1,361 results on '"Møller, Niels"'
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2. Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
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Gopalasingam, Nigopan, Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Ladefoged, Bertil T., Poulsen, Steen Hvitfeldt, Andersen, Mads Jønsson, Borlaug, Barry A., Nielsen, Roni, Møller, Niels, and Wiggers, Henrik
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- 2024
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3. Cerebral and myocardial kinetics of [11C]acetoacetate and [11C]β-hydroxybutyrate: A comparative crossover study in healthy rats
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Kjærulff, Mette Louise Gram, Luong, Thien Vinh, Richard, Gabriel, St-Pierre, Valérie, Søndergaard, Esben, Møller, Niels, Gormsen, Lars Christian, Tremblay, Sébastien, Croteau, Etienne, and Cunnane, Stephen C.
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- 2024
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4. Farming during turbulent times: Agriculture, food crops, and manuring practices in Bronze Age to Viking Age Denmark
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Hald, Mette Marie, Styring, Amy, Mortensen, Morten Fischer, Maltas, Tom, Vidas, Doris, Henriksen, Peter Steen, Pihl, Anders, Jensen, Peter Mose, Christensen, Lotte Bach, Hansen, Jesper, Dollar, Scott, Egeberg, Torben, Lundø, Michael Borre, Haue, Niels, Hertz, Eivind, Iversen, Rasmus B., Jørgensen, Thomas, Kristensen, Inge Kjær, Klassen, Lutz, Møller, Niels Algreen, Pedersen, Vibeke J., Ravn, Mads, Vestergaard, Katrine, and Jessen, Mads Dengsø
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- 2024
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5. Acute and prolonged ketosis lower serum IGF-I levels in human subjects
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Svart, Mads, Kjaergaard, Alisa D., Luong, Thien Vinh, Gormsen, Lars C., Møller, Niels, Jørgensen, Jens Otto L., and Søndergaard, Esben
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- 2024
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6. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
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Zhou, Bin, Bennett, James E, Wickham, Aidan P, Singleton, Rosie K, Mishra, Anu, Carrillo-Larco, Rodrigo M, Ikeda, Nayu, Jain, Lakshya, Barradas-Pires, Ana, Heap, Rachel A, Lhoste, Victor PF, Sheffer, Kate E, Phelps, Nowell H, Rayner, Archie W, Gregg, Edward W, Woodward, Mark, Stevens, Gretchen A, Iurilli, Maria LC, Danaei, Goodarz, Di Cesare, Mariachiara, Aguilar-Salinas, Carlos A, Ahmad, Noor Ani, Bovet, Pascal, Chen, Zhengming, Damasceno, Albertino, Filippi, Sarah L, Janszky, Imre, Kengne, Andre P, Khang, Young-Ho, Khunti, Kamlesh, Laxmaiah, Avula, Lim, Lee-Ling, Lissner, Lauren, Margozzini, Paula, Mbanya, Jean Claude N, McGarvey, Stephen T, Shaw, Jonathan E, Söderberg, Stefan, Soto-Mota, Luis Adrián, Wang, Junyang, Zaccardi, Francesco, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Aekplakorn, Wichai, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkhatib, Buthaina M, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amougou, Norbert, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Auvinen, Juha, Avdičová, Mária, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Bacopoulou, Flora, Bahijri, Suhad, Bajramovic, Izet, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Basit, Abdul, Bastos, Joao Luiz, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bettiol, Heloísa, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bhargava, Santosh K, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, 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Chiolero, Arnaud, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Chong, Chean Lin, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Cohen, Emmanuel, Confortin, Susana