26 results on '"Praderio L"'
Search Results
2. IgG4-related disease in Italy: clinical features and outcomes of a large cohort of patients.
- Author
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Campochiaro, C, Ramirez, GA, Bozzolo, EP, Lanzillotta, M, Berti, A, Baldissera, E, Dagna, L, Praderio, L, Scotti, R, Tresoldi, M, Roveri, L, Mariani, A, Balzano, G, Castoldi, R, Doglioni, C, Sabbadini, MG, and Della-Torre, E
- Subjects
IMMUNOGLOBULIN G ,IMMUNOGLOBULIN analysis ,TISSUE wounds ,THERAPEUTIC use of glucocorticoids ,ADRENOCORTICAL hormones ,IMMUNOSUPPRESSIVE agents ,AUTOIMMUNE diseases ,EYE-socket tumors ,IMMUNOGLOBULINS ,LONGITUDINAL method ,PANCREATITIS ,RETROPERITONEUM ,DISEASE relapse ,DISEASE remission ,RETROSPECTIVE studies ,CYTOREDUCTIVE surgery ,SIALADENITIS ,DISEASE complications - Abstract
Objectives: To describe the clinical features, treatment response, and follow-up of a large cohort of Italian patients with immunoglobulin (Ig)G4-related disease (IgG4-RD) referred to a single tertiary care centre. Method: Clinical, laboratory, histological, and imaging features were retrospectively reviewed. IgG4-RD was classified as ‘definite’ or ‘possible’ according to international consensus guidelines and comprehensive diagnostic criteria for IgG4-RD. Disease activity was assessed by means of the IgG4-RD Responder Index (IgG4-RD RI). Results: Forty-one patients (15 females, 26 males) were included in this study: 26 with ‘definite’ IgG4-RD and 15 with ‘possible’ IgG4-RD. The median age at diagnosis was 62 years. The median follow-up was 36 months (IQR 24–51). A history of atopy was present in 30% of patients. The pancreas, retroperitoneum, and major salivary glands were the most frequently involved organs. Serum IgG4 levels were elevated in 68% of cases. Thirty-six patients were initially treated with glucocorticoids (GCs) to induce remission. IgG4-RD RI decreased from a median of 7.8 at baseline to 2.9 after 1 month of therapy. Relapse occurred in 19/41 patients (46%) and required additional immunosuppressive drugs to maintain long-term remission. Multiple flares occurred in a minority of patients. A single case of orbital pseudotumour did not respond to medical therapy and underwent surgical debulking. Conclusions: IgG4-RD is an elusive inflammatory disease to be considered in the differential diagnosis of isolated or multiple tumefactive lesions. Long-term disease control can be achieved with corticosteroids and immunosuppressive drugs in the majority of cases. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
- Full Text
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3. Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: Implications for pathogenesis.
- Author
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Stoppacciaro A, Ferrarini M, Salmaggi C, Colarossi C, Praderio L, Tresoldi M, Beretta AA, and Sabbadini MG
- Abstract
OBJECTIVE: Erdheim-Chester disease (ECD) is a rare form of non-Langerhans' cell histiocytosis (LCH) of unknown etiology, characterized by diffuse histiocyte infiltration of bones and soft tissue. The purpose of this study was to assess cell proliferation and expression of cytokines, chemokines, and chemokine receptors that may potentially be important in histiocyte accumulation in ECD lesions. METHODS: Biopsies were performed on 3 patients with ECD. The diagnosis of the disease was based on clinical signs including typical radiologic osteosclerosis, and on the detection of foamy CD68+,CD1a- non-Langerhans' cell histiocytes on histologic examination. The expression of the proliferation marker Ki-67 as well as of selected chemokine/chemokine receptor pairs and cytokines was analyzed by immunohistochemistry. RESULTS: In all samples, Ki-67 was undetectable in CD68+ histiocytes. Conversely, these cells expressed the chemokines CCL2 (monocyte chemotactic protein 1), CCL4/macrophage inflammatory protein 1beta (MIP-1beta), CCL5/RANTES, CCL20/MIP-3alpha, and CCL19/MIP-3beta, and their counter-receptors CCR1, CCR2, CCR3, CCR5, CCR6, and CCR7. Moreover, ECD histiocytes expressed interferon-gamma-inducible 10-kd protein (CXCL10), which is specifically induced by interferon-gamma, and interleukin-6 and RANKL, which are both implicated in bone remodeling. Finally, all cases showed a Th1-type lymphocyte infiltrate. CONCLUSION: Our data indicate that, similar to LCH, ECD lesions are characterized by a complex cytokine and chemokine network, which may orchestrate histiocyte activation and accumulation through an autocrine loop and contribute to the pathogenesis of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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4. Electrophysiological and MRI evaluation of neurological involvement in Behçet's disease.
