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The objective of the present study was to evaluate the risk factors and outcomes associated with hyponatremia in patients with Guillain-Barré syndrome (GBS). We retrospectively studied 80 consecutive patients with GBS who visited our hospital and compared clinical, laboratory, and electrophysiological findings of patients with and without hyponatremia. Disability was evaluated using the Hughes grading system. Of the 80 patients, 18 (23%) had hyponatremia. Hyponatremia was significantly associated with older age (P = 0.003), urinary retention (P < 0.0001), Hughes grade ≥ 4 at admission and nadir (P = 0.003 and P < 0.001, respectively), acute inflammatory demyelinating polyneuropathy subtype (P = 0.017), sepsis (P = 0.001), mechanical ventilator support (P = 0.013), longer hospitalization length of stay (P < 0.0001), and inability to walk independently at 6 months (P < 0.001). Multivariate analysis performed to assess the risk factors of hyponatremia revealed that urinary retention (odds ratio [OR] 30.7, 95% confidence interval [CI] 3.6–264.4; P = 0.002) and mechanical ventilator support (OR 13.8, 95% CI 1.6–118.0; P = 0.017) were significant independent risk factors of hyponatremia. In assessing the outcomes of patients with hyponatremia, multivariate analysis showed that hyponatremia was independently associated with hospitalization length of stay ≥ 60 days and inability to walk independently at 6 month, with the former showing statistical significance but the latter not (OR 9.3, 95% CI 1.8–47.7; P = 0.007 and OR 4.9, 95% CI 0.9–26.3; P = 0.066, respectively). Therefore, we demonstrate that, along with mechanical ventilator support, urinary retention—possibly indicating autonomic dysfunction—is a risk factor of hyponatremia in GBS. Moreover, we confirm that hyponatremia is associated with poor outcome in GBS. [ABSTRACT FROM AUTHOR]

We present ionized gas properties of nine local ultra/luminous infrared galaxies (U/LIRGs) at z < 0.04 through Integral Field Unit (IFU) observations with KOOLS-IFU on the Seimei Telescope. The observed targets are drawn from the Great Observatories All-sky LIRG Survey (GOALS), covering a wide range of merger stages. We successfully detect emission lines such as Hβ, [O  iii ]λ5007, Hα, [N  ii ]λλ6549, 6583, and [S  ii ]λλ6717, 6731 with a spectral resolution of R = 1500–2000, which provides (i) a spatially resolved (∼200–700 pc) moment map of ionized gas and (ii) diagnostics for an active galactic nucleus (AGN) within the central ∼3–11 kpc in diameter for our sample. We find that the [O  iii ] outflow that is expected to be driven by an AGN tends to be stronger (i) towards the galactic center and (ii) as a sequence of the merger stage. In particular, the outflow strength in the late-stage (stage D) mergers is about 1.5 times stronger than that in the early-state (stage B) mergers, which indicates that galaxy mergers could induce AGN-driven outflow and play an important role in the co-evolution of galaxies and supermassive black holes. [ABSTRACT FROM AUTHOR]

The design of a 7T three pole superconducting wiggler to be used as a light source for the 700 MeV synchrotron radiation ring AURORA-2D is described. Its main parts are three pairs of racetrack superconducting coils in an iron yoke, bismuth-based oxide superconducting current lead unit and Gifford-McMahon cryocoolers. The magnet was cooled down in 62 hours without the use of liquid helium. A central field of 7 T was obtained within 360 seconds.

