645 results on '"Obika, Satoshi"'
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2. Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation
3. Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer
4. In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity
5. Lantern-type G-quadruplex fluorescent sensors for detecting divalent metal ions
6. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine
7. Separation of the diastereomers of phosphorothioated siRNAs by anion-exchange chromatography under non-denaturing conditions
8. An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells
9. Development of simple purification method for oligonucleotides synthesized using phosphoramidite for 5′-end modification as capping reagent
10. Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study
11. Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities
12. Retention behavior of short double-stranded oligonucleotide and its potential impurities by anion-exchange chromatography under non-denaturing conditions
13. Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide
14. 2′-N-Alkylaminocarbonyl-2′-amino-LNA: Synthesis, duplex stability, nuclease resistance, and in vitro anti-microRNA activity
15. Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides
16. Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
17. Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways
18. Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA)
19. Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide
20. Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer
21. THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides.
22. A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides.
23. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery.
24. Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid.
25. Synthesis and biophysical properties of 5′-thio-2′,4′-BNA/LNA oligonucleotide
26. Conformations and Dynamics of Ets-1 ETS Domain-DNA Complexes
27. Evaluation of size-exclusion chromatography for the analysis of phosphorothioate oligonucleotides
28. Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA
29. Systematic Analysis of 2′- O -Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties.
30. Post‐Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex‐Forming Ability.
31. A novel human muscle cell model of Duchenne muscular dystrophy created by CRISPR/Cas9 and evaluation of antisense-mediated exon skipping
32. Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides
33. Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides
34. GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling
35. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease
36. A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer
37. Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin‐2.
38. Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids.
39. Development of 8–17 XNAzymes that are functional in cells.
40. Synthesis and fluorescence properties of 4-diarylmethylene analogues of the green fluorescent protein chromophore
41. Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid containing an exocyclic methylene group in the sugar moiety
42. Synthesis and properties of a novel modified nucleic acid, 2′-N-methanesulfonyl-2′-amino-locked nucleic acid
43. Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18F-incorporated oligodeoxynucleotides
44. Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs.
45. Triplex-forming ability of oligonucleotides containing 1-aryl-1,2,3-triazole nucleobases linked via a two atom-length spacer
46. Synthesis of novel polyesteramine dendrimers by divergent and convergent methods
47. Base-pair recognition ability of hydroxyphenyl nucleobases in parallel triplex DNA
48. Synthesis and properties of thymidines with six-membered amide bridge
49. Efficient reduction of serum cholesterol by combining a liver-targeted gene delivery system with chemically modified apolipoprotein B siRNA
50. Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2′‑OMe-RNA and scpBNA Bearing a 5‑Hydroxycytosine Nucleobase.
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