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457 results on '"Obara, Wataru"'

9. Effect of genetic polymorphisms on outcomes following nivolumab for advanced renal cell carcinoma in the SNiP-RCC trial

Author

Shiota, Masaki, Miyake, Hideaki, Takahashi, Masayuki, Oya, Mototsugu, Tsuchiya, Norihiko, Masumori, Naoya, Matsuyama, Hideyasu, Obara, Wataru, Shinohara, Nobuo, Fujimoto, Kiyohide, Nozawa, Masahiro, Ohba, Kojiro, Ohyama, Chikara, Hashine, Katsuyoshi, Akamatsu, Shusuke, Kamba, Tomomi, Mita, Koji, Gotoh, Momokazu, Tatarano, Shuichi, Fujisawa, Masato, Tomita, Yoshihiko, Mukai, Shoichiro, Ito, Keiichi, Tanegashima, Tokiyoshi, Tokunaga, Shoji, and Eto, Masatoshi

Published
2023
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10. Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals

Author

Matsuda, Koichi, Yamanashi, Yuji, Furukawa, Yoichi, Morisaki, Takayuki, Okada, Yukinori, Murakami, Yoshinori, Muto, Kaori, Nagai, Akiko, Nakamura, Yusuke, Obara, Wataru, Yamaji, Ken, Takahashi, Kazuhisa, Asai, Satoshi, Takahashi, Yasuo, Higashiue, Shinichi, Kobayashi, Shuzo, Yamaguchi, Hiroki, Nagata, Yasunobu, Wakita, Satoshi, Nito, Chikako, Iwasaki, Yu-Ki, Murayama, Shigeo, Yoshimori, Kozo, Miki, Yoshio, Obata, Daisuke, Higashiyama, Masahiko, Masumoto, Akihide, Koga, Yoshinobu, Koretsune, Yukihiro, Aihara, Makoto, Sakata, Rei, Kashiwagi, Kenji, Mabuchi, Fumihiko, Kawase, Kazuhide, Iwata, Takeshi, Tsujikawa, Motokazu, Nishiguchi, Koji M., Akiyama, Masato, Tamiya, Gen, Fujiwara, Kohta, Shiga, Yukihiro, Yokoyama, Yu, Hashimoto, Kazuki, Sato, Masataka, Sato, Kota, Narita, Akira, Hashimoto, Sawako, Ueda, Emi, Furuta, Yoshihiko, Hata, Jun, Miyake, Masahiro, Ikeda, Hanako O., Suda, Kenji, Numa, Shogo, Mori, Yuki, Morino, Kazuya, Murakami, Yusuke, Shimokawa, Sakurako, Nakamura, Shun, Yawata, Nobuyo, Fujisawa, Kimihiko, Yamana, Satoshi, Mori, Kenichiro, Ikeda, Yasuhiro, Miyata, Kazunori, Mori, Keisuke, Ogino, Ken, Koyanagi, Yoshito, Kamatani, Yoichiro, Ninomiya, Toshiharu, Sonoda, Koh-Hei, and Nakazawa, Toru

Published
2024
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13. Correction to: Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era – a multi‑institutional retrospective study

Author

Kato, Renpei, Naito, Sei, Numakura, Kazuyuki, Hatakeyama, Shingo, Koguchi, Tomoyuki, Kojima, Takahiro, Kawasaki, Yoshihide, Kandori, Shuya, Kawamura, Sadafumi, Arai, Yoichi, Ito, Akihiro, Nishiyama, Hiroyuki, Kojima, Yoshiyuki, Ohyama, Chikara, Habuchi, Tomonori, Tsuchiya, Norihiko, and Obara, Wataru

Published
2023
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15. Significance of upfront cytoreductive nephrectomy stratified by IMDC risk for metastatic renal cell carcinoma in targeted therapy era – a multi-institutional retrospective study

Author

Kato, Renpei, Naito, Sei, Numakura, Kazuyuki, Hatakeyama, Shingo, Koguchi, Tomoyuki, Kojima, Takahiro, Kawasaki, Yoshihide, Kandori, Shuya, Kawamura, Sadafumi, Arai, Yoichi, Ito, Akihiro, Nishiyama, Hiroyuki, Kojima, Yoshiyuki, Ohyama, Chikara, Habuchi, Tomonori, Tsuchiya, Norihiko, and Obara, Wataru

Published
2022
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16. Emphysematous pyelonephritis diagnosed by acute changes detected via computed tomography: A case report.

Author

Kato, Yoichiro, Ishii, Shuhei, Goto, Yuta, Nozaki, Yasushi, Kawamura, Tatsuya, Morino, Gota, Hoshi, Shintaro, Takahashi, Gaku, and Obara, Wataru

Subjects
URINARY tract infections, COMPUTED tomography, CONSERVATIVE treatment, DIABETES, REFRACTORY materials
Abstract

Key Clinical Message: This is the first case report in which computed tomography (CT) images of a patient with emphysematous pyelonephritis (EPN) capture the time course of emphysema from onset to resolution through conservative treatment. To re‐evaluate EPN, including refractory urinary tract infections, CT scans after 72 h might be helpful. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss.

