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502 results on '"Pellon A"'

2. Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation

Author

Peña-Cearra, Ainize, Palacios, Ainhoa, Pellon, Aize, Castelo, Janire, Pasco, Samuel Tanner, Seoane, Iratxe, Barriales, Diego, Martin, Jose Ezequiel, Pascual-Itoiz, Miguel Ángel, Gonzalez-Lopez, Monika, Martín-Ruiz, Itziar, Macías-Cámara, Nuria, Gutiez, Naiara, Araujo-Aris, Sarai, Aransay, Ana Mª, Rodríguez, Héctor, Anguita, Juan, and Abecia, Leticia

Published
2024
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3. Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis

Author

Anjali Chander, Jacopo Iacovacci, Aize Pellon, Radhika Kataria, Anita Grigoriadis, John Maher, Cynthia Sears, Gilad Bachrach, Teresa Guerrero Urbano, Mary Lei, Imran Petkar, Anthony Kong, Tony Ng, Ester Orlandi, Nicola Alessandro Iacovelli, Loris De Cecco, Mara Serena Serafini, David Moyes, Tiziana Rancati, and Miguel Reis Ferreira

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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4. EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway

Author

Ruth E. Dickenson, Aize Pellon, Nicole O. Ponde, Olivia Hepworth, Lydia F. Daniels Gatward, Julian R. Naglik, and David L. Moyes

Subjects
EGR1, Candida, epithelial cell, Infectious and parasitic diseases, RC109-216
Abstract

Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C. albicans invades mucosal tissues activating EGFR-MAPK signalling pathways in epithelial cells via the action of its peptide toxin candidalysin. However, our knowledge of the epithelial mechanisms involved during C. albicans colonization is rudimentary. Here, we describe the role of the transcription factor early growth response protein 1 (EGR1) in human oral epithelial cells (OECs) in response to C. albicans. EGR1 expression increases in OECs when exposed to C. albicans independently of fungal viability, morphology, or candidalysin release, suggesting EGR1 is involved in the fundamental recognition of C. albicans, rather than in response to invasion or “pathogenesis.” Upregulation of EGR1 is mediated by EGFR via Raf1, ERK1/2, and NF-κB signalling but not PI3K/mTOR signalling. Notably, EGR1 mRNA silencing impacts on anti-C. albicans immunity, reducing GM-CSF, IL-1α and IL-1β release, and increasing IL-6 and IL-8 production. These findings identify an important role for EGR1 in priming epithelial cells to respond to subsequent invasive infection by C. albicans and elucidate the regulation circuit of this transcription factor after contact.

Published
2024
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5. EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids

Author

Childs, Charlie J, Holloway, Emily M, Sweet, Caden W, Tsai, Yu-Hwai, Wu, Angeline, Vallie, Abigail, Eiken, Madeline K, Capeling, Meghan M, Zwick, Rachel K, Palikuqi, Brisa, Trentesaux, Coralie, Wu, Joshua H, Pellon-Cardenas, Oscar, Zhang, Charles J, Glass, Ian A, Loebel, Claudia, Yu, Qianhui, Camp, J Gray, Sexton, Jonathan Z, Klein, Ophir D, Verzi, Michael P, and Spence, Jason R

Subjects
Biomedical and Clinical Sciences, Stem Cell Research, Regenerative Medicine, Digestive Diseases, Stem Cell Research - Embryonic - Human, Biotechnology, Clinical Research, Stem Cell Research - Nonembryonic - Human, Stem Cell Research - Nonembryonic - Non-Human, 1.1 Normal biological development and functioning, Underpinning research, Humans, Epidermal Growth Factor, Epiregulin, Intestines, Intestinal Mucosa, Cell Differentiation, Development, Human stem cells, Organogenesis, Stem cells, Biomedical and clinical sciences, Health sciences
Abstract

Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development. Here, we interrogated the cell signaling environment within the developing human intestine to identify niche cues that may be important for epithelial development and homeostasis. We identified an EGF family member, EPIREGULIN (EREG), which is robustly expressed in the developing human crypt. Enteroids generated from the developing human intestine grown in standard culture conditions, which contain EGF, are dominated by stem and progenitor cells and feature little differentiation and no spatial organization. Our results demonstrate that EREG can replace EGF in vitro, and EREG leads to spatially resolved enteroids that feature budded and proliferative crypt domains and a differentiated villus-like central lumen. Multiomic (transcriptome plus epigenome) profiling of native crypts, EGF-grown enteroids, and EREG-grown enteroids showed that EGF enteroids have an altered chromatin landscape that is dependent on EGF concentration, downregulate the master intestinal transcription factor CDX2, and ectopically express stomach genes, a phenomenon that is reversible. This is in contrast to EREG-grown enteroids, which remain intestine like in culture. Thus, EREG creates a homeostatic intestinal niche in vitro, enabling interrogation of stem cell function, cellular differentiation, and disease modeling.

