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We present Heterogeneous Parallel Virtual Machine (HPVM), a compiler framework for hardware-agnostic programming on heterogeneous compute platforms. HPVM introduces a hardware-agnostic parallel intermediate representation with constructs for the hierarchical task, data, and pipeline parallelism, including dataflow parallelism, and supports multiple front-end languages. In addition, HPVM provides optimization passes that navigate performance, energy, and accuracy tradeoffs, and includes retargetable back ends for a wide range of diverse hardware targets, including central processing units, graphics processing units, domain-specific accelerators, and field-programmable gate arrays. Across diverse hardware platforms, HPVM optimizations provide significant performance and energy improvements, while preserving object-code portability. With these capabilities, HPVM facilitates developers, domain experts, and hardware vendors in programming modern heterogeneous systems. [ABSTRACT FROM AUTHOR]