15 results on '"Naya, Abdallah"'
Search Results
2. IL-1 and CD40/CD40L platelet complex: elements of induction of Crohn’s disease and new therapeutic targets
- Author
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Anka Idrissi, Doha, Senhaji, Nezha, Aouiss, Asmae, Khalki, Loubna, Tijani, Youssef, Zaid, Nabil, Marhoume, Fatima Zahra, Naya, Abdallah, Oudghiri, Mounia, Kabine, Mostafa, and Zaid, Younes
- Published
- 2021
- Full Text
- View/download PDF
3. Exploring the multifaceted effects of Ammi visnaga: subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities.
- Author
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Ndayambaje, Martin, Wahnou, Hicham, Sow, Marieme, Chgari, Oumaima, Habyarimana, Thierry, Karkouri, Mehdi, Limami, Youness, Naya, Abdallah, and Oudghiri, Mounia
- Subjects
PHYTOCHEMICALS ,OXIDANT status ,LEUKOCYTE count ,ANTI-inflammatory agents ,MOLECULAR docking ,IMMUNOGLOBULINS ,LABORATORY mice - Abstract
Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to treat various ailments attributed to the presence of its bioactive compounds. The purpose of this study was to identify and examine the phytochemical properties of the hydroalcoholic extract of A. visnaga using in vitro and in vivo models. Our findings demonstrated that the extract contained a variety of beneficial components, including phenols, flavonoids, tannins, coumarins, saponins, khellin, and visnagin. The total polyphenolic content and total flavonoid content were 23.26 mg/GAE/g dry weight and 13.26 mg/GAE/g dry weight, respectively. In vitro tests demonstrated that the extract possessed antioxidant properties as evidenced by the ability to scavenge free radicals, including DPPH, ABTS, nitric oxide (NO), phosphomolybdate, and ferric-reducing antioxidant power (FRAP). Further, the extract was found to inhibit hydrogen peroxide (H
2 O2 )-induced hemolysis. In a 90-d in vivo study, female Wistar rats were administered 1 g/kg of A. visnaga extract orally resulting in a significant increase in total white blood cell count. Although morphological changes were observed in the liver, no marked alterations were noted in kidneys and spleen. In a female Swiss albino mice model of acetic acid-induced vascular permeability, A. visnaga significantly inhibited extravasations of Evans blue at doses of 0.5 or 1 g/kg with inhibition percentages of 51 and 65%, respectively, blocking tissue necrosis. The extract also demonstrated potential immunomodulatory properties in mice by enhancing antibody production in response to antigens. In silico molecular docking studies demonstrated a strong affinity between khellin or visnagin and immunomodulatory proteins, NF-κB, p52, and TNF-α. These findings suggest that A. visnaga may be considered a beneficial antioxidant with immunomodulatory properties and might serve as a therapeutic agent to combat certain diseases. [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
4. Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19
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Zaid, Younes, Puhm, Florian, Allaeys, Isabelle, Naya, Abdallah, Oudghiri, Mounia, Khalki, Loubna, Limami, Youness, Zaid, Nabil, Sadki, Khalid, Ben El Haj, Rafiqua, Mahir, Wissal, Belayachi, Lamiae, Belefquih, Bouchra, Benouda, Amina, Cheikh, Amine, Langlois, Marc-André, Cherrah, Yahia, Flamand, Louis, Guessous, Fadila, and Boilard, Eric
- Published
- 2020
- Full Text
- View/download PDF
5. Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients.
- Author
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Zaid, Younes, Khalki, Loubna, Jalali, Farid, Tijani, Youssef, Zaid, Nabil, Naya, Abdallah, Oudghiri, Mounia, Akarid, Khadija, Agbani, Ejaife O., and Guessous, Fadila
- Published
- 2023
- Full Text
- View/download PDF
6. The Pathophysiological Role of Platelet-Derived Extracellular Vesicles.
- Author
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Mabrouk, Meryem, Guessous, Fadila, Naya, Abdallah, Merhi, Yahye, and Zaid, Younes
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EXTRACELLULAR vesicles ,SYNOVIAL fluid ,EXTRACELLULAR space ,BONE marrow ,NUCLEIC acids - Abstract
Platelets are very abundant in the blood, where they play a role in hemostasis, inflammation, and immunity. When activated, platelets undergo a conformational change that allows the release of numerous effector molecules as well as the production of extracellular vesicles, which are circulating submicron vesicles (10 to 1,000 nm in diameter) released into the extracellular space. Extracellular vesicles are formed by the budding of platelet and they carry some of its contents, including nucleic acids, surface proteins, and organelles. While platelets cannot cross tissue barriers, platelet-derived extracellular vesicles can enter the lymph, bone marrow, and synovial fluid. This allows the transfer of diverse contents carried by these platelet-derived vesicles to cell recipients and organs inaccessible to platelets where they can perform many functions. This review highlights the importance of these platelet-derived extracellular vesicles under different physiological and pathophysiological conditions. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Aspirin use Reduces Platelet Hyperreactivity and Degranulation in COVID-19 Patients.