Published
2023

6. Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation

Author

Ainize Peña-Cearra, Ainhoa Palacios, Aize Pellon, Janire Castelo, Samuel Tanner Pasco, Iratxe Seoane, Diego Barriales, Jose Ezequiel Martin, Miguel Ángel Pascual-Itoiz, Monika Gonzalez-Lopez, Itziar Martín-Ruiz, Nuria Macías-Cámara, Naiara Gutiez, Sarai Araujo-Aris, Ana Mª Aransay, Héctor Rodríguez, Juan Anguita, and Leticia Abecia

Subjects
Biology (General), QH301-705.5
Abstract

Abstract The initial exposure to pathogens and commensals confers innate immune cells the capacity to respond distinctively upon a second stimulus. This training capacity might play key functions in developing an adequate innate immune response to the continuous exposure to bacteria. However, the mechanisms involved in induction of trained immunity by commensals remain mostly unexplored. A. muciniphila represents an attractive candidate to study the promotion of these long-term responses. Here, we show that priming of macrophages with live A. muciniphila enhances bacterial intracellular survival and decreases the release of pro- and anti-inflammatory signals, lowering the production of TNF and IL-10. Global transcriptional analysis of macrophages after a secondary exposure to the bacteria showed the transcriptional rearrangement underpinning the phenotype observed compared to acutely exposed cells, with the increased expression of genes related to phagocytic capacity and those involved in the metabolic adjustment conducing to innate immune training. Accordingly, key genes related to bacterial killing and pro-inflammatory pathways were downregulated. These data demonstrate the importance of specific bacterial members in the modulation of local long-term innate immune responses, broadening our knowledge of the association between gut microbiome commensals and trained immunity as well as the anti-inflammatory probiotic potential of A. muciniphila.

Published
2024
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17. TGFB1 induces fetal reprogramming and enhances intestinal regeneration

Author

Chen, Lei, Qiu, Xia, Dupre, Abigail, Pellon-Cardenas, Oscar, Fan, Xiaojiao, Xu, Xiaoting, Rout, Prateeksha, Walton, Katherine D., Burclaff, Joseph, Zhang, Ruolan, Fang, Wenxin, Ofer, Rachel, Logerfo, Alexandra, Vemuri, Kiranmayi, Bandyopadhyay, Sheila, Wang, Jianming, Barbet, Gaetan, Wang, Yan, Gao, Nan, Perekatt, Ansu O., Hu, Wenwei, Magness, Scott T., Spence, Jason R., and Verzi, Michael P.

Published
2023
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25. SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

Author

Gu, Wei, Wang, Hua, Huang, Xiaofeng, Kraiczy, Judith, Singh, Pratik N.P., Ng, Charles, Dagdeviren, Sezin, Houghton, Sean, Pellon-Cardenas, Oscar, Lan, Ying, Nie, Yaohui, Zhang, Jiaoyue, Banerjee, Kushal K., Onufer, Emily J., Warner, Brad W., Spence, Jason, Scherl, Ellen, Rafii, Shahin, Lee, Richard T., Verzi, Michael P., Redmond, David, Longman, Randy, Helin, Kristian, Shivdasani, Ramesh A., and Zhou, Qiao

Published
2022
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27. Computational Oil-Slick Hub for Offshore Petroleum Studies

Author

Nelson F. F. Ebecken, Fernando Pellon de Miranda, Luiz Landau, Carlos Beisl, Patrícia M. Silva, Gerson Cunha, Maria Célia Santos Lopes, Lucas Moreira Dias, and Gustavo de Araújo Carvalho

Subjects
WebGIS, machine learning, oil pollution, oil slicks, oil seeps, oil spills, Naval architecture. Shipbuilding. Marine engineering, VM1-989, Oceanography, GC1-1581
Abstract

