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830 results on '"Morita, Akio"'

15. Experience Using Gentian Violet-Free Dyes for Tissue Visualization.

Author

Matano, Fumihiro, Murai, Yasuo, Nounaka, Yohei, Higuchi, Tadashi, Mihara, Riku, Isayama, Koshiro, and Morita, Akio

Subjects
GENTIAN violet, TEMPORAL arteries, DYES & dyeing, CEREBRAL arteries, BLOOD vessels, FREE flaps
Abstract

Background Gentian violet ink is used as a skin marker in various surgical procedures, including neurosurgery. The dye is also used to visualize the edges of blood vessels during bypass surgery. However, gentian violet ink carries the risks of carcinogenicity and venous injury, which causes microvascular thrombosis. In this study, we compare the gentian violet–free dye C.I. Basic Violet 4 (BV4) and gentian violet. The usefulness, in terms of color, and formation of microvascular thrombosis in anastomosis were compared. Methods We used the gentian violet–free dye in 20 cases involving 3 vascular anastomoses. The bone cutting lines on the bone surface, superior temporal artery, and middle cerebral artery were drawn using BV4 and gentian violet ink. Results The colors of BV4 and gentian violet ink were similar. No thrombus formation was observed at the vascular anastomosis when using BV4. Conclusion BV4 can be used similarly to gentian violet ink. No adverse effects such as thrombus formation in microvascular anastomosis were experienced when BV4 was used. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Transcriptomic Profiling of Lactotroph Pituitary Neuroendocrine Tumors via RNA Sequencing and Ingenuity Pathway Analysis.

Author

Hattori, Yujiro, Tahara, Shigeyuki, Ozawa, Hitoshi, Morita, Akio, and Ishii, Hirotaka

Subjects
RNA sequencing, PITUITARY tumors, NEUROENDOCRINE tumors, GENE expression, LINCRNA, PROLACTINOMA
Abstract

Introduction: Lactotroph pituitary neuroendocrine tumors (PitNETs) are common pituitary tumors, but their underlying molecular mechanisms remain unclear. This study aimed to investigate the transcriptomic landscape of lactotroph PitNETs and identify potential molecular mechanisms and therapeutic targets through RNA sequencing and ingenuity pathway analysis (IPA). Methods: Lactotroph PitNET tissues from five surgical cases without dopamine agonist treatment underwent RNA sequencing. Normal pituitary tissues from 3 patients served as controls. Differentially expressed genes (DEGs) were identified, and the functional pathways and gene networks were explored by IPA. Results: Transcriptome analysis revealed that lactotroph PitNETs had gene expression patterns that were distinct from normal pituitary tissues. We identified 1,172 upregulated DEGs, including nine long intergenic noncoding RNAs (lincRNAs) belonging to the top 30 DEGs. IPA of the upregulated DEGs showed that the estrogen receptor signaling, oxidative phosphorylation signaling, and EIF signaling were activated. In gene network analysis, key upstream regulators, such as EGR1, PRKACA, PITX2, CREB1, and JUND, may play critical roles in lactotroph PitNETs. Conclusion: This study provides a comprehensive transcriptomic profile of lactotroph PitNETs and highlights the potential involvement of lincRNAs and specific signaling pathways in tumor pathogenesis. The identified upstream regulators may be potential therapeutic targets for future investigations. [ABSTRACT FROM AUTHOR]

Published
2024
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34. In-hospital mortality and poor outcome after surgical clipping and endovascular coiling for aneurysmal subarachnoid hemorrhage using nationwide databases: a systematic review and meta-analysis

Author

Ikawa, Fusao, Michihata, Nobuaki, Matsushige, Toshinori, Abiko, Masaru, Ishii, Daizo, Oshita, Jumpei, Okazaki, Takahito, Sakamoto, Shigeyuki, Kurogi, Ryota, Iihara, Koji, Nishimura, Kunihiro, Morita, Akio, Fushimi, Kiyohide, Yasunaga, Hideo, and Kurisu, Kaoru

Published
2020
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35. Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events

Author

Hasegawa, Mitsuhiro, Hatayama, Toru, Kondo, Akinori, Nagahiro, Shinji, Fujimaki, Takamitsu, Amagasaki, Kenichi, Arita, Kazunori, Date, Isao, Fujii, Yukihiko, Goto, Takeo, Hanaya, Ryosuke, Higuchi, Yoshinori, Hongo, Kazuhiro, Inoue, Toru, Kasuya, Hidetoshi, Kayama, Takamasa, Kawashima, Masatou, Kohmura, Eiji, Maehara, Taketoshi, Matsushima, Toshio, Mizobuchi, Yoshihumi, Morita, Akio, Nishizawa, Shigeru, Noro, Shusaku, Saito, Shinjiro, Shimano, Hirofumi, Shirane, Reizo, Takeshima, Hideo, Tanaka, Yuichiro, Tanabe, Hidenori, Toda, Hiroki, Yamakami, Iwao, Nishiyama, Yuya, Ohba, Shigeo, Hirose, Yuichi, and Suzuki, Takeya

Published
2019
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39. Pathological Findings of Donor Vessels in Bypass Surgery.