- Author
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Besana, C, Comi, G, Del Maschio, A, Praderio, L, Vergani, A, Medaglini, S, Martinelli, V, Triulzi, F, and Locatelli, T
- Abstract
Eight patients with stable Behçet's disease were studied by means of multimodality evoked potentials and magnetic resonance imaging to evaluate the possibility of an earlier and objective demonstration of clinical and subclinical Central Nervous System (CNS) involvement. It was shown that both diagnostic techniques are useful for quantitative evaluation of neurological involvement in Behçet's disease; of particular interest was the demonstration of subclinical CNS changes. [ABSTRACT FROM AUTHOR]
- Published
- 1989
5. Budd-Chiari syndrome in a patient with ulcerative colitis: association with anticardiolipin antibodies.
- Author
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Praderio, Luisa, Dagna, Lorenzo, Longhi, Paolo, Rubin, Gianpaolo, Sabbadini, Maria Grazia, Praderio, L, Dagna, L, Longhi, P, Rubin, G, and Sabbadini, M G
- Published
- 2000
- Full Text
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6. Rheumatoid arthritis, systemic lupus erythematosus, and STAT4.
- Author
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Dagna L, Frontino G, Praderio L, Remmers EF, Plenge RM, and Gregersen PK
- Published
- 2007
7. A relapsing inflammatory syndrome and active human herpesvirus 8 infection.
- Author
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Dagna L, Broccolo F, Paties CT, Ferrarini M, Sarmati L, Praderio L, Sabbadini MG, Lusso P, and Malnati MS
- Published
- 2005
8. Sustainability in Internal Medicine: A Year-Long Ward-Wide Observational Study.
- Author
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Ramirez GA, Damanti S, Caruso PF, Mette F, Pagliula G, Cariddi A, Sartorelli S, Falbo E, Scotti R, Di Terlizzi G, Dagna L, Praderio L, Sabbadini MG, Bozzolo EP, and Tresoldi M
- Abstract
Population aging and multimorbidity challenge health system sustainability, but the role of assistance-related variables rather than individual pathophysiological factors in determining patient outcomes is unclear. To identify assistance-related determinants of sustainable hospital healthcare, all patients hospitalised in an Internal Medicine Unit (n = 1073) were enrolled in a prospective year-long observational study and split 2:1 into a training (n = 726) and a validation subset (n = 347). Demographics, comorbidities, provenance setting, estimates of complexity (cumulative illness rating scale, CIRS: total, comorbidity, CIRS-CI, and severity, CIRS-SI subscores) and intensity of care (nine equivalents of manpower score, NEMS) were analysed at individual and Unit levels along with variations in healthcare personnel as determinants of in-hospital mortality, length of stay and nosocomial infections. Advanced age, higher CIRS-SI, end-stage cancer, and the absence of immune-mediated diseases were correlated with higher mortality. Admission from nursing homes or intensive care units, dependency on activity of daily living, community- or hospital-acquired infections, oxygen support and the number of exits from the Unit along with patient/physician ratios were associated with prolonged hospitalisations. Upper gastrointestinal tract disorders, advanced age and higher CIRS-SI were associated with nosocomial infections. In addition to demographic variables and multimorbidity, physician number and assistance context affect hospitalisation outcomes and healthcare sustainability.
- Published
- 2024
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9. Juxta-vertebral lesions in granulomatosis with polyangiitis.