The paper introduces the Oil-Slick Hub (OSH), a computational platform to facilitate the data visualization of a large database of petroleum signatures observed on the surface of the ocean with synthetic aperture radar (SAR) measurements. This Internet platform offers an information search and retrieval system of a database resulting from >20 years of scientific projects that interpreted ~15 thousand offshore mineral oil “slicks”: natural oil “seeps” versus operational oil “spills”. Such a Digital Mega-Collection Database consists of satellite images and oil-slick polygons identified in the Gulf of Mexico (GMex) and the Brazilian Continental Margin (BCM). A series of attributes describing the interpreted slicks are also included, along with technical reports and scientific papers. Two experiments illustrate the use of the OSH to facilitate the selection of data subsets from the mega collection (GMex variables and BCM samples), in which artificial intelligence techniques—machine learning (ML)—classify slicks into seeps or spills. The GMex variable dataset was analyzed with simple linear discriminant analyses (LDAs), and a three-fold accuracy performance pattern was observed: (i) the least accurate subset (~65%) solely used acquisition aspects (e.g., acquisition beam mode, date, and time, satellite name, etc.); (ii) the best results (>90%) were achieved with the inclusion of location attributes (i.e., latitude, longitude, and bathymetry); and (iii) moderate performances (~70%) were reached using only morphological information (e.g., area, perimeter, perimeter to area ratio, etc.). The BCM sample dataset was analyzed with six traditional ML methods, namely naive Bayes (NB), K-nearest neighbors (KNN), decision trees (DT), random forests (RF), support vector machines (SVM), and artificial neural networks (ANN), and the most effective algorithms per sample subsets were: (i) RF (86.8%) for Campos, Santos, and Ceará Basins; (ii) NB (87.2%) for Campos with Santos Basins; (iii) SVM (86.9%) for Campos with Ceará Basins; and (iv) SVM (87.8%) for only Campos Basin. The OSH can assist in different concerns (general public, social, economic, political, ecological, and scientific) related to petroleum exploration and production activities, serving as an important aid in discovering new offshore exploratory frontiers, avoiding legal penalties on oil-seep events, supporting oceanic monitoring systems, and providing valuable information to environmental studies.

Published
2023
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32. Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis.

Author

Chander, Anjali, Iacovacci, Jacopo, Pellon, Aize, Kataria, Rhadika, Grigoriadis, Anita, Maher, John, Sears, Cynthia, Bachrach, Gilad, Urbano, Teresa Guerrero, Lei, Mary, Petkar, Imran, Kong, Anthony, Ng, Tony, Orlandi, Ester, Iacovelli, Nicola Alessandro, De Cecco, Loris, Serafini, Mara Serena, Moyes, David, Rancati, Tiziana, and Ferreira, Miguel Reis

Published
2024
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33. Insights into Caribbean tectonics from a detrital zircon U-Pb provenance study of siliciclastic strata in western and central Cuba.

Author

Ascanio-Pellon, Patricia, Stockli, Daniel F., Ruiz-Arriaga, Daniel, and Stockli, Lisa

Subjects
*PROVENANCE (Geology), *LASER ablation inductively coupled plasma mass spectrometry, *SILICICLASTIC rocks, *ZIRCON
Abstract

The tectonic affinity and origins of the Jurassic, siliciclastic San Cayetano and Constancia formations exposed in western and central Cuba in the Caribbean region remain debated. The scarcity of modern geochronologic studies on these Cuban units hampers both sedimentary provenance and palinspastic reconstructions, resulting in Caribbean models that tend to oversimplify the formation of Cuba and correlate the Jurassic strata to various regions such as North America, South America, the Yucatán margin, or the conceptual Caribeana domain. Using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), we conducted a detailed detrital zircon (DZ) U-Pb provenance study of these Cuban siliciclastic strata that provides critical insights into understanding the formation of Cuba during the Early Jurassic rifting stages of Pangea. Results from 19 San Cayetano Formation samples show a dominant Oaxaquia (ca. 1 Ga) and Chiapas batholith (ca. 250 Ma) signature, while six Constancia samples display variable ca. 1 Ga and ca. 250 Ma grains. The Lower Cretaceous Polier Formation and the Paleocene Moncada Formation also display the same ca. 1 Ga and ca. 250 Ma signatures. After comparing these Cuban data with data from other regional DZ studies, we propose that that the San Cayetano and Constancia formations are correlative to the Todos Santos Formation located in the southwestern Yucatán region of Mexico. These Cuban units were predominantly deposited adjacent to the Chiapas batholith during the Early Jurassic in northwest-southeast-trending basins created by Pangean rifting. They were eventually sheared during eastward migration of the Caribbean plate and transported northward until they collided with the North American continent in the Paleogene. This DZ study provides new constraints on the tectonic provenance of western and central Cuba and improves plate tectonic reconstructions of the Caribbean. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Comparative Profiling of Circulating Exosomal Small RNAs Derived From Peruvian Patients With Tuberculosis and Pulmonary Adenocarcinoma

Author

Heinner Guio, Victor Aliaga-Tobar, Marco Galarza, Oscar Pellon-Cardenas, Silvia Capristano, Henry L. Gomez, Mivael Olivera, Cesar Sanchez, and Vinicius Maracaja-Coutinho

