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Background Movement-related cortical potentials (MRCPs) are electrophysiological activities that reflect neurological mechanisms that occur in the cortex during the planning of and preparation for movement. We aimed to evaluate the MRCPs that occur due to saccadic eye movement in multiple sclerosis (MS). Methods Twenty-five patients aged 18–55 years with good cognitive functions who were diagnosed with MS according to the McDonald criteria and scored 0–5 on the Expanded Disability Status Scale (EDSS) were included. Twenty healthy volunteers in a similar age range also participated. Voluntary horizontal conjugate gaze and MRCPs were recorded and averaged. Results It was observed that the latency of the Bereitshaftpotential (BP; preparation potential) was longer in the patient group, and the latency values were consistent with the values reported in the literature. The peak-pit (PP) amplitude, which can be regarded as a component of the negative slope (NS) and motor potential (MP), was higher in the patient group and may indicate that the target movement was more difficult for the patient group. Conclusion Studies on cognitive impairment in MS have generally been conducted using neuropsychological tests. Although we could not obtain a record that corresponded to the typical MRCP pattern reported in the literature, our findings make a contribution to the field of MCRP-based studies by raising new questions about the measurement and use of MRCP values.

Aim:This study aimed to examine the relationship between short-term mortality and blood glucose values (BGV) obtained during the first week of ischemic stroke, when neurological causes, such as increased intracranial pressure, are mainly predominant in mortality prediction.Materials and Methods:This is a retrospective study that includes 417 patients with acute ischemic stroke (AIS), who were admitted to our hospital within the first 24 hours of the stroke. Data were recorded using the International Classification of Diseases Code. On the first, third, fifth, and seventh days of the stroke, the effect of BGV on the patient’s functional outcome was evaluated.Results:Of 417 patients, 90 (21.58%) died within a one-month follow-up period. There was no difference between the mortality and survival groups in terms of diabetes mellitus (DM) history (χ2=0.783; p=0.224). On the first, third, fifth, and seventh day of the stroke, BGV were significantly higher in the mortality group (130.5 mg/dL, 124.5 mg/dL, 133.5 mg/dL, and 132.5 mg/dL, respectively, according to the receiver operating characteristic analysis) than in the survival group (p

Amaç: Klinik seyir üzerine yapılan çalışmalar inme progresyonunu takip etmede çok önemli bir yer tutar. Perfüzyon MR görüntülemelerinin akut iskemik inmede kullanıma girmesi penumbral alanın tespiti ve kurtarılması adına önemli bir köşe taşı olmuştur. Gereç ve Yöntem: İlk 24 saat içinde akut iskemik inme atağı geçiren hastaların geliş difüzyon ve perfüzyon ağırlıklı manyetik rezonans görüntülemeleri MRG tespit edildi. Perfüzyon-difüzyon uyumsuzluğu ciddi, orta-hafif ve olmama durumlarına göre 3 gruba ayrıldı. İyi klinik yanıt İKY gelişip gelişmediği başlangıç ve 15. gün klinik skorları The National Institute of Health Stroke Scale, European Stroke Scale and Modified Rankin Scale kullanılarak tespit edildi. Finalde lezyon hacim FLH büyümesi tespiti için 15. gün çekilen T2 ağırlıklı MRG ile başlangıç difüzyon ağırlıklı MRG hacim farkları alındı. Bulgular: Ciddi uyumsuzluğun olduğu grupta FLH de büyüme, hafif-orta uyumsuzluk olan gruba ve uyumsuzluğu olmayan gruba göre anlamlı derecede yüksek idi sırasıyla, median: 37 cm3, %95 CoI: 26.0-55.0; median: 10 cm3, %95CoI: 0-16.0; median: - 1.50 cm3, %95 CoI: -4.0 /8.0, χ2 = 8.294, p=0.017 . Uyumsuzluk ciddiyetinin İKY ile sonlanmaya etkisi ise istatistiksel olarak anlamlı değildi χ2:1.959, p:0,162 . İKY’nin elde edilme oranı FLH de büyüme olmayan grupta büyüme olan gruba göre istatistiksel olarak anlamlı düzeyde yüksek bulundu χ2:7,62, p:0,02 . Ancak ile İKY elde etme adına FLH hacim değişiminin bağımsız bir prediktör özelliği bulunmamıştır p:0.086, OR:0.972, %95CI:0.942-1.004 . Sonuç: Bu çalışmanın sonuçları şiddetli difüzyon-perfüzyon uyumsuzluğu olan akut iskemik inmeli hastaların radyolojik ve klinik gidişatları daha ciddi olabilir ve tedavide daha dikkatli olunmalıdır.

