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4. Versorgung von Patienten mit kardialer Amyloidose: Konsensuspapier der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK), AG 40 Onkologische Kardiologie, und der Deutschen Gesellschaft für Hämatologie und medizinische Onkologie e. V. (DGHO), der Deutschen Gesellschaft für Neurologie e. V. (DGN) und der Deutschen Gesellschaft für Nephrologie e. V. (DGfN)

Author

Pfister, Roman, Hagenacker, Tim, Heemann, Uwe, Hegenbart, Ute, Heidecker, Bettina, Kruck, Sebastian, Knebel, Fabian, Lehmann, Lorenz, Morbach, Caroline, Rischpler, Christoph, Schulze, P. Christian, Yilmaz, Ali, and Perings, Christian

Published
2024
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8. Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Schweiger, Victor, Cammann, Victoria L., Crisci, Giulia, Gilhofer, Thomas, Schlenker, Rabea, Niederseer, David, Chen, Shaojie, Ebrahimi, Ramin, Wenzl, Florian, Würdinger, Michael, Citro, Rodolfo, Vecchione, Carmine, Gili, Sebastiano, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Miłosz, Noutsias, Michel, Knorr, Maike, Jansen, Thomas, D’Ascenzo, Fabrizio, Dichtl, Wolfgang, von Lewinski, Dirk, Burgdorf, Christof, Kherad, Behrouz, Tschöpe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Koenig, Wolfgang, Pott, Alexander, Meyer, Philippe, Roffi, Marco, Banning, Adrian, Wolfrum, Mathias, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K.E. Juhani, Napp, L. Christian, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clément, Lairez, Olivier, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Poledniková, Karolina, Toušek, Petr, Winchester, David E., Massoomi, Michael, Galuszka, Jan, Ukena, Christian, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Hauck, Christian, Paolini, Carla, Bilato, Claudio, Kobayashi, Yoshio, Kato, Ken, Ishibashi, Iwao, Himi, Toshiharu, Din, Jehangir, Al-Shammari, Ali, Prasad, Abhiram, Rihal, Charanjit S., Liu, Kan, Schulze, P. Christian, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Pestana, Gonçalo, Nguyen, Thanh H., Böhm, Michael, Maier, Lars S., Pinto, Fausto J., Widimský, Petr, Felix, Stephan B., Braun-Dullaeus, Ruediger C., Rottbauer, Wolfgang, Hasenfuß, Gerd, Pieske, Burkert M., Schunkert, Heribert, Budnik, Monika, Opolski, Grzegorz, Thiele, Holger, Bauersachs, Johann, Horowitz, John D., Di Mario, Carlo, Kong, William, Dalakoti, Mayank, Imori, Yoichi, Münzel, Thomas, Liberale, Luca, Montecucco, Fabrizio, Bax, Jeroen J., Crea, Filippo, Ruschitzka, Frank, Lüscher, Thomas F., Ghadri, Jelena R., Bossone, Eduardo, Templin, Christian, and Di Vece, Davide

Published
2024
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10. GLIDE Score: Scoring System for Prediction of Procedural Success in Tricuspid Valve Transcatheter Edge-to-Edge Repair

Author

Gerçek, Muhammed, Narang, Akhil, Körber, M. Isabel, Friedrichs, Kai P., Puthumana, Jyothy J., Ivannikova, Maria, Al-Kazaz, Mohamed, Cremer, Paul, Baldridge, Abigail S., Meng, Zhiying, Luedike, Peter, Thomas, James D., Rudolph, Tanja K., Geisler, Tobias, Rassaf, Tienush, Pfister, Roman, Rudolph, Volker, and Davidson, Charles J.

