 0.001), and a significant negative correlation with inhibitory control (r = -0.423, p < 0.001). Inhibitory control was found to be significantly positively correlated with physical exercise (r = 0.143, p < 0.001) and significantly negatively correlated with internet addiction (r = -0.368, p < 0.001). After controlling for demographic variables, anxiety significantly positively predicted Internet addiction (β = 0.311, p < 0.001) in adolescents, and it also indirectly predicted Internet addiction through inhibitory control (β = -0.231, p < 0.001). Physical activity significantly weakened the predictive effect of anxiety on inhibitory control (β = -0.092, p < 0.001). Conclusions: This study further explored the issue of psychological mechanisms between anxiety and Internet addiction in adolescents, and added that physical activity alleviates the negative effects of anxiety on adolescents. Schools and families are encouraged to promote physical exercise among adolescents to alleviate the influence of negative emotions on their psychological and behavioral health. [ABSTRACT FROM AUTHOR]

Background/AimsMethodsResultsConclusionsInhibitory control training (ICT) is a cognitive intervention that has been suggested to reduce problematic appetitive behaviours, such as unhealthy eating and excessive alcohol consumption. We conducted a meta-analytic review of ICT for reducing appetitive behaviours.Two meta-analyses were conducted for behavioural (objective) outcomes and self-report outcomes, along with 14 moderator analyses, and two secondary analyses investigating changes in cue-devaluation and inhibitory control.The review included 46 articles (67 effect sizes and 4231 participants) and four appetitive health behaviours (eating, drinking, smoking, gambling). A significant effect of ICT on behavioural outcomes was found (SMD = 0.241, p .001). The self-report outcomes meta-analysis was not significant (p > .05). Secondary analyses also demonstrated greater inhibitory control (p < .05) and cue devaluation (p < .05) following ICT.This meta-analytic review is the largest synthesis of ICT interventions for appetitive behaviours. ICT significantly reduced problematic eating behaviours when adopting behavioural outcomes, but this was not found for other appetitive behaviours. ICT also significantly improved inhibitory control and reduced cue evaluations. Further studies are required before drawing any conclusions regarding impacts on other appetitive behaviours. [ABSTRACT FROM AUTHOR]

Although some studies have revealed the association between bullying victimization and internet addiction in adolescents, the mediating and moderating factors between the two need to be further discussed. This study aimed to discuss the chain mediating role of anxiety and inhibitory control between bullying victimization and internet addiction among Chinese adolescents. A cross-sectional study was conducted in seven schools in five provinces of China by convenience sampling from February to March 2024. A total of 1673 participants (695 boys and 978 girls) with an average age of 15.86 ± 0.74 years were included in this study. Subjective data on bullying victimization, internet addiction, anxiety, inhibitory control were collected and analyzed, and a mediation model test was carried out. After controlling for age and gender, bullying victimization was found to be a significant predictor of internet addiction (β = 0.098, p < 0.001). However, when anxiety and inhibitory control were added, the predictive effect was no longer significant (β = 0.006, p > 0.05). Bullying victimization can predict internet addiction through anxiety and inhibitory control. It is suggested that guardians should provide adequate support to adolescent bullying victims in order to reduce the negative impact of bullying victimization on adolescents and prevent the occurrence of internet addiction. [ABSTRACT FROM AUTHOR]

Background Methods Results Conclusions Internet documents are characterised by their non‐linear hyperlink structure, which allows for more flexible reading, at the cost of higher cognitive loads. Linear text reading comprehension skills contribute to hypertext comprehension (either directly or through its impact on navigation behaviours) but cannot fully account for its complexity. There is also evidence that hypertext reading engages executive functions, but few studies have addressed the core executive function processes simultaneously. This study examined hypertext comprehension and navigation skills and their association with linear text reading comprehension and executive functions in adolescents.One hundred thirty‐six third‐year students (61% boys; age: M = 14.03, SD = 0.44 years) participated in the study. Students were assessed with a paper‐and‐pencil expository text comprehension test, a computerised neuropsychological battery to measure executive functioning (perceptual and response inhibition, shifting and working memory [WM]) and a hypertext comprehension task.We found direct contributions of shifting, linear text comprehension and navigation efficiency to hypertext comprehension. Linear text comprehension was associated with shifting, while navigation efficiency increased with WM and linear text comprehension skills. In addition, navigation partially mediated the effects of linear text comprehension and fully mediated those of WM on hypertext comprehension.We found direct and indirect contributions of executive function to hypertext comprehension, mediated by linear text comprehension and navigation efficiency. This suggests that finding and integrating information from hypertexts engages shifting beyond its contribution to linear text reading. The role of WM was explained by its contribution to navigation efficiency (providing a workspace to keep track of navigation paths, reading goals and inferential processing). These findings underline the relevance of high‐level cognitive abilities for Internet reading in adolescents, as well as the importance of teaching boosting navigation strategies in middle school, given their impact on hypertext comprehension. [ABSTRACT FROM AUTHOR]

