24 results on '"Morise S"'
Search Results
2. Etiology, management and outcome of children with non-cirrhotic portal vein thrombosis: a single center experience.
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Gavaise, M. P., Pallitto, M. B., Morise, S., Silvestri, G., and Vidal, J.
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- 2022
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3. P0320 AUTOIMMUNE HEPATITIS: MULTICENTRE DATA AT DIAGNOSIS IN 245 CHILDREN.
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Galoppo, C., Ciocca, M., González, T., Ramonet, M., Cañero Velasco, C., Afazani, A., Cuarterolo, M., López, S., Ferro, A., Pedreira, A., Caglio, P., Morise, S., D’Agostino, D., Marco, I., de D ávila, M. T. G, Alvarez, E., and Badía, I.
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- 2004
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4. P0210 STOOL COLOR CARDS SCREENING FOR INFANTS AGED ONE MONTH.
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Ramonet, M. D., Gomez, S., Ramos, S., Morise, S., Parga, L., Caglio, P., De Micheli, M., and Garsd, A.
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- 2004
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5. P0265 EPIDEMIOLOGIC OVERVIEW OF REYE’S SYNDROME.
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Ramonet, M. D., Morise, S. F., Ciocca, M. E., Galoppo, C., Wagener, M., and Garsd, A.
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- 2004
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6. [A case of atezolizumab- and bevacizumab-induced myositis showing high intensity in the pterygoid muscles, soft palate, and tongue on STIR-MRI].
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Ono S, Nakamura M, Morise S, Kunieda T, and Yakushiji Y
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- Female, Humans, Middle Aged, Bevacizumab adverse effects, Tongue diagnostic imaging, Palate, Soft, Immune Checkpoint Inhibitors, Magnetic Resonance Imaging, Pterygoid Muscles, Myositis chemically induced, Myositis diagnostic imaging, Myositis drug therapy
- Abstract
A 61-year-old woman was treated with atezolizumab plus bevacizumab for hepatocellular carcinoma with peritoneal dissemination. Blood tests revealed elevated creatine kinase (CK) that peaked at 2,657 U/l. After two cycles of atezolizumab plus bevacizumab combination therapy, she complained of progressive dysarthria and dysphagia. Needle electromyography showed myopathic changes. Initial MRI showed high signal intensity in the orbicularis oris muscle, soft palate, tongue, pterygoid muscles, and paravertebral muscles on STIR images. Myositis-specific autoantibodies were not detected. Based on these findings, the patient was diagnosed with immune checkpoint inhibitor-associated myositis. The clinical symptoms improved after administration of oral prednisone, and follow-up MRI showed reduced extent of areas of high signal intensity and almost complete resolution of signal abnormality in the paravertebral muscles. The CK level normalized after 1 months of oral steroid administration. MRI of the head and neck, including the tongue and soft palate, may be useful in diagnosis and for evaluating therapeutic efficiency in cases of bulbar symptoms that occur following the introduction of immune checkpoint inhibitors.
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- 2023
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7. Differences in rectoanal inhibitory reflex duration between patients with refractory functional constipationand myelomeningocele.
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Fernández J, Messere G, Ortiz G, Oviedo A, Vidal J, Morise S, Nurko S, and Bigliardi R
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- Humans, Manometry methods, Male, Female, Child, Preschool, Child, Adolescent, Prevalence, Reflex physiology, Constipation diagnosis, Constipation epidemiology, Meningomyelocele diagnosis, Meningomyelocele epidemiology, Anal Canal physiopathology, Rectum physiopathology
- Abstract
Introduction. Usually, during anorectal manometry, only the presence or absence of rectoanal inhibitory reflex (RAIR) is investigated. Studies have reported that a detailed analysis may provide data of interest. Our hypothesis is that RAIR measurement may provide information to detect organic causes (tethered cord, lipoma, etc.) in patients in whom a functional cause had been previously considered. Objectives. To compare RAIR duration in anorectal manometry between patients with refractory functional constipation (RFC) and myelomeningocele (MMC). Population and methods. Observational, analytical, cross-sectional study (2004-2019). Patients with chronic constipation and functional and organic fecal incontinence (myelomeningocele). The anorectal manometry was performed with a water-perfused system, and the duration of RAIR was measured with different volumes (20, 40, and 60 cc). Group 1 (G1): 81 RFC. Group 2 (G2): 54 MMC. Patients with developmental delay, compliant anal sphincter, sacral agenesis and non-cooperative patients were excluded. Results. A total of 135 individuals were included (62 were male). Their median age was 9.57 years in G1 and 9.63 years in G2. Average duration in G1 versus G2 with 20 cc: 8.89 versus 15.21 seconds; 40 cc: 11.41 versus 21.12 seconds; 60 cc: 14.15 versus 26.02 seconds. The difference in RAIR duration with the varying volumes was statistically significant (p = 0.0001). Conclusion. RAIR duration was longer with increasing balloon inflation volumes in both populations. RAIR duration was longer in patients with MMC than in those with RFC. Spinal injury should be ruled out in patients with prolonged RAIR.
