618 results on '"Munz P"'
Search Results
2. Low reoperation rate after fixation of displaced femoral neck fractures with the femoral neck system (FNS)
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Obey, Mitchel R., Falgons, Christian G., Eastman, Jonathan G., Choo, Andrew M., Achor, Timothy S., Munz, John W., and Warner, Stephen J.
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- 2024
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3. Isolation of a pentadienyl-type radical featuring a central secondary carbon
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Loh, Ying Kai, Gojiashvili, Levan, Melaimi, Mohand, Gembicky, Milan, Munz, Dominik, and Bertrand, Guy
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- 2024
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4. What if precision agriculture is not profitable?: A comprehensive analysis of the right timing for exiting, taking into account different entry options
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Munz, Johannes
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- 2024
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5. Reproductive Justice and Critical Communication Pedagogy: An Analysis of the Overturning of 'Roe V. Wade'
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Leandra Hinojosa Hernández and Stevie M. Munz
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In this article, we provide an overview of the overturning of Roe v. Wade and consider its implications for communication classrooms in higher education. We assert that we as communication educators have a moral imperative to consider the role of intersectionality and reproductive justice in our teaching philosophies and implementation, and to do so, we discuss the interrelated nature of intersectionality, reproductive justice, and critical communication pedagogy.
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- 2024
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6. Transport and retention of micro-polystyrene in coarse riverbed sediments: effects of flow velocity, particle and sediment sizes
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Munz, Matthias, Loui, Constantin, Postler, Denise, Pittroff, Marco, and Oswald, Sascha E.
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- 2024
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7. The synthesis and characterization of an iron(VII) nitrido complex
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Keilwerth, Martin, Mao, Weiqing, Malischewski, Moritz, Jannuzzi, Sergio A. V., Breitwieser, Kevin, Heinemann, Frank W., Scheurer, Andreas, DeBeer, Serena, Munz, Dominik, Bill, Eckhard, and Meyer, Karsten
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- 2024
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8. Metodologias ativas em aulas de Sociologia no Ensino Médio: uma revisão sistemática de literatura
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Maristela Santos Lopes, Natana Alvina Botezini, Daniela Garcez Wives, and Alice Munz Fernandes
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metodologias ativas de ensino ,aprendizagem significativa ,sociologia ,ensino médio ,Education - Abstract
Metodologias ativas são instrumentos emergentes para a melhoria do processo de ensino-aprendizagem, inclusive para o público adolescente. Assim, a pesquisa realizada objetivou analisar as metodologias ativas comumente empregadas nas aulas de Sociologia ministradas junto ao Ensino Médio. Para tanto, realizou-se uma revisão sistemática da literatura disponível no Portal CAPES e nos periódicos especializados Revista Café com Sociologia, Cadernos da CABECS, Anais SBS e Anais ENESEB. O portfólio analisado foi composto por 35 manuscritos, cujos resultados indicaram que relatos de experiência apresentaram incremento a partir de 2017, sendo que o Sul e o Sudeste foram responsáveis pela maioria das publicações. Também observou-se que não há relação entre a atuação de “pibidianos” e estagiários concluintes e a implementação dessas práticas. Constatou-se ainda que a adoção de metodologias ativas independe das temáticas abordadas e que recursos audiovisuais tendem a atuarem como gatilhos para discussões, sendo jogos didáticos e escritas de si metodologias recorrentes.
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- 2024
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9. Exploring visual quality of multidimensional time series projections
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Tanja Munz-Körner and Daniel Weiskopf
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Time series ,Multidimensional data ,Dimensionality reduction ,Projection errors ,Visual quality ,Visual analytics ,Information technology ,T58.5-58.64 - Abstract
Dimensionality reduction is often used to project time series data from multidimensional to two-dimensional space to generate visual representations of the temporal evolution. In this context, we address the problem of multidimensional time series visualization by presenting a new method to show and handle projection errors introduced by dimensionality reduction techniques on multidimensional temporal data. For visualization, subsequent time instances are rendered as dots that are connected by lines or curves to indicate the temporal dependencies. However, inevitable projection artifacts may lead to poor visualization quality and misinterpretation of the temporal information. Wrongly projected data points, inaccurate variations in the distances between projected time instances, and intersections of connecting lines could lead to wrong assumptions about the original data. We adapt local and global quality metrics to measure the visual quality along the projected time series, and we introduce a model to assess the projection error at intersecting lines. These serve as a basis for our new uncertainty visualization techniques that use different visual encodings and interactions to indicate, communicate, and work with the visualization uncertainty from projection errors and artifacts along the timeline of data points, their connections, and intersections. Our approach is agnostic to the projection method and works for linear and non-linear dimensionality reduction methods alike.
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- 2024
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10. COVID-19 and the Transition to Online Learning in the Basic Course: Examining Effects on Student Learning
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Kuznekoff, Jeffrey H. and Munz, Stevie M.
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Objectives: This study examines how the transition to remote delivery during the spring of 2020 affected student learning in the basic communication course. Methods: Participants in three different course delivery modes (face-to-face, online, and live interactive) were enrolled in a public speaking course with standardized adaptive reading quizzes, exams, and speech assignments. Participants completed several measures over the course of the semester and had their responses paired up with their end-of-semester grade book data. Results: Results of this study indicate that students who were enrolled in a face-to-face course and transitioned online during the COVID-19 pandemic were outperformed by online and learning interactive students in several of the standardized assignments in the course. Conclusions: Overall, face-to-face (FtF) students performed four percentage points lower in the course than the learning interactive and online groups while also demonstrating more emotional interest in the course than the other two groups. Implication for Theory and/or Practice: In future transitions to remote learning, FtF students may experience greater disruption than existing online students. Instructors should be mindful of this finding in transitioning to remote learning during the semester.
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- 2022
11. Circularly Polarized Luminescence from Cyclic (Alkyl)(Amino) Carbene Derived Propellers
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Lorkowski, Jan, Bouetard, Dylan, Yorkgitis, Patrick, Gembicky, Milan, Roisnel, Thierry, Vanthuyne, Nicolas, Munz, Dominik, Favereau, Ludovic, Bertrand, Guy, Mauduit, Marc, and Jazzar, Rodolphe
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Carbene ,Circularly Polarized Luminescence ,Density Functional Theory ,Helical ,Propeller ,Chemical Sciences ,Organic Chemistry - Abstract
Organic circularly polarized luminescence (CPL)-active molecular emitters featuring dynamic propeller-like luminophores were prepared in one step from cyclic(alkyl)(amino) carbenes (CAACs). These molecules exhibit through-space arene-arene π-delocalization and rapid intramolecular inter-system crossing (ISC) in line with their helical character.
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- 2023
12. Distinct oxygenation modes of the Gulf of Oman over the past 43 000 years – a multi-proxy approach
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N. Burdanowitz, G. Schmiedl, B. Gaye, P. M. Munz, and H. Schulz
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Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
Changing climatic conditions can shape the strength and extent of the oxygen minimum zone (OMZ). The presence and variability of the OMZ in the Arabian Sea is of importance to the latter's ecosystem. The state of oxygenation has, for instance, an impact on the pelagic and benthic faunal community or the nitrogen and carbon cycles. It is important to understand the dynamics of the OMZ and related marine environmental conditions because of their climate feedbacks. In this study, we combined three independent proxies to reconstruct the oxygenation state of the water column and bottom water in the Gulf of Oman for the past 43 kyr approximately. This multi-proxy approach is done for the first time at the northeastern Oman margin located in the Gulf of Oman. We used bulk sedimentary nitrogen isotopes (δ15N) and the alkane ratio (lycopane +n-C35)/n-C31 and benthic foraminiferal faunal analysis to reconstruct the strength of the OMZ in the water column and bottom water oxygenation, respectively. Our results show that the Gulf of Oman experienced strong pronounced OMZ and bottom water deoxygenation during the Holocene. In contrast, during Marine Isotope Stage 2 (MIS 2), including the Last Glacial Maximum (LGM), the Gulf of Oman was very well ventilated, with a highly diverse benthic foraminiferal community. This may have been caused by stronger wind-induced mixing and better ventilation by oxygen-rich water masses. Our results also show moderate oxygenation during MIS 3, with deoxygenation events during most of the warmer Dansgaard–Oeschger (D–O) events. We propose two distinct oxygenation modes for the Gulf of Oman: (1) a stable period of either strongly pronounced water column OMZ and bottom water deoxygenation or well-oxygenated water column and bottom water conditions and (2) an unstable period of oscillating oxygenation states between moderately oxygenated (stadials) and deoxygenated (interstadials, D–O events) conditions. The unstable period may be triggered by an interstadial Atlantic meridional overturning circulation (AMOC) mode, which is required to initiate D–O events.