It has been hypothesized that one's ability to control impulses aids in sustaining effort despite experiencing painful physical sensations. Physical exercise has been used extensively as an intervention to strengthen the inhibitory control system and protect an individual's cognitive plan of action. It is unclear, however, whether the high levels of exercise tolerance could facilitate inhibitory control under varied stressors. The present study explored the relationship between subjective exercise tolerance and psychophysiological characteristics that indicate reactivity capacity when exposed to the cold pressor test. Thirty‐six participants were divided into two groups based on their subjective exercise tolerance profiles. During the test, participants' psychophysiological reactivity was monitored via heart rate variability. Participants were also required to answer questions about their perceptual and affective states at the beginning and immediately after the stress test. The study revealed insights into dominance perception and emotional states among individuals with varying subjective exercise tolerance levels. High‐tolerant individuals endured physical discomfort longer (~50 s) and exhibited higher perceived dominance at the outset of the test when compared to their low‐tolerant counterparts. Despite differences in task performance, both groups experienced more positive affective states post‐task, potentially as a result of a heightened sense of self‐accomplishment. Notably, both groups showed similar levels of psychophysiological reactivity, suggesting a protective effect of physical tolerance on ensuing biological responses. Overall, this study sheds light on the complex relationship between exercise tolerance, dominance perception, and psychophysiological reactivity during physically demanding tasks, enriching our understanding of how developing physical tolerance may impact inhibitory control under stress. [ABSTRACT FROM AUTHOR]

Background: Considering the importance of cognitive and motor functions of the elderly people, the present study was conducted to evaluate the effectiveness of a cognitive exergame, called Neurolight compared to computerized cognitive games, in enhancing core executive functions and motor performance. Methods: A total of 36 individuals in the age range of 60 to 69 years were studied in the form of three groups: The control group continued their daily activities, while the Neurolight group underwent a cognitive-motor training and the Maghzineh performed a computer-based cognitive training program for 24 sessions. Before and after interventions, working memory, inhibitory control, and balance were measured respectively by the N-back, Stroop, and TUG tests. Results: The results showed that cognitive-motor exercises using Neurolight, for 24 sessions, were able to significantly improve working memory, inhibitory control, and balance in individuals in this age group. Conclusion: This finding supports the other studies suggesting combined cognitive and physical exercises for better effect. Based on its findings, the use of this exercise system can be suggested to coaches and therapists working with the elderly. [ABSTRACT FROM AUTHOR]

Sagittaria trifolia, a perennial weed of Alismataceae in Japanese rice paddies, has a single ALS gene, and both target and non‐target‐site resistance are known in the SU resistance of this species. In this study, the target‐site resistance profile at the whole‐plant and enzyme levels was investigated using self‐pollinated S1 seedlings from a parent plant heterozygous for a Pro197Ser ALS mutation and their clonal tubers. Our objectives were to reveal differences and similarities between whole‐plant resistance of seedlings to imazosulfuron and that of tuber‐derived plants and to correlate the whole‐plant responses to enzymatic inhibition, as well as to quantify the effects of mutant ALS allele stacking. Genotyping confirmed a Mendelian segregation ratio (1:2:1) among S1 plants for wild‐type, heterozygous, and homozygous ALS mutations. Enzymatic assays showed that resistance correlated with the number of mutant alleles, and heterozygous plants exhibited a double‐sigmoid curve plateauing at 50%, indicating the function of a 50:50 wild‐type to mutant enzyme ratio. Studies of tuber‐derived plants showed that resistance increased with more mutant alleles, but with a disproportionate jump over 3000‐fold from wild‐type to heterozygous, and only 5‐fold from heterozygous to homozygous, indicating a saturating tendency in the stacking effect of mutations. The dose response of S1 seedlings was consistent with Mendelian segregation of genotypes and suggested a similar saturation of resistance increase due to allele stacking as observed in tubers, with comparable dose–response patterns across identical genotypes. [ABSTRACT FROM AUTHOR]

The Hayling Completion Sentence Test (HSCT) is dedicated to assess inhibition of the dominant response and includes two conditions, an automatic condition in which the participants are asked to complete sentences properly and an inhibition condition in which the participants were asked to produce a word completely unrelated to the sentence. The aim of our study was 1) to adapt, 2) to evaluate the psychometric properties and 3) to standardize the HSCT into a French-school-aged pediatric population. We developed the Child-Hayling Test, a child adaptation of the adult French version of the HSCT. The reliability and validity of the Child-Hayling Test were then evaluated in a sample of 134 children aged 6–11 years. In the inhibition condition, children had lower response latency, as they get older. No effect of gender was observed. Reliability indices were low to moderate. Concerning the convergent and divergent validity, response latencies in the Child-Hayling Test correlated with latency scores in the Barre-Joe inhibition test, whereas the Child-Hayling Test scores were not related to children’s lexical abilities. The Child-Hayling Test was then administered to 393 typically developing 6- to 11-year-old children. Normative data were calculated in the inhibition condition using a regression-based approach. Regression equations to calculate Z scores are provided for clinical use. In addition, we proposed a clear guideline on how to score children’s inhibition responses. The Child-Hayling Test provides a useful tool for assessing prepotent response inhibition in children and can be recommended for use in clinical research and practice. [ABSTRACT FROM AUTHOR]