Author

Sonehara, Kyuto, Yano, Yoshitaka, Naito, Tatsuhiko, Goto, Shinobu, Yoshihara, Hiroyuki, Otani, Takahiro, Ozawa, Fumiko, Kitaori, Tamao, Yamanashi, Yuji, Furukawa, Yoichi, Morisaki, Takayuki, Murakami, Yoshinori, Kamatani, Yoichiro, Muto, Kaori, Nagai, Akiko, Nakamura, Yusuke, Obara, Wataru, Yamaji, Ken, Takahashi, Kazuhisa, and Asai, Satoshi

Subjects
RECURRENT miscarriage, GENETIC variation, GENOME-wide association studies, HAPLOTYPES, MAJOR histocompatibility complex, ANTIPHOSPHOLIPID syndrome
Abstract

Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry. We detect significant associations in the major histocompatibility complex (MHC) region at 6p21 (lead variant=rs9263738; P = 1.4 × 10−10; odds ratio [OR] = 1.51 [95% CI: 1.33–1.72]; risk allele frequency = 0.871). The MHC associations are fine-mapped to the classical HLA alleles, HLA-C*12:02, HLA-B*52:01, and HLA-DRB1*15:02 (P = 1.1 × 10−10, 1.5 × 10−10, and 1.2 × 10−9, respectively), which constitute a population-specific common long-range haplotype with a protective effect (P = 2.8 × 10−10; OR = 0.65 [95% CI: 0.57–0.75]; haplotype frequency=0.108). Genome-wide copy-number variation (CNV) calling demonstrates rare predicted loss-of-function (pLoF) variants of the cadherin-11 gene (CDH11) conferring the risk of uRPL (P = 1.3 × 10−4; OR = 3.29 [95% CI: 1.78–5.76]). Our study highlights the importance of reproductive immunology and rare variants in the uRPL etiology. Here, the authors perform a genome-wide association study for recurrent pregnancy loss without apparent clinical causes and identify a protective HLA haplotype. They also show that rare predicted loss-of-function variants in CDH11 are associated with risk of recurrent pregnancy loss. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Prognosis of Japanese metastatic renal cell carcinoma patients in the targeted therapy era

Author

Naito, Sei, Kato, Tomoyuki, Numakura, Kazuyuki, Hatakeyama, Shingo, Koguchi, Tomoyuki, Kandori, Shuya, Kawasaki, Yoshihide, Adachi, Hisanobu, Kato, Renpei, Narita, Shintaro, Yamamoto, Hayato, Ogawa, Soichiro, Kawamura, Sadafumi, Obara, Wataru, Ito, Akihiro, Nishiyama, Hiroyuki, Kojima, Yoshiyuki, Ohyama, Chikara, Habuchi, Tomonori, and Tsuchiya, Norihiko

Published
2021
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20. Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial

Author

Park, Se Hoon, van der Heijden, Michiel S., Necchi, Andrea, Castellano, Daniel, Bamias, Aristotelis, Lee, Jae Lyun, De Giorgi, Ugo, Bögemann, Martin, Eigl, Bernhard J., Tsiatas, Marinos, Powles, Thomas, Novikov, Andrey, Skoneczna, Iwona, Mukherjee, Som D., Suarez, Cristina, Westgeest, Hans, Fradet, Yves, Flechon, Aude, Ou, Yen-Chuan, Park, Inkeun, Matveev, Vsevolod, Pérez-Valderrama, Begoña, Cheng, Susanna, Frank, Stephen, Gurney, Howard, Anido, Urbano, Hamzaj, Alketa, Retz, Margitta, Sridhar, Srikala, Scagliotti, Giorgio Vittorio, Voortman, Jens, Alekseev, Boris, Alyasova, Anna, Komyakov, Boris, Dumez, Herlinde, Pavic, Michel, Kimura, Go, Mizokami, Atsushi, Osanto, Susanne, Arranz, Jose Angel, Piersma, Djura, Shin, Sang Joon, Karyakin, Oleg, Delgado, Ignacio, Gonzalez, Jose Luis, Pang, See-Tong, Tran, Anna, Lipatov, Oleg, Su, Wen-Pin, Flaig, Thomas, Alva, Ajjai, Park Kyong, Hwa, Kopyltsov, Evgeny, Almagro, Elena, Domenech, Monserrat, Chang, Yen-Hwa, Sautois, Brieuc, Ravaux, Andre, Aravantinos, Gerasimos, Georgoulias, Vasileios, Mulder, Sasja, Kim, Yu Jung, Kater, Fabio, Chevreau, Christine, Tagawa, Scott, Zalewski, Pawel, Joly, Florence, Loriot, Yohann, Hatiboglu, Gencay, Gianni, Luca, Morelli, Franco, Tambaro, Rosa, Hashimoto, Yasuhiro, Nosov, Alexander, Font, Albert, Rodriguez-Vida, Alejo M., Jones, Robert, Vasudev, Naveen, Srinivas, Sandhya, Zhang, Jingsong, Gil, Thierry, Finch, Daygen, Grimm, Marc-Oliver, Su, Yu-Li, Chowdhury, Simon, Hocking, Christopher, Plas, Eugen, North, Scott, Jensen, Niels Viggo, Theodore, Christine, Imkamp, Florian, Peer, Avivit, Kobayashi, Takashi, Sakai, Hideki, Sassa, Naoto, Yoshimura, Kazuhiro, Aarts, Maureen, Ferreira Castro, Ana, Topuzov, Marlen, Rodriguez, Juan Francisco, Vazquez, Federico Jose, Tsai, Yu-Chieh, Crabb, Simon, Hussain, Syed, Bendell, Johanna, Gross-Goupil, Marine, Gwenaelle, Gravis, Berger, Raanan, Statsenko, Galina, Evans, Linda, Drakaki, Alexandra, Somer, Bradley, Davis, Ian, Lynam, James, Borges, Giuliano, Dettino, Aldo, Fay, André P., Martins, Graziella, Zucca, Luis Eduardo, Agerbaek, Mads, Kalofonos, Haralambos, Rosenbaum, Eli, Enokida, Hideki, Kikukawa, Hiroaki, Nishimura, Kazuo, Tamada, Satoshi, Uemura, Motohide, Lopez, Yamil, Gietema, Jourik, Slojewski, Marcin, Fernandes, Isabel, Smolin, Alexey, Mazhar, Danish, Kalebasty, Arash Rezazadeh, Carthon, Bradley, Loidl, Wolfgang, Franke, Fabio, Girotto, Gustavo, Alimohamed, Nimira, Macfarlane, Robyn, Pappot, Helle, Niegisch, Guenter, Mavroudis, Dimitrios, Sella, Avishay, Porta, Camillo, Ebara, Shin, Nakamura, Motonobu, Obara, Wataru, Okuno, Norihiko, Shinohara, Nobuo, Sugimoto, Mikio, Suzuki, Akitaka, Tokuda, Noriaki, Uemura, Hiroji, Yamaguchi, Akito, Ramirez, Francisco, Rozanowski, Pawel, Wiechno, Pawel, Keam, Bhumsuk, Kislov, Nikolay, Plaksin, Denis, Cicin, Irfan, Kumar, Satish, Galsky, Matthew D., Petrylak, Daniel P., Rosales, Joseph, Vaishampayan, Ulka, Culine, Stephane, Papandreou, Christos, Nara, Taketoshi, Erman, Mustafa, Kreiger, Laurence, Janoski, Juliana, Rosa, Diogo, Siqueira, Mariana, Canil, Christina, Sengelov, Lisa, Tourani, Jean-Marc, Arai, Gaku, Hashine, Katsuyoshi, Kawakita, Mutsushi, Nakaigawa, Noboru, Nomi, Hayahito, Shiina, Hiroaki, Suzuki, Hiroyoshi, Yonese, Junji, Kuri, Roberto, Macedo, Eleazar, Rivera, Samuel, Villalobos Prieto, Alberto, Polakiewicz-Gilowska, Anna, Zaucha, Renata, Lopes, Fabio, Ponomarev, Roman, Pomerantz, Mark, Shariat, Shahrokh, Luk, Cynthia, Lesniewski-Kmak, Krzysztof, van der Heijden, Michiel S, Galsky, Matthew D, Petrylak, Daniel P, Ogawa, Osamu, Lee, Jae-Lyun, Eigl, Bernhard J, Mukherjee, Som D, Suárez, Cristina, Fay, André P, Duran, Ignacio, Wildsmith, Sophie, He, Philip, Angra, Natasha, Gupta, Ashok K, Levin, Wendy, and Bellmunt, Joaquim