To investigate the origins of the warm absorbers in active galactic nuclei (AGNs), we study the ionization-state structure of the radiation-driven fountain model in a low-mass AGN and calculate the predicted X-ray spectra utilizing the spectral synthesis code Cloudy. The spectra show many absorption and emission line features originating in the outflowing ionized gas. The O viii 0.654 keV lines are produced mainly in the polar region much closer to the supermassive black hole than the optical narrow-line regions. The absorption measure distribution of the ionization parameter (Îľ) at a low inclination spreads over 4 orders of magnitude in Îľ, indicating the multiphase ionization structure of the outflow, as actually observed in many type 1 AGNs. We compare our simulated spectra with the high energy resolution spectrum of the narrow-line Seyfert 1 galaxy NGC 4051. The model reproduces slowly outflowing (a few hundred kilometers per second) warm absorbers. However, the faster components with a few thousand kilometers per second observed in NGC 4051 are not reproduced. The simulation also underproduces the intensity and width of the O viii 0.654 keV line. These results suggest that the ionized gas launched from subparsec or smaller regions inside the torus, which is not included in the current fountain model, must be an important ingredient of the warm absorbers with a few thousand kilometers per second. The model also consistently explains the Chandra/HETG spectrum of the Seyfert 2 galaxy Circinus. [ABSTRACT FROM AUTHOR]

The location of the obscuring "torus" in an active galactic nucleus (AGN) is still an unresolved issue. The line widths of X-ray fluorescence lines originating from the torus, particularly Fe Kα, carry key information on the radii of line-emitting regions. Utilizing XCLUMPY, an X-ray clumpy torus model, we develop a realistic model of emission line profiles from an AGN torus where we take into account line broadening due to the Keplerian motion around the black hole. Then, we apply the updated model to the best available broadband spectra (3–100 keV) of the Circinus galaxy observed with Suzaku, XMM-Newton, Nuclear Spectroscopic Telescope Array, and Chandra, including 0.62 Ms Chandra/HETG data. We confirm that the torus is Compton-thick (hydrogen column density along the equatorial plane is), geometrically thin (torus angular width), viewed edge-on (inclination), and has supersolar abundance (times solar). Simultaneously analyzing the Chandra/HETG first-, second-, and third-order spectra with consideration of the spatial extent of the Fe Kα line-emitting region, we constrain the inner radius of the torus to be times the gravitational radius, or for a black hole mass of (1.7 ± 0.3) × 106M⊙. This is about three times smaller than that estimated from the dust sublimation radius, suggesting that the inner side of the dusty region of the torus is composed of dust-free gas. [ABSTRACT FROM AUTHOR]

We present the results of a systematic, broadband X-ray spectral analysis of nearby active galactic nuclei (AGNs) with the X-ray clumpy torus model (XCLUMPY). By adding 16 AGNs newly analyzed in this paper, we study a total of 28 AGNs, including unabsorbed and absorbed AGNs taken from Ichikawa et al. and García-Bernete et al. This is the largest sample whose X-ray and infrared spectra are analyzed by the clumpy torus models XCLUMPY and CLUMPY, respectively. The relation between the Eddington ratio and the torus covering factor determined from the X-ray torus parameters of each object follows the trend found by Ricci et al. based on a statistical analysis. We confirm the results by Tanimoto et al. that (1) the torus angular widths determined by the infrared data are larger than those by the X-ray data and (2) the ratios of hydrogen column density to V-band extinction (NH/AV) along the line of sight in obscured AGNs are similar to the Galactic value, on average. Unobscured AGNs show apparently smaller line-of-sight NH/AV ratios than the Galactic one. Our findings can be well explained by an updated unified picture of AGN structure including a dusty torus, dusty polar outflows, and dust-free gas, where the inclination determines the X-ray and optical classifications and observed torus properties in the X-ray and infrared bands. [ABSTRACT FROM AUTHOR]

We apply XCLUMPY, an X-ray spectral model from a clumpy torus in an active galactic nucleus (AGN), to the broadband X-ray spectra of 10 obscured AGNs observed with both Suzaku and NuSTAR. The infrared spectra of these AGNs were analyzed by Ichikawa et al. with the CLUMPY code. Because XCLUMPY adopts the same clump distribution as that in the CLUMPY, we can directly compare the torus parameters obtained from the X-ray spectra and those from the infrared spectra. The torus angular widths determined from the infrared spectra (σIR) are systematically larger than those from the X-ray data (σX); the difference () correlates with the inclination angle determined from the X-ray spectrum. These results can be explained by the contribution from dusty polar outflows to the observed infrared flux, which becomes more significant at higher inclinations (more edge-on views). The ratio of the hydrogen column density to the V-band extinction in the line-of-sight absorber shows a large scatter (≃1 dex) around the Galactic value, suggesting that a significant fraction of AGNs have dust-rich circumnuclear environments. [ABSTRACT FROM AUTHOR]