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- 2024
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13. An Air-Stable “Masked” Bis(imino)carbene: A Carbon-Based Dual Ambiphile
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Loh, Ying Kai, Melaimi, Mohand, Munz, Dominik, and Bertrand, Guy
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Chemical Sciences ,General Chemistry - Abstract
Carbenes, once considered laboratory curiosities, now serve as powerful tools in the chemical and material sciences. To date, all stable singlet carbenes are single-site ambiphiles. Here we describe the synthesis of a carbene which is a carbon-based dual ambiphile (both single-site and dual-site). The key is to employ imino substituents derived from a cyclic (alkyl)(amino)carbene (CAAC), which imparts a 1,3-dipolar character to the carbene. Its dual ambiphilic nature is consistent with the ability to activate simple organic molecules in both 1,1- and 1,3-fashion. Furthermore, its 1,3-ambiphilicity facilitates an unprecedented reversible intramolecular dearomative [3 + 2] cycloaddition with a proximal arene substituent, giving the carbene the ability to "mask" itself as an air-stable cycloadduct. We perceive that the concept of dual ambiphilicity opens a new dimension for future carbene chemistry, expanding the repertoire of applications beyond that known for classical single-site ambiphilic carbenes.
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- 2023
14. Pd8(PDip)6: Cubic, Unsaturated, Zerovalent
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Kevin Breitwieser, Matteo Bevilacqua, Sneha Mullassery, Fabian Dankert, Bernd Morgenstern, Samuel Grandthyll, Frank Müller, Andrea Biffis, Christian Hering‐Junghans, and Dominik Munz
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atomically precise ,cluster ,cube ,phosphinidene ,unsaturation ,Science - Abstract
Abstract Atomically precise nanoclusters hold promise for supramolecular assembly and (opto)electronic‐ as well as magnetic materials. Herein, this work reports that treating palladium(0) precursors with a triphosphirane affords strongly colored Pd8(PDip)6 that is fully characterized by mass spectrometry, heteronuclear and Cross‐Polarization Magic‐Angle Spinning (CP‐MAS) NMR‐, infrared (IR), UV–vis, and X‐ray photoelectron (XP) spectroscopies, single‐crystal X‐Ray diffraction (sc‐XRD), mass spectrometry, and cyclovoltammetry (CV). This coordinatively unsaturated 104‐electron Pd(0) cluster features a cubic Pd8‐core, µ4‐capping phosphinidene ligands, and is air‐stable. Quantum chemical calculations provide insight to the cluster's electronic structure and suggest 5s/4d orbital mixing as well as minor Pd─P covalency. Trapping experiments reveal that cluster growth proceeds via insertion of Pd(0) into the triphosphirane. The unsaturated cluster senses ethylene and binds isocyanides, which triggers the rearrangement to a tetrahedral structure with a reduced frontier orbital energy gap. These experiments demonstrate facile cluster manipulation and highlight non‐destructive cluster rearrangement as is required for supramolecular assembly.
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- 2024
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15. Spatio-temporal variations of climate along possible African-Arabian routes of H. sapiens expansion
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Markus L. Fischer, Philipp M. Munz, Asfawossen Asrat, Verena Foerster, Stefanie Kaboth-Bahr, Norbert Marwan, Frank Schaebitz, Wolfgang Schwanghart, and Martin H. Trauth
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Eastern Africa ,Arabia ,Chew Bahir ,Gulf of Aden ,Pleistocene ,Human evolution ,Geography. Anthropology. Recreation ,Archaeology ,CC1-960 - Abstract
Eastern Africa and Arabia were major hominin hotspots and critical crossroads for migrating towards Asia during the late Pleistocene. To decipher the role of spatiotemporal environmental change on human occupation and migration patterns, we remeasured the marine core from Meteor Site KL 15 in the Gulf of Aden and reanalyzed its data together with the aridity index from ICDP Site Chew Bahir in eastern Africa and the wet-dry index from ODP Site 967 in the eastern Mediterranean Sea using linear and nonlinear time series analysis. These analyses show major changes in the spatiotemporal paleoclimate dynamics at 400 and 150 ka BP (thousand years before 1950), presumably driven by changes in the amplitude of the orbital eccentricity. From 400 to 150 ka BP, eastern Africa and Arabia show synchronized wet-dry shifts, which changed drastically at 150 ka BP. After 150 ka BP, an overall trend to dry climate states is observable, and the hydroclimate dynamics between eastern Africa and Arabia are negatively correlated. Those spatio-temporal variations and interrelationships of climate potentially influenced the availability of spatial links for human expansion along those vertices. We observe positively correlated network links during the supposed out-of-Africa migration phases of H. sapiens. Furthermore, our data do not suggest hominin occupation phases during specific time intervals of humid or stable climates but provide evidence of the so far underestimated potential role of climate predictability as an important factor of hominin ecological competitiveness.
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- 2024
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16. Transport and retention of micro-polystyrene in coarse riverbed sediments: effects of flow velocity, particle and sediment sizes
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Matthias Munz, Constantin Loui, Denise Postler, Marco Pittroff, and Sascha E. Oswald
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Microplastic ,Column experiment ,Saturated sediments ,Riverbed ,Fluorescence microscopy ,Environmental pollution ,TD172-193.5 ,Polymers and polymer manufacture ,TP1080-1185 - Abstract
Abstract Riverbed sediments have recently been found to be an important reservoir for microplastics. But the hydrogeological factors that control the abundance of microplastics are complex and conceptual frameworks priorising the parameters affecting their transport and retention during deep riverbed filtration are still missing. In this study a series of saturated column experiments was conducted to investigate the vertical distribution patterns of secondary polystyrene fragments (100–2000 μm) in dependence on their particle size, grain size of the sediment, seepage velocity and duration of infiltration flow. The columns with a length of 50 cm were operated with flow velocities between 1.8 m d−1 and 27 m d−1. Invasive samples obtained after the experiments were density separated and then depth profiles of microplastic concentrations were retrieved using fluorescence imaging analysis. Most polystyrene particles were retained in the upper 20 cm and 15 cm of the medium gravel and coarse sand sediments, respectively. Through the high particle retention riverbed sediments can act as a temporary sink or long term retention site for the transport of microplastic particles (MPPs) from streams to oceans. A small fraction of particles ranging from 100 to 500 μm in size was observed down to infiltration depths of 50 cm suggesting that MPPs at the pore scale have the potential to be advectively transferred via hyporheic exchange or induced bank filtration into coarse riverbed sediments and alluvial aquifers. MPP abundance over column depth follows an exponential relationship with a filter coefficient that was found to depend significantly on the flow rate, MPP and sediment grain size, as indicated by multiple linear regression (R2 = 0.92). The experimentally derived empirical relation allows to estimate particle abundances of initially negatively buoyant MPP in riverbed sediments by surface water infiltration.
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- 2024
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17. A crystalline doubly oxidized carbene
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Loh, Ying Kai, Melaimi, Mohand, Gembicky, Milan, Munz, Dominik, and Bertrand, Guy
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- 2023
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18. Yield stability and weed dry matter in response to field-scale soil variability in pea-oat intercropping
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Munz, Sebastian, Zachmann, Julian, Chongtham, Iman Raj, Dhamala, Nawa Raj, Hartung, Jens, Jensen, Erik Steen, and Carlsson, Georg
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- 2023
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19. Stigmatisierung und soziale Angst bei Patient:innen mit Hauterkrankungen
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Munz, J., Kupfer, J., Schepko, M., Weisshaar, E., and Schut, C.
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- 2023
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20. A Time Window Analysis for Time-Critical Decision Systems with Applications on Sports Climbing
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Heiko Oppel and Michael Munz
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convolutional neuronal network ,inertial measurement unit ,time series analysis ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Human monitoring systems are already utilized in various fields like assisted living, healthcare or sport and fitness. They are able to support in everyday life or act as a pre-warning system. We developed a system to monitor the ascent of a sport climber. It is integrated in a belay device. This paper presents the first time series analysis regarding the fall of a climber utilizing such a system. A Convolutional Neural Network handles the feature engineering part of the sensor information as well as the classification of the task at hand. In this way, the time is implicitly considered by the network. An analysis regarding the size of the time window was carried out with a focus on exploring the respective results. The neural network models were then tested against an already-existing principle based on a mechanical mechanism. We show that the size of the time window is a decisive factor in a time critical system. Depending on the size of the window, the mechanical principle was able to outperform the neural network. Nevertheless, most of our models outperformed the basic principle and returned promising results in predicting the fall of a climber within up to 91.8 ms.
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- 2023
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21. Choose Your Own Adventure: Expanding Students' Theoretical and Methodological Vocabularies
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Munz, Elizabeth A., Gatchet, Roger Davis, and Gesualdi, Maxine
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Inspired by "choose your own adventure" books, this unit activity helps students differentiate between ontology, epistemology, axiology, methodology, and method. While completing the activity over two weeks, students apply these concepts to the study of a topic of the instructor's choosing (illustrated here through the lens of family communication). Students who completed the full unit activity improved their exam performance compared to students in a previous semester who did not. Courses: Communication Research, Communication Theory. Objectives: Upon completion of this unit, students will be able to (1) apply the concepts ontology, epistemology, axiology, methodology, and method to a research exemplar; (2) differentiate between ontology, epistemology, and axiology; and (3) differentiate between methodology and method.
