14 results on '"Mbakilwa, Hilda"'
Search Results
2. Malaria overdiagnosis: is patient pressure the problem?
- Author
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Chandler, Clare I R, Mwangi, Rose, Mbakilwa, Hilda, Olomi, Raimos, Whitty, Chris J M, and Reyburn, Hugh
- Published
- 2008
3. The Impact of Response to the Results of Diagnostic Tests for Malaria: Cost-Benefit Analysis
- Author
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Lubell, Yoel, Reyburn, Hugh, Mbakilwa, Hilda, Mwangi, Rose, Chonya, Semkini, Whitty, Christopher J. M., and Mills, Anne
- Published
- 2008
- Full Text
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4. Rapid Diagnostic Tests Compared with Malaria Microscopy for Guiding Outpatient Treatment of Febrile Illness in Tanzania: Randomised Trial
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Reyburn, Hugh, Mbakilwa, Hilda, Mwangi, Rose, Mwerinde, Ombeni, Olomi, Raimos, Drakeley, Chris, and Whitty, Christopher J. M.
- Published
- 2007
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5. "It is good to take her early to the doctor" -- mothers' understanding of childhood pneumonia symptoms and health care seeking in Kilimanjaro region, Tanzania.
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Muro, Florida, Meta, Judith, Renju, Jenny, Mushi, Adiel, Mbakilwa, Hilda, Olomi, Raimos, Reyburn, Hugh, and Hildenwall, Helena
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PNEUMONIA treatment ,PEDIATRICS ,CHILD mortality ,FEVER ,FOCUS groups ,INTERVIEWING ,MOTHER-child relationship ,PNEUMONIA ,ADULT respiratory distress syndrome ,QUALITATIVE research ,SOCIOECONOMIC factors ,ATTITUDES of mothers ,ATTITUDES toward illness ,SYMPTOMS ,CHILDREN ,PSYCHOLOGY - Abstract
Background: Pneumonia is among the leading causes of avoidable deaths for young children globally. The main burden of mortality falls on children from poor and rural families who are less likely to obtain the treatment they need, highlighting inequities in access to effective care and treatment. Caretakers' illness perceptions and care-seeking practices are of major importance for children with pneumonia to receive adequate care. This study qualitatively explores the caretaker concepts of childhood pneumonia in relation to treatment seeking behaviour and health worker management in Moshi urban district, Tanzania. Methods: In May - July 2013 data was gathered through different qualitative data collection techniques including five focus group discussions (FGDs) with mothers of children under-five years of age. The FGDs involved free listing of pneumonia symptoms and video presentations of children with respiratory symptoms done, these were triangulated with ten case narratives with mothers of children admitted with pneumonia and eleven in-depth interviews with hospital health workers. Transcripts were coded and analysed using qualitative content analysis. Results: Mothers demonstrated good awareness of common childhood illnesses including pneumonia, which was often associated with symptoms such as cough, flu, chest tightness, fever, and difficulty in breathing. Mothers had mixed views on causative factors and treatments options but generally preferred modern medicine for persisting and severe symptoms. However, all respondent reported access to health facilities as a barrier to care, associated with transport, personal safety and economic constraints. Conclusion: Local illness concepts and traditional treatment options did not constitute barriers to care for pneumonia symptoms. Poor access to health facilities was the main barrier. Decentralisation of care through community health workers may improve access to care but needs to be combined with strengthened referral systems and accessible hospital care for those in need. [ABSTRACT FROM AUTHOR]
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- 2017
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6. Bringing the state into the clinic? Incorporating the rapid diagnostic test for malaria into routine practice in Tanzanian primary healthcare facilities.