Published
2020
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21. Abnormal carnitine metabolism in hemodialysis patients on different anticoagulants.

Author

Sekiguchi, Kie, Abe, Takaya, Shiomi, Ei, Ikarashi, Daiki, Matsuura, Tomohiko, Maekawa, Shigekatsu, Kato, Renpei, Kanehira, Mitsugu, Takata, Ryo, Sugimura, Jun, Sekiguchi, Takashi, and Obara, Wataru

Subjects
LOW-molecular-weight heparin, HEMODIALYSIS patients, CARNITINE, FREE fatty acids, ANTICOAGULANTS
Abstract

Introduction: We aimed to determine whether unfractionated heparin (UH) and low molecular weight heparin (LH) contribute to aberrant carnitine metabolism in patients receiving hemodialysis. Methods: The rate of increase in serum free fatty acids (FFAs) and the ratio of acylcarnitine to free carnitine (AC/FC) from before to after hemodialysis were determined in patients receiving UH and LH. Additionally, the effect of switching patients to UH from LH was examined. Results: AC/FC was significantly higher in the UH group. In addition, serum FFAs in that group increased to 0.825 ± 0.270 after dialysis from 0.172 ± 0.160 before dialysis, showing a positive correlation with AC/FC. Furthermore, AC/FC was observed to be significantly higher in patients who were switched to UH from LH at 3 months after the change. Conclusion: Compared with UH, LH has a lesser effect on lipid metabolism, suggesting that it also has a lesser effect on carnitine metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Prevalence of germline BRCA1/2 pathogenic variants in Japanese patients treated with castration-resistant prostate cancer and efficacy of CRPC treatment in real-world clinical practice.

Author

Maekawa, Shigekatsu, Takata, Ryo, Sekiguchi, Kie, Kagabu, Masahiro, Toyoshima, Moe, Tamada, Shinji, Takahashi, Kenta, Ikarashi, Daiki, Matsuura, Tomohiko, Kato, Renpei, Kato, Yoichiro, Kanehira, Mitsugu, Sugimura, Jun, Abe, Takaya, Baba, Tsukasa, and Obara, Wataru

Published
2024
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23. Sunitinib Versus Sorafenib as Initial Targeted Therapy for mCC-RCC With Favorable/Intermediate Risk: Multicenter Randomized Trial CROSS-J-RCC

Author

Tomita, Yoshihiko, Naito, Sei, Sassa, Naoto, Takahashi, Atsushi, Kondo, Tsunenori, Koie, Takuya, Obara, Wataru, Kobayashi, Yasuyuki, Teishima, Jun, Takahashi, Masayuki, Matsuyama, Hideyasu, Ueda, Takeshi, Yamaguchi, Kenya, Kishida, Takeshi, Shiroki, Ryoichi, Saika, Takashi, Shinohara, Nobuo, Oya, Mototsugu, and Kanayama, Hiro-omi

Published
2020
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24. Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

