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Start Over Author "Maity, Amit" Publication Type Academic Journals
367 results on '"Maity, Amit"'

2. Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps

Author

Zou, Wei, Zhang, Rongxiao, Schüler, Emil, Taylor, Paige A, Mascia, Anthony E, Diffenderfer, Eric S, Zhao, Tianyu, Ayan, Ahmet S, Sharma, Manju, Yu, Shu-Jung, Lu, Weiguo, Bosch, Walter R, Tsien, Christina, Surucu, Murat, Pollard-Larkin, Julianne M, Schuemann, Jan, Moros, Eduardo G, Bazalova-Carter, Magdalena, Gladstone, David J, Li, Heng, Simone, Charles B, Petersson, Kristoffer, Kry, Stephen F, Maity, Amit, Loo, Billy W, Dong, Lei, Maxim, Peter G, Xiao, Ying, and Buchsbaum, Jeffrey C

Subjects
Clinical Research, Cancer, Clinical Trials and Supportive Activities, Humans, Credentialing, Electrons, Health Facilities, Patient Positioning, Technology, Radiotherapy Dosage, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR), may allow patients to be treated with less normal tissue toxicity for a given tumor dose compared with currently used conventional dose rate. Clinical trials are being carried out and are needed to test whether this improved therapeutic ratio can be achieved clinically. During the clinical trials, quality assurance and credentialing of equipment and participating sites, particularly pertaining to UHDR-specific aspects, will be crucial for the validity of the outcomes of such trials. This report represents an initial framework proposed by the NRG Oncology Center for Innovation in Radiation Oncology FLASH working group on quality assurance of potential UHDR clinical trials and reviews current technology gaps to overcome. An important but separate consideration is the appropriate design of trials to most effectively answer clinical and scientific questions about FLASH. This paper begins with an overview of UHDR RT delivery methods. UHDR beam delivery parameters are then covered, with a focus on electron and proton modalities. The definition and control of safe UHDR beam delivery and current and needed dosimetry technologies are reviewed and discussed. System and site credentialing for large, multi-institution trials are reviewed. Quality assurance is then discussed, and new requirements are presented for treatment system standard analysis, patient positioning, and treatment planning. The tables and figures in this paper are meant to serve as reference points as we move toward FLASH-RT clinical trial performance. Some major questions regarding FLASH-RT are discussed, and next steps in this field are proposed. FLASH-RT has potential but is associated with significant risks and complexities. We need to redefine optimization to focus not only on the dose but also on the dose rate in a manner that is robust and understandable and that can be prescribed, validated, and confirmed in real time. Robust patient safety systems and access to treatment data will be critical as FLASH-RT moves into the clinical trials.

Published
2023

11. Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria

Author

Pradhan, Sayantan, Hore, Samrat, Roy, Stabak, Manna, Simi, Dam, Paulami, Mondal, Rittick, Ghati, Amit, Biswas, Trishanjan, Shaw, Subhajit, Sharma, Supriya, Singh, Waikhom Somraj, Maji, Suman Kumar, Roy, Sankarsan, Basu, Aparajita, Pandey, Kailash C., Samanta, Soumadri, Vashisht, Kapil, Dolai, Tuphan Kanti, Kundu, Pratip Kumar, Mitra, Saptarshi, Biswas, Debasish, Sadat, Abdul, Shokriyan, Masuma, Maity, Amit Bikram, Mandal, Amit Kumar, and İnce, İkbal Agah

Published
2023
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18. Cherenkov imaging for total skin electron therapy (TSET)

Author

Xie, Yunhe, Petroccia, Heather, Maity, Amit, Miao, Tianshun, Zhu, Yihua, Bruza, Petr, Pogue, Brian W, Plastaras, John P, Dong, Lei, and Zhu, Timothy C

Subjects
Medical and Biological Physics, Physical Sciences, Biomedical Imaging, Cancer, Clinical Research, Adult, Aged, Aged, 80 and over, Electrons, Female, Humans, Male, Middle Aged, Optical Imaging, Radiotherapy Dosage, Skin Neoplasms, biomedical optics, cherenkov imaging, radiation therapy, total skin electron therapy, Other Physical Sciences, Biomedical Engineering, Oncology and Carcinogenesis, Nuclear Medicine & Medical Imaging, Biomedical engineering, Medical and biological physics
Abstract