- Author
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Ramirez GA, Della-Torre E, Campochiaro C, Bozzolo E, Berti A, Praderio L, Dagna L, and Sabbadini MG
- Subjects
- Aged, Back Pain etiology, Back Pain physiopathology, Cohort Studies, Female, Fluorodeoxyglucose F18, Granulomatosis with Polyangiitis complications, Granulomatosis with Polyangiitis immunology, Humans, Male, Middle Aged, Myeloblastin immunology, Positron-Emission Tomography, Radiopharmaceuticals, Spinal Diseases etiology, Spinal Diseases immunology, Spinal Diseases physiopathology, Tomography, X-Ray Computed, Granulomatosis with Polyangiitis diagnostic imaging, Spinal Diseases diagnostic imaging
- Abstract
Objectives: To describe the clinical, pathological, serological, and radiological characteristics of juxta-vertebral masses occurring in patients with granulomatosis with polyangiitis (GPA)., Methods: We analyzed the clinical records of patients with juxta-vertebral lesions from our GPA study cohort and reviewed the English literature for other cases of GPA with juxta-vertebral localization., Results: Out of 74 patients in our GPA study cohort, six (8%) had juxta-vertebral lesions. We found 10 cases of juxta-vertebral GPA described in the English literature. Overall, juxta-vertebral lesions were detected at GPA onset in 11/16 (69%) patients, and preferentially occurred on the right side of the spine (12/15 patients, 80%). Fifteen patients (94%) with juxta-vertebral lesions had systemic GPA. Juxta-vertebral lesions were associated with back pain at GPA onset in 8/16 (50%) patients. In all of them juxta-vertebral lesions resolved or improved after treatment., Conclusions: Preference for the right-anterior side of the spine, increased
18 FDG uptake on PET scan, low or absent invasiveness of the surrounding tissues, and occurrence in the context of systemic disease were the main features of juxta-vertebral GPA. Symptomatic lesions showed a better response to immunosuppressive therapies., (Copyright © 2016 Elsevier Inc. All rights reserved.)- Published
- 2016
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10. Giant cell arteritis restricted to the limb arteries: An overlooked clinical entity.
- Author
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Berti A, Campochiaro C, Cavalli G, Pepe G, Praderio L, Sabbadini MG, and Dagna L
- Subjects
- Aged, Angiography, Aorta cytology, Arteries diagnostic imaging, Arteries pathology, Biopsy, Blood Sedimentation, Extremities pathology, Female, Giant Cell Arteritis classification, Giant Cell Arteritis pathology, Humans, Male, Middle Aged, Positron-Emission Tomography, Ultrasonography, Extremities blood supply, Giant Cell Arteritis diagnosis, Giant Cell Arteritis physiopathology
- Abstract
Objective: Giant cell arteritis (GCA) is a systemic vasculitis typically affecting temporal arteries. In at least 15% of cases, GCA also features inflammation of the aorta and its primary branches. Large-vessel inflammation restricted to proximal limb arteries in the absence of temporal and aortic involvement (Limb Restricted, LR) is rare and not well described in literature. Hence, we aim to characterize this neglected clinical entity., Methods: We describe a series of three cases of LR-GCA. All patients were older than 50 years, had increased erythrocyte sedimentation rate (ESR), normal cholesterol and triglycerides serum levels, negative temporal artery biopsy, suggestive F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings, and responded to immunosuppressive therapy. We also reviewed all published cases of LR-GCA (76 cases), for a total of 79 patients., Results: Limb claudication was reported in 87% of the patients, and cranial symptoms and polymyalgia rheumatica in 20%. Constitutional symptoms were never reported. Median ESR levels were 66.5mm/1h. Upper and lower limb arteries were involved in 86% and 9% of the patients respectively, and the remaining 5% had simultaneous upper and lower limb vessel involvement. Conventional angiography was performed in 63% of the cases, color-doppler ultrasound in 20%, FDG-PET in 14%, and computed tomography angiography in 3%., Conclusion: If temporal biopsy and aortic imaging are negative for GCA in patients older than 50 years with bilateral limb claudication, elevated ESR, and suggestive vascular radiological findings, LR-GCA should be suspected. Upper limb arteries are more frequently involved. Since constitutional symptoms are typically absent in LR-GCA, differential diagnosis with atherosclerotic plaques may be challenging., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2015
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11. Bortezomib in type I cryoglobulinemic vasculitis: are we acting too late?