- Author
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Hutchinson, Eleanor, Reyburn, Hugh, Hamlyn, Eleanor, Long, Katie, Meta, Judith, Mbakilwa, Hilda, and Chandler, Clare
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MALARIA diagnosis ,ATTITUDE (Psychology) ,CHANGE ,HEALTH services accessibility ,INTERVIEWING ,MEDICAL quality control ,MEDICAL personnel ,QUALITY assurance ,RESEARCH funding ,DECISION making in clinical medicine ,POINT-of-care testing ,HEALTH & social status - Abstract
The roles that rapid, point-of-care tests will play in healthcare in low-income settings are likely to expand over the coming years. Yet, very little is known about how they are incorporated into practice, and what it means to use and rely upon them. This paper focuses on the rapid diagnostic test for malaria (mRDT), examining its introduction into low-level public health facilities in Tanzania within an intervention to improve the targeting of costly malaria medication. We interviewed 26 health workers to explore how a participatory training programme, mobile phone messages, posters and leaflets shaped the use and interpretation of the test. Drawing on notions of biopolitics, this paper examines how technologies of the self and mechanisms of surveillance bolstered the role mRDT in clinical decision-making. It shows how the significance of the test interacted with local knowledge, the availability of other medication, and local understandings of good clinical practice. Our findings suggest that in a context in which care is reduced to the provision of medicines, strict adherence to mRDT results may be underpinned by increasing the use of other pharmaceuticals or may leave health workers with patients for whom they are unable to provide care. [ABSTRACT FROM PUBLISHER]
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- 2017
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7. Monitoring patient care through health facility exit interviews: an assessment of the Hawthorne effect in a trial of adherence to malaria treatment guidelines in Tanzania.
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Leurent, Baptiste, Reyburn, Hugh, Muro, Florida, Mbakilwa, Hilda, and Schellenberg, David
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MEDICAL care research ,HEALTH facilities ,EXIT interviewing ,HAWTHORNE effect ,MALARIA treatment ,DRUG therapy for malaria ,ANTIMALARIALS ,COGNITION ,COMPARATIVE studies ,EPIDEMIOLOGY ,INTERVIEWING ,MALARIA ,RESEARCH methodology ,MEDICAL care ,MEDICAL cooperation ,MEDICAL personnel ,MEDICAL protocols ,MEDICAL referrals ,PATIENTS ,RESEARCH ,EVALUATION research ,RANDOMIZED controlled trials ,THERAPEUTICS - Abstract
Background: Survey of patients exiting health facilities is a common way to assess consultation practices. It is, however, unclear to what extent health professionals may change their practices when they are aware of such interviews taking place, possibly paying more attention to following recommended practices. This so-called Hawthorne effect could have important consequences for interpreting research and programme monitoring, but has rarely been assessed.Methods: A three-arm cluster-randomised trial of interventions to improve adherence to guidelines for the use of anti-malarial drugs was conducted in Tanzania. Patient interviews were conducted outside health facilities on two randomly-selected days per week. Health workers also routinely documented consultations in their ledgers. The Hawthorne effect was investigated by comparing routine data according to whether exit interviews had been conducted on three key indicators of malaria care. Adjusted logistic mixed-effects models were used, taking into account the dependencies within health facilities and calendar days.Results: Routine data were collected on 19,579 consultations in 18 facilities. The odds of having a malaria rapid diagnostic test (RDT) result reported were 11 % higher on days when exit surveys were conducted (adjusted odds ratio 95 % CI: 0.98-1.26, p = 0.097), 17 % lower for prescribing an anti-malarial drug to patients with a negative RDT result (0.56-1.23, p = 0.343), and 27 % lower for prescribing an anti-malarial when no RDT result was reported (0.53-1.00, p = 0.052). The effect varied with time, with a U-shaped association over the study period (p < 0.001). We also observed a higher number of consultations recorded on days when exit-interviews were conducted (adjusted mean difference = 2.03, p < 0.001).Conclusions: Although modest, there was some suggestion of better practice by health professionals on days when exit interviews were conducted. Researchers should be aware of the potential Hawthorne effect, and take into account assessment methods when generalising findings to the 'real word' setting. This effect is, however, likely to be context dependent, and further controlled evaluation across different settings should be conducted.Trial Registration: ClinicalTrials.gov: NCT01292707 . Registered on 29th January 2011. [ABSTRACT FROM AUTHOR]- Published
- 2016
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8. Prescriber and patient-oriented behavioural interventions to improve use of malaria rapid diagnostic tests in Tanzania: facility-based cluster randomised trial.
