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Your search keyword '"Papir, Galia"' showing total 2 results
Start Over Author "Papir, Galia" Publication Type Academic Journals
2 results on '"Papir, Galia"'

1. Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model

Author

Grossman, Iris, Kolitz, Sarah, Komlosh, Arthur, Zeskind, Benjamin, Weinstein, Vera, Laifenfeld, Daphna, Gilbert, Adrian, Bar‐Ilan, Oren, Fowler, Kevin D., Hasson, Tal, Konya, Attila, Wells‐Knecht, Kevin, Loupe, Pippa, Melamed‐Gal, Sigal, Molotsky, Tatiana, Krispin, Revital, Papir, Galia, Sahly, Yousif, and Hayden, Michael R.

Published
2017
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2. Inhibition of Streptomyces griseus aminopeptidase and effects of calcium ions on catalysis and binding.

Author

Papir, Galia, Spungin-Bialik, Anya, Ben-Meir, Daniella, Fudim, Ella, Gilboa, Rotem, Greenblatt, Harry M., Shoham, Gil, Lessel, Uta, Schomburg, Dietmar, Ashkenazi, Ruth, and Blumberg, Shmaryahu

Subjects
*STREPTOMYCES griseus, *CALCIUM ions, *BINDING sites, *AMINOPEPTIDASES
Abstract

Streptomyces griseus aminopeptidase is a zinc metalloenzyme containing 2 mol zinc/mol protein, similar to the homologous enzyme Aeromonas proteolytica aminopeptidase. In addition, a unique Ca2+-binding site has been identified in the Streptomyces enzyme, which is absent in the Aeromonas enzyme. Binding of Ca2+ enhances stability of the Streptomyces enzyme and modulates its activity and affinity towards substrates and inhibitors in a structure-dependent manner. Among the three hydrophobic 4-nitroanilides of alanine, valine and leucine, the latter displays the largest overall activation (increase in kcat/Km). Large enhancements in affinity (1/Ki) upon Ca2+ binding have been observed for inhibitors with flexible (leucine-like) residues at their N-termini and smaller enhancements for inhibitors with rigid (phenylalanine-like) residues. [ABSTRACT FROM AUTHOR]

Published
1998
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