Subjects
exosomes, circulating RNAs, small RNAs, small RNA sequencing, microRNAs, non-small cell lung cancer, Microbiology, QR1-502
Abstract

Tuberculosis (TB) is one of the most fatal infectious diseases, caused by the aerobic bacteria Mycobacterium tuberculosis. It is estimated that one-third of the world’s population is infected with the latent (LTB) version of this disease, with only 5-10% of infected individuals developing its active (ATB) form. Pulmonary adenocarcinoma (PA) is the most common and diverse form of primary lung carcinoma. The simultaneous or sequential occurrence of TB and lung cancer in patients has been widely reported and is known to be an issue for diagnosis and surgical treatment. Raising evidence shows that patients cured of TB represent a group at risk for developing PA. In this work, using sRNA-sequencing, we evaluated the expression patterns of circulating small RNAs available in exosomes extracted from blood samples of Peruvian patients affected by latent tuberculosis, active tuberculosis, or pulmonary adenocarcinoma. Differential expression analysis revealed a set of 24 microRNAs perturbed in these diseases, revealing potential biomarker candidates for the Peruvian population. Most of these miRNAs are normally expressed in healthy lung tissue and are potential regulators of different shared and unique KEGG pathways related to cancers, infectious diseases, and immunology.

Published
2022
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36. First-line panitumumab plus capecitabine for the treatment of older patients with wild-type RAS metastatic colorectal cancer. The phase II, PANEL study

Author

Méndez Méndez, José Carlos, Salgado Fernández, Mercedes, de la Cámara Gómez, Juan, Pellón Augusto, Mari Luz, Covela Rua, Marta, Quintero Aldana, Guillermo, Fernández Montes, Ana, Reboredo López, Margarida, Valladares Ayerbes, Manuel, Jorge Fernández, Mónica, González Villarroel, Paula, Romero Reinoso, Carlos, and Ramos Vázquez, Manuel

Published
2020
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39. Factors that determine the loss of control when reducing therapy by steps in the treatment of moderate-severe asthma in standard clinical practice: A multicentre Spanish study