Published
2024
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11. Prognostic Implications of Residual Tricuspid Regurgitation Grading After Transcatheter Tricuspid Valve Repair

Author

Ajmone-Marsan, Nina, Alessandrini, Hannes, Badano, Luigi, Bartko, Philipp, Bax, Jeroen, Bazire, Baptiste, Benfari, Giovanni, Bernick, Jordan, Bohbot, Yohan, Carnero-Alcazar, Manuel, Chan, Vincent, Coisne, Augustin, Crestanello, Juan, De Bonis, Michele, Doguet, Fabien, Donal, Erwan, Dreyfus, Julien, Eggenspieler, Florian, Enriquez-Sarano, Maurice, Eixerés-Esteve, Andrea, Loureiro, Rodrigo Estevez, Eyharts, Damien, Fam, Neil, Flagiello, Michele, Galloo, Xavier, Gavazzoni, Mara, Habib, Gilbert, Hahn, Rebecca, Hausleiter, Jörg, Heitzinger, Gregor, Himbert, Dominique, Iliadis, Christos, Iung, Bernard, Juarez-Casso, Fernando, Kresoja, Karl-Patrick, Latib, Azeem, Lauten, Alexander, Lavie-Badie, Yoan, Le Tourneau, Thierry, Lim, Pascal, Lubos, Edith, Lurz, Philipp, Maisano, Francesco, Mbaki, Yannick, Michelena, Hector, Modine, Thomas, Messika-Zeitoun, David, Muraru, Denisa, Nejjari, Mohammed, Nickenig, Georg, Nicol, Martin, Nombela-Franco, Luis, Obadia, Jean-François, Omran, Hazem, Pedrazzini, Giovanni, Pfister, Roman, Piayda, Kerstin, Praz, Fabien, Radu, Costin, El Idrissi, Kenza Rahmouni, Riant, Elisabeth, Rodés-Cabau, Josep, Rudolph, Volker, Ruf, Tobias, Russo, Giulio, Sala, Alessandra, Schofer, Joachim, Selton-Suty, Christine, Senage, Thomas, Sievert, Horst, Stolz, Lukas, Tang, Gilbert H.L., Taramasso, Maurizio, Tomasi, Jacques, Topilsky, Yan, Tribouilloy, Christophe, Viau, Florence, von Bardeleben, Ralph Stephan, Webb, John, Weber, Marcel, Wells, George A., Windecker, Stephan, Zamorano, Jose Luis, Kresoja, Karl-Patrik, and Estevez Loureiro, Rodrigo

Published
2024
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12. Guideline-Directed Medical Therapy and Survival After TEER for Secondary Mitral Regurgitation With Right Ventricular Impairment

Author

Mazzola, Matteo, Giannini, Cristina, Adamo, Marianna, Stolz, Lukas, Praz, Fabien, Butter, Christian, Pfister, Roman, Iliadis, Christos, Melica, Bruno, Sampaio, Francisco, Kalbacher, Daniel, Koell, Benedikt, Spieker, Maximilian, Metra, Marco, Stephan von Bardeleben, Ralph, Karam, Nicole, Kresoja, Karl-Patrik, Lurz, Philipp, Petronio, Anna Sonia, Hausleiter, Jörg, and De Carlo, Marco

Published
2024
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20. Sex-Related Differences in Clinical Characteristics and Outcome Prediction Among Patients Undergoing Transcatheter Tricuspid Valve Intervention

Author

Fortmeier, Vera, Lachmann, Mark, Körber, Maria I., Unterhuber, Matthias, Schöber, Anne R., Stolz, Lukas, Stocker, Thomas J., Kassar, Mohammad, Gerçek, Muhammed, Rudolph, Tanja K., Praz, Fabien, Windecker, Stephan, Pfister, Roman, Baldus, Stephan, Laugwitz, Karl-Ludwig, Hausleiter, Jörg, Lurz, Philipp, and Rudolph, Volker

Published
2023
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21. Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation

Author

Higuchi, Satoshi, Orban, Mathias, Adamo, Marianna, Giannini, Cristina, Melica, Bruno, Karam, Nicole, Praz, Fabien, Kalbacher, Daniel, Lubos, Edith, Stolz, Lukas, Braun, Daniel, Näbauer, Michael, Wild, Mirjam, Doldi, Philipp, Neuss, Michael, Butter, Christian, Kassar, Mohammad, Ruf, Tobias, Petrescu, Aniela, Schofer, Niklas, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias, Thiele, Holger, Baldus, Stephan, von Bardeleben, Ralph Stephan, Massberg, Steffen, Windecker, Stephan, Lurz, Philipp, Petronio, Anna Sonia, Metra, Marco, and Hausleiter, Jörg

Published
2023
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25. Early Outcomes of 2 Mitral Valve Transcatheter Leaflet Approximation Devices: A Propensity Score–Matched Multicenter Comparison