BackgroundTotal skin electron therapy (TSET) utilizes high-energy electrons to treat malignancies on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interactions between the high-energy electron beam and tissue.Methods and materialsWith a time-gated intensified camera system, the Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real time. Fifteen patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. Each patient was monitored during TSET via in vivo detectors (IVD) in nine locations. For accurate Cherenkov imaging, a comparison between IVD and Cherenkov profiles was conducted using a polyvinyl chloride board to establish the perspective corrections.Results and discussionWith proper corrections developed in this study including the perspective and inverse square corrections, the Cherenkov imaging provided two-dimensional maps proportional to dose and projected on patient skin. The results of ratio between chest and umbilicus points were in good agreement with in vivo point dose measurements, with a standard deviation of 2.4% compared to OSLD measurements.ConclusionsCherenkov imaging is a viable tool for validating patient-specific dose distributions during TSET.

Published
2020

22. Study of epidemiological behaviour of malaria and its control in the Purulia district of West Bengal, India (2016–2020)

Author

Pradhan, Sayantan, Hore, Samrat, Maji, Suman Kumar, Manna, Simi, Maity, Abhijit, Kundu, Pratip Kumar, Maity, Krishna, Roy, Stabak, Mitra, Saptarshi, Dam, Paulami, Mondal, Rittick, Ghorai, Suvankar, Jawed, Junaid Jibran, Dutta, Subhadeep, Das, Sandip, Mandal, Sukhendu, Mandal, Sanjib, Kati, Ahmet, Sinha, Sangram, Maity, Amit Bikram, Dolai, Tuphan Kanti, Mandal, Amit Kumar, and İnce, İkbal Agah

Published
2022
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33. High anticancer activity in short response time exhibited by a new azobenzene derivative and its copper complex.

Author

Dev, Samrat, Mitra, Debarpan, Sinha, Chittaranjan, Das, Gaurav, Murmu, Nabendu, Maity, Amit Ranjan, and Pandey, Souvik

Subjects
AZOBENZENE derivatives, DIMETHYL sulfoxide, COPPER compounds, ANTINEOPLASTIC agents, COPPER, NUCLEAR fragmentation
Abstract

o‐Aminoazotoluene (OAT), capable of photoisomerization, and o‐vanillin, a potent comutagen, have been used to synthesize a new ligand, HL, [C6H4(CH3)N=NC6H3(CH3)N=CHC6H3(OH)(OCH3)], which, upon complexation with copper(II), results in a new copper(II) complex‐Cu(L)2, [Cu{C6H4(CH3)N=NC6H3(CH3)N=CHC6H3(OCH3)O}2]. Both HL and Cu(L)2 have been characterized by single‐crystal X‐ray diffraction measurements along with other analytical techniques, for example, IR spectroscopy, NMR spectroscopy, UV–Vis spectroscopy, elemental analysis and mass spectrometry. These compounds were tested with different in vitro anticancer assay as well as with in silico studies. A comparative study has been demonstrated on anticancer activity of HL and Cu(L)2 with the ligand HAZ, {C6H5N=NC6H4N=CHC6H3(OH)(OCH3)} and its Cu‐complex, [Cu(AZ)2, Cu{C6H5N=NC6H4N=CHC6H3(OCH3)O}2]. The sensing properties of HAZ, along with the synthesis and structural properties of both HAZ and Cu(AZ)2, have been reported by our group earlier. Cytotoxicity measurements on MCF7 cell lines show that Cu(L)2 and Cu(AZ)2 have higher anticancer activity than their corresponding ligands. The apoptotic effect of Cu‐complex was studied through nuclear fragmentation assay and AO/EB dual‐staining assay on MCF7 cell line. The IC50 value of Cu(L)2 in 0.01% DMSO/water after 24‐h treatment was found 4.2 μM, which is one of the lowest values with this response time compared to the other analogous anticancer compounds. Finally, we have evaluated the expression of hERα protein with respect to Cu‐complexes, and it was observed that Cu(L)2 caused more down‐regulation of hERα as compared to Cu(AZ)2. [ABSTRACT FROM AUTHOR]