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- 2023
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22. Correction: How attractive is the participation in a Living Lab study? Experimental evidence and recommendations
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Brohmer, Hilmar, Munz, Katinka, Röderer, Kathrin, Anzengruber, Christoph, Wendland, Matthias, and Corcoran, Katja
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- 2023
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23. How attractive is the participation in a Living Lab study? Experimental evidence and recommendations
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Brohmer, Hilmar, Munz, Katinka, Röderer, Kathrin, Anzengruber, Christoph, Wendland, Matthias, and Corcoran, Katja
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- 2023
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24. Targeting CD19-positive lymphomas with the antibody-drug conjugate loncastuximab tesirine: preclinical evidence as single agent and in combination therapy
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Chiara Tarantelli, David Wald, Nicolas Munz, Filippo Spriano, Alessio Bruscaggin, Eleonora Cannas, Luciano Cascione, Eugenio Gaudio, Alberto J. Arribas, Shivaprasad Manjappa, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Giorgio Inghirami, Patrick H. van Berkel, Davide Rossi, Paolo F. Caimi, Francesca Zammarchi, and Francesco Bertoni
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Antibody-drug conjugates (ADCs) represent one of the most successful therapeutic approaches introduced in clinical practice in the last few years. Loncastuximab tesirine (ADCT-402) is a CD19 targeting ADC, in which the antibody is conjugated through a protease cleavable dipeptide linker to a pyrrolobenzodiazepine (PBD) dimer warhead (SG3199). Based on the results of a phase 2 study, loncastuximab tesirine was recently approved for adult patients with relapsed/refractory large B-cell lymphoma. We assessed the activity of loncastuximab tesirine using in vitro and in vivo models of lymphomas, correlated its activity with CD19 expression levels, and identified combination partners providing synergy with loncastuximab tesirine. Loncastuximab tesirine was tested across 60 lymphoma cell lines. Loncastuximab tesirine had strong cytotoxic activity in B-cell lymphoma cell lines. The in vitro activity was correlated with CD19 expression level and intrinsic sensitivity of cell lines to the ADC’s warhead. Loncastuximab tesirine was more potent than other anti-CD19 ADCs (coltuximab ravtansine, huB4-DGN462), albeit the pattern of activity across cell lines was correlated. Loncastuximab tesirine activity was also largely correlated with cell line sensitivity to R-CHOP. Combinatorial in vitro and in vivo experiments identified the benefit of adding loncastuximab tesirine to other agents, especially BCL2 and PI3K inhibitors. Our data support the further development of loncastuximab tesirine as a single agent and in combination for patients affected by mature B-cell neoplasms. The results also highlight the importance of CD19 expression and the existence of lymphoma populations characterized by resistance to multiple therapies.
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- 2024
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25. Deep Surgical Site Infection after Fracture Has a Profound Effect on Functional Outcomes
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Ida Leah Gitajn, MD, MS, Paul M. Werth, PhD, Anthony R. Carlini, MS, Michael J. Bosse, MD, Joshua L. Gary, MD, Reza Firoozabadi, MD, MA, William Obremskey, MD, MPH, Todd O. McKinley, MD, Renan C. Castillo, PhD, Robert V. O’Toole, MD, and METRC, Edward R. Westrick, Eben A. Carroll, James Brett Goodman, Martha B. Holden, Anna N. Miller, Amanda Spraggs-Hughes, PhD, Michael L. Brennan, Paul Tornetta, III, Michael J. Weaver, Marilyn Heng, Patrick M. Osborn, Jessica C. Rivera, Clinton K. Murray, Joseph E. Kimmel, Charles Moon, Joseph R. Hsu, Madhav A. Karunakar, Laurence B. Kempton, Rachel B. Seymour, Stephen H. Sims, Christine Churchill, Rachel M. Reilly, Robert D. Zura, Cameron Howes, Hassan Mir, Emily A. Wagstrom, Brian Mullis, Jeffrey O. Anglen, Leilani S. Mullis, Karl D. Shively, Greg E. Gaski, Roman M. Natoli, Anthony Sorkin, Walter Virkus, Robert A. Hymes, Michael A. Holzman, A. Stephen Malekzadeh, Jeff E. Schulman, Cary C. Schwartzbach, Olivia C. Lee, Peter C. Krause, Massimo "Max" Morandi, Andrew Choo, John W. Munz, Sterling Boutte, Matthew C. Galpin, H. Michael Frisch, Adam M. Kaufman, C. Michael LeCroy, Christopher S. Smith, Alec C. Stall, Andrea Horne, Jason W. Nascone, Nathan N. O'Hara, Ebrahim Paryavi, Marcus F. Sciadini, Yasmin Degani, Andrea L. Howe, Roman Hayda, Andrew R. Evans, Debra L. Sietsema, Stanislaw P. Stawicki, Thomas Wojda, Michael J. Gardner, Julius A. Bishop, Saqib Rehman, Cyrus Caroom, Elizabeth Sheridan, Theodore Miclau, Saam Morshed, Thomas F. Higgins, Justin M. Haller, Paul E. Matuszewski, Arun Aneja, Raymond D. Wright, Jr., Patrick F. Bergin, Eldrin Bhanat, Matt L. Graves, John Morellato, Clay A. Spitler, David Teague, William Ertl, Jaimo Ahn, Patrick Hesketh, Gele B. Moloney, John C. Weinlein, Boris A. Zelle, Animesh Agarwal, Ravi A. Karia, Ashoke Sathy, Drew T. Sanders, David B. Weiss, Seth R. Yarboro, Veronica Lester-Ballard, Eric D. McVey, Arman Dagal, Michael Githens, Conor Kleweno, Julie Agel, Paul S. Whiting, Natasha M. Simske, Alexander B. Siy, Basem Attum, Eduardo Burgos, Vamshi Gajari, Andres Rodriguez-Buitrago, Manish Sethi, Rajesh R. Tummuru, Jean-Claude G. D'Alleyrand, Lauren E. Allen, Susan C. Collins, Yanjie Huang, and Tara J. Taylor
- Subjects
Orthopedic surgery ,RD701-811 - Abstract
Background:. Fracture-related infection is one of the most challenging complications in orthopaedic trauma surgery. However, the effect of infection on functional and pain-related outcomes has not been well established. The aims of this study were to evaluate functional recovery for patients with fracture and a deep surgical site infection compared with patients with fracture without infection and to evaluate whether pain severity, social support, and preinjury mental health have a moderating effect on the magnitude and direction of the relationship between deep surgical site infection and functional recovery. Methods:. This is a secondary retrospective cohort study using prospectively collected data from the VANCO trial (Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection) and the OXYGEN (Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery) trial. In this study, 2,116 patients with tibial plateau, pilon, or calcaneal fractures at high risk for infection were included. Patients were divided into cohorts of patients who experienced a deep surgical site infection and those who did not. The primary outcome measure was the functional outcome using the Veterans RAND 12-Item Health Survey (VR-12). Results:. After controlling for covariates, deep surgical site infection was independently associated with functional outcome, with a 3.3-point reduction in the VR-12 Physical Component Score, and pain severity was independently associated with functional outcome, with a 2.5-point reduction in the VR-12 Physical Component Score. Furthermore, the Brief Pain Inventory pain severity demonstrated an important moderating effect on the relationship between infection and functional outcome. In patients with lower pain scores, infection had a large negative impact on functional outcome, whereas, in patients with higher pain scores, infection had no significant impact on functional outcome. Furthermore, the functional outcome in the entire cohort remains at only 61% of baseline. Conclusions:. This study documents the negative impact of postoperative infection on functional recovery after injury, as well as the novel finding of pain severity as an important moderating factor. This study emphasizes not only the importance of developing effective interventions designed to reduce postoperative infection, but also the role that factors that moderate pain severity plays in limiting recovery of physical function. Level of evidence:. Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
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- 2024
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26. Evaluating the suitability of granular anammox biomass for nitrogen removal from vegetable tannery wastewater
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Polizzi, C., Lotti, T., Ricoveri, A., Mori, G., Gabriel, D., and Munz, G.
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- 2023
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27. Impact of Simulated Reduced-Dose Chest CT on Diagnosing Pulmonary T1 Tumors and Patient Management
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Alan Arthur Peters, Jaro Munz, Jeremias Bendicht Klaus, Ana Macek, Adrian Thomas Huber, Verena Carola Obmann, Njood Alsaihati, Ehsan Samei, Waldo Valenzuela, Andreas Christe, Johannes Thomas Heverhagen, Justin Bennion Solomon, and Lukas Ebner
- Subjects
chest ,CT scan ,lung neoplasms ,computer simulation ,radiation dosage ,Medicine (General) ,R5-920 - Abstract
To determine the diagnostic performance of simulated reduced-dose chest CT scans regarding pulmonary T1 tumors and assess the potential impact on patient management, a repository of 218 patients with histologically proven pulmonary T1 tumors was used. Virtual reduced-dose images were simulated at 25%- and 5%-dose levels. Tumor size, attenuation, and localization were scored by two experienced chest radiologists. The impact on patient management was assessed by comparing hypothetical LungRADS scores. The study included 210 patients (41% females, mean age 64.5 ± 9.2 years) with 250 eligible T1 tumors. There were differences between the original and the 5%—but not the 25%—dose simulations, and LungRADS scores varied between the dose levels with no clear trend. Sensitivity of Reader 1 was significantly lower using the 5%-dose vs. 25%-dose vs. original dose for size categorization (0.80 vs. 0.85 vs. 0.84; p = 0.007) and segmental localization (0.81 vs. 0.86 vs. 0.83; p = 0.018). Sensitivities of Reader 2 were unaffected by a dose reduction. A CT dose reduction may affect the correct categorization and localization of pulmonary T1 tumors and potentially affect patient management.
