Search

Your search keyword '"McLaughlin, Sarah A"' showing total 410 results
Start Over Author "McLaughlin, Sarah A" Publication Type Academic Journals
410 results on '"McLaughlin, Sarah A"'

2. Lymphedema Rates Following Axillary Lymph Node Dissection With and Without Immediate Lymphatic Reconstruction: A Prospective Trial

Author

Jakub, James W., Boughey, Judy C., Hieken, Tina J., Piltin, Mara, Forte, Antonio Jorge, Vijayasekaran, Aparna, Mazur, Monica, Sturz, Jenna, Corbin, Kim, Vallow, Laura, Johnson, Jeffrey E., Mrdutt, Mary, Fahradyan, Vahe, Li, Zhuo, Blumenfeld, Sophia, Degnim, Amy, Yost, Kathleen J., Cheville, Andrea, and McLaughlin, Sarah A.

Published
2024
Full Text
View/download PDF

4. ASO Visual Abstract: Lymphedema Rates Following Axillary Lymph Node Dissection With and Without Immediate Lymphatic Reconstruction: A Prospective Trial

Author

Jakub, James W., Boughey, Judy C., Hieken, Tina J., Piltin, Mara, Forte, Antonio Jorge, Vijaysakaran, Aparna, Mazur, Monica, Sturz, Jenna, Corbin, Kim, Vallow, Laura, Johnson, Jeffrey E., Mrdutt, Mary, Fahradyan, Vahe, Li, Zhuo, Blumenfeld, Sophia, Degnim, Amy, Yost, Kathleen J., Cheville, Andrea, and McLaughlin, Sarah A.

Published
2024
Full Text
View/download PDF

5. Pre-treatment peripheral blood immunophenotyping and response to neoadjuvant chemotherapy in operable breast cancer

Author

Leon-Ferre, Roberto A., Whitaker, Kaitlyn R., Suman, Vera J., Hoskin, Tanya, Giridhar, Karthik V., Moore, Raymond M., Al-Jarrad, Ahmad, McLaughlin, Sarah A., Northfelt, Donald W., Hunt, Katie N., Conners, Amy Lynn, Moyer, Ann, Carter, Jodi M., Kalari, Krishna, Weinshilboum, Richard, Wang, Liewei, Ingle, James N., Knutson, Keith L., Ansell, Stephen M., Boughey, Judy C., Goetz, Matthew P., and Villasboas, Jose C.

Published
2024
Full Text
View/download PDF

6. The core metabolome and root exudation dynamics of three phylogenetically distinct plant species

Author

McLaughlin, Sarah, Zhalnina, Kateryna, Kosina, Suzanne, Northen, Trent R, and Sasse, Joelle

Subjects
Medical Biochemistry and Metabolomics, Plant Biology, Biological Sciences, Biomedical and Clinical Sciences, Plant Roots, Plant Exudates, Metabolome, Arabidopsis, Microbiota
Abstract

Root exudates are plant-derived, exported metabolites likely shaping root-associated microbiomes by acting as nutrients and signals. However, root exudation dynamics are unclear and thus also, if changes in exudation are reflected in changes in microbiome structure. Here, we assess commonalities and differences between exudates of different plant species, diurnal exudation dynamics, as well as the accompanying methodological aspects of exudate sampling. We find that exudates should be collected for hours rather than days as many metabolite abundances saturate over time. Plant growth in sterile, nonsterile, or sugar-supplemented environments significantly alters exudate profiles. A comparison of Arabidopsis thaliana, Brachypodium distachyon, and Medicago truncatula shoot, root, and root exudate metabolite profiles reveals clear differences between these species, but also a core metabolome for tissues and exudates. Exudate profiles also exhibit a diurnal signature. These findings add to the methodological and conceptual groundwork for future exudate studies to improve understanding of plant-microbe interactions.