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- 2023
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8. Quantitative and Morphological Assessment of Computed Tomography-depicted Gynecomastia in Spinal and Bulbar Muscular Atrophy.
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Iida S, Nakamura M, Itani K, Morise S, Kunieda T, Takenouchi N, Kaneko S, and Yakushiji Y
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- Humans, Male, Tomography, X-Ray Computed, Tomography, Gynecomastia diagnostic imaging, Gynecomastia epidemiology, Amyotrophic Lateral Sclerosis, Bulbo-Spinal Atrophy, X-Linked
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Rationale and Objectives: To evaluate the prevalence, size, and characteristics of gynecomastia on thoracic computed tomography (CT) in patients with spinal and bulbar muscular atrophy (SBMA) or amyotrophic lateral sclerosis (ALS), compared to those of patients with myasthenia gravis (as controls)., Materials and Methods: A total of 189 male patients (SBMA [n = 15]; ALS [n = 76]; control [n = 98]) who underwent thoracic computed tomography were included. The size of breast glandular tissue diameters, and characteristic of CT-depicted gynecomastia were compared., Results: On multivariate logistic regression analysis, mean breast glandular tissue diameter (adjusted odds ratio [aOR] 1.13, 95% confidence interval [CI] 1.08-1.19), maximum breast glandular tissue diameter (aOR 1.14, 95% CI 1.08-1.20), prevalence of CT-depicted gynecomastia (aOR 21.71, 95% CI 5.39-87.38), dendritic or diffuse pattern of gynecomastia (aOR 35.30, 95% CI 8.02-155.40), and bilateral gynecomastia (aOR 41.96, 95% CI 10.20-172.69) were positively associated with SBMA, but not ALS. On receiver operating characteristic (ROC) analysis, the area under the curve of the mean breast tissue diameter for predicting SBMA was 0.92 with the optimal cutoff value of 16.5 mm. The ROC analysis showed that a maximum breast tissue diameter of 18.6 mm can also effectively distinguish SBMA from controls., Conclusion: These findings suggest that the evaluation of breast glandular tissue on thoracic CT could be a screening examination to distinguish SBMA patients and assist in its differential diagnosis., (Copyright © 2022 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
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- 2022
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9. Early presentation of lower urinary tract and bowel dysfunction in sporadic amyotrophic lateral sclerosis: A case report.
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Nakamura M, Nakayama K, Murakami A, Morise S, Kaneko S, Kusaka H, and Yakushiji Y
- Abstract
An autopsy case of sporadic amyotrophic lateral sclerosis (ALS) with lower urinary tract (LUT) and bowel dysfunction is reported. The dysfunction occurred simultaneously with motor neuron symptoms in the early stages of the illness. A 75-year-old man developed exertional dyspnea and constipation following weight loss. Subsequently, he developed swallowing disturbance, fecal incontinence, and urinary retention. Neurological examination showed dysphagia, muscle weakness of the upper limbs, and prominent fasciculation affecting all four limbs and the tongue. All deep tendon reflexes were diminished, but the left plantar response was extensor. Orthostatic hypotension (OH) and the anal reflex were absent. Neuropathological findings did not show neuronal loss and gliosis in the thoracic and sacral intermediolateral nucleus (IML) and in Onuf's nucleus, whereas gliosis was observed in the periaqueductal gray (PAG) and striatum. Therefore, urinary retention may have resulted from involvement of the PAG. Phosphorylated TAR DNA binding protein 43 kDa (p-TDP-43)-positive inclusions were present in the peripheral nerves within the thoracic sympathetic ganglia, as well as the IML of the thoracic spinal cord. However, considering the lack of OH, the IML and peripheral sympathetic nerves unlikely played major roles. Furthermore, neuronal loss or p-TDP-43-immunoreactive deposits were absent in the Auerbach and Meissner plexuses of the rectum, suggesting that the responsible anatomical sites for fecal incontinence could not be found. Although it is difficult to elucidate the precise neuropathological lesions corresponding to LUT and bowel dysfunction, physicians need to recognize that neurogenic bladder and bowel dysfunction can occur in patients with ALS., (© 2022 The Authors.)
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- 2022
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10. Changes in shoulder muscle activities and glenohumeral motion after rotator cuff repair: an assessment using ultrasound real-time tissue elastography.