ABSTRACT Background: Multiple sclerosis (MS) is an inflammatory and neurodegenerative autoimmune chronic neurological disease. Currently, there are no effective serum biomarkers to verify MS diagnosis, to assess disease prognosis, and evaluate response to MS treatment. Objective: The present study is a preliminary assessment of irisin and nesfatin-1 serum levels in patients with relapsing- remitting MS (RRMS). Methods: A total of 86 participants, 42 patients with RRMS diagnosis and 44 healthy controls were included in the study. The serum irisin and nesfatin-1 parameters of the patients and control group members were analyzed. Results: Irisin and nesfatin-1 levels of the RRMS patients were significantly lower than the controls (z: -3.82, p

OBJECTIVE: Multiple Sclerosis(MS) is an autoimmune-neurodegenerative disease of the central nervous system. The pain prevalence differentiates between 29% and 86 % in this disease and besides the neuropathic, somatic pain types might emerge together or separately. In this study we aimed to analyse the relationship between pain and other clinical featuresin MS. METHODS: 100 cases,of whom are followed in MS polyclinic and who have complaints of pain, have been included to this study.By ensuring the forms that we prepared to be filled by the cases, we examined the pain type and localization. Thereafter we applied Visual Pain Scale (VPS), Ashworth Spasticity Scale (ASS) and Beck Depression Scale(BDS). RESULTS: When female and male patients are compared, significant difference has not been observed statistically among age, disease period and EDDS scores. 77 % of the cases have suffered from neuropathic pain, 21 % of the cases have displayed Lhermitte symptoms, trigeminal neuralgia has been observed in 1 % of the cases and 55 % of the cases have had complaints of neuropathic extremity pain. In 60 % of the cases nociceptive pains, in 12 % of the cases joint-extremity-muscle pain, in 47 % headache and in 1 % painful tonic spasms have existed. Pain depending on the treatment has been observed only in 2 % of the cases. The pain score has been detected significantly on patients with spasticity and depression (p= 0.008, p= 0.001 in return). While there has been reasonable positive correlation between age, EDDS score and VPS (p= 0.010, p= 0.002 in return), poor correlation has been obtained between disease period and number of attacks (p= 0.002, p= 0.045 in return). CONCLUSION: These findings indicate that MS pain is related with spasticity, disability and depression and these clinical findings should be taken into account during pain treatment and the above factors should be treated.

ABSTRACT Background: Characterized by demyelination, inflammation and axonal damage, multiple sclerosis (MS) is one of the most common disorders of central nervous system led by the immune system. There is an urgent and obvious need for biomarkers for the diagnosis and follow-up of MS. Objective: To investigate serum levels of sestrin2 (SESN2), a protein that responds to acute stress, in MS patients. Methods: A total of 85 participants, 40 patients diagnosed previously with relapsing-remitting MS and 45 healthy controls, were included. Serum SESN2 parameters were investigated in blood samples drawn from each participant in the patient and control groups. Results: SESN2 levels were significantly lower in MS patients than in controls (z: -3.06; p=0.002). In the ROC analysis of SESN2, the predictive level for MS was 2.36 ng/mL [sensitivity, 72.50%; specificity, 55.56%; p=0.002; area under the curve (AUC)=0.693]. For the cut-off value in both groups, SESN2 was an independent predictor for MS [Exp (B)=3.977, 95% confidence interval (95%CI) 1.507-10.494 and p=0.013]. Conclusions: The decreased expression of SESN2 may play a role in MS pathogenesis, and SESN2 could be used as a biomarker for MS and as immunotherapeutic agent to treat MS.

Background: Cerebellar infarct is a rare condition with very nonspecific clinical features. The aim of this study was to assess the full spectrum of the clinical characteristics, neuroimaging findings and neurofunctional analyses of cerebellar infarction, and the relationship between them. Materials and Methods: Data were collected from 59 patients admitted to our department during an 8-year period. We retrospectively analyzed the relationship between demographic characteristics, clinical symptomatology, etiological factors, functional condition, vascular distribution, frequency of subcortical white matter lesions (WMLs), and concomitant lesion outside the cerebellum in patients with acute cerebellar infarct (ACI) at time of admission. Results: The mean age in our series was 65.2 years, with most being male (57.6%). The posterior inferior cerebellar (PICA) artery was the most commonly affected territory at 62.7%. There was concomitant lesion outside the cerebellum in 45.7%. The main etiology in PICA was cardioembolism. While mean National Institutes of Health Stroke Scale on admission was 2.08 ± 1.67 in study group, modified Rankin Scale (mRS) on admission was detected to be mRS1 (n: 44, 74.5%) and mRS2 (n: 12, 20.3%) most frequently. Fourteen (35%) patients were detected to be in Fazekas stage 0; 11 (27.5%) patients in Fazekas stage 1; 6 (15%) patients in Fazekas stage 2; and 9 (22.5%) patients in Fazekas stage 3. Conclusion: Cerebellar infarct is very heterogeneous. The other cerebral area infarcts which accompany ACI negatively affect neurologic functional scores. Although it is difficult to detect the relationship between WMLs and neurologic functional severity, timely detection of risk factors and their modulation may be associated with prevention and treatability of WMLs, and this may be one of the important points for prevention of stroke-related disability.