Author

Wong, Suet-Lai Shirley, Tan, Thean Hsiang, Hovey, Elizabeth Jane, Clay, Timothy Dudley, Wan Ng, Siobhan Su, Rutten, Annemie, Machiels, Jean-Pascal, Dumez, Herlinde, Cheng, Susanna Yee-Shan, Ferrario, Cristiano, Sengeloev, Lisa, Jensen, Niels Viggo, Thibault, Constance, Laguerre, Brigitte, Joly, Florence, Culine, Stéphane, Becht, Catherine, Niegisch, Günter, Stöckle, Michael, Grimm, Marc-Oliver, Schwentner, Christina A, Schultze-Seemann, Wolfgang, Kalofonos, Haralambos, Mavroudis, Dimitrios, Papandreou, Christos, Karavasilis, Vasilis, Révész, Janos, Rosenbaum, Eli, Leibowitz-Amit, Raya, Kejzman, Daniel, Sarid, David, Scagliotti, Giorgio Vittorio, Bracarda, Sergio, Massari, Francesco, Osawa, Takahiro, Miyajima, Naoto, Shinohara, Nobuo, Fukuta, Fumimasa, Ohyama, Chikara, Obara, Wataru, Yamashita, Shinichi, Tomita, Yoshihiko, Kawai, Koji, Fukasawa, Satoshi, Oyama, Masafumi, Yonese, Junji, Nagata, Masayoshi, Uemura, Motohide, Nishimura, Kazuo, Kawakita, Mutsushi, Tsunemori, Hiroyuki, Hashine, Katsuyoshi, Inokuchi, Junichi, Yokomizo, Akira, Nagamori, Satoshi, Lee, Hyo Jin, Park, Se Hoon, Rha, Sun Young, Kim, Yu Jung, Lee, Yun-Gyoo, Vazquez Cortés, Leticia, Lorena Urzua Flores, Claudia, Blaisse, Reinoud J.B., Erdkamp, Fransiscus L.G., Aarts, Maureen J.B., Wojcik-Tomaszewska, Joanna, Tomczak, Piotr, Sikora-Kupis, Bozena, Schenker, Michael, Herzal, Alina Amalia, Udrea, Anghel Adrian, Karlov, Petr, Fomkin, Roman, Gajate Borau, Pablo, Grande, Enrique, Delgado Mignorance, Juan Ignacio, Su, Yu-Li, Li, Jian-Ri, Lin, Chien-Liang, Lin, Chia-Chi, Yeh, Su-Peng, Erman, Mustafa, Urun, Yuksel, Golovko, Yuriy, Bondarenko, Igor, Sinielnikov, Ivan, Crabb, Simon J., Syndikus, Isabel, Huddart, Robert, Sundar, Santhanam, Chowdhury, Simon, Sarwar, Naveed, Flaig, Thomas W., Pan, Chong Xian, Schwarz, James K., Cultrera, Jennifer Lyn, Acs, Peter Istvan, Hainsworth, John D., Herms, Benjamin T., Lawler, William Eyre, Lowe, Thomas Eugene, Petrylak, Daniel P, de Wit, Ronald, Chi, Kim N, Drakaki, Alexandra, Sternberg, Cora N, Nishiyama, Hiroyuki, Castellano, Daniel, Hussain, Syed A, Fléchon, Aude, Bamias, Aristotelis, Yu, Evan Y, van der Heijden, Michiel S, Matsubara, Nobuaki, Alekseev, Boris, Necchi, Andrea, Géczi, Lajos, Ou, Yen-Chuan, Coskun, Hasan Senol, Su, Wen-Pin, Bedke, Jens, Gakis, Georgios, Percent, Ivor J, Lee, Jae-Lyun, Tucci, Marcello, Semenov, Andrey, Laestadius, Fredrik, Peer, Avivit, Tortora, Giampaolo, Safina, Sufia, Garcia del Muro, Xavier, Rodriguez-Vida, Alejo, Cicin, Irfan, Harputluoglu, Hakan, Tagawa, Scott T, Vaishampayan, Ulka, Aragon-Ching, Jeanny B, Hamid, Oday, Liepa, Astra M, Wijayawardana, Sameera, Russo, Francesca, Walgren, Richard A, Zimmermann, Annamaria H, Hozak, Rebecca R, Bell-McGuinn, Katherine M, and Powles, Thomas

Published
2020
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26. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Author

Ishigaki, Kazuyoshi, Akiyama, Masato, Kanai, Masahiro, Takahashi, Atsushi, Kawakami, Eiryo, Sugishita, Hiroki, Sakaue, Saori, Matoba, Nana, Low, Siew-Kee, Okada, Yukinori, Terao, Chikashi, Amariuta, Tiffany, Gazal, Steven, Kochi, Yuta, Horikoshi, Momoko, Suzuki, Ken, Ito, Kaoru, Koyama, Satoshi, Ozaki, Kouichi, Niida, Shumpei, Sakata, Yasushi, Sakata, Yasuhiko, Kohno, Takashi, Shiraishi, Kouya, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Ikeda, Masashi, Iwata, Nakao, Ikegawa, Shiro, Kou, Ikuyo, Tanaka, Toshihiro, Nakagawa, Hidewaki, Suzuki, Akari, Hirota, Tomomitsu, Tamari, Mayumi, Chayama, Kazuaki, Miki, Daiki, Mori, Masaki, Nagayama, Satoshi, Daigo, Yataro, Miki, Yoshio, Katagiri, Toyomasa, Ogawa, Osamu, Obara, Wataru, Ito, Hidemi, Yoshida, Teruhiko, Imoto, Issei, Takahashi, Takashi, Tanikawa, Chizu, Suzuki, Takao, Sinozaki, Nobuaki, Minami, Shiro, Yamaguchi, Hiroki, Asai, Satoshi, Takahashi, Yasuo, Yamaji, Ken, Takahashi, Kazuhisa, Fujioka, Tomoaki, Takata, Ryo, Yanai, Hideki, Masumoto, Akihide, Koretsune, Yukihiro, Kutsumi, Hiromu, Higashiyama, Masahiko, Murayama, Shigeo, Minegishi, Naoko, Suzuki, Kichiya, Tanno, Kozo, Shimizu, Atsushi, Yamaji, Taiki, Iwasaki, Motoki, Sawada, Norie, Uemura, Hirokazu, Tanaka, Keitaro, Naito, Mariko, Sasaki, Makoto, Wakai, Kenji, Tsugane, Shoichiro, Yamamoto, Masayuki, Yamamoto, Kazuhiko, Murakami, Yoshinori, Nakamura, Yusuke, Raychaudhuri, Soumya, Inazawa, Johji, Yamauchi, Toshimasa, Kadowaki, Takashi, Kubo, Michiaki, and Kamatani, Yoichiro

