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10. Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials.

Author

Rabinowitz, Jonathan, Werbeloff, Nomi, Mandel, Francine S., Menard, François, Marangell, Lauren, and Kapur, Shitij

Subjects
MENTAL depression risk factors, ANTIDEPRESSANTS, PLACEBOS, RANDOMIZED controlled trials, DATA analysis, CLINICAL trials, MENTAL depression, META-analysis, HEALTH outcome assessment, RESEARCH funding, EVIDENCE-based medicine, PROFESSIONAL practice, ACQUISITION of data, SEVERITY of illness index, SECOND-generation antidepressants
Abstract

Several often-cited meta-analyses have reported that the efficacy of antidepressant medications depends on the severity of depression. They found that drug-placebo differences increased as a function of initial severity, which was attributed to decreased responsiveness to placebo among patients with severe depression rather than to increased responsiveness to medication. We retested this using patient-level data and also undertaking a meta-analysis of trial-level data from 34 randomised placebo controlled trials (n = 10 737) from the NEWMEDS registry. Although our trial-level data support prevous findings, patient-level data did not show any significant effect of initial depression severity on drug v. placebo difference. [ABSTRACT FROM AUTHOR]

Published
2016
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