Author

López, Jesús Jiménez, Orenes, Miguel Ángel Moscardó, Montaño, Patricia Prieto, Toro, Miguel Torrecillas, Oliver, Begoña Cueva, Torres, Ángel Ferrer, Delgado, Purificación González, Rodríguez, Teodorikez Wilfox Jiménez, Auli, Brian Vila, Yebenes, Juan José Zapata, Berasategui, María Teresa Audicana, Jiménez, Marta Frias, Ruibio, Nieves Hurtado De Mendoza, Azagra, Marta Velasco, Fernández, Jose Antonio Álvarez, Sainz, Sara Acero, González, Rosa Mª Blanco, Nieves, María Estela Gómez, Carpio, Diego Aisa, Sellés, Núria Angrill, García, Cristina Berastegui, Lessmann, Astrid Crespo, Carrillo, David De La Rosa, Pla, Jordi Juanola, Giraldo, Alejandra López, Sánchez, Olga Luengo, Rivera, Carlos Martínez, Olondris, Pilar Martínez, Gall, Xavier Muñoz, Nogués, Ester Pinto, Coimerma, Francisco Planas, Carroz, Karina Portillo, Blanch, Antoni Riba, Ortún, Mª Luisa Rivera, Berenguer, Dan Sánchez, Batlles, Joan Serra, Mitjà, Pere Serra, Sagardía, Ana Sogo, Retes, Lorena Soto, Combas, Joan Valldeperas, Giralte, Xavier Vila, Zubeldia, Ignacio Ansotegui, Ercoreca, Ignacio Antepara, Peña, Miguel Herrerías, Pascual, María Milagros Iriberri, Michelena, Carmen Jaca, Castro, Adolfo Lahuerta, Legarreta, Amaia Laita, Llorente, Paula Losada, Prieto, Joaquina Prieto, Lorenzo, Vanessa Zorrilla, Gil, Lidia Alonso, Muñoz, Juan Pablo García, Durantez, Marisa Marcos, Miguel, Teresa Peña, Ahmida, Tahar, Izquierdo, María Isabel Alvarado, Olbah, Michael Alwakil, Muñoz, Aurelio Arnedillo, Núñez, Ignacio García, Fernández, Diego Gutiérrez, Camacho, Antonio Letran, Pellon, Luis Fernández, Miguel, Eva Maria Morchon, Portal, Félix Ortiz, Raducan, Isabela, Prats, Juan Antonio Royo, Segarra, María Dolores Salvador, Soler, Frederic Tatay, Naon, Alberto Levy, Bonilla, Pedro Galindo, Muñoz, Francisco Luis Gil, Calderón, Patricia Mata, Costa, Luis Manuel Entrenas, Aparicio, Marina Blanco, Pazos, Jose Manuel García, Paz, Vanessa García, Barcala, Francisco-Javier González, Sotes, Pilar Iriarte, Rodríguez, Pedro Jorge Marcos, Nieto, Fernando Molina, Orjales, Ramón Nuñez, Martín, Carracedo Sevillano, Antelo, Juan Suárez, Rodríguez, Julia Tábara, Español, Santiago Aparicio, Nieto, Carlos Sabadell, Talaverano, Gladis Sabater, Rodríguez, Mª Mar Escribano, López, José Fernando Florido, Jiménez, María Ángeles Lara, Vílchez, María José Rojas, Palacín, Susana Chic, Quintana, Silvia Dorronsoro, Echeverria, Jose Antonio Navarro, Guardia, Eduardo Figueroa De La, Jara, Belén Hinojosa, García, Victoria Moreno, Vazquez, Lucía Valverde, De Sus, Joaquín Cegoñino, Santonio, Jose, López, Juan Alfonso Almagro, Campillo, Eduardo Arcalá, Molina, Compaired Villa Jose María Cruz, Venegas, Antonia Dolores Soto, Martínez, Patricia Benito, Reinosa, Begoña Blanco, Parra, Beatriz Fernández, García, Domingo Fernández, Gutiérrez, Virginia Serrano, Lobera, Adolfo Velez Ruiz De, Alcon, Silvia Lara, González, Francisco Carballada, Fernández, Teresa González, Lázaro, Joaquín Martín, Macenlle, Noemí Mengual, Viteri, Soledad Alonso, Amerigo, Darío Antolín, Bobolea, Irina, Aguirre, M Del Puerto Cano, Contreras, Remedios Cardenas, Arias, Fernando Carrillo, Álvarez, Mercedes Cimarra, Martínez, Eva Belén De Higes, Campos, Rocío Magdalena Díaz, Cano, María Del Mar Gandolfo, Rodríguez, Leticia García, Tejada, Jose Andrés García Romero De, Mancebo, Eloina González, Seco, Emma González, Torralba, Fernando González, Santana, Aythamy Henríquez, Herrera, Pilar De Lys Herráez, Mosquete, María Ruth Herrero, Rodríguez, Pedro Landete, Ballesteros, Belén López-Muñiz, Vicente, Ester Mohedano, Chacón, Beatriz Morales, Fernández, Antonio Moreno, García, Esther Muñoz, Castillejo, Elena Ojeda, Serrano, Fernando Pedraza, Acevedo, Yesenia Peña Acevedo, Rojo, Raquel Pérez, Ruiz-Rico, Natividad Quílez, Pinedo, Ángela Ramos, Jiménez, Beatriz Rodríguez, Rodríguez, Mercedes Rodríguez, Ingelmo, Ana Rosado, Peña, Antonio Ruiz, González, María José Sánchez, Trujillo, María Jesús Trujillo, Fuertes, Laura Vázquez, Albelda, Concepción Vila, Meniz, Alexandra Yago, Grovas, Ricardo Ismael Aguilar Perez, Ramírez, José Alcázar Ramírez Alcázar, Muñoz, José Manuel Barceló, Manzanares, Miguel Bentabol, Martínez, Gustavo De Luiz, Luna, Francisco Linde De, Paez, Alfonso Miranda, Tejada, Ezequiel Ortega Sáenz De, Galo, Alicia Padilla, Cornejo, Manuel Pérez Estrada, Esojo, Carmen Soria, Alemán, Ángel Francisco Abellán, Rumayor, María Consuelo Alcalde, Espinosa, Rubén Andújar, Mora, Roberto Bernabeu, Lancharro, Francisco Javier Campano, Urra, Tamara Gutiérrez, Martín, Sonia Herrero, Lizaldre, Alfredo Resano, Quintas, R. Dacal, Martínez-Moragón, E., Delgado, J., Mogrovejo, S., and Fernández-Sánchez, T.

