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266 results on '"Poch E"'

5. THE EUROPEAN / INTERNATIONAL FIBROMUSCULAR DYSPLASIA REGISTRY: MAIN FINDINGS IN THE FIRST THOUSAND PATIENTS

Author

Pappaccogli, M., Di Monaco, S., Aparicio, L.S., Azizi, M., Bruno, R.M., de Leeuw, P.W., Delmotte, P., Gordin, D., Iwashima, Y., Januszewicz, A., Kroon, A.A., Lorthioir, A., Poch, E., Prejbisz, A., Seinturier, C., Toubiana, L., van der Niepen, P., Wang, J., Claude Wautrecht, J., Persu, A., and on behalf of the European/International Fibromuscular Dysplasia Initiative Investigators

Published
2019
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6. DISTINCTIVE FEATURES OF PATIENTS DIAGNOSED WITH FIBROMUSCULAR DYSPLASIA (FMD) AT AN OLDER AGE: A REPORT FROM THE EUROPEAN / INTERNATIONAL FMD REGISTRY

Author

Pappaccogli, M., Di Monaco, S., Amar, L., Aparicio, L.S., Azizi, M., Bruno, R.M., de Leeuw, P.W., Delmotte, P., Iwashima, Y., Januszewicz, A., Kroon, A.A., Poch, E., Prejbisz, A., Seinturier, C., Tikkanen, I., Toubiana, L., Van der Niepen, P., Scoppettuolo, P., Xu, J., Persu, A., and on behalf of the European/International Fibromuscular Dysplasia Initiative Investigators

Published
2019
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26. Factors associated with blood pressure control in diabetic patients treated in nephrology units. PRESDIAB Study.

Author

Serra, N., Oliveras, A., Bergoñon, S., Sans, L., Cobos, A., Martínez, P., Artigas, R., and Poch, E.

Abstract

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011
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27. RhoE is spatiotemporally regulated in the postnatal mouse CNS

Author

Ballester-Lurbe, B., Poch, E., Mocholí, E., Guasch, R.M., Pérez-Roger, I., and Terrado, J.

Subjects
*GUANOSINE triphosphatase, *BRAIN physiology, *AXONS, *CYTOSKELETON, *BRAIN function localization, *WESTERN immunoblotting, *IMMUNOHISTOCHEMISTRY, *LABORATORY mice
Abstract

Abstract: Rnd proteins are a family of small GTPases that have been involved in axon path finding and CNS development by their control of actin cytoskeleton dynamics. Rnd proteins are constitutively activated and, subsequently, their functions determined by their localization and expression levels. In this work we have analyzed by Western blot and immunohistochemistry the levels and localization of Rnd3/RhoE during mouse postnatal development. CNS was found to be the main tissue for RhoE protein expression, which was detected in all regions of the adult brain and spinal cord, with the highest levels in the olfactory bulb and cortex. RhoE protein levels were considerably higher in all the regions of the CNS the first 2–3 weeks of postnatal development, undergoing later a decrease that led to low levels in the adult. Immunohistochemical detection of RhoE at postnatal day 21 showed an intense and widespread labelling throughout the CNS. RhoE immunoreactivity was detected in the granular and mitral cells and anterior olfactory nuclei of the olfactory bulb and in all cerebral layers. In the striatum, diencephalon, mesencephalon, pons, medulla oblongata and spinal cord, RhoE was widely distributed with higher intensity in the motoneurones and in some brainstem nuclei such as the red nucleus or the reticulotegmental nucleus. The pyramidal cells of CA1-3 and the polymorph layer, but not the granular cells of the dentate gyrus in the hippocampus were strongly labelled. At earlier stages the labelling was nearly similar; however, a prominent labelling was detected in the cells of the rostral migratory stream and in the external granule cells of the cerebellum. Our results suggest that RhoE can play important roles in the postnatal development and maturation of the CNS, especially in the migratory processes affecting the neurones. [Copyright &y& Elsevier]

Published
2009
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31. Parathyroid hormone and platelet cytosolic calcium concentration in essential hypertension.

Author

Poch, E., Fernández-Llama, P., Botey, A., Gaya, J., Darnell, A., Rivera, F., and Revert, L.

Abstract

To investigate the possible relationships between blood pressure, parathyroid hormone (PTH) and platelet cytosolic Ca concentration ([Ca]) in patients with essential hypertension, we studied 17 patients with this disease aged 48±2 years and 17 normotensive controls aged 44±3 years. Platelet [Ca] was measured by spectrofluorimetry using the dye Fura-2 acetoxymethylester. Patients with essential hypertension displayed lower levels of serum ionized Ca (0.99±0.03 versus 1.1±0.01 mmol/l, <0.05) and higher serum intact PTH levels (37±3 versus 26±2 pg/ml, <0.01) than the normotensive controls. Although serum levels of intact PTH were significantly correlated with mean arterial pressure (MAP) in the combined group of subjects (=0.42, <0.05), there was no correlation when each group was considered separately. Resting platelet [Ca] was also higher in patients than in controls (57±3 versus 48±2nmol/l, <0.005). When platelets were stimulated with thrombin, the increment in [ca] was also greater in patients than in controls in the presence of extracellular Ca (264±24 versus 194±19 nmol/l, <0.05) but not in its absence (123±12 versus 112±10 nmol/l). The thrombin-induced increment in [ca] was correlated with MAP in the hypertensive patients (=0.64, <0.01) and in the combined group of subjects (=0.42, <0.05). There was no relationship between resting or thrombin-induced [Ca] and serum PTH in either group of patients or in the combined group of subjects. Furthermore, preincubation of platelets with PTH had no effect neither on resting platelet [Ca] or on thrombin-induced increments in [ca], both in the presence and in the absence of extracellular Ca in either group of subjects. Therefore, despite platelet [Ca] and serum PTH seem to be related to blood pressure, it appears that PTH does not participate directly in the elevated platelet [Ca] found in patients with essential hypertension. [ABSTRACT FROM PUBLISHER]

Published
1995

37. Acute tubulointerstitial nephritis associated with atezolizumab, an anti-programmed death-ligand 1 (pd-l1) antibody therapy.

Author

Xipell, M., Victoria, I., Hoffmann, V., Villarreal, J., García-Herrera, A., Reig, O., Rodas, L., Blasco, M., Poch, E., Mellado, B., and Quintana, L. F.

Subjects
TUBULOINTERSTITIAL nephritis & uveitis syndrome, CANCER treatment, BEVACIZUMAB, IMMUNE response, ATEZOLIZUMAB
Abstract

Direct stimulation of the antitumor activity of immune system through checkpoint inhibitors (ICIs) has demonstrated efficacy in the treatment of different cancer types. The activity of these antibodies takes place in the immunological synapse blocking the binding of the negative immunoregulatory proteins, thus leading to the finalization of the immune response. Despite having a favorable toxicity profile, its mechanism of action impedes the negative regulation of the immune activity which can potentially favor autoimmune attacks to normal tissues. Renal toxicity has been described in several ICI but not with atezolizumab, an IgG1 monoclonal antibody targeting PD-L1 (programmed death ligand 1), approved by FDA as a second-line therapy for advanced urothelial carcinoma. Here we present a patient with a single kidney and metastatic renal cell carcinoma treated with atezolizumab and bevacizumab combination, with biopsy-proven acute interstitial nephritis, who had a complete resolution of renal dysfunction after steroid therapy. [ABSTRACT FROM AUTHOR]

Published
2018
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