- Author
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Ramirez GA, Campochiaro C, Salmaggi C, Pagliula G, D'Aliberti T, Marcatti M, Tresoldi M, and Praderio L
- Subjects
- Amputation, Surgical, Cryoglobulinemia complications, Cryoglobulinemia diagnosis, Early Diagnosis, Foot Diseases drug therapy, Foot Diseases etiology, Humans, Male, Middle Aged, Monoclonal Gammopathy of Undetermined Significance, Necrosis etiology, Paraproteinemias complications, Severity of Illness Index, Toes blood supply, Toes pathology, Treatment Outcome, Vasculitis complications, Vasculitis etiology, Antineoplastic Agents administration & dosage, Bortezomib administration & dosage, Cryoglobulinemia drug therapy, Foot Diseases surgery, Necrosis surgery, Toes surgery, Vasculitis drug therapy
- Abstract
Type II and type III cryoglobulinemic vasculitis (CV) are characterized by a deranged immune function due to concomitant chronic infections or rheumatic disorders. Conversely, type I CV is caused by plasma cell dyscrasia. Bortezomib is a proteasome inhibitor that is largely employed as a first-line treatment for multiple myeloma. The use of bortezomib in cases of monoclonal gammopathy of undetermined significance (MGUS)-related refractory type I CV has been reported in only four patients. In the current report, we discuss the efficacy of bortezomib treatment in a patient with type I CV, with a focus on the suitability and early application of this drug.
- Published
- 2015
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12. Charcot's arthropathy of the hip.
- Author
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Cavalli G and Praderio L
- Subjects
- Aged, Humans, Male, Radiography, Arthropathy, Neurogenic diagnostic imaging, Hip Joint diagnostic imaging
- Published
- 2013
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13. Atypical presentation of Churg-Strauss syndrome or an undescribed hypereosinophilic disease?
- Author
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Della-Torre E, Tresoldi M, Scotti R, Praderio L, Mellone R, Ponzoni M, Doglioni C, and Sabbadini MG
- Subjects
- Aged, Humans, Male, Churg-Strauss Syndrome diagnosis, Churg-Strauss Syndrome pathology, Churg-Strauss Syndrome therapy, Hypereosinophilic Syndrome diagnosis, Hypereosinophilic Syndrome pathology, Hypereosinophilic Syndrome therapy
- Published
- 2011
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14. Meningeal involvement in Wegener's granulomatosis is associated with localized disease.
- Author
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Di Comite G, Bozzolo EP, Praderio L, Tresoldi M, and Sabbadini MG
- Subjects
- Adult, Antibodies, Antineutrophil Cytoplasmic analysis, Cranial Nerve Diseases etiology, Cranial Nerve Diseases pathology, Female, Headache etiology, Headache pathology, Humans, Male, Meninges chemistry, Meninges diagnostic imaging, Meningitis diagnosis, Meningitis pathology, Middle Aged, Radiography, Seizures etiology, Seizures pathology, Granulomatosis with Polyangiitis complications, Meninges pathology, Meningitis etiology
- Abstract
Meningeal involvement is a rare occurrence in Wegener's Granulomatosis (WG). A Medline search uncovered only 48 previously reported cases. Here we describe the clinical features of meningeal involvement in WG and to evaluate the association with systemic disease extension. Through a systematic literature review of papers concerning meningeal involvement in WG, we collected and analysed data about sex, age, disease extension, symptoms, cerebrospinal fluid examination, imaging, ANCA and histology about previously reported patients. Headache is almost always the first symptom of meningeal involvement in WG. Later in the course of the disease other abnormalities may develop. Among them cranial nerve palsy, seizures and encephalopathy are the most frequent. Diagnosis is obtained by neuroimaging, which may disclose two distinct patterns of meningeal thickening: diffuse or focal. 62.9% of patients tests positive for ANCA. Histology typically shows necrotizing granulomatosis. Meningeal involvement is by far more frequent in the setting of localized WG. Meningitis is a rare complication of WG. It usually develops in patients with localized disease who are more likely to have destructive lesions of the upper airways. It may be recognized by a constellation of clinical and radiological findings and by histological signs of necrotizing granulomatosis, with little or no vasculitis.