The article presents a speech by Shoji Ogawa, the Consul General of Japan in Atlanta, delivered at the monthly meeting of the West Triangle United Nations Association of the USA in North Carolina, on December 19, 2007, in which he discussed the function of the UN and what Japan and the U.S. can contribute to make it more effective.

The effects of 3-[2-({[amino(imino)methyl]amino}carbonyl)-4-chloro-1H-indol-1-yl]-1-propanesulphonic acid monohydrate (SM-198110), a novel potent Na+/H+ exchange inhibitor, and cariporide (Hoe642), another Na+/H+ exchange inhibitor, were studied in a myocardial ischaemia and reperfusion injury model. Anaesthetized rabbits were subjected to occlusion of the coronary artery for 30 min followed by reperfusion for 5 h. SM-198110 or cariporide was administered before ischaemia and before reperfusion. We also assessed the anti-necrotic effect of SM-198110 when given before reperfusion, both alone and together with glibenclamide, a KATP channel blocker, 5-hydroxydecanoate (5-HD), a mitochondrial KATP channel-selective blocker and 8-(p-sulphophenyl)-theophylline (8-SPT), an adenosine receptor blocker. The infarct size was reduced dose-dependently by i.v. administration of SM-198110 before ischaemia, with a significant reduction in serum creatine phosphokinase activity. Infarct sizes, normalized to the size of the area-at-risk (means±SE) were: vehicle 56.6±3.7%; low-dose SM-198110 39.2±6.3%; mid-dose 32.8±7.4% ( P<0.05); high-dose 22.1±6.7% ( P<0.01). This anti-necrotic effect of SM-198110 was achieved without significant haemodynamic changes. Cariporide given before ischaemia also reduced infarct size significantly and dose-dependently. SM-198110 administered before reperfusion also resulted in a dose-dependent reduction in the infarct size. Infarct sizes were: vehicle 56.6±3.7%; low-dose SM-198110 44.5±5.7%; mid-dose 36.3±6.6% ( P<0.01); high-dose 34.7±3.8% ( P<0.01). In contrast, cariporide given before reperfusion did not reduce infarct sizes significantly. The anti-necrotic effect of SM-198110 was observed even when given 10 min after the beginning of reperfusion. Glibenclamide and 5-HD abolished the anti-necrotic effect of treatment before reperfusion with SM-198110. However, the co-administration of 8-SPT with SM-198110 did not affect infarct size. These results suggest that, in addition to Na+/H+ exchange inhibition, mitochondrial and/or sarcolemmal KATP channels contribute to the anti-necrotic effect of SM-198110 when the latter is given before reperfusion. [ABSTRACT FROM AUTHOR]

Spinal cord injury (SCI) often results in various long-term sequelae, and chronically injured spinal cords exhibit a refractory feature, showing a limited response to cell transplantation therapies. To our knowledge, no preclinical studies have reported a treatment approach with results surpassing those of treatment comprising rehabilitation alone. In this study of rats with SCI, we propose a novel combined therapy involving a semaphorin 3A inhibitor (Sema3Ai), which enhances axonal regeneration, as the third treatment element in combination with neural stem/progenitor cell transplantation and rehabilitation. This comprehensive therapeutic strategy achieved significant improvements in host-derived neuronal and oligodendrocyte differentiation at the SCI epicenter and promoted axonal regeneration even in the chronically injured spinal cord. The elongated axons established functional electrical connections, contributing to significant enhancements in locomotor mobility when compared with animals treated with transplantation and rehabilitation. As a result, our combined transplantation, Sema3Ai, and rehabilitation treatment have the potential to serve as a critical step forward for chronic SCI patients, improving their ability to regain motor function., (Copyright © 2024 Yoshida et al.)