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Ishikawa H, Muraki T, Morise S, Kurokawa D, Yamamoto N, Itoi E, and Izumi SI
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- Humans, Range of Motion, Articular, Rotation, Rotator Cuff diagnostic imaging, Rotator Cuff surgery, Shoulder, Elasticity Imaging Techniques, Rotator Cuff Injuries diagnostic imaging, Rotator Cuff Injuries surgery, Shoulder Joint diagnostic imaging, Shoulder Joint surgery
- Abstract
Background: Although rotator cuff repair is performed to restore the function of the rotator cuff muscles and glenohumeral (GH) joint motion, little has been known regarding the recovery process. The purpose of this study was (1) to investigate changes over time in activities of the supraspinatus and deltoid muscles assessed by ultrasound real-time tissue elastography (RTE) after rotator cuff repair and (2) to determine contributions of the activities of these muscles to the GH joint motion., Methods: Twenty patients after rotator cuff repair and 13 control participants were enrolled in this study. Elasticity of the supraspinatus and middle deltoid muscles were measured at rest and 30° of humerothoracic elevation in the scapular plane (scaption) by using RTE. The elasticity at 30° of scaption was normalized to that at rest in each muscle to quantify their muscle activities. In addition, the supraspinatus-to-middle deltoid (SSP/MD) ratio for the normalized elasticity was calculated. The GH elevation angle was measured with a digital inclinometer, which was calculated by subtracting the scapular upward rotation angle from 30° of scaption. For patients after rotator cuff repair, all measurements were performed at 6 weeks, 8 weeks, 3 months, and 6 months after surgery. Rotator cuff integrity was examined with magnetic resonance imaging at 6 months after surgery., Results: Fifteen of 20 patients who remained intact at 6 months after surgery completed this study. The supraspinatus activity at 6 weeks was significantly smaller than that at 3 months (P = .006) and 6 months (P = .010). There was no significant difference in the supraspinatus activity between the patients at 3 months and the control participants (P = .586). The middle deltoid activity at 6 weeks was significantly greater than that at 6 months (P = .003). There was positive correlation between GH elevation angle and the activity of the supraspinatus relative to the deltoid at 6 weeks (r = 0.75, P = .001) and 8 weeks (r = 0.53, P = .041)., Conclusion: The supraspinatus activity increased from 6 weeks to 3 months after surgery. The supraspinatus activity at 3 months after surgery was the same level as that in healthy individuals. On the other hand, the deltoid activity decreased from 6 weeks to 6 months after surgery. The increase in activity of the supraspinatus relative to the deltoid was likely to be related to the increase in GH elevation during postoperative at 8 weeks., (Copyright © 2021 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.)
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- 2021
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11. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease.
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Tohge R, Kaneko S, Morise S, Oki M, Takenouchi N, Murakami A, Nakamura M, Kusaka H, and Yakushiji Y
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- Animals, Female, GABAergic Neurons drug effects, Oxidopamine, Parkinson Disease, Secondary chemically induced, RNA-Binding Proteins metabolism, Rats, Rats, Sprague-Dawley, Receptor, Serotonin, 5-HT1A drug effects, Receptor, Serotonin, 5-HT1B drug effects, Serotonin Agents therapeutic use, Anti-Dyskinesia Agents therapeutic use, Antiparkinson Agents adverse effects, Dyskinesia, Drug-Induced drug therapy, Levodopa adverse effects, Neostriatum drug effects, Parkinson Disease, Secondary drug therapy, Serotonergic Neurons drug effects, Zonisamide therapeutic use
- Abstract
Glutamate, GABA, acetylcholine, dopamine, and serotonin interact with each other to regulate the flow of neural information in the striatum. Serotonin type 1A receptor (5HT1A) is primarily expressed on glutamatergic nerve terminals, and 5HT1B is expressed on GABAergic medium spiny neurons (MSNs). Zonisamide (ZNS) reportedly improves the off period without worsening levodopa-induced dyskinesia (LID) in patients with advanced Parkinson's disease. In this study, LID model rats were prepared by administrating levodopa to unilaterally 6-OHDA-lesioned rats. We analyzed changes in serotonergic neurotransmission of LID model rats to elucidate the relationship between LID and the serotonergic system and pathomechanism of the anti-dyskinetic effects of ZNS. Abnormal involuntary movements (AIMs) were most severe in intermittently levodopa-treated rats but milder in rats intermittently medicated with levodopa and ZNS. Continuously levodopa-infused rats or intermittently ZNS-injected rats did not develop AIMs, and no differences in the expression of brain-derived neurotrophic factor, 5-HT transporter, 5HT1A, and 5HT1B mRNA between the lesioned striatum and normal side were observed. Expression of 5HT1B mRNA was elevated in the lesioned striatum of intermittently levodopa-treated rats, but this elevation was normalized by concomitant use of ZNS. The severity of AIMs was correlated with the ratio of 5HT1B to 5HT1A mRNA expression in the lesioned striatum, indicating that the anti-LID effect of ZNS is based on inhibition via 5HT1B receptors to direct pathway MSNs sensitized by intermittent levodopa treatment. Selectively acting serotonergic drugs, especially those that lower the 5HT1B to 5HT1A ratio, are promising new therapeutic agents to attenuate LID development., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
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- 2021
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12. Efficacy and safety of tacrolimus as long-term monotherapy for myasthenia gravis.
