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Errors occur rather commonly in the differential diagnosis of respiratory diseases accompanied by X-ray lung tissue changes as foci and infiltration. Infiltrative and disseminated pulmonary tuberculosis, lung cancer, and pneumonia constitute a high proportion among the detected concurrent lung diseases. The rate of diagnostic discordance for these lung abnormalities accounts for more than 30%; and the diagnosis period for an infiltrative lung process lasts 2–3 weeks in 20% of cases and above 1–3 months in 80%. In particular, clinicians are faced with great difficulties in diagnosing aspiration pneumonia; this is due to that its X-ray manifestations are not purely specific and they are characterized by the parenchymal (alveolar) infiltration oflung tissue with a varying extent of lung inflammation.This paper describes a clinical case of a patient with salivary gland adenocarcinomaand focal infiltrative lung changes. Diagnostic difficulties have emerged in establishing the genesis of the changes in the lung.

In vitro and in vivo preclinical studies of the antituberculosis activity of thiozonide designed at the ZAO “Farn-Sintez” (Moscow) were conducted at the Central Research of Tuberculosis, Russian Academy of Medical Sciences. The in vitro study indicated that thiozonide exerted an antimycobacterial effect that was comparable with the inhibitory activity of isoniazid (INH) and rifampicin (RIF) suppressed the growth of a cultured virulent laboratory M. tuberculosis H37Rv strain that was susceptible to all antituberculosis drugs, a cultured M. tuberculosis CN-40 strain that was monoresistant to INH, and a cultured M. tuberculosis MS-115 strain that was multidrug resistant The in vivo study established that the survival of the experimental animals receiving thiozonide monotherapy did not differ from that of the animals given INH and RIF. Combined therapy with thiozonide and ethionamide (ETH) and that with thiozonide and pyrazinamide (PZA) versus PZA or ETH monotherapy caused a significant increase in the survival of the experimental animals in these groups. M. tuberculosis colonyforming units in the lung of the experimental mice taking thiozonide suggested that the drug administered in vivo in a dose of 25 mg/kg produced an effective antituberculous effect that was comparable with those in the lung of the animals receiving RIF in the same dose.

The paper describes the most common reproductive health problems in women with active respiratory organ tuberculosis during their hospital stay. The toxic effect of tuberculosis infection and the long-term use of drugs favor the development of a number of female genital diseases (external and internal genital inflammatory diseases, menstrual irregularities) that should be corrected with specialized treatment and menstrual cycle regulation. The timely, rationally chosen chemotherapy prevents genital tuberculosis.