Published
2020
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40. Factores que condicionan la pérdida de control al reducir escalones terapéuticos en el tratamiento del asma moderada-grave en la práctica clínica habitual: estudio español multicéntrico

Author

Martínez-Moragón, E., Delgado, J., Mogrovejo, S., Fernández-Sánchez, T., Jesús, Jiménez López, Ángel, Moscardó Orenes Miguel, Patricia, Prieto Montaño, Miguel, Torrecillas Toro, Begoña, Cueva Oliver, Ángel, Ferrer Torres, Purificación, González Delgado, Wilfox, Jiménez Rodríguez Teodorikez, Brian, Vila Auli, José, Zapata Yebenes Juan, Teresa, Audicana Berasategui María, Marta, Frias Jiménez, Nieves, Hurtado de Mendoza Ruibio, Marta, Velasco Azagra, Antonio, Álvarez Fernández Jose, Sara, Acero Sainz, Rosa, Blanco González M., Estela, Gómez Nieves María, Diego, Aisa Carpio, Núria, Angrill Sellés, Cristina, Berastegui García, Astrid, Crespo Lessmann, David, De La Rosa Carrillo, Jordi, Juanola Pla, Alejandra, López Giraldo, Olga, Luengo Sánchez, Carlos, Martínez Rivera, Pilar, Martínez Olondris, Xavier, Muñoz Gall, Ester, Pinto Nogués, Francisco, Planas Coimerma, Karina, Portillo Carroz, Antoni, Riba Blanch, Luisa, Rivera Ortún M., Dan, Sánchez Berenguer, Joan, Serra Batlles, Pere, Serra Mitjà, Ana, Sogo Sagardía, Lorena, Soto Retes, Joan, Valldeperas Combas, Xavier, Vila Giralte, Ignacio, Ansotegui Zubeldia, Ignacio, Antepara Ercoreca, Miguel, Herrerías Peña, Milagros, Iriberri Pascual María, Carmen, Jaca Michelena, Adolfo, Lahuerta Castro, Amaia, Laita Legarreta, Paula, Losada Llorente, Joaquina, Prieto Prieto, Vanessa, Zorrilla Lorenzo, Lidia, Alonso Gil, Pablo, García Muñoz Juan, Marisa, Marcos Durantez, Teresa, Peña Miguel, Tahar, Ahmida, Isabel, Alvarado Izquierdo María, Michael, Alwakil Olbah, Aurelio, Arnedillo Muñoz, Ignacio, García Núñez, Diego, Gutiérrez Fernández, Antonio, Letran Camacho, Luis, Fernández Pellon, Maria, Morchon Miguel Eva, Félix, Ortiz Portal, Isabela, Raducan, Antonio, Royo Prats Juan, Dolores, Salvador Segarra María, Frederic, Tatay Soler, Alberto, Levy Naon, Pedro, Galindo Bonilla, Luis, Gil Muñoz Francisco, Patricia, Mata Calderón, Manuel, Entrenas Costa Luis, Marina, Blanco Aparicio, Manuel, García Pazos Jose, Vanessa, García Paz, Francisco-Javier, González Barcala, Pilar, Iriarte Sotes, Jorge, Marcos Rodríguez Pedro, Fernando, Molina Nieto, Ramón, Nuñez Orjales, Carracedo, Sevillano Martín, Juan, Suárez Antelo, Julia, Tábara Rodríguez, Santiago, Aparicio Español, Carlos, Sabadell Nieto, Gladis, Sabater Talaverano, Mar, Escribano Rodríguez M., Fernando, Florido López José, Ángeles, Lara Jiménez María, José, Rojas Vílchez María, Susana, Chic Palacín, Silvia, Dorronsoro Quintana, Antonio, Navarro Echeverria Jose, Eduardo, Figueroa de la Guardia, Belén, Hinojosa Jara, Victoria, Moreno García, Lucía, Valverde Vazquez, Joaquín, Cegoñino de Sus, Santonio, Compaired Villa Jose, Alfonso, Almagro López Juan, Eduardo, Arcalá Campillo, María, Cruz Molina Jose, Dolores, Soto Venegas Antonia, Patricia, Benito Martínez, Begoña, Blanco Reinosa, Beatriz, Fernández Parra, Domingo, Fernández García, Virginia, Serrano Gutiérrez, Adolfo, Velez Ruiz de Lobera, Silvia, Lara Alcon, Francisco, Carballada González, Teresa, González Fernández, Joaquín, Martín Lázaro, Noemí, Mengual Macenlle, Soledad, Alonso Viteri, Darío, Antolín Amerigo, Irina, Bobolea, Puerto, Cano Aguirre M. del, Remedios, Cardenas Contreras, Fernando, Carrillo Arias, Mercedes, Cimarra Álvarez, Belén, De Higes Martínez Eva, Magdalena, Díaz Campos Rocío, Mar, Gandolfo Cano María del, Leticia, García Rodríguez, Andrés, García Romero de Tejada Jose, Eloina, González Mancebo, Emma, González Seco, Fernando, González Torralba, Aythamy, Henríquez Santana, Lys, Herráez Herrera Pilar de, Ruth, Herrero Mosquete María, Pedro, Landete Rodríguez, Belén, López-Muñiz Ballesteros, Ester, Mohedano Vicente, Beatriz, Morales Chacón, Antonio, Moreno Fernández, Esther, Muñoz García, Elena, Ojeda Castillejo, Fernando, Pedraza Serrano, Yesenia, Peña Acevedo Acevedo, Raquel, Pérez Rojo, Natividad, Quílez Ruiz-Rico, Ángela, Ramos Pinedo, Beatriz, Rodríguez Jiménez, Mercedes, Rodríguez Rodríguez, Ana, Rosado Ingelmo, Antonio, Ruiz Peña, José, Sánchez González María, Jesús, Trujillo Trujillo María, Laura, Vázquez Fuertes, Concepción, Vila Albelda, Alexandra, Yago Meniz, Ismael, Aguilar Perez Grovas Ricardo, José, Alcázar Ramírez Alcázar Ramírez, Manuel, Barceló Muñoz José, Miguel, Bentabol Manzanares, Gustavo, De Luiz Martínez, Francisco, Linde de Luna, Alfonso, Miranda Paez, Ezequiel, Ortega Sáenz de Tejada, Alicia, Padilla Galo, Manuel, Pérez Estrada Cornejo, Carmen, Soria Esojo, Francisco, Abellán Alemán Ángel, Consuelo, Alcalde Rumayor María, Rubén, Andújar Espinosa, Roberto, Bernabeu Mora, Javier, Campano Lancharro Francisco, Tamara, Gutiérrez Urra, Sonia, Herrero Martín, Alfredo, Resano Lizaldre, and Raquel, Dacal Quintas

