Search

Your search keyword '"Newman, Stuart A."' showing total 379 results
Start Over Author "Newman, Stuart A." Publication Type Academic Journals
379 results on '"Newman, Stuart A."'

4. A resource of targeted mutant mouse lines for 5,061 genes

Author

Birling, Marie-Christine, Yoshiki, Atsushi, Adams, David J, Ayabe, Shinya, Beaudet, Arthur L, Bottomley, Joanna, Bradley, Allan, Brown, Steve DM, Bürger, Antje, Bushell, Wendy, Chiani, Francesco, Chin, Hsian-Jean Genie, Christou, Skevoulla, Codner, Gemma F, DeMayo, Francesco J, Dickinson, Mary E, Doe, Brendan, Donahue, Leah Rae, Fray, Martin D, Gambadoro, Alessia, Gao, Xiang, Gertsenstein, Marina, Gomez-Segura, Alba, Goodwin, Leslie O, Heaney, Jason D, Hérault, Yann, de Angelis, Martin Hrabe, Jiang, Si-Tse, Justice, Monica J, Kasparek, Petr, King, Ruairidh E, Kühn, Ralf, Lee, Ho, Lee, Young Jae, Liu, Zhiwei, Lloyd, KC Kent, Lorenzo, Isabel, Mallon, Ann-Marie, McKerlie, Colin, Meehan, Terrence F, Fuentes, Violeta Munoz, Newman, Stuart, Nutter, Lauryl MJ, Oh, Goo Taeg, Pavlovic, Guillaume, Ramirez-Solis, Ramiro, Rosen, Barry, Ryder, Edward J, Santos, Luis A, Schick, Joel, Seavitt, John R, Sedlacek, Radislav, Seisenberger, Claudia, Seong, Je Kyung, Skarnes, William C, Sorg, Tania, Steel, Karen P, Tamura, Masaru, Tocchini-Valentini, Glauco P, Wang, Chi-Kuang Leo, Wardle-Jones, Hannah, Wattenhofer-Donzé, Marie, Wells, Sara, Wiles, Michael V, Willis, Brandon J, Wood, Joshua A, Wurst, Wolfgang, Xu, Ying, Teboul, Lydia, and Murray, Stephen A

Subjects
Biological Sciences, Genetics, Infectious Diseases, Biotechnology, 2.1 Biological and endogenous factors, Animals, Gene Deletion, Genetic Association Studies, Genome, Genotype, Information Dissemination, International Cooperation, Internet, Mice, Mice, Knockout, Mouse Embryonic Stem Cells, Mutagenesis, Phenotype, International Mouse Phenotyping Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes, including 2,850 novel null, 2,987 novel conditional- ready, and 4,433 novel reporter alleles.

Published
2021

5. CRISPR REGULATION

Author

Darnovsky, Marcy, Comfort, Nathaniel, Alkuraya, Fowzan S., Newman, Stuart A., Stevens, Tina, and de Vries, Jantina

Published
2019

6. Reference-Quality Emission and Backscatter Modeling for the Ocean

Author

English, Stephen, Prigent, Catherine, Johnson, Ben, Yueh, Simon, Dinnat, Emmanuel, Boutin, Jacqueline, Newman, Stuart, Anguelova, Magdalena, Meissner, Thomas, Kazumori, Masahiro, Weng, Fuzhong, Supply, Alexandre, Kilic, Lise, Bettenhausen, Michael, Stoffelen, Ad, and Accadia, Christophe

Published
2020

10. High-throughput discovery of novel developmental phenotypes

Author

McKay, Matthew, Urban, Barbara, Lund, Caroline, Froeter, Erin, LaCasse, Taylor, Mehalow, Adrienne, Gordon, Emily, Donahue, Leah Rae, Taft, Robert, Kutney, Peter, Dion, Stephanie, Goodwin, Leslie, Kales, Susan, Urban, Rachel, Palmer, Kristina, Pertuy, Fabien, Bitz, Deborah, Weber, Bruno, Goetz-Reiner, Patrice, Jacobs, Hughes, Le Marchand, Elise, El Amri, Amal, El Fertak, Leila, Ennah, Hamid, Ali-Hadji, Dalila, Ayadi, Abdel, Wattenhofer-Donze, Marie, Jacquot, Sylvie, André, Philippe, Birling, Marie-Christine, Pavlovic, Guillaume, Sorg, Tania, Morse, Iva, Benso, Frank, Stewart, Michelle E, Copley, Carol, Harrison, Jackie, Joynson, Samantha, Guo, Ruolin, Qu, Dawei, Spring, Shoshana, Yu, Lisa, Ellegood, Jacob, Morikawa, Lily, Shang, Xueyuan, Feugas, Pat, Creighton, Amie, Castellanos Penton, Patricia, Danisment, Ozge, Griggs, Nicola, Tudor, Catherine L, Green, Angela L, Icoresi Mazzeo, Cecilia, Siragher, Emma, Lillistone, Charlotte, Tuck, Elizabeth, Gleeson, Diane, Sethi, Debarati, Bayzetinova, Tanya, Burvill, Jonathan, Habib, Bishoy, Weavers, Lauren, Maswood, Ryea, Miklejewska, Evelina, Woods, Michael, Grau, Evelyn, Newman, Stuart, Sinclair, Caroline, Brown, Ellen, Ayabe, Shinya, Iwama, Mizuho, and Murakami, Ayumi