The task-switch cost is one of the most robust phenomena in human task performance, but it can disappear after nogo trials where the actors decide not to respond to the target. According to the response-selection account, it is the occurrence of response selection that generates a task-switch cost on the subsequent trial, and the absence of a switch cost after nogo trials has been attributed to a nonoccurrence of response selection on nogo trials. However, an alternative account is that a task-switch cost is generated but is abolished on nogo trials because of the interference from the nogo signal with the activated task set, suggesting that the absence of a task-switch cost does not necessarily imply the nonoccurrence of response selection. The present study tested these competing accounts by using selective go/nogo procedures for which withholding a response would require selecting a response and inhibiting the selected response. Bayes factors in five experiments provided evidence for the absence of a task-switch cost after selective nogo trials, indicating that the occurrence of response selection does not necessarily result in a task-switch cost on the subsequent trial. The present results are consistent with the task-set interference account that a task-switch cost could be generated on nogo trials but is abolished because a nogo signal interferes with the activated task-set. [ABSTRACT FROM AUTHOR]

Objective: Research about the impact of acute stress on inhibitory control remains a contentious topic, with no consensus reached thus far. This study aims to investigate the effects of acute stress on an individual's inhibitory control abilities and to elucidate the underlying neural mechanisms by analyzing resting state electroencephalogram (EEG) data. Methods: We recruited 32 male college students through participant recruitment information to undergo within-subject experiments under stress and non-stress conditions. Physiological indicators (cortisol and heart rate), self-report questionnaires, and behavioral data from the Stroop task were collected before, during, and after the experiment. Additionally, a five-minute eyes closed resting state EEG data collection was conducted during the Stroop task before. Results: (1) Acute stress led to a reduction in the conflict effect during the participants' Stroop task in individuals. (2) Stress resulted in an increase in the power of the beta in the resting state EEG. (3) Acute stress caused an increase in the duration of class D and an increase in the transition probabilities from classes C and B to class D in the microstates of the resting state EEG. (4) Acute stress leads to an increase in beta power values in individuals' resting state EEGs, which is significantly negatively correlated with the reduction of the conflict effect in the Stroop task under stress. Conclusions: Acute stress can enhance individuals' attentional level, thereby promoting inhibitory control performance. [ABSTRACT FROM AUTHOR]

In order to explore the effect of loneliness on work engagement and the role of executive function in Chinese seafarers, two studies were carried out. Study 1 conducted a questionnaire survey of 1231 active Chinese seafarers to examine the relationship between seafarers' loneliness, work engagement, and executive functions. Study 2 involved 177 seafarers as participants and created scenarios of seafarer work loneliness and non-loneliness using a recall paradigm, measuring components of executive function such as inhibitory control, working memory, and cognitive flexibility, as well as willingness to engage in work. The findings indicate that seafarers' sense of loneliness can significantly negatively predict their work engagement, with inhibition control, working memory, and cognitive flexibility playing mediating roles. This provides new references and insights for alleviating the negative impact of loneliness on seafarers and enhancing their work engagement through cognitive approaches. [ABSTRACT FROM AUTHOR]

This study investigated the psychological factors related to the attitudes of Chinese arts college students toward integrated arts education. It also examined predictive models incorporating psychological variables, demographic profiles, and art education-related characteristics to offer valuable insights for future research and art education practices. The sample comprised 303 Chinese college students majoring in arts and aged 18–22 years. The predictive models were examined using stepwise regression and decision tree analyses. The results indicated positive correlations between attitudes toward integrated arts education and several psychological variables, including extraversion, openness, conscientiousness, agreeableness, the Behavioral Inhibition System (BIS), hardiness, creativity, self-efficacy, and purpose orientation for personal growth. Neuroticism and the Behavioral Activation System (BAS) were negatively correlated with attitudes toward integrated arts education. Further, extraversion accounted for the greatest variance in attitudes toward integrated arts education. Extraversion, self-efficacy, purpose orientation for personal growth, BIS, and commitment accounted for approximately 38.3% of the variance. The decision tree model, predicting the attitudes of college students majoring in the arts toward integrated arts education, included extraversion, self-efficacy, teaching experience in their major, and academic year. This study contributes to a better understanding of the psychological and educational factors that shape the attitudes of Chinese arts students toward integrated arts education and provides a predictive framework that can inform future research and educational practices. [ABSTRACT FROM AUTHOR]

