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As a result of increasing number of studies in the field of health, the dental literature is expanding rapidly. Due to the difficulties of following all the developments in the literature, inconsistencies occur between the research results and clinical applications. For this reason, decision process depending on the individual experience has been replaced by evidence-based practice. Evidence-based dentistry is based on the entire evaluation of scientific evidences and patient-related factors to provide the best treatment. The most important goal of evidence-based dentistry practices is to improve treatment services. However, due to very fast flow of information, problems about reaching and evaluating evidence can be encountered. In the evidence-based decision-making process, clinical practice of evidence-based dentistry ensures reaching the best possible healthcare by enabling clinicians to integrate their experience into modern research. In this review, evidence-based dentistry and applications in pediatric dentistry are included.