Published
2023

11. INTERNATIONAL REGULATION OF SEXUAL ORIENTATION, GENDER IDENTITY, AND SEXUAL ANATOMY

Author

Aban, Leanne, Rahrig, E Laina, Dozier, Emma, Mclaughlin, Sarah, Zhang, Yiruo, Brinker, Sydney, Chhoy, Mell, Gharia, Hema, Sergi, Lindsay, Sturges, Julia, Tassin, Quinn, and Yao, Cindy

Subjects
Privacy, Right of -- Laws, regulations and rules, Family law -- Evaluation, International obligations -- Laws, regulations and rules, Human anatomy -- Laws, regulations and rules, Criminal law -- Evaluation, Human rights -- Laws, regulations and rules, Equality before the law -- Laws, regulations and rules, Gender identity -- Laws, regulations and rules, Freedom of expression -- Laws, regulations and rules, Sexual minorities -- Laws, regulations and rules -- Demographic aspects, Government regulation, Law, Women's issues/gender studies
Abstract

I. Introduction 597 II. Current State of International Law 598 A. Yogyakarta Principles 598 B. UN Resolutions 599 C. International Jurisprudence 601 D. Asylum 601 III. Current State of Foreign [...]

Published
2023

12. FREEDOM OF EXPRESSIVE ASSOCIATION AND DISCRIMINATION ON THE BASIS OF SEXUAL ORIENTATION

Author

Rahrig, Elaina, Mclaughlin, Sarah, and Wright, Arie

Subjects
Students' societies -- Laws, regulations and rules, Freedom of association -- Laws, regulations and rules, Freedom of speech -- Laws, regulations and rules, Church and state -- Laws, regulations and rules, Freedom of religion -- Laws, regulations and rules, Government regulation, Law, Women's issues/gender studies, Christian Legal Society v. Martinez (130 S. Ct. 2971 (2010)), Roberts v. United States Jaycees (468 U.S. 609 (1984)), Hurley v. Irish-American Gay, Lesbian & Bisexual Group (515 U.S. 557 (1995)), United States Constitution (U.S. Const. amend. 1)
Abstract

I. Introduction 553 II. First Amendment Challenges to State Public Accommodations Laws 554 A. Roberts v. United States Jaycees 554 B. Hurley v. Irish-American Gay, Lesbian, & Bisexual Group of [...]

Published
2023

17. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways

Author

Weinschutz Mendes, Hellen, Neelakantan, Uma, Liu, Yunqing, Fitzpatrick, Sarah E., Chen, Tianying, Wu, Weimiao, Pruitt, April, Jin, David S., Jamadagni, Priyanka, Carlson, Marina, Lacadie, Cheryl M., Enriquez, Kristen D., Li, Ningshan, Zhao, Dejian, Ijaz, Sundas, Sakai, Catalina, Szi, Christina, Rooney, Brendan, Ghosh, Marcus, Nwabudike, Ijeoma, Gorodezky, Andrea, Chowdhury, Sumedha, Zaheer, Meeraal, McLaughlin, Sarah, Fernandez, Joseph M., Wu, Jia, Eilbott, Jeffrey A., Vander Wyk, Brent, Rihel, Jason, Papademetris, Xenophon, Wang, Zuoheng, and Hoffman, Ellen J.

Published
2023
Full Text
View/download PDF

22. CONSTITUTIONALITY OF SEXUALLY ORIENTED SPEECH: OBSCENITY, INDECENCY, AND CHILD PORNOGRAPHY

Author

Himonas, Alexandra, Alrashoodi, Rania, Brown, Alexandra, Matlack, Kerry, Mclaughlin, Sarah, Patel, Kavisha, Pierce, Maya, and Roche, Olivia

Subjects
Child pornography -- Laws, regulations and rules, Freedom of speech -- Laws, regulations and rules -- Research -- Social aspects, Sex oriented businesses -- Laws, regulations and rules, Obscenity (Law) -- Laws, regulations and rules, Government regulation, Law, Women's issues/gender studies
Abstract

INTRODUCTION 243 I. THE FIRST AMENDMENT AND SEXUAL SPEECH 244 A. Unprotected Speech: Obscenity 245 1. Community Standards 246 2. Prurient Interest 247 3. Patently Offensive 248 4. Societal Value [...]