Author

Mauri, Victor, Sugiura, Atsushi, Spieker, Max, Iliadis, Christos, Horn, Patrick, Öztürk, Can, Besler, Christian, Riebisch, Matthias, Al-Hammadi, Osamah, Ruf, Tobias, Gerçek, Muhammed, Grothusen, Christina, Mehr, Michael, Becher, Marc Ulrich, Mues, Christoph, Boeder, Niklas, Kreidel, Felix, Friedrichs, Kai, Westenfeld, Ralf, Braun, Daniel, Baldus, Stephan, Rassaf, Tienush, Thiele, Holger, Nickenig, Georg, Hausleiter, Jörg, Möllmann, Helge, Kelm, Malte, Rudolph, Volker, von Bardeleben, Ralph Stephan, Nef, Holger M., Luedike, Peter, Lurz, Philipp, and Pfister, Roman

Published
2022
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26. Transcatheter Mitral Valve Repair in Patients With Atrial Functional Mitral Regurgitation

Author

Doldi, Philipp, Stolz, Lukas, Orban, Mathias, Karam, Nicole, Praz, Fabien, Kalbacher, Daniel, Lubos, Edith, Braun, Daniel, Adamo, Marianna, Giannini, Cristina, Melica, Bruno, Näbauer, Michael, Higuchi, Satoshi, Wild, Mirjam, Neuss, Michael, Butter, Christian, Kassar, Mohammad, Petrescu, Aniela, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias, Thiele, Holger, Baldus, Stephan, von Bardeleben, Ralph Stephan, Schofer, Niklas, Hagl, Christian, Petronio, Anna Sonia, Massberg, Steffen, Windecker, Stephan, Lurz, Philipp, Metra, Marco, and Hausleiter, Jörg

Published
2022
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28. Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry

Author

Imori, Yoichi, Kato, Ken, Cammann, Victoria L., Szawan, Konrad A., Wischnewsky, Manfred, Dreiding, Sara, Würdinger, Michael, Schönberger, Maximilian, Petkova, Vanya, Niederseer, David, Levinson, Rena A., Di Vece, Davide, Gili, Sebastiano, Seifert, Burkhardt, Wakita, Masaki, Suzuki, Noriko, Citro, Rodolfo, Bossone, Eduardo, Heiner, Susanne, Knorr, Maike, Jansen, Thomas, Münzel, Thomas, D’Ascenzo, Fabrizio, Franke, Jennifer, Sorici-Barb, Ioana, Katus, Hugo A., Sarcon, Annahita, Shinbane, Jerold, Napp, L. Christian, Bauersachs, Johann, Jaguszewski, Milosz, Shiomura, Reiko, Nakamura, Shunichi, Takano, Hitoshi, Noutsias, Michel, Burgdorf, Christof, Ishibashi, Iwao, Himi, Toshiharu, Koenig, Wolfgang, Schunkert, Heribert, Thiele, Holger, Kherad, Behrouz, Tschöpe, Carsten, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Mizuno, Shingo, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuß, Gerd, Karakas, Mahir, Mochizuki, Hiroki, Pott, Alexander, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian, Isogai, Toshiaki, Kimura, Akihisa, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Tomita, Yasuhiro, Budnik, Monika, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang, Murakami, Tsutomu, Ikari, Yuji, Empen, Klaus, Beug, Daniel, Felix, Stephan B., Delmas, Clément, Lairez, Olivier, Yamaguchi, Tetsuo, El-Battrawy, Ibrahim, Akin, Ibrahim, Borggrefe, Martin, Horowitz, John D., Kozel, Martin, Tousek, Petr, Widimský, Petr, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Neuhaus, Michael, Meyer, Philippe, Arroja, Jose David, Chan, Christina, Bridgman, Paul, Galuszka, Jan, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Pinto, Fausto J., Hauck, Christian, Maier, Lars S., Liu, Kan, Di Mario, Carlo, Paolini, Carla, Bilato, Claudio, Bianco, Matteo, Jörg, Lucas, Rickli, Hans, Winchester, David E., Ukena, Christian, Böhm, Michael, Bax, Jeroen J., Prasad, Abhiram, Rihal, Charanjit S., Saito, Shigeru, Kobayashi, Yoshio, Lüscher, Thomas F., Ruschitzka, Frank, Shimizu, Wataru, Ghadri, Jelena R., and Templin, Christian

