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Your search keyword '"Michelet, Pierre"' showing total 284 results
Start Over Author "Michelet, Pierre" Publication Type Academic Journals
284 results on '"Michelet, Pierre"'

12. Adenosine plasma level in patients with paroxysmal or persistent atrial fibrillation and normal heart during ablation procedure and/or cardioversion

Author

Maille, Baptiste, Marlinge, Marion, Vairo, Donato, Mottola, Giovanna, Koutbi, Linda, Deharo, Pierre, Gastaldi, Marguerite, Gaudry, Marine, Guiol, Claire, Bottone, Sara, Mace, Patrick, Gueant, Rosita, Chefrour, Mohamed, Martinez, Elsa, Michelet, Pierre, Gueant, Jean Louis, Boussuges, Alain, Ruf, Jean, Fenouillet, Emmanuel, Deharo, Jean Claude, Guieu, Régis, and Franceschi, Frederic

Published
2019
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14. Chest trauma: First 48 hours management

Author

Bouzat, Pierre, Raux, Mathieu, David, Jean Stéphane, Tazarourte, Karim, Galinski, Michel, Desmettre, Thibault, Garrigue, Delphine, Ducros, Laurent, Michelet, Pierre, Freysz, Marc, Savary, Dominique, Rayeh-Pelardy, Fatima, Laplace, Christian, Duponq, Raphaelle, Monnin Bares, Valérie, D’Journo, Xavier Benoît, Boddaert, Guillaume, Boutonnet, Mathieu, Pierre, Sébastien, Léone, Marc, Honnart, Didier, Biais, Mathieu, and Vardon, Fanny

Published
2017
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22. Adenosinergic System and Neuroendocrine Syncope: What Is the Link?

Author

Guieu, Régis, Fromonot, Julien, Mottola, Giovanna, Maille, Baptiste, Marlinge, Marion, Groppelli, Antonella, Conte, Samantha, Bechah, Yassina, Lalevee, Nathalie, Michelet, Pierre, Hamdan, Mohamed, Brignole, Michele, and Deharo, Jean Claude

Subjects
G protein coupled receptors, NEUROENDOCRINE system, SYNCOPE, TRANSMEMBRANE domains, BLOOD pressure, CARDIOVASCULAR system
Abstract

Although very common, the precise mechanisms that explain the symptomatology of neuroendocrine syncope (NES) remain poorly understood. This disease, which can be very incapacitating, manifests itself as a drop in blood pressure secondary to vasodilation and/or extreme slowing of heart rate. As studies continue, the involvement of the adenosinergic system is becoming increasingly evident. Adenosine, which is an ATP derivative, may be involved in a large number of cases. Adenosine acts on G protein-coupled receptors with seven transmembrane domains. A1 and A2A adenosine receptor dysfunction seem to be particularly implicated since the activation leads to severe bradycardia or vasodilation, respectively, two cardinal symptoms of NES. This mini-review aims to shed light on the links between dysfunction of the adenosinergic system and NHS. In particular, signal transduction pathways through the modulation of cAMP production and ion channels in relation to effects on the cardiovascular system are addressed. A better understanding of these mechanisms could guide the pharmacological development of new therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Stress Cardiomyopathy Managed with Extracorporeal Support after Self-Injection of Epinephrine

Author

Bourenne Jeremy, Fresco Raphaëlle, Kerbaul François, Michelet Pierre, and Gainnier Marc

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

A 28-year-old man was admitted to the ICU for self-injection of Epinephrine. This injection resulted in the rapid development of a catecholamine-induced cardiomyopathy (inverted Takotsubo) with a severe cardiogenic shock. The importance of ventricular dysfunction required the implementation of a temporary arteriovenous circulatory support until the recovery of myocardial stunning. This case allows redefining the role of circulatory assistance during cardiotropic agents intoxication.

Published
2017
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25. Pathophysiological and diagnostic implications of cardiac biomarkers and antidiuretic hormone release in distinguishing immersion pulmonary edema from decompression sickness

Author

Louge, Pierre, Coulange, Mathieu, Beneton, Frederic, Gempp, Emmanuel, Le Pennetier, Olivier, Algoud, Maxime, Dubourg, Lorene, Naibo, Pierre, Marlinge, Marion, Michelet, Pierre, Vairo, Donato, Kipson, Nathalie, Kerbaul, François, Jammes, Yves, Jones, Ian M., Steinberg, Jean-Guillaume, Ruf, Jean, Guieu, Régis, Boussuges, Alain, and Fenouillet, Emmanuel

Published
2016
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26. Sédation et analgésie en structure d’urgence (aéactualisation de la Conférence d’experts de la Sfar of 1999)

Author

Vivien, Benoît, Adnet, Frédéric, Bounes, Vincent, Chéron, Gérard, Combes, Xavier, David, Jean-Stéphane, Diependaele, Jean-François, Eledjam, Jean-Jacques, Eon, Béatrice, Freysz, Marc, Fontaine, Jean-Paul, Michelet, Pierre, Orliaguet, Gilles, Puidupin, Alain, Ricard-Hibon, Agnès, Riou, Bruno, Wiel, Eric, and de La Coussaye, Jean-Emmanuel

Published
2010
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46. Pneumothorax diagnosis with lung sliding quantification by speckle tracking: A prospective multicentric observational study.