Published
2022

23. How to ... deconstruct the research paradigm: Supporting the non‐social scientist researching in medical education.

Author

Allsop, Sarah and Mclaughlin, Sarah

Subjects
*MEDICAL education, *MEDICAL scientists, *EDUCATION research, *CAREER development, *MEDICAL research
Abstract

This article discusses the importance of understanding research paradigms in medical education and provides a method for novice researchers to deconstruct their own paradigms. The authors use gamification techniques and Socratic questioning to guide researchers in thinking openly about their assumptions and improving the conduct of research. The article emphasizes the need for healthcare professionals to be aware of different paradigms, such as positivism, interpretivism, and critical theory, and how these paradigms can influence research methodology. The authors believe that their approach can be applied to researchers in other disciplines and can help educators teach the philosophy of research practice. [Extracted from the article]

Published
2024
Full Text
View/download PDF

24. Future Fertility Among Pediatric Cancer Patients: Experiences and Perspectives of Health Workers in a Low-Resource Setting.

Author

Kayiira, Anthony, McLaughlin, Sarah, John, Jennifer Neda, Zaake, Daniel, Xiong, Serena, Balagadde, Joyce Kambugu, Gomez-Lobo, Veronica, Wabinga, Henry, and Ghebre, Rahel

Subjects
*WORK, *HEALTH services accessibility, *CANCER treatment, *PEDIATRIC nurses, *TUMORS in children, *RESEARCH funding, *INTERVIEWING, *HEALTH, *CANCER patients, *INFORMATION resources, *PEDIATRIC oncology nursing, *PROFESSIONS, *HOSPITAL medical staff, *ATTITUDES of medical personnel, *RESEARCH, *RESEARCH methodology, *FERTILITY preservation, *RESOURCE-limited settings, *ONCOLOGISTS, *GROUNDED theory, *EXPERIENTIAL learning, *SPECIALTY hospitals, *COMMUNICATION barriers
Abstract

Purpose:Although fertility preservation for patients with childhood and adolescent cancer is considered standard of care in the high-resource settings, it is rarely offered in low-resource settings. This study explores the experiences and perspectives of oncology health care professionals in Uganda to identify contextual barriers and facilitators to addressing oncofertility in low-resource settings. Methods: Using ground theory, we conducted in-depth face-to-face interviews of health care professionals managing pediatric patients at the Uganda Cancer Institute (UCI). Using a systematic, semi-structured interview guide, participants were asked open-ended questions about their understanding of fertility preservation and their perspectives on implementing this care at their institution. Although all the eligible health care providers were interviewed, interview transcripts were uploaded into NVivo version 12 and openly coded as per theoretical requirements. Codes were refined into categories and later into structured themes. Results: Twelve health care professionals were interviewed. Most participants identified as female (n = 9). Their role in the medical team varied from nurses (n = 6), medical officers (n = 3), pediatric oncologists (n = 2), and pediatric oncology fellow (n = 1). Six themes were noted as follows: (1) importance of information, (2) importance of future fertility, (3) inadequate consideration to future fertility, (4) communication barriers, (5) inadequate knowledge, and (6) resource barriers. Conclusion: Although health care providers at the UCI face contextual barriers to addressing future fertility among patients with pediatric cancer, they value preserving fertility in this population. Future initiatives that aim to introduce oncofertility care in low-resource settings should prioritize educating providers and building capacity to meet the oncofertility needs in this setting. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. Melanoma-Derived Extracellular Vesicles Induce CD36-Mediated Pre-Metastatic Niche.