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Itani K, Nakamura M, Wate R, Kaneko S, Fujita K, Iida S, Morise S, Murakami A, Kunieda T, Takenouchi N, Yakushiji Y, and Kusaka H
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- Activities of Daily Living, Adult, Aged, Female, Humans, Male, Middle Aged, Tacrolimus administration & dosage, Thymectomy, Immunosuppressive Agents therapeutic use, Myasthenia Gravis drug therapy, Tacrolimus therapeutic use
- Abstract
The objective was to evaluate the long-term efficacy and safety of tacrolimus monotherapy in myasthenia gravis (MG) patients. Immunosuppressive drug-naïve MG patients were administered tacrolimus, followed by thymectomy in some of the cases according to the clinical guideline for MG. Additional aggressive immunosuppressive therapies were allowed if the patients without thymectomy did not achieve minimal manifestation (MM) or better status after 3 weeks of tacrolimus administration or in the thymectomized patients by 1-2 weeks after the operation (i.e., 1st evaluation). Of all 14 patients included in this study, 8 of them (57%) achieved MM or better status at the 1st evaluation, and the remaining 6 (43%), who had failed to gain MM or better status at the 1st evaluation, also achieved MM or better status with 1 course of aggressive immunosuppressive therapy. The quantitative MG (QMG) scores, MG-Activities of Daily Living (ADL) scales, and anti-acetylcholine receptor (AchR) antibody levels were significantly decreased at 6 months and maintained thereafter. At the end of the follow-up period (41-70 months), all patients were in MM or better status. None of the patients experienced severe adverse effects. Our small preliminary study indicates that long-term tacrolimus monotherapy is possibly effective and safe for MG patients., Competing Interests: Declaration of Competing Interest The authors declared no conflict of interest., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2021
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13. Differences in scapular motion and parascapular muscle activities among patients with symptomatic and asymptomatic rotator cuff tears, and healthy individuals.
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Ishikawa H, Muraki T, Morise S, Yamamoto N, Itoi E, and Izumi SI
- Abstract
Background: Altered scapular motion is thought to be one of the factors associated with the development of symptomatic rotator cuff tears. However, the differences in kinematics and muscle activities of scapular upward/downward rotation between patients with symptomatic and asymptomatic tears are unclear. The purpose of this study was to compare the differences in kinematics and muscle activities of scapular rotation among patients with symptomatic and asymptomatic tears, and healthy individuals., Methods: Twenty-three patients with rotator cuff tears and 9 healthy individuals (healthy group) participated in this study. Based on a visual analog scale (VAS, 0-100 mm), the patients were divided into symptomatic (13 patients; VAS ≥20 mm) and asymptomatic (10 patients; VAS <20 mm) groups. Scapular upward rotation was measured with a digital inclinometer. Elasticities of the upper trapezius, levator scapulae, and rhomboid major were assessed by using ultrasound real-time tissue elastography to quantify their muscle activities. All measurements were performed at 0°, 60°, 90°, and 120° of active arm elevation in the scapular plane., Results: Scapular upward rotation was significantly less in the symptomatic group (9.4° ± 5.6°) compared with the asymptomatic group (15.7° ± 6.0°; P = .022) at 90° of arm elevation. The activity of the levator scapulae was significantly higher in the symptomatic group compared with the asymptomatic and healthy groups ( P = .013 and P = .005, respectively) at 90° of arm elevation. The activity of the upper trapezius was significantly higher in the symptomatic group compared with the healthy group ( P = .015) at 120° of arm elevation., Conclusion: Patients with symptomatic rotator cuff tears showed less scapular upward rotation and higher activity of the levator scapulae at 90° of arm elevation compared to patients with asymptomatic rotator cuff tears., (© 2020 The Authors.)
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- 2020
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14. Influence of thoracic posture on scapulothoracic and glenohumeral motions during eccentric shoulder external rotation.