Author

Nounaka, Yohei, Murai, Yasuo, Kubota, Asami, Tsukiyama, Atsushi, Matano, Fumihiro, Koketsu, Kenta, and Morita, Akio

Subjects
MOYAMOYA disease, RADIAL artery, ARTERIAL stenosis, TEMPORAL arteries, CEREBRAL revascularization, CAROTID intima-media thickness, ANKLE brachial index
Abstract

(1) Background Cerebral revascularization is necessary to treat intracranial arterial stenosis caused by moyamoya disease, atherosclerosis, or large complex aneurysms. Although various donor vascular harvesting methods have been reported safe, there are no reports on the histological evaluation of donor vessels for each disease, despite the variety of diseases wherein vascular anastomosis is required. (2) Methods Pathological findings of the superficial temporal artery (STA), radial artery (RA), occipital artery (OA), and saphenous vein (SV) harvested at the institution were analyzed. Patients classified according to aneurysm, atherosclerosis, and moyamoya disease were assessed for pathological abnormalities, medical history, age, sex, smoking, and postoperative anastomosis patency. (3) Results There were 38 cases of atherosclerosis, 15 cases of moyamoya disease, and 30 cases of aneurysm in 98 donor vessels (mean age 57.2) taken after 2006. Of the 84 STA, 11 RA, 2 OA, and 1 SV arteries that were harvested, 71.4% had atherosclerosis, 11.2% had dissection, and 10.2% had inflammation. There was no significant difference in the proportion of pathological findings according to the disease. A history of hypertension is associated with atherosclerosis in donor vessels. (4) Conclusions This is the first study to histologically evaluate the pathological findings of donor vessels according to disease. The proportion of dissection findings indicative of vascular damage due to surgical manipulation was not statistically different between the different conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Time-frequency analysis reveals an association between the specific nuclear magnetic resonance (NMR) signal properties of serum samples and arteriosclerotic lesion progression in a diabetes mouse model.

Author

Yui, Kanako, Kanawaku, Yoshimasa, Morita, Akio, Hirakawa, Keiko, and Cui, Fanlai

Subjects
NUCLEAR magnetic resonance, PARTIAL least squares regression, TIME-frequency analysis, LABORATORY mice, HEMATOXYLIN & eosin staining, SERUM
Abstract

Diabetes causes arteriosclerosis, primarily due to persistent hyperglycemia, subsequently leading to various cardiovascular events. No method has been established for directly detecting and evaluating arteriosclerotic lesions from blood samples of diabetic patients, as the mechanism of arteriosclerotic lesion formation, which involves complex molecular biological processes, has not been elucidated. "NMR modal analysis" is a technology that enables visualization of specific nuclear magnetic resonance (NMR) signal properties of blood samples. We hypothesized that this technique could be used to identify changes in blood status associated with the progression of arteriosclerotic lesions in the context of diabetes. The study aimed to assess the possibility of early detection and evaluation of arteriosclerotic lesions by NMR modal analysis of serum samples from diabetes model mice. Diabetes model mice (BKS.Cg db/db) were bred in a clean room and fed a normal diet. Blood samples were collected and centrifuged. Carotid arteries were collected for histological examination by hematoxylin and eosin staining on weeks 10, 14, 18, 22, and 26. The serum was separated and subjected to NMR modal analysis and biochemical examination. Mice typically show hyperglycemia at an early stage (8 weeks old), and pathological findings of a previous study showed that more than half of mice had atheromatous plaques at 18 weeks old, and severe arteriosclerotic lesions were observed in almost all mice after 22 weeks. Partial least squares regression analysis was performed, which showed that the mice were clearly classified into two groups with positive and negative score values within 18 weeks of age. The findings of this study revealed that NMR modal properties of serum are associated with arteriosclerotic lesions. Thus, it may be worth exploring the possibility that the risk of cardiovascular events in diabetic patients could be assessed using serum samples. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Common Data Elements for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage Clinical Research: A National Institute for Neurological Disorders and Stroke and National Library of Medicine Project

Author

Suarez, Jose I., Sheikh, Muniza K., Macdonald, R. Loch, Amin-Hanjani, Sepideh, Brown, Jr., Robert D., de Oliveira Manoel, Airton Leonardo, Derdeyn, Colin P., Etminan, Nima, Keller, Emanuela, Leroux, Peter D., Mayer, Stephan A., Morita, Akio, Rinkel, Gabriel, Rufennacht, Daniel, Stienen, Martin N., Torner, James, Vergouwen, Mervyn D. I., Wong, George K. C., and the Unruptured Intracranial Aneurysms and SAH CDE Project Investigators

Published
2019
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