Author

Suman, Shankar, Nevala, Wendy K., Leontovich, Alexey A., Ward, Caitlin, Jakub, James W., Kim, Yohan, Geng, Liyi, Stueven, Noah A., Atherton, Chathu L., Moore, Raymond M., Schimke, Jill M., Lucien-Matteoni, Fabrice, McLaughlin, Sarah A., and Markovic, Svetomir N.

Subjects
SENTINEL lymph nodes, EXTRACELLULAR vesicles, ENDOTHELIAL cells, IMMUNOSUPPRESSION, IMAGE analysis
Abstract

CD36 expression in both immune and non-immune cells is known to be directly involved in cancer metastasis. Extracellular vesicles (EVs) secreted by malignant melanocytes play a vital role in developing tumor-promoting microenvironments, but it is unclear whether this is mediated through CD36. To understand the role of CD36 in melanoma, we first analyzed the SKCM dataset for clinical prognosis, evaluated the percentage of CD36 in lymphatic fluid-derived EVs (LEVs), and tested whether melanoma-derived EVs increase CD36 expression and induce M2-macrophage-like characteristics. Furthermore, we performed a multiplex immunofluorescence (MxIF) imaging analysis to evaluate the CD36 expression and its colocalization with various other cells in the lymph node (LN) of patients and control subjects. Our findings show that cutaneous melanoma patients have a worse clinical prognosis with high CD36 levels, and a higher percentage of CD36 in total LEVs were found at baseline in melanoma patients compared to control. We also found that monocytic and endothelial cells treated with melanoma EVs expressed more CD36 than untreated cells. Furthermore, melanoma-derived EVs can regulate immunosuppressive macrophage-like characteristics by upregulating CD36. The spatial imaging data show that cells in tumor-involved sentinel LNs exhibit a higher probability of CD36 expression than cells from control LNs, but this was not statistically significant. Conclusively, our findings demonstrated that CD36 plays a vital role in controlling the immunosuppressive microenvironment in the LN, which can promote the formation of a protumorigenic niche. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Ultrasound‐guided fascial plane blocks for post‐breast surgery pain syndrome.

Author

Ferreira‐Silva, Nuno, Hurdle, Mark Friedrich B., Clendenen, Steven R., Gulati, Amitabh, McLaughlin, Sarah A., Troyer, Wesley, and Rosario‐Concepción, Raúl A.

Subjects
MAMMAPLASTY, CHRONIC pain, PATIENT safety, POSTOPERATIVE pain, AXILLARY vein, NERVES, PECTORALIS muscle, ULTRASONIC imaging, TREATMENT effectiveness, SERRATUS anterior muscles, CHEST (Anatomy), MASTECTOMY, WOMEN'S health, NERVE block, INNERVATION
Abstract

Introduction: Persistent pain following breast surgery is common and may be challenging to treat. In patients refractory to conservative treatments, ultrasound‐guided fascial plane blocks of thoracic nerves can be a useful option. Results: This type of neuro blockade technique provides advantages in terms of safety and efficacy that are convenient for physicians managing refractory and complex cases of post‐breast surgery syndrome. Conclusion: This technical review aims to present an up‐to‐date summary of the most common ultrasound‐guided fascial plane blocks for chronic pain in post‐breast surgery patients, provide a detailed technical description of each intervention, and propose preferred injections based on the anatomical location of the pain. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

33. Correction to: Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Author

Yu, Jia, Qin, Bo, Moyer, Ann M., Sinnwell, Jason P., Thompson, Kevin J., Copland, III, John A., Marlow, Laura A., Miller, James L., Yin, Ping, Gao, Bowen, Minter-Dykhouse, Katherine, Tang, Xiaojia, McLaughlin, Sarah A., Moreno-Aspitia, Alvaro, Schweitzer, Anthony, Lu, Yan, Hubbard, Jason, Northfelt, Donald W., Gray, Richard J., Hunt, Katie, Conners, Amy L., Suman, Vera J., Kalari, Krishna R., Ingle, James N., Lou, Zhenkun, Visscher, Daniel W., Weinshilboum, Richard, Boughey, Judy C., Goetz, Matthew P., and Wang, Liewei