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Suzuki Y, Muraki T, Sekiguchi Y, Ishikawa H, Yaguchi H, Suzuki Y, Morise S, Honda K, and Izumi SI
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- Adult, Biomechanical Phenomena, Humans, Imaging, Three-Dimensional methods, Male, Scapula physiology, Posture physiology, Range of Motion, Articular physiology, Shoulder Joint physiology, Thorax physiology
- Abstract
Background: Throwing injuries to the shoulder joint often occur during shoulder external rotation. An appropriate combination of thoracic, scapular, and humeral motion during throwing is important to prevent such injuries, but it is unclear how thoracic posture contributes to shoulder motion during throwing., Research Question: The purpose of this study, therefore, was to clarify the influence of thoracic posture on scapulothoracic and glenohumeral motion during shoulder external rotation., Methods: Eccentric external rotation at 90° of shoulder abduction in thoracic flexion and extension postures was performed by 15 asymptomatic participants. Three-dimensional scapulothoracic and glenohumeral movements were measured with an electromagnetic tracking device at 75°, 80°, 85°, and maximum shoulder external rotation. The thoracic angle and maximum shoulder external rotation in absolute coordination were measured with a three-dimensional motion capture system., Results: The results showed that scapular posterior tilting and external rotation in the thoracic extension posture were significantly greater than those in the flexion posture (p < 0.05). Glenohumeral horizontal extension was significantly less in the thoracic extension posture than in the flexion posture (p < 0.05), whereas maximum shoulder external rotation was significantly greater (p < 0.01). Thus, thoracic extension increased scapulothoracic posterior tilting and external rotation and reduced glenohumeral horizontal extension during shoulder external rotation, as well as increasing maximum shoulder external rotation., Significance: These findings suggest that thoracic extension may contribute to reduction of mechanical demand in the glenohumeral joint during throwing, potentially reducing shoulder injuries., (Copyright © 2018 Elsevier B.V. All rights reserved.)
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- 2019
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15. Leptomeningeal Collaterals Strongly Correlate with Reduced Cerebrovascular Reactivity Measured by Acetazolamide-challenged Single-photon Emission Computed Tomography Using a Stereotactic Extraction Estimation Analysis in Patients with Unilateral Internal Carotid Artery Stenosis.
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Kunieda T, Miyake K, Sakamoto H, Iwasaki Y, Iida S, Morise S, Fujita K, Nakamura M, Kaneko S, and Kusaka H
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- Acetazolamide pharmacokinetics, Aged, Aged, 80 and over, Brain pathology, Carotid Stenosis pathology, Cerebral Angiography, Cerebrovascular Circulation physiology, Constriction, Pathologic, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Middle Cerebral Artery pathology, Retrospective Studies, Brain diagnostic imaging, Carotid Stenosis diagnostic imaging, Middle Cerebral Artery diagnostic imaging, Tomography, Emission-Computed, Single-Photon methods
- Abstract
Objective To assess the correlation between the angiographic appearance of cerebral collateral pathways or the degree of internal carotid artery stenosis (ICAS) and reduced cerebrovascular reactivity (CVR) estimated by single-photon emission computed tomography (SPECT) image analysis in patients with unilateral ICAS. Methods A retrospective analysis was performed in 42 patients with unilateral ICAS who underwent cerebral angiography and acetazolamide-challenged SPECT of the brain. Cerebral blood flow quantitation was performed using the quantitative SPECT/dual-table autoradiography method. The CVR in the middle cerebral artery (MCA) territory was evaluated using the stereotactic extraction estimation based on the Japanese extracranial-intracranial bypass trial (SEE-JET) program and classified as reduced (<18.4%) or non-reduced (≥18.4%). Angiographic collateralization was classified as circle of Willis (type 1), extracranial-intracranial (type 2), and leptomeningeal (type 3). The degree of ICAS was defined as severe (≥70% stenosis) or non-severe (<70%). Results Eight patients showed reduced CVR, including 6 (46%) of 13 with type 3 collaterals and 2 (7%) of 29 without type 3 collaterals (p=0.006). In contrast, type 1 and type 2 collaterals and severe ICAS were not significantly associated with reduced CVR. Conclusion In patients with unilateral ICAS, leptomeningeal collaterals are strongly correlated with reduced CVR in the MCA territory, which presumably increases the risk of cerebral hyperperfusion after carotid artery stenting (CAS). Therefore, these findings may be clinically applicable to the perioperative management of CAS.
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- 2017
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16. Age-Related Changes in Morphology and Function of Scapular Muscles in Asymptomatic People.
