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Your search keyword '"Petersen, Lars J."' showing total 278 results
Start Over Author "Petersen, Lars J." Publication Type Academic Journals
278 results on '"Petersen, Lars J."'

6. Use of modern imaging methods to facilitate trials of metastasis-directed therapy for oligometastatic disease in prostate cancer: a consensus recommendation from the EORTC Imaging Group

Author

Lecouvet, Frédéric E, Oprea-Lager, Daniela E, Liu, Yan, Ost, Piet, Bidaut, Luc, Collette, Laurence, Deroose, Christophe M, Goffin, Karolien, Herrmann, Ken, Hoekstra, Otto S, Kramer, Gem, Lievens, Yolande, Lopci, Egesta, Pasquier, David, Petersen, Lars J, Talbot, Jean-Noël, Zacho, Helle, Tombal, Bertrand, and deSouza, Nandita M

Published
2018
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33. The clinical consequences of routine 68Ga-PSMA-11 PET/CT in patients with newly diagnosed prostate cancer, ISUP grade 5 and no metastases based on standard imaging – preliminary results.

Author

Zacho, Helle D., Nalliah, Surenth, Petersen, Astrid, and Petersen, Lars J.

Subjects
PROSTATE cancer, RADIONUCLIDE imaging, LYMPHATIC metastasis, BONE metastasis, METASTASIS, PALLIATIVE treatment
Abstract

To evaluate the clinical consequences of prostate specific membrane antigen (PSMA) PET/CT for primary staging in patients with ISUP grade 5 (Gleason score ≥9) prostate cancer (PCa), and no definitive distant metastases based on standard imaging. At our tertial referral center, PSMA PET/CT became standard of care from August 2018 for primary staging of prostate cancer given the following criteria: (1) no prior treatment for prostate cancer, (2) ISUP grade 5, (3) no definitive metastases on standard imaging (contrast enhanced CT and bone scintigraphy), and (4) deemed suitable for treatment with curative intent based on comorbidity and life expectancy. We present the preliminary results of first six months recruitment with 12 months of follow-up. Forty-eight patients (mean age 69 years, median PSA 13.0 ng/mL, 20 patients with locally advanced PCa) were included. CT was positive in pelvic lymph nodes in two patients, bone scintigraphy was equivocal in three patients. PSMA PET/CT showed pathological uptake outside the prostatic bed in 22 patients (46%) of which 13 patients (27%) showed lesions confined to regional lymph nodes, and nine patients (19%) showed nonregional lymph node metastases and/or bone metastases. PSMA PET/CT changed the treatment strategy from curatively intended treatment to palliative treatment in 18 patients (38%) PMSA PET/CT revealed pathological uptake in a large proportion of high-risk patients at primary staging among patients with no definite metastases on standard imaging leading to change of patient management in 38% of the patients. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Influence of Prior Imaging Information on Diagnostic Accuracy for Focal Skeletal Processes—A Retrospective Analysis of the Consistency between Biopsy-Verified Imaging Diagnoses.

Author

Lange, Mine Benedicte, Petersen, Lars J., Lausen, Mads, Bruun, Niels Henrik, Nielsen, Michael Bachmann, and Zacho, Helle D.

Subjects
*DIAGNOSTIC imaging, *ACCURACY of information, *RETROSPECTIVE studies, *DIAGNOSTIC errors, *DIAGNOSIS
Abstract

Introduction: Comparing imaging examinations with those previously obtained is considered mandatory in imaging guidelines. To our knowledge, no studies are available on neither the influence, nor the sequence, of prior imaging and reports on diagnostic accuracy using biopsy as the reference standard. Such data are important to minimize diagnostic errors and to improve the preparation of diagnostic imaging guidelines. The aim of our study was to provide such data. Materials and methods: A retrospective cohort of 216 consecutive skeletal biopsies from patients with at least 2 different imaging modalities (X-ray, CT and MRI) performed within 6 months of biopsy was identified. The diagnostic accuracy of the individual imaging modality was assessed. Finally, the possible influence of the sequence of imaging modalities was investigated. Results: No significant difference in the accuracy of the imaging modalities was shown, being preceded by another imaging modality or not. However, the sequence analyses indicate sequential biases, particularly if MRI was the first imaging modality. Conclusion: The sequence of the imaging modalities seems to influence the diagnostic accuracy against a pathology reference standard. Further studies are needed to establish evidence-based guidelines for the strategy of using previous imaging and reports to improve diagnostic accuracy. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Validity of negative bone biopsy in suspicious bone lesions.

Author

Lange, Mine B, Petersen, Lars J, Nielsen, Michael B, and Zacho, Helle D

Subjects
*CANCER cells, *BIOPSY, *BONE metastasis, *STANDARD deviations, *BONE cells, *CALCIFICATIONS of the breast
Abstract

Background: The presence of malignant cells in bone biopsies is considered gold standard to verify occurrence of cancer, whereas a negative bone biopsy can represent a false negative, with a risk of increasing patient morbidity and mortality and creating misleading conclusions in cancer research. However, a paucity of literature documents the validity of negative bone biopsy as an exclusion criterion for the presence of skeletal malignancies. Purpose: To investigate the validity of a negative bone biopsy in bone lesions suspicious of malignancy. Material and Method: A retrospective cohort of 215 consecutive targeted non-malignant skeletal biopsies from 207 patients (43% women, 57% men, median age 64, and range 94) representing suspicious focal bone lesions, collected from January 1, 2011, to July 31, 2013, was followed over a 2-year period to examine any additional biopsy, imaging, and clinical follow-up information to categorize the original biopsy as truly benign, malignant, or equivocal. Standard deviations and 95% confidence intervals were calculated. Results: 210 of 215 biopsies (98%; 95% CI 0.94–0.99) showed to be truly benign 2 years after initial biopsy. Two biopsies were false negatives (1%; 95% CI 0.001–0.03), and three were equivocal (lack of imaging description). Conclusion: Our study documents negative bone biopsy as a valid criterion for the absence of bone metastasis. Since only 28% had a confirmed diagnosis of prior cancer and not all patients received adequately sensitive imaging, our results might not be applicable to all cancer patients with suspicious bone lesions. [ABSTRACT FROM AUTHOR]

Published
2021
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