Published
2020
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32. Association between nocturnal polyuria and 24‐h blood pressure fluctuations in males with lower urinary tract symptoms: A multicenter prospective study.

Author

Kato, Yoichiro, Akaihata, Hidenori, Takezawa, Kentaro, Maekawa, Shigekatsu, Matsuoka, Kanako, Fukuhara, Shinichiro, Kato, Renpei, Kojima, Yoshiyuki, Nonomura, Norio, and Obara, Wataru

Subjects
POLYURIA, NOCTURIA, BLOOD pressure, URINARY organs, DIASTOLIC blood pressure, SYSTOLIC blood pressure
Abstract

Objectives: Nocturnal polyuria (NP) is one of the causes of nocturia that impairs quality of life. It is necessary to consider that NP is latent when the initial treatment for nocturia is unsatisfactory. Therefore, it is important to establish a treatment for NP based on the pathophysiology. We have previously reported the relationship between NP and fluctuation in blood pressure. The present study aimed to investigate the association between NP and 24‐h blood pressure fluctuations in a multicenter prospective study. Methods: This study included male patients with lower urinary tract symptoms. We categorized the patients into the nonnocturnal polyuria (non‐NP) group (≤0.33) and the NP group (>0.33) based on the nocturnal polyuria index from the frequency volume chart. We measured the 24‐h diurnal blood pressure and compared the two groups. Results: Among 90 patients, 46 in the non‐NP group and 44 in the NP group were included. There was no significant difference in the systolic and diastolic blood pressure during waking time between the two groups; however, the degree of systolic blood pressure reduction during sleep time in the NP group was significantly less than that in the non‐NP group (p = 0.039). In the multivariate analysis, systolic BP during sleep was significantly associated with NP (OR 0.970, p = 0.028). Conclusion: NP is associated with inadequate nocturnal blood pressure reduction in males, suggesting that reduction in nocturnal blood pressure may lead to improvement in nocturia. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Postoperative recurrence detection using individualized circulating tumor DNA in upper tract urothelial carcinoma.

Author

Tamura, Daichi, Abe, Masakazu, Hiraki, Hayato, Sasaki, Noriyuki, Yashima‐Abo, Akiko, Ikarashi, Daiki, Kato, Renpei, Kato, Yoichiro, Maekawa, Shigekatsu, Kanehira, Mitsugu, Takata, Ryo, Maejima, Kazuhiro, Sasagawa, Shota, Fujita, Masashi, Suzuki, Yutaka, Nakagawa, Hidewaki, Iwaya, Takeshi, Nishizuka, Satoshi S., and Obara, Wataru

Abstract

Biomarkers that could detect the postoperative recurrence of upper tract urothelial carcinoma (UTUC) have not been established. In this prospective study, we aim to evaluate the utility of individualized circulating tumor DNA (ctDNA) monitoring using digital PCR (dPCR) as a tumor recurrence biomarker for UTUC in the perioperative period. Twenty‐three patients who underwent radical nephroureterectomy (RNU) were included. In each patient, whole exome sequencing by next‐generation sequencing and TERT promoter sequencing of tumor DNA were carried out. Case‐specific gene mutations were selected from sequencing analysis to examine ctDNA by dPCR analysis. We also prospectively collected plasma and urine ctDNA from each patient. The longitudinal variant allele frequencies of ctDNA during the perioperative period were plotted. Case‐specific gene mutations were detected in 22 cases (96%) from ctDNA in the preoperative samples. Frequently detected genes were TERT (39%), FGFR3 (26%), TP53 (22%), and HRAS (13%). In all cases, we obtained plasma and urine samples for 241 time points and undertook individualized ctDNA monitoring for 2 years after RNU. Ten patients with intravesical recurrence had case‐specific ctDNA detected in urine at the time of recurrence. The mean lead time of urinary ctDNA in intravesical recurrence was 60 days (range, 0–202 days). Two patients with distal metastasis had case‐specific ctDNA in plasma at the time of metastasis. In UTUC, tumor‐specific gene mutations can be monitored postoperatively as ctDNA in plasma and urine. Individualized ctDNA might be a minimally invasive biomarker for the early detection of postoperative recurrence. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Molecular Mechanisms of Prostate Cancer Development in the Precision Medicine Era: A Comprehensive Review.