Author

Fissore, Estelle, Zieleskiewicz, Laurent, Markarian, Thibaut, Muller, Laurent, Duclos, Gary, Bourgoin, Mathias, Michelet, Pierre, Leone, Marc, Claret, Pierre-Géraud, and Bobbia, Xavier

Abstract

Introduction: Lung ultrasound is commonly used for the diagnosis of pneumothorax. However, recognition of pleural sliding is subjective and can be difficult for novice. The primary objective was to compare a novices physician's performance in diagnosing pneumothorax from ultrasound (US) scans either with visual evaluation or with maximum longitudinal pleural strain (MLPS). The secondary objective was to compare the diagnostic relevance of US with visual evaluation or MLPS to diagnose pneumothorax with an intermediately experienced and an expert physician.Methods: We conducted a prospective, observational study in two emergency department and two intensive care unit, between February 2019 and June 2020. We included 99 adult patients with suspected pneumothorax, who received a chest computed tomography (CT). Three physicians with different experience of interpreting US scans (a novice physician, an intermediately experienced physician, and an expert) analyzed the US scans of 99 patients with suspected pneumothorax (50 (51%) with confirmed pneumothorax), which were confirmed by CT scan.Results: With a threshold of 5%, the MLPS sensitivity was 94% (95% CI [83%; 98%]), and the specificity was 100% (95% CI [93%; 100%]). The novice physician had an area under the curve (AUC) with visual analysis of 0.75 (95% CI [0.67; 0.83]) vs 0.86 (95% CI [0.79; 0.94]) with MLPS (p = 0.04). The intermediate physician's AUC for diagnosing pneumothorax with visual analysis was 0.93 (95% CI [0.88; 0.99]) vs 1.00 (95% CI [1.00; 1.00]) with MLPS (p < 0.01) and for the expert physician it was 0.98 (95% CI [0.95;1.00]) vs 0.97 (95% CI [0.93; 1.00]), respectively (p = 0.69).Conclusion: In our study, speckle tracking analysis improved the accuracy of US for the novice and the intermediate but not the expert sonographer in the diagnosis of pneumothorax. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious Diseases.

Author

Ait Belkacem, Ines, Mossadegh‐keller, Noushine, Bourgoin, Penelope, Arnoux, Isabelle, Loosveld, Marie, Morange, Pierre‐emmanuel, Markarian, Thibaut, Michelet, Pierre, Busnel, Jean Marc, Roulland, Sandrine, Galland, Franck, and Malergue, Fabrice

Subjects
DRIED blood spot testing, CELL analysis, COVID-19, ERYTHROCYTES, COMMUNICABLE diseases, HEMATOLOGY, LEUCOCYTES
Abstract

Blood cell analysis is a major pillar of biomedical research and healthcare. These analyses are performed in central laboratories. Rapid shipment from collection site to the central laboratories is currently needed because cells and biomarkers degrade rapidly. The dried blood spot from a fingerstick allows the preservation of cellular molecules for months but entire cells are never recovered. Here leucocyte elution is optimized from dried blood spots. Flow cytometry and mRNA expression profiling are used to analyze the recovered cells. 50–70% of the leucocytes that are dried on a polyester solid support via elution after shaking the support with buffer are recovered. While red blood cells lyse upon drying, it is found that the majority of leucocytes are preserved. Leucocytes have an altered structure that is improved by adding fixative in the elution buffer. Leucocytes are permeabilized, allowing an easy staining of all cellular compartments. Common immunophenotyping and mRNAs are preserved. The ability of a new biomarker (CD169) to discriminate between patients with and without Severe Acute Respiratory Syndrome induced by Coronavirus 2 (SARS‐CoV‐2) infections is also preserved. Leucocytes from blood can be dried, shipped, and/or stored for at least 1 month, then recovered for a wide variety of analyses, potentially facilitating biomedical applications worldwide. [ABSTRACT FROM AUTHOR]

Published
2021
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50. CD169 and CD64 could help differentiate bacterial from CoVID‐19 or other viral infections in the Emergency Department.

Author

Bourgoin, Pénélope, Soliveres, Thomas, Barbaresi, Alexandra, Loundou, Anderson, Belkacem, Inès Ait, Arnoux, Isabelle, Bernot, Denis, Loosveld, Marie, Morange, Pierre‐Emmanuel, Michelet, Pierre, Malergue, Fabrice, and Markarian, Thibaut

Abstract

The identification of a bacterial, viral, or even noninfectious cause is essential in the management of febrile syndrome in the emergency department (ED), especially in epidemic contexts such as flu or CoVID‐19. The aim was to assess discriminative performances of two biomarkers, CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), using a new flow cytometry procedure, in patients presenting with fever to the ED during epidemics. Eighty five adult patients presenting with potential infection were included during the 2019 flu season in the ED of La Timone Hospital. They were divided into four diagnostic outcomes according to their clinical records: no‐infection, bacterial infection, viral infection and co‐infection. Seventy six patients with confirmed SARS‐CoV‐2 infection were also compared to 48 healthy volunteers. For the first cohort, 38 (45%) patients were diagnosed with bacterial infections, 11 (13%) with viral infections and 29 (34%) with co‐infections. mCD169 was elevated in patients with viral infections, with a majority of Flu A virus or Respiratory Syncytial Virus, while nCD64 was elevated in subjects with bacterial infections, with a majority of Streptococcus pneumoniae and Escherichia coli. nCD64 and mCD169 showed 90% and 80% sensitivity, and 78% and 91% specificity, respectively, for identifying patients with bacterial or viral infections. When studied in a second cohort, mCD169 was elevated in 95% of patients with SARS‐CoV‐2 infections and remained at normal level in 100% of healthy volunteers. nCD64 and mCD169 have potential for accurately distinguishing bacterial and acute viral infections. Combined in an easy and rapid flow cytometry procedure, they constitute a potential improvement for infection management in the ED, and could even help for triage of patients during emerging epidemics. [ABSTRACT FROM AUTHOR]

Published
2021
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