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- 2024
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28. An Efficient hp-Adaptive Strategy for a Level-Set Ghost-Fluid Method
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Mossier, Pascal, Appel, Daniel, Beck, Andrea D., and Munz, Claus-Dieter
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- 2023
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29. Modeling soil-plant functioning of intercrops using comprehensive and generic formalisms implemented in the STICS model
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Vezy, Rémi, Munz, Sebastian, Gaudio, Noémie, Launay, Marie, Lecharpentier, Patrice, Ripoche, Dominique, and Justes, Eric
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- 2023
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30. How attractive is the participation in a Living Lab study? Experimental evidence and recommendations
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Hilmar Brohmer, Katinka Munz, Kathrin Röderer, Christoph Anzengruber, Matthias Wendland, and Katja Corcoran
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Living Lab ,Conjoint study ,Participation ,Energy consumption ,Incentives ,Environmental sciences ,GE1-350 - Abstract
Abstract Living Labs, which are urban sites that include households and workplaces and are used to study the real-time use of technological innovations and devices, have become increasingly popular among environmental scientists to gain insights into energy consumption in peoples’ everyday life. However, recruiting a viable number of participants for such studies can pose a challenge to researchers: Factors like month-long study durations and the requirements to handle smart technology proficiently or frequently exchange information with researchers and other users do not necessarily make participation attractive for everyone. To identify relevant factors for participation, we conducted three large preregistered surveys (total N = 1479) in Austria: two conjoint studies and one experimental study. We found that advertising a Living Lab with a shorter duration (less than a month), providing the option to participate from home, and—a crucial point—offering financial incentives should be considered when considering promotion strategies and conducting thorough study planning. However, we discuss the fact that there might be a risk of selection bias for technic-savvy and future-oriented people.
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- 2023
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31. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
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Aragam, Krishna G., Jiang, Tao, Goel, Anuj, Kanoni, Stavroula, Wolford, Brooke N., Atri, Deepak S., Weeks, Elle M., Wang, Minxian, Hindy, George, Zhou, Wei, Grace, Christopher, Roselli, Carolina, Marston, Nicholas A., Kamanu, Frederick K., Surakka, Ida, Venegas, Loreto Muñoz, Sherliker, Paul, Koyama, Satoshi, Ishigaki, Kazuyoshi, Åsvold, Bjørn O., Brown, Michael R., Brumpton, Ben, de Vries, Paul S., Giannakopoulou, Olga, Giardoglou, Panagiota, Gudbjartsson, Daniel F., Güldener, Ulrich, Haider, Syed M. Ijlal, Helgadottir, Anna, Ibrahim, Maysson, Kastrati, Adnan, Kessler, Thorsten, Kyriakou, Theodosios, Konopka, Tomasz, Li, Ling, Ma, Lijiang, Meitinger, Thomas, Mucha, Sören, Munz, Matthias, Murgia, Federico, Nielsen, Jonas B., Nöthen, Markus M., Pang, Shichao, Reinberger, Tobias, Schnitzler, Gavin, Smedley, Damian, Thorleifsson, Gudmar, von Scheidt, Moritz, Ulirsch, Jacob C., Arnar, David O., Burtt, Noël P., Costanzo, Maria C., Flannick, Jason, Ito, Kaoru, Jang, Dong-Keun, Kamatani, Yoichiro, Khera, Amit V., Komuro, Issei, Kullo, Iftikhar J., Lotta, Luca A., Nelson, Christopher P., Roberts, Robert, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Webb, Thomas R., Baras, Aris, Björkegren, Johan L. M., Boerwinkle, Eric, Dedoussis, George, Holm, Hilma, Hveem, Kristian, Melander, Olle, Morrison, Alanna C., Orho-Melander, Marju, Rallidis, Loukianos S., Ruusalepp, Arno, Sabatine, Marc S., Stefansson, Kari, Zalloua, Pierre, Ellinor, Patrick T., Farrall, Martin, Danesh, John, Ruff, Christian T., Finucane, Hilary K., Hopewell, Jemma C., Clarke, Robert, Gupta, Rajat M., Erdmann, Jeanette, Samani, Nilesh J., Schunkert, Heribert, Watkins, Hugh, Willer, Cristen J., Deloukas, Panos, Kathiresan, Sekar, and Butterworth, Adam S.
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- 2022
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32. Integrating Service-Learning in the Public Speaking Course
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Munz, Elizabeth A., Gatchet, Roger Davis, and Meier, Matthew R.
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This best practices article endorses incorporating service-learning into the foundational public speaking course. The article explains connections between service-learning and the rhetorical tradition, highlights pedagogical approaches that would benefit from a service-learning component, and discusses the benefits of service-learning for community partners and students. The remainder of the article focuses on how to implement service-learning in a public speaking course, including reflection and assessment recommendations.
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- 2018
33. Cannabis Hunger Games: nutrient stress induction in flowering stage – impact of organic and mineral fertilizer levels on biomass, cannabidiol (CBD) yield and nutrient use efficiency
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Danilo Crispim Massuela, Sebastian Munz, Jens Hartung, Peteh Mehdi Nkebiwe, and Simone Graeff-Hönninger
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cannabidiol ,nutrient stress ,indoor cultivation ,organic fertilization ,mineral fertilization ,environmental impact ,Plant culture ,SB1-1110 - Abstract
Indoor medicinal cannabis cultivation systems enable year-round cultivation and better control of growing factors, however, such systems are energy and resource intensive. Nutrient deprivation during flowering can trigger nutrient translocation and modulate the production of cannabinoids, which might increase agronomic nutrient use efficiency, and thus, a more sustainable use of fertilizers. This experiment compares two fertilizer types (mineral and organic) applied in three dilutions (80, 160 and 240 mg N L−1) to evaluate the effect of nutrient deprivation during flowering on biomass, Cannabidiol (CBD) yield and nutrient use efficiency of N, P and K. This is the first study showing the potential to reduce fertilizer input while maintaining CBD yield of medicinal cannabis. Under nutrient stress, inflorescence yield was significantly lower at the final harvest, however, this was compensated by a higher CBD concentration, resulting in 95% of CBD yield using one-third less fertilizer. The higher nutrient use efficiency of N, P, and K in nutrient-deprived plants was achieved by a larger mobilization and translocation of nutrients increasing the utilization efficiency of acquired nutrients. The agronomic nutrient use efficiency of CBD yield – for N and K – increased 34% for the organic fertilizers and 72% for the mineral fertilizers comparing the dilution with one-third less nutrients (160) with the highest nutrient concentration (240). Differences in CBD yield between fertilizer types occurred only at the final harvest indicating limitations in nutrient uptake due to nutrient forms in the organic fertilizer. Our results showed a lower acquisition and utilization efficiency for the organic fertilizer, proposing the necessity to improve either the timing of bio-availability of organic fertilizers or the use of soil amendments.
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- 2023
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34. Nature-Inspired Intelligent Synthesis of a Spherical Mechanism for Passive Ankle Rehabilitation Using Differential Evolution
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Luis Ernesto Valencia-Segura, Miguel Gabriel Villarreal-Cervantes, Leonel German Corona-Ramirez, Francisco Cuenca-Jimenez, and Jose Saul Munz-Reina
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Mechanism synthesis ,spherical four-bar mechanism ,optimization ,differential evolution ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The ankle rehabilitation in certain injuries requires passive movements to aid in the prompt recovery of ankle movement. In the last years, parallel ankle rehabilitation robots with multiple degrees of freedom have been the most studied for providing such movements in a controlled way. Nevertheless, the high cost does not make it viable for home healthcare. Then, this paper presents an optimization approach where a spherical mechanism of one-degree-of-freedom is proposed as a low-cost ankle rehabilitation device to provide the passive rehabilitation exercise for plantar flexion/dorsiflexion and adduction/abduction ankle movements. The approach is formulated as a mono-objective constraint optimization problem where the relative motion angle of the mechanism, the Grashof criterion, the force transmission, and the rehabilitation routine are included. The link lengths of the mechanism parameterized in Cartesian coordinates are found by the two most representative differential evolution variants. The statistical analysis of optimizers indicates that the $DE/rand/1/bin$ finds, on average, more promising solutions through algorithm executions than the $DE/best/1/bin$ . The numerical simulation results and the motion simulation of the CAD model illustrate the obtained ankle rehabilitation mechanism, indicating that the percentage error between the desired rehabilitation path and the curve generated by the coupler point of the mechanism is in the interval $[{0.036,0.437}]\%$ . Manufacturing the ankle rehabilitation mechanism with a 3D printer validates the optimization approach and verifies the resulting mechanism.