Published
2020
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43. Uncovering the genomic potential of the Amazon River microbiome to degrade rainforest organic matter

Author

Célio Dias Santos-Júnior, Hugo Sarmento, Fernando Pellon de Miranda, Flávio Henrique-Silva, and Ramiro Logares

Subjects
Amazon River, Freshwater bacteria, Biodiversity, Metagenomics, Lignin degradation, Cellulose degradation, Microbial ecology, QR100-130
Abstract

Abstract Background The Amazon River is one of the largest in the world and receives huge amounts of terrestrial organic matter (TeOM) from the surrounding rainforest. Despite this TeOM is typically recalcitrant (i.e. resistant to degradation), only a small fraction of it reaches the ocean, pointing to a substantial TeOM degradation by the river microbiome. Yet, microbial genes involved in TeOM degradation in the Amazon River were barely known. Here, we examined the Amazon River microbiome by analysing 106 metagenomes from 30 sampling points distributed along the river. Results We constructed the Amazon River basin Microbial non-redundant Gene Catalogue (AMnrGC) that includes ~ 3.7 million non-redundant genes, affiliating mostly to bacteria. We found that the Amazon River microbiome contains a substantial gene-novelty compared to other relevant known environments (rivers and rainforest soil). Genes encoding for proteins potentially involved in lignin degradation pathways were correlated to tripartite tricarboxylates transporters and hemicellulose degradation machinery, pointing to a possible priming effect. Based on this, we propose a model on how the degradation of recalcitrant TeOM could be modulated by labile compounds in the Amazon River waters. Our results also suggest changes of the microbial community and its genomic potential along the river course. Conclusions Our work contributes to expand significantly our comprehension of the world’s largest river microbiome and its potential metabolism related to TeOM degradation. Furthermore, the produced gene catalogue (AMnrGC) represents an important resource for future research in tropical rivers. Video abstract.

Published
2020
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44. Características moleculares y microanatómicas de la grasa y su aplicación en el tratamiento de quemaduras agudas y secuelas

Author

Marco Aurelio Pellon

Subjects
Quemados, Grasa, Secuelas quemaduras, Medicine, Surgery, RD1-811
Abstract

Resumen Introducción y objetivo Durante los últimos 20 años, el tejido adiposo ha sido reconocido universalmente como algo más que solo un depósito de energía y ahora se sabe que la grasa es un tejido que tiene funciones endocrinas, paracrinas y autocrinas, capaz de sintetizar y secretar varias citocinas de señalización llamadas adipocinas, en además de hormonas, pro hormonas, enzimas y material genético. Este artículo tiene como objetivo analizar la biología molecular, la microanatomía, la comunicación intercelular y el potencial regenerativo del tejido adiposo, presentando la experiencia del autor en el uso de grasa para tratar lesiones producidas por quemaduras en diversas fases, profundidades y regiones anatómicas. Material y método Estudio realizado en varios pacientes que sufrieron quemaduras térmicas, eléctricas y químicas, agudas y tardías, tratados en la Unidad de Tratamiento de Quemaduras de la Clinica Sáo Vicente en Rio de Janeiro, Brasil. Abordamos las técnicas de aplicación tópica e inyección de grasa, según los tipos de quemaduras o secuelas. Resultados Presentamos los resultados obtenidos con esta técnica a corto y largo plazo. Conclusiones La preservación de la actividad metabólica del tejido adiposo aspirado es muy importante para lograr el resultado regenerativo esperado.