Aims and objectives/purpose/research questions: Prior research has put forward that asymmetrical switch costs in language switching do not occur when bilinguals are in a voluntary language-switching context. While several studies have provided evidence along these lines, two very recent studies have put this into question. This study further investigates the possibility that voluntary language switching abolishes asymmetrical switch costs. Design/methodology/approach: We presented German-English bilinguals (n = 79) with pictures that had to be named in either German or English, whichever they chose, by typing. Data and analysis: Reaction times (both the latency of the first keystroke and interkeystroke intervals) were analyzed using linear mixed-effects regression modeling with the factors Trial type (switch vs. repetition trial) and Language (German vs. English), whereas the error rates were analyzed using logistic mixed-effects regression modeling. Findings/conclusions: The onset latencies and inter-keystroke intervals both showed larger second-language (English) than first-language (German) switch costs (i.e., reversed asymmetrical switch costs). As switch costs were modulated by language dominance in a voluntary language-switching context, this study provides evidence that voluntary language switching is not a boundary condition for asymmetrical switch costs. Originality: In contrast to most previous language-switching studies, we used typed rather than vocal responses in a voluntary language-switching paradigm. In addition, our findings further support and generalize very recent findings of (reversed) asymmetrical switch costs in voluntary language switching. Significance/implications: Since asymmetrical switch costs, an important measure of bilingual inhibitory control, are not consistently observed throughout the language-switching literature, it is essential to understand its boundary conditions. [ABSTRACT FROM AUTHOR]

Glaucoma is a progressive optic neuropathic disorder that significantly impacts the activities of daily life (ADLs) of individuals. Emerging studies indicate degenerative changes in cortical and subcortical regions in individuals with glaucoma, which are associated with cognitive processes and oculomotor control. Cognitive processes involving top-down processes such as attention, planning, task management and execution, are crucial for meeting the demands of everyday tasks, and are affected in glaucoma. This study investigated the executive functions, specifically inhibitory control (IC) and working memory (WM), in individuals with glaucoma compared to age-matched controls, using eye movements. This was achieved through four tasks sensitive to executive functions, including antisaccade, memory-guided prosaccade and antisaccade, and the Go-NoGo tasks. Saccadic eye-movement parameters were also assessed in a prosaccade task, considered as a control condition with minimal IC and WM load. The results indicated that glaucoma is associated with changes in both IC and WM. Increased anticipatory saccadic errors might be linked to inhibitory deficiencies during the preparatory stage of the saccadic suppression mechanism. The increased omission errors in the antisaccade task might be due to the lack of regulation of the WM component. Taken together, these findings provide evidence for the involvement of cognitive deficits in individuals with glaucoma. [ABSTRACT FROM AUTHOR]

We examined whether math anxiety is related to a response inhibition deficit and, if so, whether it is a domain‐specific inhibition deficit in numerical tasks or a general inhibition deficit. Behavioral performance and electroencephalogram activity were recorded while 28 highly math–anxious (HMA) and 28 low math–anxious (LMA) individuals performed both a numerical and a non‐numerical Go/Nogo task. In the numerical task, single‐digit numbers were presented, and participants were asked to press a button if the number was even. In the non‐numerical task, letters were presented, and the button had to be pressed if the letter was a vowel. Nogo trials were answered less accurately and elicited larger Nogo‐N2 and Nogo‐P3 than Go trials in both tasks and both groups. Importantly, behavioral and brain response differences between tasks were only found in the HMA group. First, they were more error‐prone in numerical Nogo than in non‐numerical Nogo trials; and second, their Nogo‐N2 and N2d (Nogo–Go difference) were smaller in the numerical task than in the non‐numerical task. No differences were found in the LMA group. These results suggest that HMA individuals' response inhibition is impaired specifically when dealing with numbers, which could contribute to their low achievement in math tasks. [ABSTRACT FROM AUTHOR]

Background: It seems that children's anxiety is affected by parental factors and the child's personality characteristics. The objective of this study was to develop a model of child anxiety based on maternal overprotection, anxious beliefs, and the mediating role of child inhibition in clients referred to the Urmia Police Force Counseling Center, Urmia, Iran. Methods: In this modeling type of correlational study, among the clients referring to the Urmia Police Force Counseling Center in 2021-2022, 218 mothers with children aged 2 to 8 years were selected using a convenience sampling method. Mothers completed the Roth Manual of Mother-Child Relationship Evaluation (MCRE), Spence et al. Preschool Anxiety Scale (PAS), Francis and Chorpita Parental Beliefs about Anxiety Questionnaire (PBA-Q), and Bishop et al. Behavioral Inhibition Questionnaire (BIQ). The obtained data were analyzed in SPSS [mean, standard deviation (SD), and correlation] and Amos software using the path analysis method. Results: A significant positive relationship was found between maternal overprotection (r = 0.49, P < 0.001), anxious beliefs (r = 0.54, P < 0.001), child inhibition (r = 0.48, P < 0.001), and child anxiety. Moreover, overprotection had an indirect and positive effect (p = 0.41, P < 0.02) on the child's anxiety given the mediating role of the child's inhibition (p = 0.073, P < 0.01). Anxious beliefs directly (p = 0.41, P < 0.01), indirectly, and positively affected a child's anxiety given the mediating role of the child's inhibition (p = 0.098, P < 0.001). It should be noted that the root mean square error of approximation (RMSEA) index was 0.09 and the comparative fit index (CFI) was 0.987, which were acceptable. Conclusion: Based on the results, the mother's cognitive and behavioral characteristics can affect anxiety through the child's behavioral inhibition characteristic. In addition to parents' cognitive and behavioral characteristics, the child's temperament and parents' response based on the children's temperament should be also considered in the diagnosis and treatment of children's anxiety disorders. [ABSTRACT FROM AUTHOR]