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- 2023
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35. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
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Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han H. Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T. Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Mi Yeong Hwang, Sohee Han, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Aki S. Havulinna, Yogasudha Veturi, Jennifer Allen Pacheco, Elisabeth A. Rosenthal, Todd Lingren, QiPing Feng, Iftikhar J. Kullo, Akira Narita, Jun Takayama, Hilary C. Martin, Karen A. Hunt, Bhavi Trivedi, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, Kuang Lin, Iona Y. Millwood, Asif Rasheed, George Hindy, Jessica D. Faul, Wei Zhao, David R. Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Ananyo Choudhury, Dhriti Sengupta, Anubha Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian’an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Andrew R. Wood, Yingji Ji, Zishan Gao, Simon Haworth, Noha A. Yousri, Ruth E. Mitchell, Jin Fang Chai, Mette Aadahl, Anne A. Bjerregaard, Jie Yao, Ani Manichaikul, Chii-Min Hwu, Yi-Jen Hung, Helen R. Warren, Julia Ramirez, Jette Bork-Jensen, Line L. Kårhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Pala Mauro, Floris Matteo, Aaron F. McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T. Møllehave, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E. Galesloot, Jonathan P. Bradfield, Sanni E. Ruotsalainen, EWarwick Daw, Joseph M. Zmuda, Jonathan S. Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A. Brody, Miguel Vazquez-Moreno, Mary F. Feitosa, Mary K. Wojczynski, Zhe Wang, Michael H. Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W. Benjamins, Jorgen Engmann, Noah L. Tsao, Anurag Verma, Roderick C. Slieker, Ken Sin Lo, Nuno R. Zilhao, Phuong Le, Marcus E. Kleber, Graciela E. Delgado, Shaofeng Huo, Daisuke D. Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Ayşe Demirkan, Hampton L. Leonard, Jonathan Marten, Mirjam Frank, Börge Schmidt, Laura J. Smyth, Marisa Cañadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kähönen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Suraj S. Nongmaithem, Swati Bayyana, Heather M. Stringham, Marguerite R. Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R. H. J. Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A. Lange, Gauri Prasad, Laura Lorés-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N. Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C. Warner, Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A. Kentistou, Bernhard Banas, Giuseppe Giovanni Nardone, Karina Meidtner, Lawrence F. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Maria Pina Concas, Simona Vaccargiu, Peter J. van der Most, Niina Pitkänen, Brian E. Cade, Sander W. van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Amy R. Bentley, Ayo P. Doumatey, Adebowale A. Adeyemo, Jong Young Lee, Eva R. B. Petersen, Aneta A. Nielsen, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikäinen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hidalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O. Obura, Jessica van Setten, Xiaoyin Li, Jingjing Liang, Hua Tang, Natalie Terzikhan, Jae Hun Shin, Rebecca D. Jackson, Alexander P. Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Takahisa Kawaguchi, Joachim Thiery, Joshua C. Bis, Lenore J. Launer, Huaixing Li, Mike A. Nalls, Olli T. Raitakari, Sahoko Ichihara, Sarah H. Wild, Christopher P. Nelson, Harry Campbell, Susanne Jäger, Toru Nabika, Fahd Al-Mulla, Harri Niinikoski, Peter S. Braund, Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya, Dominique de Kleijn, Gert J. de Borst, Eung Kweon Kim, Hieab H. H. Adams, M. Arfan Ikram, Xiaofeng Zhu, Folkert W. Asselbergs, Adriaan O. Kraaijeveld, Joline W. J. Beulens, Xiao-Ou Shu, Loukianos S. Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W. Hewitt, Mika Kähönen, Louis Pérusse, Claude Bouchard, Anke Tönjes, Yii-Der Ida Chen, Craig E. Pennell, Trevor A. Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson, Dan Mellström, Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan, Woon-Puay Koh, Sang Youl Rhee, Jeong-Taek Woo, Iris M. Heid, Klaus J. Stark, Martina E. Zimmermann, Henry Völzke, Georg Homuth, Michele K. Evans, Alan B. Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E. Hoefer, Susan Redline, Katja Pahkala, Albertine J. Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon L. R. Kardia, Patricia A. Peyser, Norihiro Kato, Matthias B. Schulze, Giorgia Girotto, Carsten A. Böger, Bettina Jung, Peter K. Joshi, David A. Bennett, Philip L. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris Brown, Mark J. Caulfield, Patricia B. Munroe, Xiuqing Guo, Marina Ciullo, Jost B. Jonas, Nilesh J. Samani, Jaakko Kaprio, Päivi Pajukanta, Teresa Tusié-Luna, Carlos A. Aguilar-Salinas, Linda S. Adair, Sonny Augustin Bechayda, H. Janaka de Silva, Ananda R. Wickremasinghe, Ronald M. Krauss, Jer-Yuarn Wu, Wei Zheng, Anneke Iden Hollander, Dwaipayan Bharadwaj, Adolfo Correa, James G. Wilson, Lars Lind, Chew-Kiat Heng, Amanda E. Nelson, Yvonne M. Golightly, James F. Wilson, Brenda Penninx, Hyung-Lae Kim, John Attia, Rodney J. Scott, D. C. Rao, Donna K. Arnett, Steven C. Hunt, Mark Walker, Heikki A. Koistinen, Giriraj R. Chandak, Josep M. Mercader, Maria C. Costanzo, Dongkeun Jang, Noël P. Burtt, Clicerio Gonzalez Villalpando, Lorena Orozco, Myriam Fornage, EShyong Tai, Rob M. van Dam, Terho Lehtimäki, Nish Chaturvedi, Mitsuhiro Yokota, Jianjun Liu, Dermot F. Reilly, Amy Jayne McKnight, Frank Kee, Karl-Heinz Jöckel, Mark I. McCarthy, Colin N. A. Palmer, Veronique Vitart, Caroline Hayward, Eleanor Simonsick, Cornelia M. van Duijn, Zi-Bing Jin, Jia Qu, Haretsugu Hishigaki, Xu Lin, Winfried März, Vilmundur Gudnason, Jean-Claude Tardif, Guillaume Lettre, Leen M.‘t Hart, Petra J. M. Elders, Scott M. Damrauer, Meena Kumari, Mika Kivimaki, Pim van der Harst, Tim D. Spector, Ruth J. F. Loos, Michael A. Province, Esteban J. Parra, Miguel Cruz, Bruce M. Psaty, Ivan Brandslund, Peter P. Pramstaller, Charles N. Rotimi, Kaare Christensen, Samuli Ripatti, Elisabeth Widén, Hakon Hakonarson, Struan F. A. Grant, Lambertus A. L. M. Kiemeney, Jacqueline de Graaf, Markus Loeffler, Florian Kronenberg, Dongfeng Gu, Jeanette Erdmann, Heribert Schunkert, Paul W. Franks, Allan Linneberg, J. Wouter Jukema, Amit V. Khera, Minna Männikkö, Marjo-Riitta Jarvelin, Zoltan Kutalik, Cucca Francesco, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Hugh Watkins, David P. Strachan, Niels Grarup, Peter Sever, Neil Poulter, Lee-Ming Chuang, Jerome I. Rotter, Thomas M. Dantoft, Fredrik Karpe, Matt J. Neville, Nicholas J. Timpson, Ching-Yu Cheng, Tien-Yin Wong, Chiea Chuen Khor, Hengtong Li, Charumathi Sabanayagam, Annette Peters, Christian Gieger, Andrew T. Hattersley, Nancy L. Pedersen, Patrik K. E. Magnusson, Dorret I. Boomsma, Allegonda H. M. Willemsen, LAdrienne Cupples, Joyce B. J. van Meurs, Mohsen Ghanbari, Penny Gordon-Larsen, Wei Huang, Young Jin Kim, Yasuharu Tabara, Nicholas J. Wareham, Claudia Langenberg, Eleftheria Zeggini, Johanna Kuusisto, Markku Laakso, Erik Ingelsson, Goncalo Abecasis, John C. Chambers, Jaspal S. Kooner, Paul S. de Vries, Alanna C. Morrison, Scott Hazelhurst, Michèle Ramsay, Kari E. North, Martha Daviglus, Peter Kraft, Nicholas G. Martin, John B. Whitfield, Shahid Abbas, Danish Saleheen, Robin G. Walters, Michael V. Holmes, Corri Black, Blair H. Smith, Aris Baras, Anne E. Justice, Julie E. Buring, Paul M. Ridker, Daniel I. Chasman, Charles Kooperberg, Gen Tamiya, Masayuki Yamamoto, David A. van Heel, Richard C. Trembath, Wei-Qi Wei, Gail P. Jarvik, Bahram Namjou, M. Geoffrey Hayes, Marylyn D. Ritchie, Pekka Jousilahti, Veikko Salomaa, Kristian Hveem, Bjørn Olav Åsvold, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada, Yoshinori Murakami, Bong-Jo Kim, Unnur Thorsteinsdottir, Kari Stefansson, Jifeng Zhang, YEugene Chen, Yuk-Lam Ho, Julie A. Lynch, Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, John M. Gaziano, Peter W. F. Wilson, Timothy M. Frayling, Joel N. Hirschhorn, Sekar Kathiresan, Karen L. Mohlke, Yan V. Sun, Andrew P. Morris, Michael Boehnke, Christopher D. Brown, Pradeep Natarajan, Panos Deloukas, Cristen J. Willer, Themistocles L. Assimes, and Gina M. Peloso