The patient is an 18-year-old female. She had a history of acute disseminated encephalomyelitis at the age of 6 and 7. She visited our hospital due to acute disturbance of consciousness, quadriplegia, and numbness of left upper and lower extremities. Brain MRI showed multiple DWI/FLAIR high-signal lesions in the bilateral cerebral hemispheres, cerebellum, and brainstem. Qualitative test indicated that serum anti-MOG antibodies was positive, and she was diagnosed with anti-MOG antibody-positive polyphasic disseminated encephalomyelitis. Intravenous mPSL pulse therapy was performed twice, but the symptoms worsened. As a second line treatment, plasma exchange was started. However, she developed transfusion related acute lung injury. Alternatively, she was treated with immunoadsorption plasmapheresis. Her symptoms were significantly improved. This case seems to be valuable because there are few reports showing effectiveness of immunoadsorption therapy on anti-MOG antibody-related diseases, especially for polyphasic disseminated encephalomyelitis.

Changes in body weight (BW), systolic blood pressure (SBP), and localization of renin in the kidneys of neonates born to normal mothers (C neonates) or to five-sixths (5/6) nephrectomized (2/3 left kidney and right kidney) mothers (Nx neonates) were studied. Maternal 5/6 nephrectomy caused weight loss in neonates but no differences in SBP or renin localization. Culling Nx neonates to a litter of 3 at 1 day after birth resulted in growth catching up with C neonates from 3 weeks old and increases in both SBP and renin-positive cells in neonatal kidney. These findings revealed that maternal 5/6 nephrectomy results in low-birth-weight neonates and that these neonates are at increased risk of metabolic syndrome by catch-up growth.

An 84-year-old woman developed blepharoptosis, diplopia, weakness of extremities, and dysphagia with elevation of serum CK levels after treatment with nivolumab against renal cell carcinoma. 3 Hz repetitive stimulation showed waning in the trapezius muscle, leading to the diagnosis of myasthenia gravis. Laboratory examination showed that anti-acetylcholine receptor antibody was negative. We performed IVIg and steroid therapy. However, her symptoms did not improve, and she died of respiratory failure, although serum CK levels ameliorated to the normal range. The results of autopsy showed atrophy of muscle fibers and massive infiltration of inflammatory cells in the endomysium of the iliopsoas muscle and diaphragm, indicating occurrence of myositis. Immunohistochemical analysis showed that CD8-positive T cells mainly infiltrates in the endomysium with a small number of CD4-potive T cells. Here, we report an autopsy case of nivolumab-induced myasthenia gravis and myositis.

The photoluminescence intensity of ZnS-AgInS(2) solid solution nanoparticles was remarkably enhanced by increasing the heating temperature to 180 degrees C, above which the emission was simply diminished, while ZnS coating of the particles resulted in further enhancement of PL intensity, giving the highest quantum yield of ca. 80%.

Mutations of Fas (CD95/Apo-1) gene have been reported in various malignancies and therefore the Fas gene has been considered to be a tumor suppressor gene. To examine an involvement of Fas gene as a tumor suppressor gene in radiation lymphomagenesis, we examined the loss of heterozygosity (LOH) in lymphomas from (MSM/Ms x MRL-MpJ/Fas (lpr)) F(1) and (BALB/cHeA x MRL-MpJ/Fas (lpr)) F(1) hybrid mice. Lymphoma development by X-irradiation was efficiently observed in both F(1) hybrids. Frequent LOH was found on chromosomes 12 and 4 in the tumors from both F(1) mice, but no allelic loss on chromosome 19 containing Fas locus was found, and no wild-type allele of the Fas gene was lost in 51 lymphomas. Therefore, the putative tumor-suppressor gene regions responsible for lymphomagenesis might not considerably differ due to the Fas gene status.