Published
2024
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36. ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

Author

Hart, Lori S, Cunningham, John T, Datta, Tatini, Dey, Souvik, Tameire, Feven, Lehman, Stacey L, Qiu, Bo, Zhang, Haiyan, Cerniglia, George, Bi, Meixia, Li, Yan, Gao, Yan, Liu, Huayi, Li, Changhong, Maity, Amit, Thomas-Tikhonenko, Andrei, Perl, Alexander E, Koong, Albert, Fuchs, Serge Y, Diehl, J Alan, Mills, Ian G, Ruggero, Davide, and Koumenis, Constantinos

Subjects
Rare Diseases, Cancer, Hematology, Genetics, Lymphoma, 2.1 Biological and endogenous factors, Aetiology, Animals, Apoptosis, Autophagy, Burkitt Lymphoma, Calcium Signaling, Caspases, Cell Line, Tumor, Cell Proliferation, Cell Survival, Cell Transformation, Neoplastic, Cluster Analysis, Endoplasmic Reticulum Stress, Gene Knockout Techniques, Heterozygote, Humans, Mice, Oligonucleotide Array Sequence Analysis, Proto-Oncogene Mas, Proto-Oncogene Proteins c-myc, Ribosomal Proteins, Transcriptome, Unfolded Protein Response, eIF-2 Kinase, Medical and Health Sciences, Immunology
Abstract

The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc-induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorigenesis. The accumulation of unfolded proteins in the ER initiates a cellular stress program termed the unfolded protein response (UPR) to support cell survival. Analysis of spontaneous mouse and human lymphomas demonstrated significantly higher levels of UPR activation compared with normal tissues. Using multiple genetic models, we demonstrated that c-Myc and N-Myc activated the PERK/eIF2α/ATF4 arm of the UPR, leading to increased cell survival via the induction of cytoprotective autophagy. Inhibition of PERK significantly reduced Myc-induced autophagy, colony formation, and tumor formation. Moreover, pharmacologic or genetic inhibition of autophagy resulted in increased Myc-dependent apoptosis. Mechanistically, we demonstrated an important link between Myc-dependent increases in protein synthesis and UPR activation. Specifically, by employing a mouse minute (L24+/-) mutant, which resulted in wild-type levels of protein synthesis and attenuation of Myc-induced lymphomagenesis, we showed that Myc-induced UPR activation was reversed. Our findings establish a role for UPR as an enhancer of c-Myc-induced transformation and suggest that UPR inhibition may be particularly effective against malignancies characterized by c-Myc overexpression.

Published
2012

40. A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours

Author

Maity, Amit, Mick, Rosemarie, Huang, Alexander C., George, Sangeeth M., Farwell, Michael D., Lukens, John N., Berman, Abigail T., Mitchell, Tara C., Bauml, Josh, Schuchter, Lynn M., O’Hara, Mark, Lin, Lilie L., Demichele, Angela, Christodouleas, John P., Haas, Naomi B., Patsch, Dana M., Hahn, Stephen M., Minn, Andy J., Wherry, E. John, and Vonderheide, Robert H.

Published
2018
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46. N-Heterocyclic imino-catalyzed 1,4-regioselective azide–alkyne cycloaddition (AAC): a metal-free approach.

Author

Revathi, Shanmugam, Shinde, Aditya L., Rajashekhar, Mulimani K., Mandal, Debasish, Maity, Amit Ranjan, Garai, Somenath, and Ghatak, Tapas

Subjects
RING formation (Chemistry), CATALYSTS
Abstract

An unprecedented synthetic approach has been devised to efficiently synthesize regioselective 1,4-disubstituted 1,2,3-triazoles. This technique relies on the use of innovative metal-free highly basic N-heterocyclic imino catalysts. The experimental observations have been supported further by TD-DFT computational studies. [ABSTRACT FROM AUTHOR]

Published
2023
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