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Cholesterol ,Lipids ,Genetics ,Genome-wide association study ,GWAS ,Biology (General) ,QH301-705.5 ,QH426-470 - Abstract
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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- 2022
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36. A saturated map of common genetic variants associated with human height
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Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U., Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D., Graham, Sarah E., Mukamel, Ronen E., Spracklen, Cassandra N., Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H., Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E., Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S., Akiyama, Masato, Allison, Matthew A., Alvarez, Marcus, Andersen, Mette K., Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F., Bollepalli, Sailalitha, Bonnycastle, Lori L., Bork-Jensen, Jette, Bradfield, Jonathan P., Bradford, Yuki, Braund, Peter S., Brody, Jennifer A., Burgdorf, Kristoffer S., Cade, Brian E., Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, Chang, Yi-Cheng, Chen, Chien-Hsiun, Chesi, Alessandra, Choi, Seung Hoan, Chung, Ren-Hua, Cocca, Massimiliano, Concas, Maria Pina, Couture, Christian, Cuellar-Partida, Gabriel, Danning, Rebecca, Daw, E. Warwick, Degenhard, Frauke, Delgado, Graciela E., Delitala, Alessandro, Demirkan, Ayse, Deng, Xuan, Devineni, Poornima, Dietl, Alexander, Dimitriou, Maria, Dimitrov, Latchezar, Dorajoo, Rajkumar, Ekici, Arif B., Engmann, Jorgen E., Fairhurst-Hunter, Zammy, Farmaki, Aliki-Eleni, Faul, Jessica D., Fernandez-Lopez, Juan-Carlos, Forer, Lukas, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian, Galesloot, Tessel E., Gao, Yan, Gao, Zishan, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette P., Goel, Anuj, Gordon, Scott D., Gorski, Mathias, Grove, Jakob, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeffrey, Hansen, Thomas F., Havulinna, Aki S., Haworth, Simon J., He, Jing, Heard-Costa, Nancy, Hebbar, Prashantha, Hindy, George, Ho, Yuk-Lam A., Hofer, Edith, Holliday, Elizabeth, Horn, Katrin, Hornsby, Whitney E., Hottenga, Jouke-Jan, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia, Huffman, Jennifer E., Hung, Yi-Jen, Huo, Shaofeng, Hwang, Mi Yeong, Iha, Hiroyuki, Ikeda, Daisuke D., Isono, Masato, Jackson, Anne U., Jäger, Susanne, Jansen, Iris E., Johansson, Ingegerd, Jonas, Jost B., Jonsson, Anna, Jørgensen, Torben, Kalafati, Ioanna-Panagiota, Kanai, Masahiro, Kanoni, Stavroula, Kårhus, Line L., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kawaguchi, Takahisa, Kember, Rachel L., Kentistou, Katherine A., Kim, Han-Na, Kim, Young Jin, Kleber, Marcus E., Knol, Maria J., Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney, Lee, Jong-Young, Leonard, Hampton L., Li, Shengchao A., Li, Xiaohui, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shih-Yi, Liu, Jun, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian’an, Lyssenko, Valeriya, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Mattheisen, Manuel, Mavarani, Laven, McDaid, Aaron F., Meidtner, Karina, Melendez, Tori L., Mercader, Josep M., Milaneschi, Yuri, Miller, Jason E., Millwood, Iona Y., Mishra, Pashupati P., Mitchell, Ruth E., Møllehave, Line T., Morgan, Anna, Mucha, Soeren, Munz, Matthias, Nakatochi, Masahiro, Nelson, Christopher P., Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A., Nolte, Ilja M., Nongmaithem, Suraj S., Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva R. B., Petersen, Liselotte V., Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H., Pyarajan, Saiju, Raffield, Laura M., Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W., Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E., Ryan, Kathleen A., Sabater-Lleal, Maria, Saxena, Richa, Scholz, Markus, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M., Slieker, Roderick C., Smit, Roelof A. J., Smith, Albert V., Smith, Jennifer A., Smyth, Laura J., Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent D., Tayo, Bamidele O., Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola, Teumer, Alexander, Theusch, Elizabeth, Thompson, Deborah J., Thorleifsson, Gudmar, Timmers, Paul R. H. J., Trompet, Stella, Turman, Constance, Vaccargiu, Simona, van der Laan, Sander W., van der Most, Peter J., van Klinken, Jan B., van Setten, Jessica, Verma, Shefali S., Verweij, Niek, Veturi, Yogasudha, Wang, Carol A., Wang, Chaolong, Wang, Lihua, Wang, Zhe, Warren, Helen R., Bin Wei, Wen, Wickremasinghe, Ananda R., Wielscher, Matthias, Wiggins, Kerri L., Winsvold, Bendik S., Wong, Andrew, Wu, Yang, Wuttke, Matthias, Xia, Rui, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah, Yousri, Noha A., Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jing-Hua, Zhao, Wei, Zhou, Wei, Zimmermann, Martina E., Zoledziewska, Magdalena, Adair, Linda S., Adams, Hieab H. H., Aguilar-Salinas, Carlos A., Al-Mulla, Fahd, Arnett, Donna K., Asselbergs, Folkert W., Åsvold, Bjørn Olav, Attia, John, Banas, Bernhard, Bandinelli, Stefania, Bennett, David A., Bergler, Tobias, Bharadwaj, Dwaipayan, Biino, Ginevra, Bisgaard, Hans, Boerwinkle, Eric, Böger, Carsten A., Bønnelykke, Klaus, Boomsma, Dorret I., Børglum, Anders D., Borja, Judith B., Bouchard, Claude, Bowden, Donald W., Brandslund, Ivan, Brumpton, Ben, Buring, Julie E., Caulfield, Mark J., Chambers, John C., Chandak, Giriraj R., Chanock, Stephen J., Chaturvedi, Nish, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Ching-Yu, Christophersen, Ingrid E., Ciullo, Marina, Cole, John W., Collins, Francis S., Cooper, Richard S., Cruz, Miguel, Cucca, Francesco, Cupples, L. Adrienne, Cutler, Michael J., Damrauer, Scott M., Dantoft, Thomas M., de Borst, Gert J., de Groot, Lisette C. P. G. M., De Jager, Philip L., de Kleijn, Dominique P. V., Janaka de Silva, H., Dedoussis, George V., den Hollander, Anneke I., Du, Shufa, Easton, Douglas F., Elders, Petra J. M., Eliassen, A. Heather, Ellinor, Patrick T., Elmståhl, Sölve, Erdmann, Jeanette, Evans, Michele K., Fatkin, Diane, Feenstra, Bjarke, Feitosa, Mary F., Ferrucci, Luigi, Ford, Ian, Fornage, Myriam, Franke, Andre, Franks, Paul W., Freedman, Barry I., Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Goddard, Michael E., Golightly, Yvonne M., Gonzalez-Villalpando, Clicerio, Gordon-Larsen, Penny, Grallert, Harald, Grant, Struan F. A., Grarup, Niels, Griffiths, Lyn, Gudnason, Vilmundur, Haiman, Christopher, Hakonarson, Hakon, Hansen, Torben, Hartman, Catharina A., Hattersley, Andrew T., Hayward, Caroline, Heckbert, Susan R., Heng, Chew-Kiat, Hengstenberg, Christian, Hewitt, Alex W., Hishigaki, Haretsugu, Hoyng, Carel B., Huang, Paul L., Huang, Wei, Hunt, Steven C., Hveem, Kristian, Hyppönen, Elina, Iacono, William G., Ichihara, Sahoko, Ikram, M. Arfan, Isasi, Carmen R., Jackson, Rebecca D., Jarvelin, Marjo-Riitta, Jin, Zi-Bing, Jöckel, Karl-Heinz, Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kang, Kui Dong, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kato, Norihiro, Kee, Frank, Kessler, Thorsten, Khera, Amit V., Khor, Chiea Chuen, Kiemeney, Lambertus A. L. M., Kim, Bong-Jo, Kim, Eung Kweon, Kim, Hyung-Lae, Kirchhof, Paulus, Kivimaki, Mika, Koh, Woon-Puay, Koistinen, Heikki A., Kolovou, Genovefa D., Kooner, Jaspal S., Kooperberg, Charles, Köttgen, Anna, Kovacs, Peter, Kraaijeveld, Adriaan, Kraft, Peter, Krauss, Ronald M., Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Le Marchand, Loic, Lee, Hyejin, Lee, Nanette R., Lehtimäki, Terho, Li, Huaixing, Li, Liming, Lieb, Wolfgang, Lin, Xu, Lind, Lars, Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Loeffler, Markus, London, Barry, Lubitz, Steven A., Lye, Stephen J., Mackey, David A., Mägi, Reedik, Magnusson, Patrik K. E., Marcus, Gregory M., Vidal, Pedro Marques, Martin, Nicholas G., März, Winfried, Matsuda, Fumihiko, McGarrah, Robert W., McGue, Matt, McKnight, Amy Jayne, Medland, Sarah E., Mellström, Dan, Metspalu, Andres, Mitchell, Braxton D., Mitchell, Paul, Mook-Kanamori, Dennis O., Morris, Andrew D., Mucci, Lorelei A., Munroe, Patricia B., Nalls, Mike A., Nazarian, Saman, Nelson, Amanda E., Neville, Matt J., Newton-Cheh, Christopher, Nielsen, Christopher S., Nöthen, Markus M., Ohlsson, Claes, Oldehinkel, Albertine J., Orozco, Lorena, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin N. A., Parra, Esteban J., Pattaro, Cristian, Pedersen, Oluf, Pennell, Craig E., Penninx, Brenda W. J. H., Perusse, Louis, Peters, Annette, Peyser, Patricia A., Porteous, David J., Posthuma, Danielle, Power, Chris, Pramstaller, Peter P., Province, Michael A., Qi, Qibin, Qu, Jia, Rader, Daniel J., Raitakari, Olli T., Ralhan, Sarju, Rallidis, Loukianos S., Rao, Dabeeru C., Redline, Susan, Reilly, Dermot F., Reiner, Alexander P., Rhee, Sang Youl, Ridker, Paul M., Rienstra, Michiel, Ripatti, Samuli, Ritchie, Marylyn D., Roden, Dan M., Rosendaal, Frits R., Rotter, Jerome I., Rudan, Igor, Rutters, Femke, Sabanayagam, Charumathi, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sanghera, Dharambir K., Sattar, Naveed, Schmidt, Börge, Schmidt, Helena, Schmidt, Reinhold, Schulze, Matthias B., Schunkert, Heribert, Scott, Laura J., Scott, Rodney J., Sever, Peter, Shiroma, Eric J., Shoemaker, M. Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M., Sims, Mario, Singh, Jai Rup, Singleton, Andrew B., Sinner, Moritz F., Smith, J. Gustav, Snieder, Harold, Spector, Tim D., Stampfer, Meir J., Stark, Klaus J., Strachan, David P., ‘t Hart, Leen M., Tabara, Yasuharu, Tang, Hua, Tardif, Jean-Claude, Thanaraj, Thangavel A., Timpson, Nicholas J., Tönjes, Anke, Tremblay, Angelo, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Maria-Teresa, Uitterlinden, Andre G., van Dam, Rob M., van der Harst, Pim, Van der Velde, Nathalie, van Duijn, Cornelia M., van Schoor, Natasja M., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wacher-Rodarte, Niels H., Walker, Mark, Wang, Ya Xing, Wareham, Nicholas J., Watanabe, Richard M., Watkins, Hugh, Weir, David R., Werge, Thomas M., Widen, Elisabeth, Wilkens, Lynne R., Willemsen, Gonneke, Willett, Walter C., Wilson, James F., Wong, Tien-Yin, Woo, Jeong-Taek, Wright, Alan F., Wu, Jer-Yuarn, Xu, Huichun, Yajnik, Chittaranjan S., Yokota, Mitsuhiro, Yuan, Jian-Min, Zeggini, Eleftheria, Zemel, Babette S., Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M., Zonderman, Alan B., Zwart, John-Anker, Chasman, Daniel I., Cho, Yoon Shin, Heid, Iris M., McCarthy, Mark I., Ng, Maggie C. Y., O’Donnell, Christopher J., Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Sun, Yan V., Tai, E. Shyong, Boehnke, Michael, Deloukas, Panos, Justice, Anne E., Lindgren, Cecilia M., Loos, Ruth J. F., Mohlke, Karen L., North, Kari E., Stefansson, Kari, Walters, Robin G., Winkler, Thomas W., Young, Kristin L., Loh, Po-Ru, Yang, Jian, Esko, Tõnu, Assimes, Themistocles L., Auton, Adam, Abecasis, Goncalo R., Willer, Cristen J., Locke, Adam E., Berndt, Sonja I., Lettre, Guillaume, Frayling, Timothy M., Okada, Yukinori, Wood, Andrew R., Visscher, Peter M., and Hirschhorn, Joel N.
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- 2022
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37. Application of High-Resolution Near-Infrared Imaging Spectroscopy to Detect Microplastic Particles in Different Environmental Compartments
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Munz, Matthias, Kreiß, Jasper, Krüger, Lisa, Schmidt, Lena Katharina, Bochow, Mathias, Bednarz, Marius, Bannick, Claus Gerhard, and Oswald, Sascha E.
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- 2023
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38. Prevalence of Somatic Symptoms and Somatoform Disorders among a German Adolescent Psychiatric Inpatient Sample
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Adam Geremek, Clemens Lindner, Martin Jung, Claudia Calvano, and Manuel Munz
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somatoform disorder ,child and adolescent psychiatry ,screening ,early detection ,early intervention ,Pediatrics ,RJ1-570 - Abstract
Somatoform disorders (SD), commencing during adolescence, represent a major problem in health care systems. While literature underlines the high presence of mental health problems among children and adolescents afflicted by somatic symptoms in the general population, limited evidence is available on the prevalence of comorbid somatic symptoms in child and adolescent psychiatric populations. We assessed the prevalence of somatic symptoms, depression, and anxiety by validated questionnaires in an inpatient cohort. We further screened for the presence of SD. Out of 434 inpatients aged 11–17 years, 371 were included and a total of n = 288 (77.6%) children and adolescents participated in the study. A total of 93.8% of the inpatients reported somatic symptoms within the past six months and still almost half (45.7%) of the sample reported at least one somatic symptom within the last seven days prior to inquiry. Relating to the past six months, 59.5% were positively screened for SD, and 44.6% reported symptoms eligible for positive screening within the past seven days prior to the survey. Somatoform symptomatology was highly associated with anxiety and depression scores, but functional decline was amenable to the number of somatic symptoms only. We provide evidence that somatic symptoms are frequent in children and adolescents being treated in child and adolescent psychiatry and are relevant to everyday functioning. Screening for somatic symptoms should be introduced in the routine diagnostic procedures for early detection of SD in the commencing stages.
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- 2024
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39. Challenges to Cannabis sativa Production from Pathogens and Microbes—The Role of Molecular Diagnostics and Bioinformatics
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Zamir K. Punja, Dieter Kahl, Ron Reade, Yu Xiang, Jack Munz, and Punya Nachappa
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bioinformatics ,cannabis ,hemp ,hop latent viroid ,molecular diagnostics ,plant pathogens ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The increased cultivation of Cannabis sativa L. in North America, represented by high Δ9-tetrahydrocannabinol-containing (high-THC) cannabis genotypes and low-THC-containing hemp genotypes, has been impacted by an increasing number of plant pathogens. These include fungi which destroy roots, stems, and leaves, in some cases causing a build-up of populations and mycotoxins in the inflorescences that can negatively impact quality. Viroids and viruses have also increased in prevalence and severity and can reduce plant growth and product quality. Rapid diagnosis of the occurrence and spread of these pathogens is critical. Techniques in the area of molecular diagnostics have been applied to study these pathogens in both cannabis and hemp. These include polymerase chain reaction (PCR)-based technologies, including RT-PCR, multiplex RT-PCR, RT-qPCR, and ddPCR, as well as whole-genome sequencing (NGS) and bioinformatics. In this study, examples of how these technologies have enhanced the rapidity and sensitivity of pathogen diagnosis on cannabis and hemp will be illustrated. These molecular tools have also enabled studies on the diversity and origins of specific pathogens, specifically viruses and viroids, and these will be illustrated. Comparative studies on the genomics and metabolomics of healthy and diseased plants are urgently needed to provide insight into their impact on the quality and composition of cannabis and hemp-derived products. Management of these pathogens will require monitoring of their spread and survival using the appropriate technologies to allow accurate detection, followed by appropriate implementation of disease control measures.
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- 2023
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40. Integrating online differential titrimetry and dynamic modelling as innovative energy saving strategy in a large industrial WWTP
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Polizzi, Cecilia, Falcioni, Serena, Mannucci, Alberto, Mori, Gualtiero, Nardi, Arianna, Spennati, Francesco, and Munz, Giulio
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- 2022
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41. Associations of autozygosity with a broad range of human phenotypes.