Author

Maekawa, Shigekatsu, Takata, Ryo, and Obara, Wataru

Subjects
DISEASE progression, SEQUENCE analysis, IMMUNE checkpoint inhibitors, INDIVIDUALIZED medicine, MICRORNA, DRUG resistance, CELLULAR signal transduction, CASTRATION-resistant prostate cancer, CELL cycle, GENOMICS, ANDROGEN receptors, TUMOR markers, DNA repair, PROSTATE tumors, MEDICAL research, EPIGENOMICS, DISEASE risk factors
Abstract

Simple Summary: Prostate cancer (PCa) is characterized by various genomic alterations that play a pivotal role in carcinogenesis. Efforts in precision medicine aimed at improving diagnosis, prevention, and surveillance based on genetic alterations are advancing. Notably, no tumor markers surpass prostate-specific antigen in specificity, and existing treatments primarily target the androgen receptor axis, with exceptions for patients with alterations in homologous recombination repair-related genes, such as BRCA1/2 and ATM, who may benefit from poly (ADP-ribose) polymerase inhibitors. In order to delineate the current state of research on PCa, we provide an overview of cutting-edge genomic research, including genome alterations, cancer immunology, and non-coding RNAs, in PCa. These aspects are relevant to comprehending the molecular mechanisms underlying health disparities, PCa initiation and progression, and drug resistance in the precision medicine era. The progression of prostate cancer (PCa) relies on the activation of the androgen receptor (AR) by androgens. Despite efforts to block this pathway through androgen deprivation therapy, resistance can occur through several mechanisms, including the abnormal activation of AR, resulting in castration-resistant PCa following the introduction of treatment. Mutations, amplifications, and splicing variants in AR-related genes have garnered attention in this regard. Furthermore, recent large-scale next-generation sequencing analysis has revealed the critical roles of AR and AR-related genes, as well as the DNA repair, PI3K, and cell cycle pathways, in the onset and progression of PCa. Moreover, research on epigenomics and microRNA has increasingly become popular; however, it has not translated into the development of effective therapeutic strategies. Additionally, treatments targeting homologous recombination repair mutations and the PI3K/Akt pathway have been developed and are increasingly accessible, and multiple clinical trials have investigated the efficacy of immune checkpoint inhibitors. In this comprehensive review, we outline the status of PCa research in genomics and briefly explore potential future developments in the field of epigenetic modifications and microRNAs. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Nivolumab in patients with unresectable locally advanced or metastatic urothelial carcinoma: CheckMate 275 2-year global and Japanese patient population analyses

Author

Ohyama, Chikara, Kojima, Takahiro, Kondo, Tsunenori, Naya, Yoshio, Inoue, Takamitsu, Tomita, Yoshihiko, Eto, Masatoshi, Hisasue, Shinichi, Uemura, Hirotsugu, Obara, Wataru, Kikuchi, Eiji, Sharma, Padmanee, Galsky, Matthew D., Siefker-Radtke, Arlene, Grossfeld, Gary, Collette, Sandra, Gooden, Kyna, and Kimura, Go

Published
2019
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39. Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

Author

Wong, Suet-Lai Shirley, Tan, Thean Hsiang, Hovey, Elizabeth Jane, Clay, Timothy Dudley, Ng, Siobhan Su Wan, Rutten, Annemie, Machiels, Jean-Pascal, Dumez, Herlinde, Cheng, Susanna Yee-Shan, Chi, Kim Nguyen, Ferrario, Cristiano, Sengeloev, Lisa, Jensen, Niels Viggo, Thibault, Constance, Laguerre, Brigitte, Laestadius, Fredrik, Joly, Florence, Flechon, Aude, Culine, Stéphane, Becht, Catherine, Niegisch, Günter, Stöckle, Michael, Grimm, Marc-Oliver, Gakis, Georgios, Schultze-Seemann, Wolfgang, Kalofonos, Haralambos, Mavroudis, Dimitrios, Papandreou, Christos, Karavasilis, Vasilis, Bamias, Aristotelis, Révész, Janos, Geczi, Lajos, Rosenbaum, Eli, Leibowitz-Amit, Raya, Kejzman, Daniel, Peer, Avivit, Sarid, David, Scagliotti, Giorgio Vittorio, Sternberg, Cora N, Tortora, Giampaolo, Bracarda, Sergio, Necchi, Andrea, Massari, Francesco, Osawa, Takahiro, Miyajima, Naoto, Shinohara, Nobuo, Fukuta, Fumimasa, Ohyama, Chikara, Obara, Wataru, Yamashita, Shinichi, Tomita, Yoshihiko, Kawai, Koji, Fukasawa, Satoshi, Matsubara, Nobuaki, Oyama, Masafumi, Yonese, Junji, Nagata, Masayoshi, Uemura, Motohide, Nishimura, Kazuo, Kawakita, Mutsushi, Tsunemori, Hiroyuki, Hashine, Katsuyoshi, Inokuchi, Junichi, Yokomizo, Akira, Nagamori, Satoshi, Lee, Jae-Lyun, Lee, Hyo Jin, Park, Se Hoon, Rha, Sun Young, Kim, Yu Jung, Lee, Yun-Gyoo, Cortés, Leticia Vazquez, Flores, Claudia Lorena Urzua, Blaisse, Reinoud J B, van der Heijden, Michiel S, de Wit, Ronald, Erdkamp, Fransiscus L G, Aarts, Maureen J B, Wojcik-Tomaszewska, Joanna, Tomczak, Piotr, Sikora-Kupis, Bozena, Schenker, Michael, Herzal, Alina Amalia, Udrea, Anghel Adrian, Karlov, Petr, Safina, Sufia Z, Alekseev, Boris, Semenov, Andrey, Fomkin, Roman, Pulido, Enrique Grande, Del Muro, F Xavier García, Mignorance, Juan Ignacio Delgado, Gauna, Daniel Castellano, Rodríguez-Vida, Alejo, Su, Yu-Li, Ou, Yen-Chuan, Lin, Chien-Liang, Su, Wen-Pin, Lin, Chia-Chi, Yeh, Su-Peng, Çiçin, Irfan, Harputluoglu, Hakan, Erman, Mustafa, Coskun, Hasan Senol, Urun, Yuksel, Golovko, Yurii, Bondarenko, Igor, Sinielnikov, Ivan, Powles, Thomas, Crabb, Simon, Syndikus, Isabel, Huddart, Robert, Sundar, Santhanam, Chowdhury, Simon, Sarwar, Naveed, Drakaki, Alexandra, Flaig, Thomas, Pan, Chong Xian, Petrylak, Daniel, Schwarz, James, Percent, Ivor, Cultrera, Jennifer, Hainsworth, John, Herms, Benjamin, Lawler, William, Lowe, Thomas, Tagawa, Scott, Aragon-Ching, Jeanny, Vaishampayan, Ulka, Petrylak, Daniel P, Chi, Kim N, Nishiyama, Hiroyuki, Castellano, Daniel, Hussain, Syed, Fléchon, Aude, Yu, Evan Y, Géczi, Lajos, Hegemann, Miriam, Percent, Ivor J, Tucci, Marcello, Safina, Sufia, del Muro, Xavier Garcia, Rodriguez-Vida, Alejo, Cicin, Irfan, Widau, Ryan C, Liepa, Astra M, Walgren, Richard A, Hamid, Oday, Zimmermann, Annamaria H, and Bell-McGuinn, Katherine M