- Author
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Cundill, Bonnie, Mbakilwa, Hilda, Chandler, Clare I. R., Mtove, George, Mtei, Frank, Willetts, Annie, Foster, Emily, Muro, Florida, Mwinyishehe, Rahim, Mandike, Renata, Olomi, Raimos, Whitty, Christopher J., and Reyburn, Hugh
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MALARIA diagnosis , *ROUTINE diagnostic tests , *TRANSMISSION of protozoan diseases , *ANTIMALARIALS , *PRIMARY care , *THERAPEUTICS - Abstract
Background: The increasing investment in malaria rapid diagnostic tests (RDTs) to differentiate malarial and non-malarial fevers, and an awareness of the need to improve case management of non-malarial fever, indicates an urgent need for high quality evidence on how best to improve prescribers' practices. Methods: A three-arm stratified cluster-randomised trial was conducted in 36 primary healthcare facilities from September 2010 to March 2012 within two rural districts in northeast Tanzania where malaria transmission has been declining. Interventions were guided by formative mixed-methods research and were introduced in phases. Prescribing staff from all facilities received standard Ministry of Health RDT training. Prescribers from facilities in the health worker (HW) and health worker-patient (HWP) arms further participated in small interactive peer-group training sessions with the HWP additionally receiving clinic posters and patient leaflets. Performance feedback and motivational mobile-phone text messaging (SMS) were added to the HW and HWP arms in later phases. The primary outcome was the proportion of patients with a non-severe, non-malarial illness incorrectly prescribed a (recommended) antimalarial. Secondary outcomes investigated RDT uptake, adherence to results, and antibiotic prescribing. Results: Standard RDT training reduced pre-trial levels of antimalarial prescribing, which was sustained throughout the trial. Both interventions significantly lowered incorrect prescribing of recommended antimalarials from 8% (749/8,942) in the standard training arm to 2% (250/10,118) in the HW arm (adjusted RD (aRD) 4%; 95% confidence interval (CI) 1% to 6%; P = 0.008) and 2% (184/10,163) in the HWP arm (aRD 4%; 95% CI 1% to 6%; P = 0.005). Small group training and SMS were incrementally effective. There was also a significant reduction in the prescribing of antimalarials to RDT-negatives but no effect on RDT-positives receiving an ACT. Antibiotic prescribing was significantly lower in the HWP arm but had increased in all arms compared with pre-trial levels. Conclusions: Small group training with SMS was associated with an incremental and sustained improvement in prescriber adherence to RDT results and reducing over-prescribing of antimalarials to close to zero. These interventions may become increasingly important to cope with the wider range of diagnostic and treatment options for patients with acute febrile illness in Africa. Trial registration: ClinicalTrials.gov (#NCT01292707) 29 January 2011. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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9. The development of effective behaviour change interventions to support the use of malaria rapid diagnostic tests by Tanzanian clinicians.
- Author
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Chandler, Clare I. R., Meta, Judith, Ponzo, Célia, Nasuwa, Fortunata, Kessy, John, Mbakilwa, Hilda, Haaland, Ane, and Reyburn, Hugh
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MALARIA diagnosis ,ROUTINE diagnostic tests ,MEDICAL practice ,RANDOMIZED controlled trials ,ARTEMISININ - Abstract
Background Parasitological confirmation is now recommended for all cases of suspected malaria. The roll-out of rapid diagnostic tests (RDTs) is hoped to enable this goal in low resource settings through point of care testing. However, simply making RDTs available has not led to high uptake of the tests or adherence to results by clinicians, with malaria continuing to be overdiagnosed in many settings. We undertook to design an evidence-based intervention package that would be sufficient to support the introduction of RDTs at dispensaries in Tanzania, to be evaluated through the Targeting Artemisinin Combination Therapy (TACT) cluster randomised controlled trial. Methods We describe five steps in our intervention design: formative research, review of existing evidence and theory, a workshop to define the intervention approach and content and results of formative research, engagement with behaviour change theory and literature, detailed design of intervention materials and piloting and pretesting of intervention materials. This involved fieldwork with a total of 19 health workers and 212 community members in northeast Tanzania. Results The formative research suggested that RDTs were a potential source of conflict in the health worker-patient interaction, but that health workers used various techniques to resolve this, including provision of antimalarial drugs for RDT-negative patients. Our reviews showed that evidence was mixed regarding the effectiveness of different methods and theories to support change in prescribing practice. Our design process is presented, drawing from this collective evidence. We describe the final TACT intervention package (including interactive small group workshops, feedback text messages, motivational text messages and patient information leaflets and posters) in terms of its programme theory and implementation theory. Conclusions Our study suggests that evidence-based design of complex interventions is possible. The use of formative research to understand malaria overdiagnosis in context was central to the design of the intervention as well as empirical research to test materials and methods prior to implementation. The TACT interventions may be appropriate for other settings where clinicians face similar challenges with malaria diagnostics. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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10. The practice of 'doing' evaluation: lessons learned from nine complex intervention trials in action.