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Morise S, Muraki T, Ishikawa H, and Izumi SI
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- Adult, Age Factors, Aged, Cross-Sectional Studies, Female, Healthy Volunteers, Humans, Male, Middle Aged, Pilot Projects, Reference Values, Risk Assessment, Scapula anatomy & histology, Scapula diagnostic imaging, Scapula physiology, Sex Factors, Shoulder anatomy & histology, Shoulder physiology, Superficial Back Muscles diagnostic imaging, Young Adult, Aging physiology, Electromyography methods, Range of Motion, Articular physiology, Superficial Back Muscles anatomy & histology, Superficial Back Muscles physiology
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Background: Aging is a contributing factor to rotator cuff tears. Dysfunction of the scapular muscles can be a potential cause of rotator cuff tears. Although aging can contribute to dysfunction of the scapular muscles and subsequently result in rotator cuff tears, the effects of aging on scapular muscles are unclear., Objective: To determine changes in sizes and electromyographic activities of the scapular muscles with age in asymptomatic subjects., Design: Cross-sectional study., Patients: Fifty-four asymptomatic subjects without shoulder pain and dysfunction (18 male and 36 female) were recruited for this study. Subjects consisted of 19 people aged 20-39 years (young adult group, 27.2 ± 5.2 years), 17 people aged 40-59 years (middle age group, 49.9 ± 6.6 years), and 18 people aged 60-79 years (elderly group, 68.0 ± 7.1 years)., Methods: Using ultrasonography, we measured the muscle thickness of the trapezius (upper and lower portions), serratus anterior, and middle deltoid muscles during rest with the subject in a sitting position. Activities of the same muscles were measured with surface electromyography during shoulder elevation in the scapular plane up to 120°. The electromyographic data were analyzed at ranges 0°-30°, 30°-60°, and 60°-90°. Analysis of variance and Bonferroni multiple comparisons were used for statistical analysis., Results: Muscle thickness of the lower trapezius in the elderly group was decreased significantly compared with that in the young adult group (95% confidence interval -0.40, 2.24; P < .001) and middle age group (95% confidence interval -0.34, 1.89; P = .012). There were no significant differences in muscle activity and activity ratio between groups., Conclusion: In scapular muscles, muscle thickness of the lower trapezius significantly decreased with aging, although there were no decreases in muscle thicknesses of the other muscles between different age groups. For the functional change, aging may not affect the scapular muscle activities and balance of the activities between the deltoid and scapular muscles., Level of Evidence: IV., (Copyright © 2017 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
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17. Zonisamide ameliorates levodopa-induced dyskinesia and reduces expression of striatal genes in Parkinson model rats.
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Oki M, Kaneko S, Morise S, Takenouchi N, Hashizume T, Tsuge A, Nakamura M, Wate R, and Kusaka H
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- Animals, Anticonvulsants administration & dosage, Dopamine Agents administration & dosage, Dopamine Agents adverse effects, Dyskinesia, Drug-Induced metabolism, Female, Isoxazoles administration & dosage, Levodopa administration & dosage, Levodopa adverse effects, Rats, Rats, Sprague-Dawley, Zonisamide, Anticonvulsants pharmacology, Corpus Striatum drug effects, Dopamine Agents pharmacology, Dyskinesia, Drug-Induced drug therapy, Gene Expression drug effects, Isoxazoles pharmacology, Levodopa pharmacology, Parkinson Disease drug therapy, Receptor, Adenosine A2A drug effects, Receptor, Cannabinoid, CB1 drug effects, Receptors, Dopamine D1 drug effects, Receptors, Dopamine D2 drug effects
- Abstract
To investigate the difference in results according to the mode of levodopa administration and the effect of zonisamide (ZNS), we analyzed the mRNA expression of dopaminergic and non-dopaminergic receptors in the striatum of Parkinson model rats in relation to the development of levodopa-induced dyskinesia (LID). Unilateral Parkinson model rats were subdivided into 4 groups and treated as follows: no medication (group N), continuous levodopa infusion (group C), intermittent levodopa injection (group I), and intermittent levodopa and ZNS injection (group Z). Two weeks after the treatment, LID was observed in group I and Z, but less severe in group Z. The level of both D1 and D2 receptor mRNAs was elevated in groups I and Z, but only D2 receptor mRNA expression was elevated in group C. Adenosine A2A receptor mRNA showed increased expression only in group I. The level of endocannabinoid CB1 receptor mRNA was elevated in groups N, C, and I, but not in group Z. Intermittent injection of levodopa caused LID, in association with elevated expression of D1 and A2A receptors. ZNS ameliorated the development of LID and inhibited up-regulation of A2A and CB1 receptors. Modulation of these receptors may lead to therapeutic approaches for dyskinesia., (Copyright © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.)
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- 2017
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18. Changes in stiffness of the dorsal scapular muscles before and after computer work: a comparison between individuals with and without neck and shoulder complaints.