- Published
- 2006
15. [Wegener's granulomatosis: an analysis of 50 patients].
- Author
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Di Comite G, Bonavida G, Bozzolo E, Bianchi S, Ciboddo G, Tresoldi M, Praderio L, and Sabbadini MG
- Subjects
- Adolescent, Adult, Aged, Child, Female, Granulomatosis with Polyangiitis drug therapy, Humans, Male, Middle Aged, Granulomatosis with Polyangiitis complications
- Abstract
Objectives: To evaluate the rate of different organs involvement in 50 patients with Wegener's Granulomatosis (GW), and to describe their clinical manifestations and their response to treatment., Methods: We evaluated 50 consecutive patients with GW, come to our attention from January 1987 to May 2003. 43 patients met the 1990 American College of Rheumatology (ACR) criteria for classification of GW; 7 patients the 1993 ELK criteria., Results: 82% of patients presented Ear/Nose/Throat (ENT) involvement, which is the most common site of inflammation. 22% of our patients had ENT-restricted disease; in 78% of cases disease extended to other organs. Lungs were involved in 72% of cases; kidney in 36%; eye in 24%; nervous system (NS) in 14% (central NS in 10% and peripheral NS in 4%); skin in 10%; heart in 8%; testis in 4%. Arthritis was present in 10% of patients. We discuss treatment of all patients and response to therapy of those 28 whose follow-up is available., Conclusions: Involvement of airways and kidney is by far the most common in GW, though potentially any other organ or system may be affected. The total rate of other organs involvement is 70%.
- Published
- 2005
- Full Text
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16. Polymyalgia rheumatica and giant-cell arteritis.
- Author
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Praderio L, Di Comite G, and Saporiti N
- Subjects
- Bone Density, Female, Humans, Male, Osteoporosis chemically induced, Diphosphonates therapeutic use, Giant Cell Arteritis drug therapy, Glucocorticoids adverse effects, Osteoporosis prevention & control, Polymyalgia Rheumatica drug therapy
- Published
- 2002
17. Hypoglycaemia and lactic acidosis in a MALT non Hodgkin's lymphoma.
- Author
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Di Comite G, Dagna L, Piatti PM, Monti LD, Tantardini F, and Praderio L
- Subjects
- Acute Kidney Injury etiology, Fatal Outcome, Female, Humans, Lymphoma, B-Cell, Marginal Zone metabolism, Middle Aged, Stomach Neoplasms metabolism, Tumor Lysis Syndrome complications, Acidosis, Lactic etiology, Hypoglycemia etiology, Lymphoma, B-Cell, Marginal Zone complications, Stomach Neoplasms complications
- Abstract
Hypoglycaemia associated with lactic acidosis is a rare complication of lymphomas; only four cases have been previously reported. Recent studies provide evidence of direct consumption of glucose by the tumour cells, leading to lactic acidosis. We report the case of a 64-year-old patient with a gastric diffuse large B cell non-Hodgkin's lymphoma transformed from an indolent mucosa associated lymphoid tissue (MALT) lymphoma, admitted to our department for acute renal failure due to a tumour lysis syndrome. After recovery from renal failure, she developed severe hypoglycaemia and lactic acidosis refractory to therapy. She died after the onset of shock and coma.
- Published
- 2002
- Full Text
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18. PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation.