Published
2017
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40. Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan

Author

Matsu-bayashi, Sunao, Harada, Hiromasa, Misumi, Kazuo, Komi, Rieko, Minami, Shiro, Sugihara, Hitoshi, Emoto, Naoya, Kanazawa, Akio, Suzuki, Yusuke, Hiratsuka, Yoshimune, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Ugi, Satoshi, Maegawa, Hiroshi, Koretsune, Yukihiro, Taki, Hideki, Osawa, Takeshi, Yokomichi, Hiroshi, Nagai, Akiko, Hirata, Makoto, Kiyohara, Yutaka, Muto, Kaori, Ninomiya, Toshiharu, Matsuda, Koichi, Kamatani, Yoichiro, Tamakoshi, Akiko, Kubo, Michiaki, Nakamura, Yusuke, and Yamagata, Zentaro

Published
2017
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41. Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan

Author

Misumi, Kazuo, Iha, Kiyoshi, Matsubayashi, Sunao, Matsuura, Kei, Minami, Shiro, Sugihara, Hitoshi, Kodani, Eitaro, Tamura, Naoto, Matsushita, Masakazu, Gotoh, Akihiko, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Ugi, Satoshi, Maegawa, Hiroshi, Koretsune, Yukihiro, Kusuoka, Hideo, Okumura, Masao, Yokomichi, Hiroshi, Noda, Hokuto, Nagai, Akiko, Hirata, Makoto, Tamakoshi, Akiko, Kamatani, Yoichiro, Kiyohara, Yutaka, Matsuda, Koichi, Muto, Kaori, Ninomiya, Toshiharu, Kubo, Michiaki, Nakamura, Yusuke, and Yamagata, Zentaro

Published
2017
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42. Overview of BioBank Japan follow-up data in 32 diseases

Author

Shiono, Masaki, Misumi, Kazuo, Kaieda, Reiji, Harada, Hiromasa, Minami, Shiro, Watanabe, Atsushi, Emoto, Naoya, Takahashi, Kazuhisa, Takeda, Satoru, Funaki, Toshinari, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Sugimoto, Yoshihisa, Koretsune, Yukihiro, Kusuoka, Hideo, Yoshimori, Kozo, Hirata, Makoto, Nagai, Akiko, Kamatani, Yoichiro, Ninomiya, Toshiharu, Tamakoshi, Akiko, Yamagata, Zentaro, Kubo, Michiaki, Muto, Kaori, Kiyohara, Yutaka, Mushiroda, Taisei, Murakami, Yoshinori, Yuji, Koichiro, Furukawa, Yoichi, Zembutsu, Hitoshi, Tanaka, Toshihiro, Ohnishi, Yozo, Nakamura, Yusuke, and Matsuda, Koichi

Published
2017
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43. Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project

Author

Harada, Hiromasa, Hibino, Makoto, Okuyama, Atsushi, Kano, Nobuyasu, Minami, Shiro, Genma, Akihiko, Usuda, Jitsuo, Suzuki, Kenji, Sekiya, Mitsuaki, Takeda, Satoru, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Tezuka, Noriaki, Nakano, Yasutaka, Koretsune, Yukihiro, Ogawara, Mitsumasa, Yamana, Kazunari, Nakamura, Koshi, Ukawa, Shigekazu, Okada, Emiko, Hirata, Makoto, Nagai, Akiko, Yamagata, Zentaro, Ninomiya, Toshiharu, Muto, Kaori, Kiyohara, Yutaka, Matsuda, Koichi, Kamatani, Yoichiro, Kubo, Michiaki, Nakamura, Yusuke, and Tamakoshi, Akiko

Published
2017
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44. Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project

Author

Ono, Wataru, Harada, Hiromasa, Kawamoto, Shunji, Shinozaki, Nobuaki, Minami, Shiro, Yamada, Takeshi, Suzuki, Hideyuki, Sakamoto, Kazuhiro, Kaneko, Kazuo, Ohba, Shinichi, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Shimizu, Tomoharu, Naka, Shigeyuki, Koretsune, Yukihiro, Sekimoto, Mitsugu, Kokuto, Hiroyuki, Tamakoshi, Akiko, Nakamura, Koshi, Ukawa, Shigekazu, Okada, Emiko, Hirata, Makoto, Nagai, Akiko, Matsuda, Koichi, Kamatani, Yoichiro, Muto, Kaori, Kiyohara, Yutaka, Yamagata, Zentaro, Ninomiya, Toshiharu, Kubo, Michiaki, and Nakamura, Yusuke

Published
2017
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45. Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases

Author

Shiono, Masaki, Misumi, Kazuo, Kaieda, Reiji, Harada, Hiromasa, Minami, Shiro, Emi, Mitsuru, Emoto, Naoya, Arai, Hajime, Yamaji, Ken, Hiratsuka, Yoshimune, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Sugimoto, Yoshihisa, Koretsune, Yukihiro, Kusuoka, Hideo, Yoshiyama, Takashi, Hirata, Makoto, Kamatani, Yoichiro, Nagai, Akiko, Kiyohara, Yutaka, Ninomiya, Toshiharu, Tamakoshi, Akiko, Yamagata, Zentaro, Kubo, Michiaki, Muto, Kaori, Mushiroda, Taisei, Murakami, Yoshinori, Yuji, Koichiro, Furukawa, Yoichi, Zembutsu, Hitoshi, Tanaka, Toshihiro, Ohnishi, Yozo, Nakamura, Yusuke, and Matsuda, Koichi

Published
2017
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46. Characteristics of patients with liver cancer in the BioBank Japan project

Author

Harada, Hiromasa, Kaneko, Kiyoshi, Matsumoto, Shuichi, Shiono, Masaki, Minami, Shiro, Yoshida, Hiroshi, Taniai, Nobuhiko, Watanabe, Sumio, Fujiwara, Noriko, Yamataka, Atsuyuki, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Naka, Shigeyuki, Endo, Yoshihiro, Koretsune, Yukihiro, Mita, Eiji, Morimoto, Kozo, Ukawa, Shigekazu, Okada, Emiko, Nakamura, Koshi, Hirata, Makoto, Nagai, Akiko, Matsuda, Koichi, Yamagata, Zentaro, Kamatani, Yoichiro, Ninomiya, Toshiharu, Kiyohara, Yutaka, Muto, Kaori, Kubo, Michiaki, Nakamura, Yusuke, and Tamakoshi, Akiko

Published
2017
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47. Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort

Author

Harada, Hiromasa, Matsubayashi, Sunao, Komi, Rieko, Misumi, Kazuo, Minami, Shiro, Sugihara, Hitoshi, Kodani, Eitaro, Kanazawa, Akio, Gotoh, Hiromasa, Haruna, Hidenori, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Ugi, Satoshi, Araki, Shinichi, Koretsune, Yukihiro, Taki, Hideki, Nakagawa, Takayuki, Yokomichi, Hiroshi, Nagai, Akiko, Hirata, Makoto, Kiyohara, Yutaka, Muto, Kaori, Ninomiya, Toshiharu, Matsuda, Koichi, Kamatani, Yoichiro, Tamakoshi, Akiko, Kubo, Michiaki, Nakamura, Yusuke, and Yamagata, Zentaro

Published
2017
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48. Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project

Author

Shimoyama, Rai, Maekawa, Koichi, Kaneko, Kiyoshi, Harada, Hiromasa, Minami, Shiro, Takei, Hiroyuki, Saito, Mitsue, Terao, Yasuhisa, Takeda, Satoru, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Abe, Hajime, Shimizu, Tomoharu, Koretsune, Yukihiro, Masuda, Norikazu, Takeda, Yasutaka, Nakamura, Koshi, Okada, Emiko, Ukawa, Shigekazu, Hirata, Makoto, Nagai, Akiko, Yamagata, Zentaro, Kiyohara, Yutaka, Muto, Kaori, Kamatani, Yoichiro, Ninomiya, Toshiharu, Matsuda, Koichi, Kubo, Michiaki, Nakamura, Yusuke, and Tamakoshi, Akiko

Published
2017
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49. Statin use and all-cause and cancer mortality: BioBank Japan cohort

Author

Misumi, Kazuo, Higa, Nobuyoshi, Matsubayashi, Sunao, Matsuura, Kei, Minami, Shiro, Sugihara, Hitoshi, Emoto, Naoya, Ohmura, Hirotoshi, Inui, Akihiro, Ogasawara, Michihiro, Asai, Satoshi, Moriyama, Mitsu- hiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Ugi, Satoshi, Maegawa, Hiroshi, Koretsune, Yukihiro, Kusuoka, Hideo, Ueyama, Masako, Yokomichi, Hiroshi, Nagai, Akiko, Hirata, Makoto, Tamakoshi, Akiko, Kiyohara, Yutaka, Kamatani, Yoichiro, Muto, Kaori, Ninomiya, Toshiharu, Matsuda, Koichi, Kubo, Michiaki, Nakamura, Yusuke, and Yamagata, Zentaro

Published
2017
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50. Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project

Author

Shimoyama, Rai, Makimoto, Shinichiro, Harada, Hiromasa, Fujikawa, Tomoaki, Minami, Shiro, Uchida, Eiji, Miyashita, Masao, Kajiyama, Yoshiaki, Tomita, Natsumi, Nagahara, Akihito, Asai, Satoshi, Moriyama, Mitsuhiko, Takahashi, Yasuo, Fujioka, Tomoaki, Obara, Wataru, Mori, Seijiro, Ito, Hideki, Nagayama, Satoshi, Miki, Yoshio, Masumoto, Akihide, Yamada, Akira, Nishizawa, Yasuko, Kodama, Ken, Ban, Hiromitsu, Murata, Satoshi, Koretsune, Yukihiro, Hirao, Motohiro, Ogata, Hideo, Okada, Emiko, Ukawa, Shigekazu, Nakamura, Koshi, Hirata, Makoto, Nagai, Akiko, Matsuda, Koichi, Ninomiya, Toshiharu, Kiyohara, Yutaka, Muto, Kaori, Kamatani, Yoichiro, Yamagata, Zentaro, Kubo, Michiaki, Nakamura, Yusuke, and Tamakoshi, Akiko

Published
2017
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