Executive control of movement enables inhibiting impulsive responses critical for successful navigation of the environment. Circuits mediating stop commands involve prefrontal and basal ganglia structures with fMRI evidence demonstrating increased activity during response inhibition in the dorsolateral prefrontal cortex (dlPFC)—often ascribed to maintaining task attentional demands. Using direct intraoperative cortical recordings in male and female human subjects, we investigated oscillatory dynamics along the rostral-caudal axis of dlPFC during a modified Go/No-go task, probing components of both proactive and reactive motor control. We assessed whether cognitive control is topographically organized along this axis and observed that low-frequency power increased prominently in mid-rostral dlPFC when inhibiting and delaying responses. These findings provide evidence for a key role for mid-rostral dlPFC low-frequency oscillations in sculpting motor control. [ABSTRACT FROM AUTHOR]

Background: Research suggests that a two-factor model of impulsivity predicts Substance Use Disorder and Gambling Disorder. We aimed to determine whether a similar factor structure was present for Gaming Disorder (GD) and Internet Gaming Disorder (IGD). Methods: Secondary data analysis was conducted on survey responses from 372 participants who had completed a series of questions on facets of impulsivity and their involvement in gaming. Participants were sampled from gaming forums and an online recruitment website. Exploratory factor analysis was conducted on the measures of trait impulsivity, and the identified factors were then analyzed against measures of Gaming Disorder and Internet Gaming Disorder. A confirmatory factor analysis was then run to confirm the model. Results: The exploratory results suggested a five-factor model of impulsivity, with gaming being related to all five factors. Interestingly, only two of those factors (Urgency (Positive Urgency, Negative Urgency, Delay Discounting) and (Impaired) Inhibitory Control (False Button Presses on Go/No-Go Tasks)) predicted symptom counts above the clinical cut-off for IGD. In addition, Urgency was related to symptom counts above 7/9 criteria for IGD, as well as symptom counts above the suggested clinical cut-off for GD. The confirmatory factor analysis suggested that this two-factor model of impulsivity had 'good fit.' Conclusions: This two-factor model of impulsivity is similar to those found in established addiction disorders, in that one factor appears to predict more problematic involvement than the other. However, the results indicate that Urgency predicts higher symptom counts than (Impaired) Inhibitory Control. This contrasts with previous findings on substance use and gambling, where (Impaired) Inhibitory Control was the factor predicting problematic use. However, there was evidence to suggest that gaming is similar to alcohol consumption, where socially acceptable, "healthy," use is related to impulsivity at some level, but Urgency is key in the transition from recreational to disordered behavior. [ABSTRACT FROM AUTHOR]

Few confrontation naming tests are designed for pediatric populations. The Children's Visual Naming Test (cVNT; Hamberger et al., 2018) was developed to fill this gap. No independent studies using cVNT with clinical populations have been published to date. We aimed to characterize cVNT performance in a clinical sample and analyze the relationship between cVNT and other neuropsychological tests/constructs. Retrospective data was collected from 126 consecutively referred youth, aged 6–15 years (M = 11.28, SD = 2.80), who underwent clinical neuropsychological evaluation through an academic medical center. Naming under 2 seconds (cVNT-L2) and the summary scores (cVNT-SUM) were lower compared to the normative sample (cVNT-L2: Mz =-1.30, SD = 2.17; cVNT-SUM: Mz =-1.26, SD = 2.15). cVNT was related to core verbal abilities, processing speed, and response inhibition. cVNT-L2 and cVNT-SUM, but not naming under 20 seconds, were related to overall intellectual functioning, verbal fluency, and working memory, and were associated with overall attention, processing speed, executive functions, and verbal fluency. The cVNT provides assessment of confrontation naming without downward extension in pediatric neuropsychological assessment. Importantly, cVNT offers variables of higher fidelity to the neural process of naming than previous measures. cVNT may be associated with commonly assessed neuropsychological functions, providing a rapidly effective tool for screening batteries or improving efficiency. [ABSTRACT FROM AUTHOR]

Children with attention-deficit/hyperactivity disorder (ADHD) experience a host of social problems, in addition to significant impairments in behavioral inhibition, working memory, and self-control. Behavioral inhibition and working memory difficulties have been linked with social functioning deficits, but to date, most studies have examined these neurocognitive problems either in isolation or as an aggregate measure in relation to social problems, and none has considered the role of self-control. Thus, it remains unclear whether all of these executive functions are linked with social problems or if the link can be more parsimoniously explained by construct overlap. Fifty-eight children with ADHD and 63 typically developing (TD) children completed tests assessing self-control, behavioral inhibition, and working memory; parents and teachers rated children's social functioning. Examination of potential indirect effects with the bootstrapping procedure indicated that working memory mediated the relation between group membership (ADHD, TD) and child social functioning based on teacher but not parent ratings. Behavioral inhibition and self-control did not have direct relations with either parent- or teacher-rated social functioning. These findings point to important differences regarding how executive functioning difficulties manifest at school compared to home, as well as the specific executive function components that predict ADHD-related social difficulties. [ABSTRACT FROM AUTHOR]