- Author
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Reynolds, Joanna, DiLiberto, Deborah, Mangham-Jefferies, Lindsay, Ansah, Evelyn K., Lal, Sham, Mbakilwa, Hilda, Bruxvoort, Katia, Webster, Jayne, Vestergaard, Lasse S., Yeung, Shunmay, Leslie, Toby, Hutchinson, Eleanor, Reyburn, Hugh, Lalloo, David G., Schellenberg, David, Cundill, Bonnie, Staedke, Sarah G., Wiseman, Virginia, Goodman, Catherine, and Chandler, Clare I. R.
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MEDICAL care ,MEDICAL personnel ,MALARIA treatment ,MEDICAL research ,ACQUISITION of data - Abstract
Background There is increasing recognition among trialists of the challenges in understanding how particular 'real-life' contexts influence the delivery and receipt of complex health interventions. Evaluations of interventions to change health worker and/or patient behaviours in health service settings exemplify these challenges. When interpreting evaluation data, deviation from intended intervention implementation is accounted for through process evaluations of fidelity, reach, and intensity. However, no such systematic approach has been proposed to account for the way evaluation activities may deviate in practice from assumptions made when data are interpreted. Methods A collective case study was conducted to explore experiences of undertaking evaluation activities in the real-life contexts of nine complex intervention trials seeking to improve appropriate diagnosis and treatment of malaria in varied health service settings. Multiple sources of data were used, including in-depth interviews with investigators, participant-observation of studies, and rounds of discussion and reflection. Results and discussion From our experiences of the realities of conducting these evaluations, we identified six key 'lessons learned' about ways to become aware of and manage aspects of the fabric of trials involving the interface of researchers, fieldworkers, participants and data collection tools that may affect the intended production of data and interpretation of findings. These lessons included: foster a shared understanding across the study team of how individual practices contribute to the study goals; promote and facilitate within-team communications for ongoing reflection on the progress of the evaluation; establish processes for ongoing collaboration and dialogue between sub-study teams; the importance of a field research coordinator bridging everyday project management with scientific oversight; collect and review reflective field notes on the progress of the evaluation to aid interpretation of outcomes; and these approaches should help the identification of and reflection on possible overlaps between the evaluation and intervention. Conclusion The lessons we have drawn point to the principle of reflexivity that, we argue, needs to become part of standard practice in the conduct of evaluations of complex interventions to promote more meaningful interpretations of the effects of an intervention and to better inform future implementation and decision-making. [ABSTRACT FROM AUTHOR]
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- 2014
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11. Perceptions of mothers and hospital staff of paediatric care in 13 public hospitals in northern Tanzania
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Mwangi, Rose, Chandler, Clare, Nasuwa, Fortunata, Mbakilwa, Hilda, Poulsen, Anja, Bygbjerg, Ib Christian, and Reyburn, Hugh
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CHILD health services ,MEDICAL care ,PEDIATRICS - Abstract
Summary: User and provider perceptions of quality of care are likely to affect both use and provision of services. However, little is known about how health workers and mothers perceive the delivery of care in hospital paediatric wards in Africa. Paediatric staff and mothers of paediatric inpatients were interviewed to explore their opinions and experience of the admission process and conditions on the ward. Overcrowding, unsanitary conditions and lack of food were major concerns for mothers on the ward, who were deterred from seeking treatment earlier due to fears that hospital admission posed a significant risk of exposure to infection. While most staff were seen as being sympathetic and supportive to mothers, a minority were reported to be judgemental and authoritarian. Health workers identified lack of trained staff, overwork and low pay as major concerns. Staff shortages, lack of effective training and equipment are established problems but our findings also highlight a need for wards to become more parent-friendly, particularly with regard to food, hygiene and space. Training programmes focused on professional conduct and awareness of the problems that mothers face in seeking and receiving care may result in a more supportive and cooperative attitude between staff and mothers. [Copyright &y& Elsevier]
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- 2008
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12. Examining Intervention Design: Lessons from the Development of Eight Related Malaria Health Care Intervention Studies.