- Author
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Fazzini F, Peri G, Doni A, Dell'Antonio G, Dal Cin E, Bozzolo E, D'Auria F, Praderio L, Ciboddo G, Sabbadini MG, Manfredi AA, Mantovani A, and Querini PR
- Subjects
- Acute Disease, Acute-Phase Reaction, Adult, Aged, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid immunology, Biomarkers, C-Reactive Protein metabolism, CREST Syndrome blood, CREST Syndrome diagnosis, CREST Syndrome immunology, Child, Churg-Strauss Syndrome diagnosis, Churg-Strauss Syndrome immunology, Endothelium, Vascular chemistry, Endothelium, Vascular immunology, Endothelium, Vascular metabolism, Female, Granulomatosis with Polyangiitis diagnosis, Granulomatosis with Polyangiitis immunology, Humans, Lupus Erythematosus, Systemic blood, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic immunology, Male, Middle Aged, Serum Amyloid P-Component metabolism, C-Reactive Protein analysis, Churg-Strauss Syndrome blood, Granulomatosis with Polyangiitis blood, Serum Amyloid P-Component analysis
- Abstract
Objective: To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis., Methods: Concentrations of PTX3, a pentraxin induced in endothelium by cytokines, were measured by enzyme-linked immunosorbent assay in the sera of 43 patients with Churg-Strauss syndrome, Wegener's granulomatosis, and microscopic polyangiitis. PTX3 was also measured in the sera of 28 patients with systemic lupus erythematosus (SLE), 22 with rheumatoid arthritis, and 16 with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias). Serum concentrations of C-reactive protein (CRP) were measured by immunoturbidimetry. The cells involved in PTX3 production in vivo were identified in skin biopsy samples., Results: Patients with active vasculitis had significantly higher concentrations of PTX3 than did those with quiescent disease (P < 0.001). PTX3 levels in the latter group were similar to those in healthy controls. PTX3 levels were higher in patients with untreated vasculitis and lower in patients who underwent immunosuppressive treatments (P < 0.005). In contrast, patients with active SLE had negligible levels of the pentraxin. PTX3 levels did not correlate with CRP levels in vasculitis patients. Endothelial cells produced PTX3 in active skin lesions., Conclusion: PTX3 represents a novel acute-phase reactant produced at sites of active vasculitis.
- Published
- 2001
- Full Text
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19. Acute echinococcosis: a case report.
- Author
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Di Comite G, Dognini G, Gaiera G, Ieri R, and Praderio L
- Subjects
- Acute Disease, Aged, Humans, Male, Echinococcosis, Pulmonary diagnosis
- Abstract
We report the case of a 69-year-old man with acute pulmonary echinococcosis. A computed tomographic scan of the thorax revealed the presence of multiple nodules in both lungs, and laboratory tests showed eosinophilia and the presence of antibodies against Echinococcus granulosus. Therapy with albendazole led to resolution of the pulmonary nodules and a normalization of the white cell count. To our knowledge this is the first described case of acute echinococcosis, as the diagnosis of this disease is usually delayed to chronic phases. Therefore, finding unexplained eosinophilia, especially in association with pulmonary nodules, should lead one to suspect acute hydatid disease.
- Published
- 2000
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20. Propionibacterium acnes sepsis in a previously healthy man.
- Author
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Praderio L, Dagna L, Beretta G, Rubin G, and Ossi C
- Subjects
- Adult, Blood microbiology, Culture Media, Humans, Male, Propionibacterium acnes growth & development, Bacteremia microbiology, Bone Marrow microbiology, Gram-Positive Bacterial Infections microbiology, Propionibacterium acnes isolation & purification
- Published
- 1998
- Full Text
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21. Peripheral neuropathy in scleroderma.
- Author
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Corbo M, Nemni R, Iannaccone S, Quattrini A, Lodi M, Praderio L, Comola M, Lorenzetti I, Comi G, and Canal N
- Subjects
- Adult, Autoantibodies analysis, Axons pathology, Biopsy, Collagen immunology, Electromyography, Female, Humans, Immunoenzyme Techniques, Immunoglobulin G analysis, Muscles innervation, Muscles pathology, Muscular Atrophy diagnosis, Muscular Atrophy pathology, Muscular Atrophy physiopathology, Nerve Fibers, Myelinated pathology, Neurologic Examination, Peripheral Nervous System Diseases diagnosis, Peripheral Nervous System Diseases pathology, Scleroderma, Systemic diagnosis, Scleroderma, Systemic pathology, Skin innervation, Skin pathology, Sural Nerve pathology, Peripheral Nervous System Diseases physiopathology, Scleroderma, Systemic physiopathology
- Abstract
Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensory motor neuropathy and PSS. In both, the sural nerve biopsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy.