- Author
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Zaid, Younes, Lahlimi, Qamar, Khalki, Loubna, Zaid, Nabil, Oudghiri, Mounia, Cheikh, Amine, Naya, Abdallah, Merhi, Yahye, and Guessous, Fadila
- Subjects
COVID-19 ,SARS-CoV-2 ,ASPIRIN ,BLOOD platelets - Abstract
Platelets were isolated from healthy donors (n = 10, green dots), COVID-19 patients treated with aspirin (n = 10, red dots), or not treated with aspirin (n = 10, blue squares). Given that aspirin was found without effect on platelet functions in certain proinflammatory conditions, [15][16][27] and since it is unclear what mediates platelet activation in COVID-19, the question of whether aspirin would have any effect on platelet activation in COVID-19 patients remained to be addressed. Thus, an aspirin regimen can reduce platelet aggregation induced by low concentrations of thrombin and collagen and the production of TxB SB 2 sb , but the effects of aspirin on platelet aggregation are lost with higher concentrations of agonists. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is spreading throughout the world at an alarming rate. [Extracted from the article]
- Published
- 2023
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8. PKC-Delta-Dependent Pathways Contribute to the Exacerbation of the Platelet Activity in Crohn's Disease.
- Author
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Limami, Youness, Senhaji, Nezha, Zaid, Nabil, Khalki, Loubna, Naya, Abdallah, Hajjaj-Hassouni, Najia, Jalali, Farid, Oudghiri, Mounia, and Zaid, Younes
- Subjects
CROHN'S disease ,BLOOD platelets ,THROMBIN ,THROMBIN receptors - Abstract
To further explore the signaling mechanism involved in the regulatory role of PKC in thrombin-induced platelet aggregation in CD patients, we assessed the phosphorylation of PKC on Tyr SP 311 sp and Thr SP 505 sp . In human platelets, pre-treatment with the specific PKC inhibitor significantly decreased platelet activation in patients with CD. The pathogenesis of inflammatory bowel diseases (IBD), representing chronic and relapsing-remitting disorders of the gastrointestinal tract, encompasses Crohn's disease (CD) and ulcerative colitis. [Extracted from the article]
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- 2022
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9. An Update of Research Animal Models of Inflammatory Bowel Disease.
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Baydi, Zineb, Limami, Youness, Khalki, Loubna, Zaid, Nabil, Naya, Abdallah, Mtairag, El Mostafa, Oudghiri, Mounia, and Zaid, Younes
- Subjects
ANIMAL models in research ,INFLAMMATORY bowel diseases ,CROHN'S disease ,INFLAMMATION ,THERAPEUTICS ,BIOLOGICAL models ,MICE - Abstract
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn's disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. Toxicological Study of the Effect in vivo and in vitro of Artemisia herba-alba Aqueous Extract in Rats.
- Author
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Lahna, Ali, Benjelloun, Naima, Seddik, Nadia, Farida, Mernissi, Naya, Abdallah, and Oudghiri, Mounia
- Abstract
Background: Artemisia herba-alba (AHA) is largely used in folk medicine in different countries. However, rare studies provided toxicological evaluation regarding their safety on human health. Objective: This study investigated the safety of the standardized aqueous extract of AHA, like used by patients, to evaluate their toxicity in vivo and in vitro. Materials and Methods: For toxicological evaluation in vivo we used acute (during 14 days) and sub-acute oral gavages in Wistar rats (rats treated daily for 42 days at 1-5 g/kg bw) and the 3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay was performed to determine the level of cell viability and the degree of cytotoxicity in vitro (0-30 µg/ml) on cultured spleen cells. Results: The LD
50 was up to 2 g/kg. Signs of mortality and toxicity were observed after single doses and no-observed-adverse-effect levels in the sub acute toxicity was up to 2 g/kg bw. Compared to the control, the treatment did not produce any statistically significant changes on alanine aminotransferase and aspartate aminotransferase serum titer. However, for creatinine and urea serum value, a significant increase (P < 0.05) was observed. The histological observations of liver and spleen tissues have shown well-preserved normal cells. Indeed for kidney tissues some artifacts of retraction and vascular congestion were noted for 3-5 g/kg doses after sub-chronic treatment. The addition of plant extracts to the spleen cells did not show any sign of toxicity for all doses tested. Conclusion: We conclude that AHA aqueous extract at the dosage up to 2g/kg bw will be toxic and can affect mainly the kidney tissues. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
11. Oxford-AstraZeneca ChAdOx1 COVID-19 Vaccine Does Not Alter Platelet Aggregation.
- Author
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Limami, Youness, Khalki, Loubna, Zaid, Nabil, Khyatti, Meriem, Turk, Joumana El, Ammara, Mounia, Mtairag, El Mostafa, Oudghiri, Mounia, Naya, Abdallah, Taberkant, Mustapha, and Zaid, Younes
- Subjects
BLOOD platelet aggregation ,COVID-19 vaccines ,CORONAVIRUS diseases ,COVID-19 ,VENOUS thrombosis - Abstract
[13] Although platelets from COVID-19 patients have shown hyperreactivity, [4][5][6] no scientific data have been able to demonstrate platelet dysfunction in people injected with the Oxford-AstraZeneca vaccine. [13] Therefore, this study aimed to assess platelet function by measuring the aggregation of platelets from participants who had been injected with the Oxford-AstraZeneca vaccine compared with platelets from a cohort of healthy donors. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF
12. Toxicological Study of the Effect in vivo and in vitro of Artemisia herba-alba Aqueous Extract in Rats.
- Author
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Lahna, Ali, Benjelloun, Naima, Seddik, Nadia, Farida, Mernissi, Naya, Abdallah, and Oudghiri, Mounia
- Subjects
LABORATORY rats ,ARTEMISIA ,ALANINE aminotransferase ,SPLEEN ,PLANT extracts ,ANTIBODY-dependent cell cytotoxicity ,ASPARTATE aminotransferase - Abstract
Background: Artemisia herba-alba (AHA) is largely used in folk medicine in different countries. However, rare studies provided toxicological evaluation regarding their safety on human health. Objective: This study investigated the safety of the standardized aqueous extract of AHA, like used by patients, to evaluate their toxicity in vivo and in vitro. Materials and Methods: For toxicological evaluation in vivo we used acute (during 14 days) and sub-acute oral gavages in Wistar rats (rats treated daily for 42 days at 1-5 g/kg bw) and the 3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay was performed to determine the level of cell viability and the degree of cytotoxicity in vitro (0-30 µg/ml) on cultured spleen cells. Results: The LD50 was up to 2 g/kg. Signs of mortality and toxicity were observed after single doses and no-observed-adverse-effect levels in the sub acute toxicity was up to 2 g/kg bw. Compared to the control, the treatment did not produce any statistically significant changes on alanine aminotransferase and aspartate aminotransferase serum titer. However, for creatinine and urea serum value, a significant increase (P < 0.05) was observed. The histological observations of liver and spleen tissues have shown well-preserved normal cells. Indeed for kidney tissues some artifacts of retraction and vascular congestion were noted for 3-5 g/kg doses after sub-chronic treatment. The addition of plant extracts to the spleen cells did not show any sign of toxicity for all doses tested. Conclusion: We conclude that AHA aqueous extract at the dosage up to 2g/kg bw will be toxic and can affect mainly the kidney tissues. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
13. Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen.
- Author
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Zaid, Younes, Marhoume, Fatimazahra, Senhaji, Nezha, Kojok, Kevin, Boufous, Hicham, Naya, Abdallah, Oudghiri, Mounia, Darif, Youssef, Habti, Norddine, Zouine, Soukaina, Mohamed, Fekhaoui, Chait, Abderahmane, and Bagri, Abdellah
- Subjects
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DIAMINES , *BLOOD platelet aggregation , *THROMBOSIS , *COLLAGEN , *CARDIAC arrest - Abstract
Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
14. An Update of Research Animal Models of Inflammatory Bowel Disease.
- Author
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Baydi Z, Limami Y, Khalki L, Zaid N, Naya A, Mtairag EM, Oudghiri M, and Zaid Y
- Subjects
- Animals, Mice, Disease Models, Animal, Inflammatory Bowel Diseases genetics, Inflammatory Bowel Diseases immunology, Inflammatory Bowel Diseases microbiology
- Abstract
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn's disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models., Competing Interests: The authors declare that the research was conducted in the absence of any competing interests., (Copyright © 2021 Zineb Baydi et al.)
- Published
- 2021
- Full Text
- View/download PDF
15. HLA-B*27 allele associated to Behçet's disease and to anterior uveitis in Moroccan patients.
- Author
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Radouane A, Oudghiri M, Chakib A, Naya A, Belhouari A, El Malki A, and Bennani S
- Subjects
- Adolescent, Adult, Alleles, Biomarkers blood, Case-Control Studies, Female, Humans, Male, Middle Aged, Morocco, Phenotype, Polymerase Chain Reaction, Behcet Syndrome genetics, Behcet Syndrome immunology, HLA-B27 Antigen genetics, Uveitis, Anterior genetics, Uveitis, Anterior immunology
- Abstract
Human leukocyte antigen HLA-B51 is the most strongly associated gene with Behçet disease (BD) in different ethnic populations. We analyze the influence of HLA-B alleles in BD predisposition in Moroccan population and its association with clinical manifestations. The HLA-B phenotype frequencies were analyzed by serologic HLA class I typing and by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) reverse dot blot hybridization in 120 unrelated Moroccan patients: all of whom fulfilled the international study group criteria for Behçet's disease, and in 112 ethnically matched healthy controls. Besides HLA-B*51 allele (20%), a significant increased frequency of the HLA-B*27 allele was found in Moroccans patients with Behçet's disease when compared to controls (13.3% of patients versus 2.7% of controls, chi square = 8.75, OR = 5.59, 95% IC [1.58-19.75] and particularly in the patients who presented an anterior uveitis (25% vs. 5.5%, p < 0.005).
- Published
- 2011
- Full Text
- View/download PDF
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