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Chandler CIR, Burchett H, Boyle L, Achonduh O, Mbonye A, DiLiberto D, Reyburn H, Onwujekwe O, Haaland A, Roca-Feltrer A, Baiden F, Mbacham WF, Ndyomugyenyi R, Nankya F, Mangham-Jefferies L, Clarke S, Mbakilwa H, Reynolds J, Lal S, Leslie T, Maiteki-Sebuguzi C, Webster J, Magnussen P, Ansah E, Hansen KS, Hutchinson E, Cundill B, Yeung S, Schellenberg D, Staedke SG, Wiseman V, Lalloo DG, and Whitty CJM
- Abstract
Abstract -Rigorous evidence of "what works" to improve health care is in demand, but methods for the development of interventions have not been scrutinized in the same ways as methods for evaluation. This article presents and examines intervention development processes of eight malaria health care interventions in East and West Africa. A case study approach was used to draw out experiences and insights from multidisciplinary teams who undertook to design and evaluate these studies. Four steps appeared necessary for intervention design: (1) definition of scope, with reference to evaluation possibilities; (2) research to inform design, including evidence and theory reviews and empirical formative research; (3) intervention design, including consideration and selection of approaches and development of activities and materials; and (4) refining and finalizing the intervention, incorporating piloting and pretesting. Alongside these steps, projects produced theories, explicitly or implicitly, about (1) intended pathways of change and (2) how their intervention would be implemented.The work required to design interventions that meet and contribute to current standards of evidence should not be underestimated. Furthermore, the process should be recognized not only as technical but as the result of micro and macro social, political, and economic contexts, which should be acknowledged and documented in order to infer generalizability. Reporting of interventions should go beyond descriptions of final intervention components or techniques to encompass the development process. The role that evaluation possibilities play in intervention design should be brought to the fore in debates over health care improvement.
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- 2016
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13. Quality of malaria microscopy in 12 district hospital laboratories in Tanzania.
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Mbakilwa H, Manga C, Kibona S, Mtei F, Meta J, Shoo A, Amos B, and Reyburn H
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- Adult, Female, Health Services Research, Hospitals, District, Humans, Male, Middle Aged, Sensitivity and Specificity, Tanzania, Clinical Laboratory Techniques standards, Laboratory Proficiency Testing, Malaria diagnosis, Microscopy standards
- Abstract
Background: The WHO recommendation for parasitological diagnosis of malaria wherever possible is challenged by evidence of poor-quality microscopy in African hospitals but the reasons are not clear., Methods: All 12 of the busier district hospital laboratories from three regions of Tanzania were assessed for quality of the working environment and slide readers read 10 reference slides under exam conditions. Slides that had been routinely read were removed for expert reading., Results: Of 44 slide readers in the study, 39 (88.6%) correctly read >90% of the reference slides. Of 206 slides that had been routinely read, 33 (16%) were judged to be unreadable, 104 (51%) were readable with difficulty, and 69 (34%) were easily readable. Compared to expert reading of the same slide, the sensitivity of routine slide results of easily readable slides was 85.7% (95% confidence interval: 77.4-94.0), falling to 44.4% (95% confidence interval: 34.5-54.4) for slides that were 'readable with difficulty'., Conclusions: The commonest cause of inaccurate results was the quality of the slide itself, correction of which is likely to be achievable within existing resources. A minority of slide readers were unable to read slides even under ideal conditions, suggesting the need for a 'slide reading licence' scheme.
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- 2012
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14. The cost-effectiveness of parasitologic diagnosis for malaria-suspected patients in an era of combination therapy.
- Author
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Lubell Y, Reyburn H, Mbakilwa H, Mwangi R, Chonya K, Whitty CJ, and Mills A
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- Artemisinins therapeutic use, Child, Preschool, Cost-Benefit Analysis, Drug Therapy, Combination, Humans, Infant, Lactones therapeutic use, Malaria drug therapy, Malaria economics, Malaria parasitology, Microscopy methods, Sensitivity and Specificity, Sesquiterpenes therapeutic use, Malaria diagnosis, Reagent Strips economics
- Abstract
The introduction of artemisinin-based combination therapy in sub-Saharan Africa has prompted calls for increased use of parasitologic diagnosis for malaria. We evaluated the cost-effectiveness of rapid diagnostic tests (RDTs) in comparison to microscopy in guiding treatment of non-severe febrile illness at varying levels of malaria endemicity using data on test accuracy and costs collected as part of a Tanzanian trial. If prescribers complied with current guidelines, microscopy would give rise to lower average costs per patient correctly treated than RDTs in areas of both high and low transmission. RDT introduction would result in an additional 2.3% and 9.4% of patients correctly treated, at an incremental cost of $25 and $7 in the low and high transmission settings, respectively. Cost-effectiveness would be worse if prescribers do not comply with test results. The cost of this additional benefit may be higher than many countries can afford without external assistance or lower RDT prices.
- Published
- 2007
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