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Start Over Author "Martin Muik" Publication Type Academic Journals
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1. A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

Author

Marc Fahrner, Michael Stadlbauer, Martin Muik, Petr Rathner, Peter Stathopulos, Mitsu Ikura, Norbert Müller, and Christoph Romanin

Subjects
Science
Abstract

Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.

Published
2018
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