Search

Your search keyword '"Ma, Sunghoon"' showing total 9 results
Start Over Author "Ma, Sunghoon" Publication Type Academic Journals
9 results on '"Ma, Sunghoon"'

1. Asymmetric syntheses of fused bicyclic lactams

Author

Lim, Sung H., Ma, Sunghoon, and Beak, Peter

Subjects
Chemistry, Organic -- Research, Ring formation (Chemistry) -- Physiological aspects, Lithium -- Physiological aspects, Alkaloids -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the enantioenriched bicyclic lactams. The lithiation-substituted or asymmetric strategies developed in combination with the ring-closing metathesis for the synthesis of these lactams are reported.

Published
2001

3. Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90

Author

Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, and Rice, Kenneth D.

Published
2012
Full Text
View/download PDF

4. Discovery of a Novel Classof Highly Potent, Selective,ATP-Competitive, and Orally Bioavailable Inhibitors of the MammalianTarget of Rapamycin (mTOR).

Author

Takeuchi, Craig S., Kim, Byung Gyu, Blazey, Charles M., Ma, Sunghoon, Johnson, Henry W. B., Anand, Neel K., Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A., Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S., Wang, Longcheng, Leahy, James W., Nuss, John M., Aay, Naing, Aoyama, Ron, and Foster, Paul

Published
2013
Full Text
View/download PDF

6. Synthesis of enantiopure five-carbon, stereodiads applicable for the preparation of the mycolactones.

Author

TONG, ZHIWEI, MA, SUNGHOON, and FUCHS, PHILIP L.

Subjects
*SULFONES, *LACTONES, *CARBON compounds, *STEREOCHEMISTRY, *CHEMICALS
Abstract

Synthesis of enantiopure γ-hydroxycyclopentenyl sulfones 16H , 16Si from cyclopentadiene is accomplished using the Trost palladium-mediated protocol. Conversion of these substrates into stereodiads 4anti and 5syn is described. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

9. An experimental and computational investigation of the enantioselective deprotonation of Boc-piperidine.

Author

Bailey WF, Beak P, Kerrick ST, Ma S, and Wiberg KB

Subjects
Lithium chemistry, Models, Molecular, Organometallic Compounds chemistry, Protons, Sparteine chemistry, Stereoisomerism, Thermodynamics, Piperidines chemistry
Abstract

The asymmetric deprotonation of N-Boc-piperidine (3) by the 1:1 complex of a sec-alkyllithium and (-)-sparteine has been investigated both experimentally and computationally. The lithiation of 3 with sec-BuL-(-)-sparteine at -78 degrees C, which is a much slower process than is the analogous deprotonation of N-Boc-pyrrolidine (1) and a minor reaction relative to the competing addition of sec-BuLi to the carbamate, proceeds with a moderate degree of selectivity (er = 87:13) for removal of the pro-S hydrogen of 3. The related deprotonation of N-Boc-4-tosyloxypiperidine (6) with two molar equiv of sec-BuL-(-)-sparteine also involves preferential transfer of the pro-S hydrogen. The computational study of the deprotonation of (3) by i-PrL-(-)-sparteine found that the proton that is preferentially transferred within three-component intermediate complex is the thermodynamically least acidic alpha-hydrogen of 3. The asymmetric deprotonation of 3 is calculated to proceed with poor enantioselectivity and to have an activation energy considerably higher than that calculated for deprotonation of N-Boc-pyrrolidine (1). The experimental and computational results are in good agreement.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results