14 results on '"Mertzman, Michael"'
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2. Use of benzofuran for concomitant protection of aldehyde and phenol groups in the preparation of mycophenolic acid analogues
3. Identification of N‑Methyl Nicotinamide and N‑Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
4. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
5. Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity
6. Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease
7. Discovery of GS-9669, a ThumbSite II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype1 Chronic Hepatitis C Infection.
8. Improved synthesis of quinaldines by the skraup reaction.
9. The solution conformation Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist.
10. Practical olefin hydroamination with nitroarenes.
11. Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
12. Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.
13. Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
14. Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors.
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