Published
2022
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30. Impact of Ischaemic and Dilated Cardiomyopathy on Short-Term and Long-Term Survival After Ventricular Assist Device Implantation: A Single-Centre Experience

Author

Ivanov, Borko, Djordjevic, Ilija, Sabashnikov, Anton, Sindhu, Dirk, Hink, Stephan, Eghbalzadeh, Kaveh, Gerfer, Stephen, Gaisendrees, Christopher, Schlachtenberger, Georg, Rustenbach, Christian, Seuthe, Katharina, Regnier, Kuhn, Mader, Navid, Pfister, Roman, Zeriouh, Mohamed, Rahmanian, Parwis, and Wahlers, Thorsten

Published
2022
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32. Profiles of Geriatric Syndromes and Resources in Older Patients with Atrial Fibrillation.

Author

Verleysdonk, Joshua, Noetzel, Nicolas, Becker, Ingrid, Pickert, Lena, Benzing, Thomas, Pfister, Roman, Polidori, Maria Cristina, and Affeldt, Anna Maria

Subjects
OLDER patients, AGE, SEX (Biology), FRAILTY, ATRIAL fibrillation
Abstract

Objective: Older patients with nonvalvular atrial fibrillation (AF) are at high risk for frailty and geriatric syndromes (GSs), which modulate their individual prognosis and are therefore relevant for further management. Because few studies have evaluated the geriatric profile of older AF patients, this secondary analysis aims to further characterize the patterns of GSs and geriatric resources (GRs) in AF patients and their association with anticoagulation use. Methods: Data from 362 hospitalized patients aged 65 years and older with AF (n = 181, 77.8 ± 5.8 years, 38% female) and without AF (non-AF [NAF]; n = 181, 77.5 ± 5.9 years, 40% female) admitted to an internal medicine and nephrology ward of a large university hospital in Germany were included. All patients underwent usual care plus a comprehensive geriatric assessment (CGA) including calculation of the Multidimensional Prognostic Index (MPI) and collection of 17 GSs and 10 GRs. Patients were followed up by telephone 6 and 12 months after discharge to collect data on their health status. Results: The mean MPI score of 0.47 indicated an average risk of poor outcome, and patients with AF had a significantly higher MPI than those without AF (p = 0.040). After adjustment for chronological age, biological sex, Cumulative Illness Rating Scale (CIRS) for relevant chronic diagnoses and MPI as a proxy for biological age, AF patients had significantly more mnestic resources (63.5% vs. 33.1%, p < 0.001), a tendency for less age-appropriate living conditions (56.4% vs. 72.9%, p = 0.051) and more sensory impairment (78.5% vs. 52.5%, p < 0.001) than NAF patients. They also had a higher number of GSs (p = 0.046). AF patients on oral anticoagulants (OACs, n = 91) had less age-appropriate living conditions (48.4% vs. 64.4%, p < 0.05) and mnestic resources (36.3% vs. 54.4%, p < 0.01), but more emotional resources (80.2% vs. 65.6%, p < 0.05) and chronic pain (56% vs. 40%, p < 0.05) than patients without OACs (n = 90). Overall, mortality at 1 year was increased in patients with a higher MPI (p < 0.009, adjusted for age, sex and CIRS), with a diagnosis of AF (p = 0.007, adjusted for age, sex, CIRS and MPI), with of male sex (p = 0.008, adjusted for age, CIRS and MPI) and those with AF and treated with hemodialysis (p = 0.022, compared to AF patients without dialysis treatment). Conclusions: Patients with AF and patients with AF and OACs show differences in their multidimensional frailty degree as well as GR and GS profiles compared to patients without AF or with AF not treated with OACs. Mortality after 1 year is increased in AF patients with a higher MPI and dialysis, independently from OAC use and overall burden of chronic disease as assessed per CIRS. GRs and GSs, especially age-appropriate living conditions, emotional resources, sensory impairment and chronic pain, can be considered as factors that may modify the individual impact of frailty, underscoring the relevance of these parameters in the management of older patients. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Outcomes Stratified by Adapted Inclusion Criteria After Mitral Edge-to-Edge Repair