Published
2021
Full Text
View/download PDF

45. DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Author

Yu, Jia, Qin, Bo, Moyer, Ann M., Nowsheen, Somaira, Liu, Tongzheng, Qin, Sisi, Zhuang, Yongxian, Liu, Duan, Lu, Shijia W., Kalari, Krishna R., Visscher, Daniel W., Copland, John A., McLaughlin, Sarah A., Moreno-Aspitia, Alvaro, Gray, Donald W. Northfel Richard J., Lou, Zhenkun, Suman, Vera J., Weinshilboum, Richard, Boughey, Judy C., Goetz, Matthew P., and Wang, Liewei

Subjects
Epigenetic inheritance -- Health aspects, Triple negative breast cancer -- Drug therapy -- Prognosis, Methyltransferases -- Physiological aspects -- Health aspects, Decitabine -- Dosage and administration, Health care industry
Abstract

Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis that lacks targeted therapies, especially in patients with chemotherapy-resistant disease. Since DNA methylation-induced silencing of tumor suppressors is common in cancer, reversal of promoter DNA hypermethylation by 5-aza-2'-deoxycytidine (decitabine), an FDA-approved DNA methyltransferase (DNMT) inhibitor, has proven effective in treating hematological neoplasms. However, its antitumor effect varies in solid tumors, stressing the importance of identifying biomarkers predictive of therapeutic response. Here, we focused on the identification of biomarkers to select decitabine-sensitive TNBC through increasing our understanding of the mechanism of decitabine action. We showed that protein levels of DNMTs correlated with response to decitabine in patient-derived xenograft (PDX) organoids originating from chemotherapy-sensitive and -resistant TNBCs, suggesting DNMT levels as potential biomarkers of response. Furthermore, all 3 methytransferases, DNMT1, DNMT3A, and DNMT3B, were degraded following low-concentration, long-term decitabine treatment both in vitro and in vivo. The DNMT proteins could be ubiquitinated by the E3 ligase, TNF receptor-associated factor 6 (TRAF6), leading to lysosome-dependent protein degradation. Depletion of TRAF6 blocked decitabine-induced DNMT degradation, conferring resistance to decitabine. Our study suggests a potential mechanism of regulating DNMT protein degradation and DNMT levels as response biomarkers for DNMT inhibitors in TNBCs., Introduction Breast cancer is the second leading cause of cancer death in women, with 40,610 women predicted to die from breast cancer in 2017 (1). Triple-negative breast cancer (TNBC), characterized [...]

Published
2018
Full Text
View/download PDF

47. Considerations for Clinicians in the Diagnosis, Prevention, and Treatment of Breast Cancer-Related Lymphedema: Recommendations from a Multidisciplinary Expert ASBrS Panel: Part 1: Definitions, Assessments, Education, and Future Directions

Author

McLaughlin, Sarah A., Staley, Alicia C., Vicini, Frank, Thiruchelvam, Paul, Hutchison, Nancy A., Mendez, Jane, MacNeill, Fiona, Rockson, Stanley G., DeSnyder, Sarah M., Klimberg, Suzanne, Alatriste, Michael, Boccardo, Francesco, Smith, Mark L., and Feldman, Sheldon M.

Published
2017
Full Text
View/download PDF

48. Considerations for Clinicians in the Diagnosis, Prevention, and Treatment of Breast Cancer-Related Lymphedema, Recommendations from an Expert Panel: Part 2: Preventive and Therapeutic Options

Author

McLaughlin, Sarah A., DeSnyder, Sarah M., Klimberg, Suzanne, Alatriste, Michael, Boccardo, Francesco, Smith, Mark L., Staley, Alicia C., Thiruchelvam, Paul T. R., Hutchison, Nancy A., Mendez, Jane, MacNeill, Fiona, Vicini, Frank, Rockson, Stanley G., and Feldman, Sheldon M.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results