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Ishikawa H, Muraki T, Morise S, Sekiguchi Y, Yamamoto N, Itoi E, and Izumi SI
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- Adult, Case-Control Studies, Female, Humans, Male, Neck Pain etiology, Occupational Diseases etiology, Shoulder Pain etiology, Workload, Elasticity, Neck Pain diagnostic imaging, Occupational Diseases diagnostic imaging, Shoulder Pain diagnostic imaging, Superficial Back Muscles diagnostic imaging
- Abstract
Purpose: The aim of this study was to compare the stiffness of the dorsal scapular muscles before and after computer work between individuals with and without neck and shoulder complaints., Methods: Thirty subjects were divided into patient (n = 18) and control (n = 12) groups. The stiffness of the upper trapezius, levator scapulae, and rhomboid major was measured using ultrasound elastography before and after a 30-min typing task. The strain ratio of the muscle to an acoustic coupler was calculated (a lower strain ratio value indicates greater muscle stiffness)., Results: At baseline, the strain ratio of the upper trapezius in the patient group (3.762 ± 1.679) (mean ± SD) was significantly lower than that of the control group (7.763 ± 5.921) (p = 0.041). No significant change in the strain ratio of the upper trapezius after the typing task was observed in the patient group (4.158 ± 3.465) (p = 0.549). A significant decrease in the strain ratio of the levator scapulae after the typing task was observed in the patient group (before: 9.006 ± 7.079, after: 5.718 ± 2.847) (p = 0.022), whereas there was no significant change in the control group (p = 0.436)., Conclusions: The increase in stiffness of the upper trapezius is an objective finding and may be a persistently altered condition in individuals with neck and shoulder complaints. The patterns of change in stiffness of the levator scapulae are different between individuals with and without neck and shoulder complaints.
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- 2017
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19. Thymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis.
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Morise S, Nakamura M, Morita JI, Miyake K, Kunieda T, Kaneko S, and Kusaka H
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- Aged, Autoantibodies, Diagnosis, Differential, Encephalomyelitis therapy, Female, Glutamate Decarboxylase immunology, Humans, Muscle Rigidity therapy, Myasthenia Gravis complications, Receptors, Glycine, Thymectomy, Thymoma therapy, Thymus Neoplasms therapy, Encephalomyelitis complications, Encephalomyelitis diagnosis, Muscle Rigidity complications, Muscle Rigidity diagnosis, Thymoma complications, Thymoma diagnosis, Thymus Neoplasms complications, Thymus Neoplasms diagnosis
- Abstract
We report a case of a 72-year-old woman who initially presented with symptoms of bulbar myasthenia and was positive for anti-acetylcholine receptor antibodies. She subsequently developed painful muscle spasms, myoclonus, and stiffness. Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found. She was diagnosed with thymoma-associated progressive encephalomyelitis with rigidity and myoclonus (PERM). She experienced marked improvement after thymectomy followed by plasma exchange and intravenous immunoglobulin and prednisolone. This case suggests that thymectomy followed by sufficient immunosuppression may be useful in the treatment of thymoma-associated PERM. Myasthenia gravis may develop in thymoma-associated PERM patients.
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- 2017
- Full Text
- View/download PDF
20. Noninvasive assessment of the activity of the shoulder girdle muscles using ultrasound real-time tissue elastography.
- Author
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Ishikawa H, Muraki T, Sekiguchi Y, Ishijima T, Morise S, Yamamoto N, Itoi E, and Izumi S
- Subjects
- Adult, Humans, Male, Muscle, Skeletal physiology, Shoulder physiology, Elasticity Imaging Techniques, Electromyography, Muscle, Skeletal diagnostic imaging, Shoulder diagnostic imaging
- Abstract
The purpose of this study was to clarify whether the activity of the shoulder girdle muscles could be estimated by measuring the elasticity of these muscles under several levels of muscle contraction through ultrasound real-time tissue elastography (RTE). Ten healthy men performed submaximal voluntary contractions (MVC) in each manual muscle testing position for the middle deltoid, upper trapezius, supraspinatus, levator scapulae, and rhomboid major. The elasticity of these muscles was measured using ultrasound RTE during the task. The strain ratio of the muscle to an acoustic coupler was calculated as an assessment index of the muscle elasticity. Higher strain ratio values imply lower elasticity. In addition, the electromyographic activity was recorded from surface electrodes attached only to the middle deltoid and upper trapezius. The strain ratios were negatively correlated with the normalized root mean square values for the middle deltoid (r=-0.659, p<0.001) and upper trapezius (r=-0.554, p<0.001). The strain ratios of all the muscles decreased with an increase from 10% MVC force to 30% MVC force. Ultrasound RTE may be useful for noninvasively assessing the activity of the shoulder girdle muscles at certain shoulder positions with low levels of muscle contraction., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
21. Ultrasound elastography-based assessment of the elasticity of the supraspinatus muscle and tendon during muscle contraction.