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Clark, David W, Okada, Yukinori, Moore, Kristjan HS, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona LK, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, de Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, van der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, van der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, de Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, and Chen, Guanjie
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Humans ,Body Size ,Risk-Taking ,Cognition ,Health Status ,Consanguinity ,Fertility ,Haplotypes ,Homozygote ,Alleles ,Inbreeding Depression - Abstract
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p
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- 2019
42. Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis
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Mina N. F. Morcos, Congxin Li, Clara M. Munz, Alessandro Greco, Nicole Dressel, Susanne Reinhardt, Katrin Sameith, Andreas Dahl, Nils B. Becker, Axel Roers, Thomas Höfer, and Alexander Gerbaulet
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Science - Abstract
Hematopoietic stem cells produce diverse cell lineages. Here, the authors apply single-cell RNA-seq, computational integration of non-perturbative approaches for fate-mapping, and mitotic tracking to chart lineage decisions in native hematopoiesis and identify megakaryocyte progenitors that directly link HSCs to megakaryocytes.
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- 2022
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43. Pancreatico-gastric fistula arising from IPMN associated with ductal adenocarcinoma of the pancreas: a case report and a literature review
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M. AbuDalu, Y. Munz, and G. Ohana
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case report ,IPMN ,adenocarcinoma ,pancreatico-gastric fistula ,total pancreatectomy ,Surgery ,RD1-811 - Abstract
IntroductionAn intraductal papillary mucinous neoplasm (IPMN) is a potentially malignant cystic tumor that is characterized by an excessive papillary proliferation of mucin-producing epithelial cells. The IPMN usually exhibits different degrees of dysplasia and is accompanied by cystic dilation of the main pancreatic duct (MPD) or side branch. We report a case of an IPMN that has penetrated the stomach and has differentiated into an adenocarcinoma.Case presentationA 69-year-old female, suffering from chronic pancreatitis of unknown etiology, visited our outpatient clinic with complaints of sudden weight loss, diarrhea, and abdominal pain. She underwent several examinations to evaluate the reasons for her sudden onset of symptoms. A gastroscopy showed an ulcerated lesion covered with mucus. CT and magnetic resonance cholangiopancreatography images revealed that the MPD was dilated to 1.3 cm with a fistula formation between the MPD and the stomach. After a multidisciplinary discussion of this case, a total pancreatectomy was proposed. An en bloc total pancreatectomy with gastric wedge resection including the fistula together with splenectomy was carried out. A Roux-en-Y choledochojejunostomy and gastrojejunostomy were performed. Histology results revealed the association of IPMN with invasive carcinoma.DiscussionMany reports on IPMN of the pancreas have been published recently. Fistula formation between IPMN and adjacent organs is possible. Given the CT and endoscopic ultrasonography findings, it shows that in our case a main duct IPMN (MD-IPMN) formed a pancreatico-gastric fistula. We point out that the adherence of invasive cancer cells contributed to the fistula formation between the pancreas and the stomach.ConclusionThis case report provides evidence for the possibility of IPMN becoming complicated with pancreatico-gastric fistula. Thus, we suggest that surgical resection should be considered in the case of MD-IPMN because of its high propensity for malignant transformation.
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- 2023
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44. BDNF signaling in correlation-dependent structural plasticity in the developing visual system.
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Elena Kutsarova, Anne Schohl, Martin Munz, Alex Wang, Yuan Yuan Zhang, Olesia M Bilash, and Edward S Ruthazer
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Biology (General) ,QH301-705.5 - Abstract
During development, patterned neural activity instructs topographic map refinement. Axons with similar patterns of neural activity converge onto target neurons and stabilize their synapses with these postsynaptic partners, restricting exploratory branch elaboration (Hebbian structural plasticity). On the other hand, non-correlated firing in inputs leads to synapse weakening and increased exploratory growth of axons (Stentian structural plasticity). We used visual stimulation to control the correlation structure of neural activity in a few ipsilaterally projecting (ipsi) retinal ganglion cell (RGC) axons with respect to the majority contralateral eye inputs in the optic tectum of albino Xenopus laevis tadpoles. Multiphoton live imaging of ipsi axons, combined with specific targeted disruptions of brain-derived neurotrophic factor (BDNF) signaling, revealed that both presynaptic p75NTR and TrkB are required for Stentian axonal branch addition, whereas presumptive postsynaptic BDNF signaling is necessary for Hebbian axon stabilization. Additionally, we found that BDNF signaling mediates local suppression of branch elimination in response to correlated firing of inputs. Daily in vivo imaging of contralateral RGC axons demonstrated that p75NTR knockdown reduces axon branch elongation and arbor spanning field volume.
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- 2023
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45. Autoethnography as Assessment: Communication Pedagogies as Social Justice Activism
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Hernández, Leandra H. and Munz, Stevie M.
- Abstract
In this article, we welcome the reader into our embodied teaching experiences. We invite the reader into our classrooms to see how our social justice pedagogies occur in real time and are experienced by the intersections of our race/ethnicity, gender, and sexuality. In this article, using narrative vignettes and autoethnography as our method, we explore the following research question: What contradictions and tensions characterize the relationship between traditional approach instructional communication and social justice/critical pedagogies? We discuss the concept of embodied positionalities, which we refer to as teaching from the flesh, and we introduce several short vignettes that highlight the intertwined nature of our identities, embodied teaching, and the importance of social justice activist approaches to communication pedagogy.
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- 2021
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46. Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis
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Morcos, Mina N. F., Li, Congxin, Munz, Clara M., Greco, Alessandro, Dressel, Nicole, Reinhardt, Susanne, Sameith, Katrin, Dahl, Andreas, Becker, Nils B., Roers, Axel, Höfer, Thomas, and Gerbaulet, Alexander
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- 2022
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47. Quantitative monitoring of paramagnetic contrast agents and their allocation in plant tissues via DCE-MRI
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Mayer, Simon, Munz, Eberhard, Hammer, Sebastian, Wagner, Steffen, Guendel, Andre, Rolletschek, Hardy, Jakob, Peter M., Borisjuk, Ljudmilla, and Neuberger, Thomas
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- 2022
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48. Implementation and evaluation of an individualized physical exercise promotion program in people with manifested risk factors for multimorbidity (MultiPill-Exercise): a study protocol for a pragmatic randomized controlled trial
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Schweda, Simone, Müller, Gerhard, Munz, Barbara, Sudeck, Gorden, Martus, Peter, Dierkes, Katja, and Krauss, Inga
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- 2022
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49. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
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Kanoni, Stavroula, Graham, Sarah E., Wang, Yuxuan, Surakka, Ida, Ramdas, Shweta, Zhu, Xiang, Clarke, Shoa L., Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J. M., Wu, Kuan-Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Yousri, Noha A., Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Hwu, Chii-Min, Hung, Yi-Jen, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, EWarwick, Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Vazquez-Moreno, Miguel, Feitosa, Mary F., Wojczynski, Mary K., Wang, Zhe, Preuss, Michael H., Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Tsao, Noah L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Le, Phuong, Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Frank, Mirjam, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Bayyana, Swati, Stringham, Heather M., Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul R. H. J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Nardone, Giuseppe Giovanni, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R. 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- 2022
- Full Text
- View/download PDF
50. Quantitative monitoring of paramagnetic contrast agents and their allocation in plant tissues via DCE-MRI
- Author
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Simon Mayer, Eberhard Munz, Sebastian Hammer, Steffen Wagner, Andre Guendel, Hardy Rolletschek, Peter M. Jakob, Ljudmilla Borisjuk, and Thomas Neuberger
- Subjects
Hordeum vulgare ,Contrast agent (CA) ,Magnetic resonance imaging (MRI) ,DCE-MRI ,Gadolinium DTPA ,Vascular bundles ,Plant culture ,SB1-1110 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Studying dynamic processes in living organisms with MRI is one of the most promising research areas. The use of paramagnetic compounds as contrast agents (CA), has proven key to such studies, but so far, the lack of appropriate techniques limits the application of CA-technologies in experimental plant biology. The presented proof-of-principle aims to support method and knowledge transfer from medical research to plant science. Results In this study, we designed and tested a new approach for plant Dynamic Contrast Enhanced Magnetic Resonance Imaging (pDCE-MRI). The new approach has been applied in situ to a cereal crop (Hordeum vulgare). The pDCE-MRI allows non-invasive investigation of CA allocation within plant tissues. In our experiments, gadolinium-DTPA, the most commonly used contrast agent in medical MRI, was employed. By acquiring dynamic T1-maps, a new approach visualizes an alteration of a tissue-specific MRI parameter T1 (longitudinal relaxation time) in response to the CA. Both, the measurement of local CA concentration and the monitoring of translocation in low velocity ranges (cm/h) was possible using this CA-enhanced method. Conclusions A novel pDCE-MRI method is presented for non-invasive investigation of paramagnetic CA allocation in living plants. The temporal resolution of the T1-mapping has been significantly improved to enable the dynamic in vivo analysis of transport processes at low-velocity ranges, which are common in plants. The newly developed procedure allows to identify vascular regions and to estimate their involvement in CA allocation. Therefore, the presented technique opens a perspective for further development of CA-aided MRI experiments in plant biology.
- Published
- 2022
- Full Text
- View/download PDF
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