Published
2020
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45. Validación de un cuestionario de frecuencia alimentaria para estimar la ingesta de azúcares libres y alimentos ultraprocesados en población argentina

Author

Luciana Olmedo, María Florencia Henning, Silvia Mónica García, and Magalí Pellon Maison

Subjects
Encuestas sobre dietas, Estudio de Validación, Carbohidratos, Ingestión de Alimentos, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Introducción: Las enfermedades crónicas no transmisibles son muy prevalentes en Argentina y el consumo de alimentos ultraprocesados y azúcares libres se asocia a su desarrollo. El objetivo de este estudio fue diseñar y validar un cuestionario de frecuencia alimentaria capaz de estimar su ingesta. Materiales y Métodos: Se elaboró un cuestionario de frecuencia alimentaria denominado CFA-UP de 211 ítems, de los cuales 122 fueron alimentos ultraprocesados. Asimismo, se construyó una tabla de composición química, recopilando información a partir de los rótulos nutricionales de los alimentos envasados. La validación relativa del cuestionario se realizó mediante un estudio transversal analítico en adultos sanos, comparando la ingesta de energía y nutrientes obtenida en el CFA-UP con la de un registro alimentario autoadministrado. La asociación y concordancia entre métodos se evaluó a nivel individual y grupal. La reproducibilidad se analizó comparando la ingesta al inicio del estudio y al cabo de tres meses. Resultados: El coeficiente de correlación de Pearson fue bueno para la ingesta de energía total y de nutrientes y aceptable para colesterol. La clasificación cruzada en terciles de ingesta fue precisa y el coeficiente kappa ponderado fue bueno para energía total y aceptable para los nutrientes. Las diferencias porcentuales de ingesta fueron mayores al 20% para carbohidratos, ácidos grasos poliinsaturados y fibra. La ingesta de azúcares totales fue de 16,4 (DE:6,6) % de la ingesta de energía total, la de azúcares libres del 9,3 (DE:5,4) % y la de alimentos ultraprocesados del 35,3 (DE:12,4) %. Conclusiones: CFA-UP constituye una herramienta adecuada para la clasificación de individuos de acuerdo a la ingesta de energía, nutrientes y alimentos, incluyendo a los azúcares totales, azúcares libres y alimentos ultraprocesados.

Published
2022

50. Correction to: Proposed nomenclature for Pseudallescheria, Scedosporium and related genera

Author

Lackner, Michaela, de Hoog, G. Sybren, Yang, Liyue, Ferreira Moreno, Leandro, Ahmed, Sarah A., Andreas, Fritz, Kaltseis, Josef, Nagl, Markus, Lass-Flörl, Cornelia, Risslegger, Brigitte, Rambach, Günter, Speth, Cornelia, Robert, Vincent, Buzina, Walter, Chen, Sharon, Bouchara, Jean-Philippe, Cano-Lira, José F., Guarro, Josep, Gené, Josepa, Fernández Silva, Fabiola, Haido, Rosa, Haase, Gerhard, Havlicek, Vladimir, Garcia-Hermoso, Dea, Meis, Jacques F., Hagen, Ferry, Kirchmair, Martin, Rainer, Johannes, Schwabenbauer, Katharina, Zoderer, Mirjam, Meyer, Wieland, Gilgado, Felix, Schwabenbauer, Katharina, Vicente, Vania A., Piecková, Elena, Regenermel, Monika, Rath, Peter-Michael, Steinmann, Joerg, de Alencar, Xisto Wellington, Symoens, Françoise, Tintelnot, Kathrin, Ulfig, Krzysztof, Velegraki, Aristea, Tortorano, Anna Maria, Giraud, Sandrine, Mina, Sara, Rigler-Hohenwarter, Kinga, Hernando, Fernando L., Ramirez-Garcia, Andoni, Pellon, Aize, Kaur, Jashanpreet, Bergter, Eliana Barreto, de Meirelles, Jardel Vieira, da Silva, Ingrid Dutra, Delhaes, Laurence, Alastruey-Izquierdo, Ana, Li, Ruo-yu, Lu, Qiaoyun, Moussa, Tarek, Almaghrabi, Omar, Al-Zahrani, Hassan, Okada, Gen, Deng, Shuwen, Liao, Wangqing, Zeng, Jingsi, Issakainen, Jouni, and Liporagi Lopes, Livia Cristina

Published
2022
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