Irritability and attention-deficit/hyperactivity disorder (ADHD) symptoms frequently co-occur in youth. Although ADHD has been associated with inhibitory control deficits, the literature on irritability and inhibitory control is mixed. Examining how irritability, ADHD symptoms, and inhibitory control interrelate both cross-sectionally and longitudinally across development could shed light on common and distinct mechanisms of youth psychopathology. We utilized a cross-lagged panel model with data from 2 time points (at ages 10 and 12 years) of the Adolescent Brain and Cognitive Development (ABCD) Study (N = 7,444, or ∼63% of the baseline sample with full data at each time point) to test cross-sectional and longitudinal associations among parent-reported irritability and ADHD symptoms and behaviorally assessed inhibitory control. This was performed separately across discovery and replication subsamples, each n = 3,722. As expected, irritability and ADHD symptoms exhibited strong cross-sectional and reciprocal cross-lagged associations. Higher ADHD symptoms at age 10 years were associated concurrently with poorer inhibitory control and predicted poorer inhibitory control at age 12. Contrary to predictions, inhibitory control was not significantly associated with irritability cross-sectionally, nor was it predictive of later irritability or ADHD symptoms. These findings highlight strong links between irritability and ADHD. Although inhibitory control deficits were linked to ADHD and predictive of its symptom course, inhibitory control had no significant associations with irritability. Future research should investigate other candidate mechanisms of the co-occurrence of irritability and ADHD symptoms and predictors of their developmental trajectories. This study investigated how irritability, ADHD symptoms, and inhibitory control interrelate both cross-sectionally and longitudinally in a sample of youth from the Adolescent Brain and Cognitive Development (ABCD) Study (N = 7,444). Results indicate that irritability and ADHD symptoms exhibit strong reciprocal predictive relationships; however, inhibitory control does not predict later irritability or ADHD, though ADHD symptoms predicted later inhibitory control deficits. These findings corroborate the predictive relations between irritability and ADHD over development and highlight the need for continued exploration of mechanisms underlying their co-occurrence. [ABSTRACT FROM AUTHOR]

Rationale: Motivation and inhibitory control are dominantly regulated by the dopaminergic (DA) and noradrenergic (NA) systems, respectively. Hypothalamic hypocretin (orexin) neurons provide afferent inputs to DA and NA nuclei and hypocretin-1 receptors (HcrtR1) are implicated in reward and addiction. However, the role of the HcrtR1 in inhibitory control is not well understood. Objectives: To determine the effects of HcrtR1 antagonism and motivational state in inhibitory control using the go/no-go task in mice. Methods: n = 23 male C57Bl/6JArc mice were trained in a go/no-go task. Decision tree dendrogram analysis of training data identified more and less impulsive clusters of animals. A HcrtR1 antagonist (BI001, 12.5 mg/kg, per os) or vehicle were then administered 30 min before go/no-go testing, once daily for 5 days, under high (food-restricted) and low (free-feeding) motivational states in a latin-square crossover design. Compound exposure levels were assessed in a satellite group of animals. Results: HcrtR1 antagonism increased go accuracy and decreased no-go accuracy in free-feeding animals overall, whereas it decreased go accuracy and increased no-go accuracy only in more impulsive, food restricted mice. HcrtR1 antagonism also showed differential effects in premature responding, which was increased in response to the antagonist in free-feeding, less impulsive animals, and decreased in food restricted, more impulsive animals. HcrtR1 receptor occupancy by BI001 was estimated at ~ 66% during the task. Conclusions: These data indicate that hypocretin signalling plays roles in goal-directed behaviour and inhibitory control in a motivational state-dependant manner. While likely not useful in all settings, HcrtR1 antagonism may be beneficial in improving inhibitory control in impulsive subpopulations. [ABSTRACT FROM AUTHOR]

Signaling high sensitivity to others may help individuals with heightened sensitivity to stimuli to craft their social relations to a preferred activation level ("assertive signaling of specific needs" hypothesis). Signaling sensitivity could be also a deceptive strategy helping to extract resources or obtain the desired treatment ("deceptive signaling" hypothesis). The study presents the construction of the measure of signaling high sensitivity to influence others and an initial test of both hypotheses. Two hundred and one participants ranging in age from 18 to 67 (M = 25.6; SD = 7.03) reported on their reinforcement sensitivity (behavioral approach and inhibition system), sensory processing sensitivity, and the Dark Triad. Signaling high sensitivity to influence others was weakly, but significantly, associated with behavioral inhibition system sensitivity, which was consistent with the "assertive signaling of specific needs" hypothesis. The behavioral approach system was positively correlated with signaling high sensitivity, which indicated that this influence strategy could be treated as an assertive self-presentational strategy helping in achieving social rewards for individuals with high reward responsiveness. Narcissism and psychopathy accounted for an additional amount of variance in signaling high sensitivity over and beyond reinforcement sensitivity. This was consistent with the "deceptive signaling" hypothesis. Signaling high sensitivity could be regarded as a strategy to achieve social goals using deception rather than as an expression of sensitive personality. [ABSTRACT FROM AUTHOR]