Author

Koell, Benedikt, Orban, Mathias, Weimann, Jessica, Kassar, Mohammad, Karam, Nicole, Neuss, Michael, Petrescu, Aniela, Iliadis, Christos, Unterhuber, Matthias, Adamo, Marianna, Giannini, Cristina, Melica, Bruno, Ludwig, Sebastian, Massberg, Steffen, Praz, Fabien, Pfister, Roman, Thiele, Holger, von Bardeleben, Ralph Stephan, Baldus, Stephan, Butter, Christian, Lurz, Philipp, Windecker, Stephan, Metra, Marco, Petronio, Anna Sonia, Hausleiter, Jörg, Lubos, Edith, and Kalbacher, Daniel

Published
2021
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37. Impact of Residual Mitral Regurgitation on Survival After Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation

Author

Higuchi, Satoshi, Orban, Mathias, Stolz, Lukas, Karam, Nicole, Praz, Fabien, Kalbacher, Daniel, Ludwig, Sebastian, Braun, Daniel, Näbauer, Michael, Wild, Mirjam G., Neuss, Michael, Butter, Christian, Kassar, Mohammad, Petrescu, Aniela, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias, Park, Sang-Don, Thiele, Holger, Baldus, Stephan, von Bardeleben, Stephan, Schofer, Niklas, Massberg, Steffen, Windecker, Stephan, Lurz, Philipp, and Hausleiter, Jörg

Published
2021
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38. Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation

Author

Park, Sang-Don, Orban, Mathias, Karam, Nicole, Lubos, Edith, Kalbacher, Daniel, Braun, Daniel, Stolz, Lukas, Neuss, Michael, Butter, Christian, Praz, Fabien, Kassar, Mohammad, Petrescu, Aniela, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias, Lurz, Philipp, Thiele, Holger, Baldus, Stephan, von Bardeleben, Stephan, Blankenberg, Stefan, Massberg, Steffen, Windecker, Stephan, and Hausleiter, Jörg

Published
2021
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40. German Multicenter Experience With a New Leaflet-Based Transcatheter Mitral Valve Repair System for Mitral Regurgitation

Author

Mauri, Victor, Besler, Christian, Riebisch, Matthias, Al-Hammadi, Osamah, Ruf, Tobias, Gerçek, Muhammed, Horn, Patrick, Grothusen, Christina, Mehr, Michael, Becher, Marc Ulrich, Mues, Christoph, Boeder, Niklas, Kreidel, Felix, Friedrichs, Kai, Westenfeld, Ralf, Braun, Daniel, Öztürk, Can, Baldus, Stephan, Rassaf, Tienush, Thiele, Holger, Nickenig, Georg, Hausleiter, Jörg, Möllmann, Helge, Kelm, Malte, Rudolph, Volker, von Bardeleben, Ralph-Stephan, Nef, Holger M., Luedike, Peter, Lurz, Philipp, and Pfister, Roman

Published
2020
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43. Artificial intelligence–enabled assessment of right ventricular to pulmonary artery coupling in patients undergoing transcatheter tricuspid valve intervention.

Author

Fortmeier, Vera, Lachmann, Mark, Stolz, Lukas, Stein, Jennifer von, Unterhuber, Matthias, Kassar, Mohammad, Gerçek, Muhammed, Schöber, Anne R, Stocker, Thomas J, Omran, Hazem, Körber, Maria I, Hesse, Amelie, Harmsen, Gerhard, Friedrichs, Kai Peter, Yuasa, Shinsuke, Rudolph, Tanja K, Joner, Michael, Pfister, Roman, Baldus, Stephan, and Laugwitz, Karl-Ludwig

Subjects
PULMONARY artery physiology, TRICUSPID valve surgery, PEARSON correlation (Statistics), RESEARCH funding, ARTIFICIAL intelligence, MULTIVARIATE analysis, HEART valve prosthesis implantation, RESEARCH, RIGHT ventricular dysfunction, ECHOCARDIOGRAPHY, CARDIAC catheterization, REGRESSION analysis
Abstract