- Author
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Muraki T, Ishikawa H, Morise S, Yamamoto N, Sano H, Itoi E, and Izumi S
- Subjects
- Adult, Elasticity, Elasticity Imaging Techniques, Female, Humans, Male, Muscle, Skeletal diagnostic imaging, Shoulder, Tendons diagnostic imaging, Young Adult, Muscle Contraction physiology, Muscle, Skeletal physiology, Rotator Cuff physiology, Tendons physiology
- Abstract
Background: Although elasticity of the supraspinatus muscle and tendon is a useful parameter to represent the conditions of the supraspinatus muscle and tendon, assessment of the elasticity in clinical settings has not been established. The purpose of this study was to determine the elasticity of the supraspinatus muscle belly and tendon under different muscle contraction conditions using ultrasound real-time tissue elastography (RTE)., Methods: Twenty-three healthy individuals participated in this study. Ultrasound RTE was used for elasticity measurements of the muscle belly and tendon of the supraspinatus muscle. The elasticity was defined as the ratio of strain in the tissues to that in an acoustic coupler (reference). A greater ratio indicated that the tissue was softer. Measurements were performed with study subjects in the lateral decubitus position at 10° of shoulder abduction under conditions of (1) no contraction, (2) isometric contraction without a weight, and (3) isometric contraction with a 1-kg weight., Results: The intraclass correlation coefficient (ICC1,3) of 3 measurements under each condition ranged from 0.931 to 0.998, showing high intraobserver reliability. Strain ratios for both the supraspinatus muscle belly and tendon significantly decreased with increases in muscle contraction (P < .001)., Conclusions: Ultrasound RTE with the acoustic coupler has the potential to noninvasively detect changes in the elasticity of the supraspinatus muscle belly and tendon that accompany varying levels of muscle contraction in clinical practice., (Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
22. Early detection of neonatal cholestasis by stool color card screening.
- Author
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Ramonet M, Gómez S, Morise S, Parga L, Caglio P, De Micheli M, and Garsd A
- Abstract
The objective of this study was to identify, by early screening, one-month old infants with acholic or hypocholic stools for the early detection of biliary atresia and other causes of neonatal cholestasis. The study was essentially exploratory (observational, prospective, statistically underpowered and with no clinical intervention) and used a color card screening of all newborns attending the first month of life checkup from 1999 to 2002 in a public hospital in Argentina. Of 12 484 newborn infants, 4239 were examined at their first month of life checkup visit with the stool color card. Eighteen infants were identified with hypocholic stools, of whom only four were proven to have cholestasis. Although no case of biliary atresia was detected, screening by stool color cards proved useful for the detection of other causes of neonatal cholestasis.
- Published
- 2013
- Full Text
- View/download PDF
23. Effect of cirrhosis at baseline on the outcome of type 1 autoimmune hepatitis.
- Author
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Landeira G, Morise S, Fassio E, Ramonet M, Alvarez E, Caglio P, Longo C, and Domínguez N
- Subjects
- Adolescent, Adult, Biopsy, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Liver pathology, Liver Cirrhosis pathology, Male, Middle Aged, Prospective Studies, Retrospective Studies, Survival Rate, Treatment Outcome, Young Adult, Hepatitis, Autoimmune drug therapy, Hepatitis, Autoimmune mortality, Immunosuppressive Agents therapeutic use, Liver Cirrhosis complications
- Abstract
Material and Methods: With the aim of analyzing the influence of presence of cirrhosis at baseline on the outcome, we revised the evolution of a cohort of patients with type 1 autoimmune hepatitis, prospectively followed at a single hospital. 139 patients (113 females, 26 males), median age 45.7 years, interquartile range 13-59 years, were followed-up for a median period of 58 months (interquartile range 27-106)., Results: At baseline, 55 patients had cirrhosis and they were significantly older, had lower prothrombin activity and serum albumin than patients without cirrhosis. In contrast, patients without cirrhosis had significantly higher bilirubin, AST and ALT levels at diagnosis time. There was no significant difference in the follow-up time between patients with and without cirrhosis at baseline and either in the percentage of patients receiving immunosupresor treatment (80 vs. 91%, respectively) or in the response to therapy (complete response in 82 vs. 95%, respectively). However, patients with cirrhosis had a significantly lower probability of remaining free of cirrhosis complications (49.1% at 102 months, 95%CI, 35.5-67.9% vs. 86.7%, 95%CI, 77.1%-97.5%, respectively) (p = 0.0000) and a significantly lower overall survival at 120 months (67.1%, 95%CI, 51.3-87.6 vs. 94.4%, 95%CI, 86.9-100%, respectively) (p = 0.003) than those without cirrhosis at presentation., Conclusion: Patients with type 1 autoimmune hepatitis and cirrhosis at presentation have a lower survival than those without cirrhosis despite a similar response to treatment.
- Published
- 2012
24. Effects of moderate changes in air temperature and clothing on pulmonary exchange and energy metabolism.
- Author
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Sato M, Morise S, Ishibashi Y, and Ishii M
- Subjects
- Adaptation, Physiological, Adult, Atmosphere Exposure Chambers, Body Temperature, Environment, Controlled, Female, Heart Rate, Humans, Seasons, Clothing, Energy Metabolism, Respiration, Temperature
- Published
- 1973
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