ABSTRACT Rhizospheric pH, an important environmental cue, severely impacts plant growth and fitness, therefore, has emerged as a major determinant of crop productivity. Despite numerous attempts, the key questions related to plants response against rhizospheric pH remains largely elusive. The present study provides a mechanistic framework for rhizospheric pH‐mediated root growth inhibition (RGI). Utilizing various genetic resources combined with pharmacological agents and high‐resolution confocal microscopy, the study provides direct evidence for the involvement of jasmonates and auxin in rhizospheric pH‐mediated RGI. We show that auxin maxima at root tip is tightly regulated by the rhizospheric pH. In contrast, jasmonates (JAs) abundance inversely correlates with rhizospheric pH. Furthermore, JA‐mediated regulation of auxin maxima through GRETCHEN HAGEN 3 (GH3) family genes explains the pattern of RGI observed over the range of rhizospheric pH. Our findings revealed auxin as the key regulator of RGI during severe pH conditions, while JAs antagonistically regulate auxin response against rhizospheric pH. [ABSTRACT FROM AUTHOR]

Adult attention-deficit/hyperactivity disorder (aADHD) represents a heterogeneous entity incorporating different subgroups in terms of symptomatology, course, and neurocognition. Although neurocognitive dysfunction is generally associated with aADHD, its severity, association with self-reported symptoms, and differences between subtypes remain unclear. We investigated 61 outpatients (65.6% male, mean age 31.5 ± 9.5) diagnosed using DSM-5 criteria together with age-, sex-, and education-matched healthy controls (HC) (n = 58, 63.8% male, mean age 32.3 ± 9.6). Neurocognitive alterations were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and compared between groups using the generalized linear model (GLM) method. Multivariate effects were tested by principal component analysis combined with multivariate pattern analysis. Self-reported symptom severity was tested for correlations with neurocognitive performance. GLM analyses revealed nominally significant differences between the aADHD and HC groups in several domains, however, only the Rapid Visual Information Processing measures survived correction, indicating impaired sustained attention and response inhibition in the aADHD group. Comparison of the predominantly inattentive and the hyperactive-impulsive/combined subtypes yielded nominally significant differences with higher levels of dysfunction in the inattentive group. In the stepwise discriminant analysis aADHD and HC groups were best separated with 2 factors representing sustained attention and reaction time. We found only weak correlations between symptom severity and CANTAB factors. aADHD patients are neuropsychologically heterogeneous and subtypes show different neurocognitive profiles. Differences between the aADHD and HC groups were driven primarily by the inattentive subtype. Sustained attention and its factor derivative showed the most significant alterations in aADHD patients. [ABSTRACT FROM AUTHOR]

Cognitive impairments affect functional capacity in individuals with schizophrenia (SZH), but their neural basis remains unclear. The Wisconsin Card Sorting Test (WCST), and the Stroop Task (SCWT), are paradigmatic tests which have been used extensively for examining executive function in SZH. However, few studies have explored how deficits on these tasks link to brain volume differences commonly seen in SZH. Here, for the first time, we tested associations between FreeSurfer-derived frontal brain volumes and performance on both WCST and SCWT, in a well-matched sample of 57 SZH and 32 control subjects. We also explored whether these associations were dissociable from links to symptom severity in SZH. Results revealed correlations between volumes and task performance which were unique to SZH. In SZH only, volumes of right middle frontal regions correlated with both WCST and Stroop performance: correlation coefficients were significantly different to those present in the control group, highlighting their specificity to the patient group. In the Stroop task, superior frontal regions also showed associations with Stroop interference scores which were unique to SZH. These findings provide important detail around how deficits on these two paradigmatic executive function tasks link to brain structural differences in SZH. Results align with converging evidence suggesting that neuropathology within right middle frontal regions (BA9 and BA46) might be of particular import in SZH. No volumetric associations with symptom severity were found, supporting the notion that the structural abnormalities underpinning cognitive deficits in SZH differ from those associated with symptomatology. [ABSTRACT FROM AUTHOR]