Aims Right ventricular to pulmonary artery (RV-PA) coupling has been established as a prognostic marker in patients with severe tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve interventions (TTVI). RV-PA coupling assesses right ventricular systolic function related to pulmonary artery pressure levels, which are ideally measured by right heart catheterization. This study aimed to improve the RV-PA coupling concept by relating tricuspid annular plane systolic excursion (TAPSE) to mean pulmonary artery pressure (mPAP) levels. Moreover, instead of right heart catheterization, this study sought to employ an extreme gradient boosting (XGB) algorithm to predict mPAP levels based on standard echocardiographic parameters. Methods and results This multicentre study included 737 patients undergoing TTVI for severe TR; among them, 55 patients from one institution served for external validation. Complete echocardiography and right heart catheterization data were available from all patients. The XGB algorithm trained on 10 echocardiographic parameters could reliably predict mPAP levels as evaluated on right heart catheterization data from external validation (Pearson correlation coefficient R : 0.68; P value: 1.3 × 10−8). Moreover, predicted mPAP (mPAPpredicted) levels were superior to echocardiographic systolic pulmonary artery pressure (sPAPechocardiography) levels in predicting 2-year mortality after TTVI [area under the curve (AUC): 0.607 vs. 0.520; P value: 1.9 × 10−6]. Furthermore, TAPSE/mPAPpredicted was superior to TAPSE/sPAPechocardiography in predicting 2-year mortality after TTVI (AUC: 0.633 vs. 0.586; P value: 0.008). Finally, patients with preserved RV-PA coupling (defined as TAPSE/mPAPpredicted > 0.617 mm/mmHg) showed significantly higher 2-year survival rates after TTVI than patients with reduced RV-PA coupling (81.5% vs. 58.8%, P < 0.001). Moreover, independent association between TAPSE/mPAPpredicted levels and 2-year mortality after TTVI was confirmed by multivariate regression analysis (P value: 6.3 × 10−4). Conclusion Artificial intelligence–enabled RV-PA coupling assessment can refine risk stratification prior to TTVI without necessitating invasive right heart catheterization. A comparison with conservatively treated patients is mandatory to quantify the benefit of TTVI in accordance with RV-PA coupling. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Congestion patterns in severe tricuspid regurgitation and transcatheter treatment: Insights from a multicentre registry.

Author

Rommel, Karl‐Philipp, Bonnet, Guillaume, Fortmeier, Vera, Stolz, Lukas, Schöber, Anne R., von Stein, Jennifer, Kassar, Mohammad, Gerçek, Muhammed, Rosch, Sebastian, Stocker, Thomas J., Körber, Maria I., Kresoja, Karl‐Patrik, Rudolph, Tanja K., Pfister, Roman, Baldus, Stephan, Windecker, Stephan, Thiele, Holger, Praz, Fabien, Hausleiter, Jörg, and Rudolph, Volker

Subjects
TRICUSPID valve insufficiency, HEART failure, TRICUSPID valve, TRICUSPID valve surgery, PULMONARY artery, CARDIAC catheterization, PROGNOSIS
Abstract

Aims: While invasively determined congestion holds mechanistic and prognostic significance in acute heart failure (HF), its role in patients with tricuspid regurgitation (TR)‐related right‐ heart failure (HF) undergoing transcatheter tricuspid valve intervention (TTVI) is less well established. A comprehensive understanding of congestion patterns might aid in procedural planning, risk stratification, and the identification of patients who may benefit from adjunctive therapies before undergoing TTVI. The aim of this study was to investigate the role of congestion patterns in patients with severe TR and its implications for TTVI. Methods and results: Within a multicentre, international TTVI registry, 813 patients underwent right heart catheterization (RHC) prior to TTVI and were followed up to 24 months. The median age was 80 (interquartile range 76–83) years and 54% were women. Both mean right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP) were associated with 2‐year mortality on Cox regression analyses with Youden index‐derived cut‐offs of 17 mmHg and 19 mmHg, respectively (p < 0.01 for all). However, RAP emerged as an independent predictor of outcomes following multivariable adjustments. Pre‐interventionally, 42% of patients were classified as euvolaemic (RAP <17 mmHg, PCWP <19 mmHg), 23% as having left‐sided congestion (RAP <17 mmHg, PCWP ≥19 mmHg), 8% as right‐sided congestion (RAP ≥17 mmHg, PCWP <19 mmHg), and 27% as bilateral congestion (RAP ≥17 mmHg, PCWP ≥19 mmHg). Patients with right‐sided or bilateral congestion had the lowest procedural success rates and shortest survival times. Congestion patterns allowed for discerning specific patient's physiology and specifying prognostic implications of right ventricular to pulmonary artery coupling surrogates. Conclusion: In this large cohort of invasively characterized patients undergoing TTVI, congestion patterns involving right‐sided congestion were associated with low procedural success and higher mortality rates after TTVI. Whether pre‐interventional reduction of right‐sided congestion can improve outcomes after TTVI should be established in dedicated studies. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Multiparametric Monitoring of Disease Progression in Contemporary Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy Initiating Tafamidis Treatment.