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Genetics, Biotechnology, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Animals, Conserved Sequence, Disease, Embryo, Mammalian, Genes, Essential, Genes, Lethal, Genome-Wide Association Study, High-Throughput Screening Assays, Humans, Imaging, Three-Dimensional, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Penetrance, Phenotype, Polymorphism, Single Nucleotide, Sequence Homology, International Mouse Phenotyping Consortium, Jackson Laboratory, Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris, Charles River Laboratories, MRC Harwell, Toronto Centre for Phenogenomics, Wellcome Trust Sanger Institute, RIKEN BioResource Center, General Science & Technology
Abstract

Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,000 knockout mouse lines, here we identify 410 lethal genes during the production of the first 1,751 unique gene knockouts. Using a standardized phenotyping platform that incorporates high-resolution 3D imaging, we identify phenotypes at multiple time points for previously uncharacterized genes and additional phenotypes for genes with previously reported mutant phenotypes. Unexpectedly, our analysis reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background. In addition, we show that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts.

Published
2016

11. A call to action for translational sciences in COVID-19 and future pandemics

Author

Wan, Kanny K., Davis, Danielle, Lee, Taylor N., Ford-Scheimer, Stephanie L., Andreu, Antonio L., Bietrix, Florence, Bryans, Justin, Castro, Marco T., Chiba, Nobuyoshi, Faupel-Badger, Jessica M., Haynes, Brittany, Hirasawa, Ryutaro, Morel, Carlos M., Souza, Thiago Moreno L., Morrow, David, Munro, Trent, Newman, Stuart, Ussi, Anton E., Zorzal, Poliana B., Hall, Matthew D., Lo, Donald C., and Cutillo, Christine M.

Published
2022
Full Text
View/download PDF

15. Bare bones pattern formation: a core regulatory network in varying geometries reproduces major features of vertebrate limb development and evolution.

Author

Zhu, Jianfeng, Zhang, Yong-Tao, Alber, Mark S, and Newman, Stuart A

Subjects
Extremities, Bone and Bones, Ectoderm, Animals, Vertebrates, Chickens, Body Patterning, Kinetics, Models, Biological, Fossils, Computer Simulation, Gene Regulatory Networks, Limb Buds, Biological Evolution, Wings, Animal, Wing, Models, Biological, Wings, Animal, General Science & Technology
Abstract

BackgroundMajor unresolved questions regarding vertebrate limb development concern how the numbers of skeletal elements along the proximodistal (P-D) and anteroposterior (A-P) axes are determined and how the shape of a growing limb affects skeletal element formation. There is currently no generally accepted model for these patterning processes, but recent work on cartilage development (chondrogenesis) indicates that precartilage tissue self-organizes into nodular patterns by cell-molecular circuitry with local auto-activating and lateral inhibitory (LALI) properties. This process is played out in the developing limb in the context of a gradient of fibroblast growth factor (FGF) emanating from the apical ectodermal ridge (AER).ResultsWe have simulated the behavior of the core chondrogenic mechanism of the developing limb in the presence of an FGF gradient using a novel computational environment that permits simulation of LALI systems in domains of varying shape and size. The model predicts the normal proximodistal pattern of skeletogenesis as well as distal truncations resulting from AER removal. Modifications of the model's parameters corresponding to plausible effects of Hox proteins and formins, and of the reshaping of the model limb, bud yielded simulated phenotypes resembling mutational and experimental variants of the limb. Hypothetical developmental scenarios reproduce skeletal morphologies with features of fossil limbs.ConclusionsThe limb chondrogenic regulatory system operating in the presence of a gradient has an inherent, robust propensity to form limb-like skeletal structures. The bare bones framework can accommodate ancillary gene regulatory networks controlling limb bud shaping and establishment of Hox expression domains. This mechanism accounts for major features of the normal limb pattern and, under variant geometries and different parameter values, those of experimentally manipulated, genetically aberrant and evolutionary early forms, with no requirement for an independent system of positional information.

