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169 results on '"Osoba, David"'

3. Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

Author

Perry, James R., Laperriere, Normand, O’Callaghan, Christopher J., Brandes, Alba A., Menten, Johan, Phillips, Claire, Fay, Michael, Nishikawa, Ryo, Cairncross, Gregory J., Roa, Wilson, Osoba, David, Rossiter, John P., Sahgal, Arjun, Hirte, Hal, Laigle-Donadey, Florence, Franceschi, Enrico, Chinot, Olivier, Golfinopoulos, Vassilis, Fariselli, Laura, Wick, Antje, Feuvret, Loic, Back, Michael, Tills, Michael, Winch, Chad, Baumert, Brigitta G., Wick, Wolfgang, Ding, Keyue, and Mason, Warren P.

Published
2017
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9. Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials

Author

Maringwa, John T., Quinten, Chantal, King, Madeleine, Ringash, Jolie, Osoba, David, Coens, Corneel, Martinelli, Francesca, Vercauteren, Jurgen, Cleeland, Charles S., Flechtner, Henning, Gotay, Carolyn, Greimel, Eva, Taphoorn, Martin J., Reeve, Bryce B., Koch, Joseph Schmucker-Von, Weis, Joachim, Smit, Egbert F., van Meerbeeck, Jan P., Bottomley, Andrew, and on behalf of the EORTC PROBE project and the Lung Cancer Group

Published
2011
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12. A Global Analysis of Multitrial Data Investigating Quality of Life and Symptoms as Prognostic Factors for Survival in Different Tumor Sites

Author

Quinten, Chantal, Martinelli, Francesca, Coens, Corneel, Sprangers, Mirjam A. G., Ringash, Jolie, Gotay, Carolyn, Bjordal, Kristin, Greimel, Eva, Reeve, Bryce B., Maringwa, John, Ediebah, Divine E., Zikos, Efstathios, King, Madeleine T., Osoba, David, Taphoorn, Martin J., Flechtner, Henning, Schmucker-Von Koch, Joseph, Weis, Joachim, and Bottomley, Andrew

Published
2014
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14. Examining the relationships among health-related quality-of-life indicators in cancer patients participating in clinical trials: a pooled study of baseline EORTC QLQ-C30 data

Author

Martinelli, Francesca, Quinten, Chantal, Maringwa, John T, Coens, Corneel, Vercauteren, Jurgen, Cleeland, Charles S, Flechtner, Henning, Gotay, Carolyn, Greimel, Eva, King, Madeleine, Mendoza, Tito, Osoba, David, Reeve, Bryce B, Ringash, Jolie, Koch, Joseph Schmucker-Von, Shi, Qiuling, Taphoorn, Martin J, Weis, Joachim, and Bottomley, Andrew

Published
2011
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47. Review: Health-related quality of life and cancer clinical trials.

Author

Osoba, David

Abstract

The measurement of patient-reported outcomes, including health-related quality of life, is a new initiative which has emerged and grown over the past four decades. Following the development of reliable and valid self-report questionnaires, health-related quality of life has been assessed in tens of thousands of patients and a wide variety of cancers. This review is based on a selection of data published in the last decade and is intended primarily for healthcare professionals. The assessments in clinical trials have been particularly useful for elucidating the effects of various cancers and their treatments on patients’ lives and have provided additional information that enhances the usual clinical endpoints used for determining the benefits and toxicity of treatment. With growing experience the quality of the health-related quality of studies has improved and, in general, recent studies are more likely to be methodologically robust than those that were performed in earlier decades. Health-related quality of life has become a more accurate predictor of survival than some other clinical parameters, such as performance status. The overall outlook for the routine assessment of patient-reported outcomes in clinical trials is assured and, eventually, it is likely to become a standard part of clinical practice. However, there is still a need for a clear method for determining the clinical meaningfulness of changes in scores. The answer will probably come from the greater use of patient-reported outcomes and the consequent growth of experience that is necessary to make such judgements. [ABSTRACT FROM PUBLISHER]

Published
2011
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50. Translating the Science of Patient-Reported Outcomes Assessment Into Clinical Practice.

Author

Osoba, David

Subjects
*QUALITY of life, *EVALUATION of medical care, *HEALTH outcome assessment, *HEALTH behavior, *PATIENT self-monitoring
Abstract

Patient-reported outcomes (PROs) are based on direct reporting by patients without the intervention of an observer. They include the self-assessment of functional status, symptoms, and other concerns such as needs and satisfaction with care. Health-related quality of life (HRQOL) assessment is a form of PRO and often includes both functional status and symptoms. The science underlying the assessment of HRQOL in clinical practice requires an understanding of the relationships between symptoms, functional status, and HRQOL, as well as instrument selection, and analysis and interpretation of the data. A modification of the Wilson and Cleary model is proposed to show the likelihood of bidirectional relationships between symptoms, functions, and HRQOL. Instrument selection should be based on the measurement properties of the instruments and patient populations in which they will be used. Analyses of data that allow a calculation of the proportion of patients who benefit from an intervention are preferred to analyses that show only the mean change in scores from baseline. HRQOL assessment in clinical practice has been shown to lead to a better understanding of patients' concerns with improvement in counseling and referral for required services. Potentially, HRQOL assessment should also be used to monitor the progress of a patient's disease and benefit from treatment. [ABSTRACT FROM AUTHOR]

Published
2007
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