- Published
- 1993
22. Association of lupus anticoagulant with polyarteritis nodosa: report of a case.
- Author
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Praderio L, D'Angelo A, Taccagni G, Peccatori S, Silvestris M, D'Angelo SV, and Rugarli C
- Subjects
- Amputation, Surgical, Blood Coagulation Factors analysis, Cyclophosphamide therapeutic use, Female, Humans, Iloprost therapeutic use, Lupus Coagulation Inhibitor, Middle Aged, Necrosis, Polyarteritis Nodosa drug therapy, Polyarteritis Nodosa pathology, Prednisone therapeutic use, Toes pathology, Toes surgery, Autoantibodies analysis, Blood Coagulation Factors immunology, Polyarteritis Nodosa immunology
- Abstract
A patient with a documented diagnosis of polyarteritis nodosa and laboratory evidence of a circulating lupus anticoagulant is described. Additional clinical features suggestive of the antiphospholipid antibody syndrome were found. The patient underwent amputation of the first two digits of the foot due to ischemic necrosis. Steroid and immunosuppressive treatment resulted in clinical improvement and disappearance of the circulating anticoagulant, without necessitating additional treatment with oral anticoagulants. The presence of the lupus anticoagulant might have worsened the vascular damage done by polyarteritis nodosa in this patient.
- Published
- 1990
23. Essential mixed cryoglobulinemia: a report on 14 cases.
- Author
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Silvestris M, Praderio L, Peccatori S, Marcatti M, Storti M, Ciboddo G, and Rugarli C
- Subjects
- Adult, Aged, Arthritis etiology, Female, Humans, Kidney Diseases etiology, Liver Diseases etiology, Male, Middle Aged, Peripheral Nervous System Diseases etiology, Skin Diseases etiology, Vasculitis etiology, Cryoglobulinemia blood, Cryoglobulinemia complications, Cryoglobulinemia pathology
- Abstract
Fourteen cases of Essential Mixed Cryoglobulinemia (EMC) are described in this report. Clinical and laboratory manifestations in our patients were similar to those previously reported in literature, although involvement of the peripheral nervous system was much more prevalent in our series. We suggest that peripheral neuropathy should be systematically searched in EMC patients.
- Published
- 1989
24. Berger's disease with polyarteritis nodosa.
- Author
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Praderio L, Corti C, Sposato E, Taccagni GL, Volpi A, and Sabbadini MG
- Subjects
- Adolescent, Biopsy, Blood Vessels pathology, Glomerulonephritis, IGA pathology, Humans, Kidney pathology, Male, Polyarteritis Nodosa drug therapy, Polyarteritis Nodosa pathology, Prednisolone therapeutic use, Skin blood supply, Skin pathology, Glomerulonephritis, IGA complications, Polyarteritis Nodosa complications
- Abstract
We describe a patient with Berger's disease and polyarteritis nodosa. This association has not been described previously in the literature. A causal relationship between the two diseases is suggested.
- Published
- 1989
- Full Text
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25. Pseudoxanthoma elasticum and rheumatoid arthritis.
- Author
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Praderio L, Marianj F, and Baldini V
- Subjects
- Adult, Female, Humans, Arthritis, Rheumatoid complications, Pseudoxanthoma Elasticum genetics
- Published
- 1987
26. Guillain-Barré syndrome in Castleman's lymphopathy.
- Author
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Ciboddo G, Praderio L, Spagnol G, Sironi M, Comi G, Medaglini S, Canal N, and Rugarli C
- Subjects
- Castleman Disease immunology, Humans, Lymphocytes immunology, Male, Middle Aged, Polyradiculoneuropathy immunology, Castleman Disease complications, Polyradiculoneuropathy complications
- Published
- 1987
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