Published
2010

21. A comparison of mental state examination documentation by junior clinicians in electronic health records before and after the introduction of a semi-structured assessment template (OPCRIT+)

Author

Lobo, Sarah E.M., Rucker, James, Kerr, Madeleine, Gallo, Fidel, Constable, Giles, Hotopf, Matthew, Stewart, Robert, Broadbent, Matthew, Baggaley, Martin, Lovestone, Simon, McGuffin, Peter, Amarasinghe, Myanthi, Newman, Stuart, Schumann, Gunter, and Brittain, Philip J.

Published
2015
Full Text
View/download PDF

23. Inherency and agency in the origin and evolution of biological functions.

Author

Newman, Stuart A

Subjects
*BIOLOGICAL evolution, *ARTIFICIAL cells, *ANIMAL species, *GENE expression, *PHILOSOPHERS
Abstract

Although discussed by 20th century philosophers in terms drawn from the sciences of non-living systems, in recent decades biological function has been considered in relationship to organismal capability and purpose. Bringing two phenomena generally neglected in evolutionary theory (i.e. inherency and agency) to bear on questions of function leads to a rejection of the adaptationist 'selected effects' notion of biological function. I review work showing that organisms such as the placozoans can thrive with almost no functional embellishments beyond those of their constituent cells and physical properties of their simple tissues. I also discuss work showing that individual tissue cells and their artificial aggregates exhibit agential behaviours that are unprecedented in the histories of their respective lineages. I review findings on the unique metazoan mechanism of developmental gene expression that has recruited, during evolution, inherent ancestral cellular functionalities into specialized cell types and organs of the different animal groups. I conclude that most essential functions in animal species are inherent to the cells from which they evolved, not selected effects, and that many of the others are optional 'add-ons', a status inimical to fitness-based models of evolution positing that traits emerge from stringent cycles of selection to meet external challenges. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

26. Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach

Author

Scavizzi, Ferdinando, Ryder, Edward, Newman, Stuart, Raspa, Marcello, Gleeson, Diane, Wardle-Jones, Hannah, Montoliu, Lluis, Fernandez, Almudena, Dessain, Marie-Laure, Larrigaldie, Vanessa, Khorshidi, Zuzana, Vuolteenaho, Reetta, Soininen, Raija, André, Philippe, Jacquot, Sylvie, Hong, Yi, de Angelis, Martin Hrabe, Ramirez-Solis, Ramiro, and Doe, Brendan

Published
2015
Full Text
View/download PDF

31. HYPERSPECTRAL EARTH OBSERVATION FROM IASI : Five Years of Accomplishments

Author

Hilton, Fiona, Armante, Raymond, August, Thomas, Barnet, Chris, Bouchard, Aurelie, Camy-Peyret, Claude, Capelle, Virginie, Clarisse, Lieven, Clerbaux, Cathy, Coheur, Pierre-Francois, Collard, Andrew, Crevoisier, Cyril, Dufour, Gaelle, Edwards, David, Faijan, Francois, Fourrié, Nadia, Gambacorta, Antonia, Goldberg, Mitchell, Guidard, Vincent, Hurtmans, Daniel, Illingworth, Samuel, Jacquinet-Husson, Nicole, Kerzenmacher, Tobias, Klaes, Dieter, Lavanant, Lydie, Masiello, Guido, Matricardi, Marco, McNally, Anthony, Newman, Stuart, Pavelin, Edward, Payan, Sebastien, Péquignot, Eric, Peyridieu, Sophie, Phulpin, Thierry, Remedios, John, Schlüssel, Peter, Serio, Carmine, Strow, Larrabee, Stubenrauch, Claudia, Taylor, Jonathan, Tobin, David, Wolf, Walter, and Zhou, Daniel

Published
2012

38. Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using a cell-permeable Cre recombinase

Author

Ryder, Edward, Doe, Brendan, Gleeson, Diane, Houghton, Richard, Dalvi, Priya, Grau, Evelyn, Habib, Bishoy, Miklejewska, Evelina, Newman, Stuart, Sethi, Debarati, Sinclair, Caroline, Vyas, Sapna, Wardle-Jones, Hannah, Bottomley, Joanna, Bussell, James, Galli, Antonella, Salisbury, Jennifer, Ramirez-Solis, Ramiro, and Sanger Mouse Genetics Project

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results