Author

Ney, Svenja, Gertz, Roman Johannes, Pennig, Lenhard, Nies, Richard J., Holtick, Udo, Völker, Linus A., Wunderlich, Gilbert, Seuthe, Katharina, Hohmann, Christopher, Metze, Clemens, Nähle, Claas Philip, von Stein, Jennifer, Brüwer, Monique, ten Freyhaus, Henrik, and Pfister, Roman

Subjects
GLOBAL longitudinal strain, CEREBRAL amyloid angiopathy, DISEASE progression, CARDIAC magnetic resonance imaging, TRANSTHYRETIN, AMYLOID
Abstract

Background: Recently, a disease modifying therapy has become available for transthyretin amyloid cardiomyopathy (ATTR-CM). A validated monitoring concept of treatment is lacking, but a current expert consensus recommends three clinical domains (clinical, biomarker and ECG/imaging) assessed by several measurable features to define disease progression. Methods: We retrospectively analyzed data of wild-type ATTR-CM patients initiating tafamidis therapy assessed within our local routine protocol at baseline and 6-months follow-up with respect to the frequency of values beyond the proposed thresholds defining disease progression. Additionally, associations of cardiac magnetic resonance (CMR) tomography with clinical domains were examined within a subgroup. Results: Sixty-two ATTR-CM patients were included (88.7% male, mean age 79 years). In total, 16.1% of patients had progress in the clinical and functional domain, 33.9% in the biomarker domain and 43.5% in the imaging/electrocardiography (ECG) domain, with the latter driven by deterioration of the diastolic dysfunction grade and global longitudinal strain. In total, 35.5% of patients showed progress in none, 35.5% in one, 29.0% in two and no patient in three domains, the latter indicating overall disease progression. A subgroup analysis of twenty-two patients with available baseline and follow-up CMR data revealed an increase in CMR-based extracellular volume by more than 5% in 18.2% of patients, with no significant correlation with progress in one of the clinical domains. Conclusions: We provide first frequency estimates of the markers of disease progression according to a recent expert consensus statement, which might help refine the multiparametric monitoring concept in patients with ATTR-CM. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Long-Term Prognosis of Patients With Takotsubo Syndrome

Author

Ghadri, Jelena R., Kato, Ken, Cammann, Victoria L., Gili, Sebastiano, Jurisic, Stjepan, Di Vece, Davide, Candreva, Alessandro, Ding, Katharina J., Micek, Jozef, Szawan, Konrad A., Bacchi, Beatrice, Bianchi, Rahel, Levinson, Rena A., Wischnewsky, Manfred, Seifert, Burkhardt, Schlossbauer, Susanne A., Citro, Rodolfo, Bossone, Eduardo, Münzel, Thomas, Knorr, Maike, Heiner, Susanne, D’Ascenzo, Fabrizio, Franke, Jennifer, Sarcon, Annahita, Napp, L. Christian, Jaguszewski, Milosz, Noutsias, Michel, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschöpe, Carsten, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuß, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K.E. Juhani, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang, Empen, Klaus, Felix, Stephan B., Delmas, Clément, Lairez, Olivier, El-Battrawy, Ibrahim, Akin, Ibrahim, Borggrefe, Martin, Horowitz, John, Kozel, Martin, Tousek, Petr, Widimský, Petr, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Winchester, David E., Ukena, Christian, Bax, Jeroen J., Prasad, Abhiram, Böhm, Michael, Lüscher, Thomas F., Ruschitzka, Frank, and Templin, Christian

Published
2018
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