Depression and obesity are associated with impaired inhibitory control. Behavioral evidence indicates an exacerbating additive effect when both conditions co-occur. However, the underlying neural mechanisms remain unclear. Moreover, systemic inflammation affects neurocognitive performance in both individuals with depression and obesity. Here, we investigate additive effects of depression and obesity on neural correlates of inhibitory control, and examine inflammation as a connecting pathway. We assessed inhibitory control processing in 64 individuals with obesity and varying degrees of depressed mood by probing neural activation and connectivity during an fMRI Stroop task. Additionally, we explored associations of altered neural responses with individual differences in systemic inflammation. Data were collected as part of the BARICO (Bariatric surgery Rijnstate and Radboudumc neuroimaging and Cognition in Obesity) study. Concurrent depression and obesity were linked to increased functional connectivity between the supplementary motor area and precuneus and between the inferior occipital and inferior parietal gyrus. Exploratory analysis revealed that circulating inflammation markers, including plasma leptin, IL-6, IL-8, and CCL-3 correlated with the additive effect of depression and obesity on altered functional connectivity. The observational design limits causal inferences. Future research employing longitudinal or intervention designs is required to validate these findings and elucidate causal pathways. These findings suggest increased neural crosstalk underlying impaired inhibitory control in individuals with concurrent obesity and depressed mood. Our results support a model of an additive detrimental effect of concurrent depression and obesity on neurocognitive functioning, with a possible role of inflammation. • Depression and obesity are both associated with impaired inhibitory control. • We studied the neurocognitive effects of co-occurring obesity and depression. • Co-occurrence of both conditions was related to increased fMRI neural crosstalk. • Inflammation markers correlated with connectivity changes in depression and obesity. • Findings support a model of additive detrimental effects on inhibitory control. [ABSTRACT FROM AUTHOR]

Prenatal maternal stress is linked to offspring outcomes; however, there is little research on adolescents, behavioral, transdiagnostic outcomes, or the mechanisms through which relations operate. We examined, in N = 268 adolescents (Mage = 15.31 years; SD = 1.063; 57.8% boys) whether prenatal maternal stress is associated with adolescent affective outcomes; whether this association is mediated, serially, by childhood home atmosphere and adolescent behavioral inhibition system (BIS) sensitivity; and whether mediational effects are moderated by adolescent attention-deficit/hyperactivity disorder or maternal internalizing symptomology. Prenatal maternal daily stress and major life events were associated with adolescent outcomes through childhood negative atmosphere/neglect and BIS sensitivity, with no evidence of moderation. Results have implications regarding the effect of prenatal maternal stress on offspring outcomes and regarding corresponding sensitive periods. [ABSTRACT FROM AUTHOR]

Rumination is a vulnerability for depression and potentially linked to inhibitory control weaknesses. We aimed to replicate the association observed in adults between inhibitory control and rumination in adolescents, and to examine putative moderating roles of childhood maltreatment and perceived family cohesion in an adolescent sample at risk for depression due to familial/personal history. Ninety adolescents aged 11–17 (M = 14.6, SD = 1.8) completed self-report scales of rumination, maltreatment, and family cohesion, and performed a task assessing inhibitory control. Hierarchical regression models showed no significant relation between inhibitory control and moderator variables on rumination. However, adolescents who reported higher levels of maltreatment and who perceived lower family cohesion tended to indicate higher levels of rumination (BChilhood Maltreatment = 27.52, 95% CIs [5.63, 49.41], BFamily Cohesion = -0.40, 95% CIs [-0.65, -0.15]). These findings demonstrate an alternative understanding of factors that increase depression onset risk and recurrence in adolescents. Summary Statement: This study was funded by the National Institute of Mental Health grants R61MH116080 and F31MH117856. S.A.L. reports financial disclosures from EPI-Q, Otsuka Pharmaceutical, Development and Commercialization, Inc, and Secondary Triad, Inc, all of which are unrelated to the present work. S.A.L. is supported by National Institute of Mental Health grants (Grant Nos. MH116080, MH112705, MH120660, and MH120168). K.L.B. is supported by the National Institutes of Mental Health grant F31MH117856. All other authors have no relevant financial or non-financial interests to disclose. [ABSTRACT FROM AUTHOR]

Background: Previous studies demonstrated the influential role of sustained attention in the reading comprehension of alphabetic writing systems. However, there is limited understanding of how these cognitive functions contribute to reading comprehension in non-alphabetic systems, such as Japanese. This study seeks to explore this gap, focusing on how sustained attention and response inhibition function in a writing system where some of the characters represent meanings rather than sounds, introducing another layer of difficulty in the complex process of reading; Methods: Seventy-five Japanese 9th grade students performed a task to assess sustained attention and response inhibition. The cognitive test was carried out using tablets to enable feasible parallel group administration while maintaining high comparability with ecological classroom settings. Reading comprehension was measured using an exam that the participants took as part of their educational routine; Results: Our results indicate that both sustained attention and response inhibition significantly contributed to the reading comprehension of Japanese 9th grade students; Conclusions: These results replicate and expand previous studies documenting the contribution of sustained attention on the reading comprehension of alphabetic writing systems to a non-alphabetic system. Moreover, our findings unravel another important cognitive factor, namely response inhibition in reading comprehension. We suggest that response inhibition may play a crucial role in reading non-alphabetic writing systems that pose high cognitive demands, such as Japanese. [ABSTRACT FROM AUTHOR]