C, Coppinger, Tara C, Cortés, Lilia Yadira, Cosmin, Cojocaru R, Costanzo, Simona, Cowan, Melanie J, Cowell, Chris, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Cucu, Alexandra M, Cureau, Felipe V, Cuschieri, Sarah, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva-Ferreira, Haroldo, Dahm, Christina C, Dallongeville, Jean, Dankner, Rachel, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, de Oliveira, Paula Duarte, de Paiva, Karina Mary, De Ridder, Karin, de Valois Correia Júnior, Marco Aurélio, Deepa, Mohan, DeGennaro, Vincent Jr, Demarest, Stefaan, Dennison, Elaine, Deschamps, Valérie, Dhimal, Meghnath, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Donoso, Silvana P, Dorobantu, Maria, Dörr, Marcus, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka L, Dushpanova, Anar, Dyussupova, Azhar, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eghtesad, Sareh, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Elosua, Roberto, Enang, Ofem, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Esmaeili, Ali, Evans, Roger G, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farzadfar, Farshad, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Fernando, Desha R, Ferrante, Daniel, Ferrari, Gerson, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galfo, Myriam, Garcia-de-la-Hera, Manoli, Garcia, Pablo, Garnett, Sarah P, Gasull, Magda, Gazzinelli, Andrea, Gehring, Ulrike, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Ghimire, Anup, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Goldberg, Marcel, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gonzalez, Angel R, Gottrand, Frederic, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Grodzicki, Tomasz, Grøholt, Else Karin, Grøntved, Anders, Guajardo, Viviana, Guallar-Castillón, Pilar, Guerchet, Maëlenn, Guerrero, Ramiro, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunter, Marc J, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gurzkowska, Beata, Gutierrez, Laura, Gwee, Xinyi, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, 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Tuija, Jackson, Rod T, Jaddou, Hashem Y, Jadoul, Michel, Jafar, Tazeen, Jan, Nataša, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jha, Anjani Kumar, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Juolevi, Anne, Juresa, Vesna, Jureša, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Karki, Khem B, Kassi Anicet, Adoubi, Katibeh, Marzieh, Katulanda, Prasad, Katzmarzyk, Peter T, Kauhanen, Jussi, Kazakbaeva, Gyulli M, Kaze, François F, Ke, Calvin, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kersting, Mathilde, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Kim, Hyeon Chang, Klakk, Heidi, Klanarong, Suntara, Klanova, Jana, Klimek, Magdalena, Knoflach, Michael, Kobel, Susanne, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Koussoh Simone, Malik, Kovács, Éva, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F, Krokstad, Steinar, Kruger, Herculina S, Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kumari, Meena, Kunešová, Marie, Kurjata, Pawel, Kyobutungi, Catherine, La, Quang Ngoc, Labadarios, Demetre, Lachat, Carl, Lai, Daphne, Laid, Youcef, Lall, Lachmie, Landaeta Jimenez, Maritza, Landais, Edwige, Lankila, Tiina, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Lateva, Mina P, Latt, Tint Swe, Laurenzi, Martino, Lazo-Porras, Maria, Le Coroller, Gwenaëlle, Le Nguyen Bao, Khanh, Lehtimäki, Terho, Lemogoum, Daniel, Leong, Elvynna, Leszczak, Justyna, Leung, Gabriel M, Li, Yanping, Liivak, Merike, Lim, Charlie, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lind, Lars, Litwin, Mieczyslaw, Liu, Liping, Liu, Xiaotian, Longo Abril, Guadalupe, Lopes, Oscar, Lopez-Garcia, Esther, López-Gil, José Francisco, Lopez, Tania, Lozano, José Eugenio, Lukrafka, Janice L, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lunogelo, Charles, Lustigová, Michala, M'Buyamba-Kabangu, Jean-René, Machado-Coelho, George LL, Machado-Rodrigues, Aristides M, Macia, Enguerran, Madar, Ahmed A, Maestre, Gladys E, Maggi, Stefania, Magliano, Dianna J, Magnacca, Sara, Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Makdisse, Marcia, Malekpour, Mohammad-Reza, Malekzadeh, Fatemeh, Malekzadeh, 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Miranda, J Jaime, Mirjalili, Mohammad Reza, Mišigoj-Duraković, Marjeta, Mistretta, Antonio, Mocanu, Veronica, Modesti, Pietro A, Moghaddam, Sahar Saeedi, Mohammad, Kazem, Mohammadi, Mohammad Reza, Mohammadi, Zahra, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohan, Viswanathan, Mohd Yusoff, Muhammad Fadhli, Mohebbi, Iraj, Møller, Niels C, Molnár, Dénes, Momenan, Amirabbas, Mondo, Charles K, Monroy-Valle, Michele M, Montenegro Mendoza, Roger A, Monterrubio-Flores, Eric, Monyeki, Kotsedi Daniel K, Moon, Jin Soo, Moosazadeh, Mahmood, Moradpour, Farhad, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Moschonis, George, Moslem, Alireza, Mosquera, Mildrey, Mossakowska, Malgorzata, Mostafa, Aya, Mostafavi, Seyed-Ali, Motlagh, Mohammad Esmaeel, Motta, Jorge, Moura-dos-Santos, Marcos André, Mridha, Malay K, Msyamboza, Kelias P, Mu, Thet Thet, Muca, Florian, Mugoša, Boban, Munroe, Patricia B, Mursu, Jaakko, Musa, Kamarul Imran, Musić Milanović, Sanja, Musil, Vera, Musinguzi, Geofrey, Mustafa, Norlaila, Muyer, Muel Telo Marie-Claire, Nabipour, Iraj, Naidu, Balkish M, Najafi, Farid, Nalecz, Hanna, Námešná, Jana, Narayan, KM Venkat, Naseri, Take, Nathalie, Michels, Neelapaichit, Nareemarn, Nejatizadeh, Azim, Nenko, Ilona, Nervi, Flavio, Neuhauser, Hannelore K, Ng, Tze Pin, Nguyen, Chung T, Nguyen, Quang V, Nguyen, Quang Ngoc, Ni, Michael Y, Nie, Peng, Nieto-Martínez, Ramfis E, Niiranen, Teemu J, Ninomiya, Toshiharu, Nishi, Nobuo, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Nogueira, Helena, Norton, Kevin I, Noto, Davide, Nowak-Szczepanska, Natalia, Nsour, Mohannad Al, Nuhoğlu, Irfan, Nurk, Eha, Nuwaha, Fred, Nyirenda, Moffat, O'Neill, Terence W, Ochimana, Caleb, Ochoa-Avilés, Angélica M, Oda, Eiji, Odili, Augustine N, Oh, Kyungwon, Ohtsuka, Ryutaro, Oldenburg, Brian, Olié, Valérie, Omar, Mohd Azahadi, Omar, Saeed M, Onat, Altan, Ong, Sok King, Onland-Moret, N Charlotte, Ono, Lariane M, Onodugo, Obinna, Ordunez, Pedro, Ornelas, Rui, Ortiz, Ana P, Ortiz, Pedro J, Osmond, Clive, Ostojic, Sergej M, Ostovar, Afshin, Otero, Johanna A, Ottendahl, Charlotte B, Otu, Akaninyene, Overvad, Kim, Owusu-Dabo, Ellis, Padez, Cristina P, Pagkalos, Ioannis, Pajula, Natalja, Palloni, Alberto, Palmieri, Luigi, Pan, Wen-Harn, Panza, Francesco, Paoli, Mariela, Papadopoulou, Sousana K, Pareja, Rossina G, Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R, Parsaeian, Mahboubeh, Pascanu, Ionela M, Pasquet, Patrick, Patel, Nikhil D, Pavlyshyn, Halyna, Pechlaner, Raimund, Pećin, Ivan, Pedro, João M, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peres, Karen GDA, Peres, Marco A, Perez-Londoño, Agustín, Pérez, Cynthia M, Peterkova, Valentina, Petrovna Kovtun, Olga, Peykari, Niloofar, Pham, Son Thai, Pichardo, Rafael N, Pierre-Marie, Preux, Pikhart, Hynek, Pilav, Aida, Piler, Pavel, Piwonska, Aleksandra, Pizarro, Andreia N, Plata, Silvia, Pop, Raluca M, Popkin, Barry M, Popovic, Stevo R, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J, Prista, Antonio, Providencia, Rui, Puder, Jardena J, Pudule, Iveta, Puhakka, Soile, Puiu, Maria, Punab, Margus, Qorbani, Mostafa, Quialheiro, Anna, Quintana, Hedley K, Quiroga-Padilla, Pedro J, Quoc Bao, Tran, Rach, Stefan, Rahimikazerooni, Salar, Rahman, Mahmudur, Raitakari, Olli, Rakhmatulloev, Sherali, Rakovac, Ivo, Ramachandran, Ambady, Ramadan, Otim PC, Ramirez-Zea, Manuel, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Ramsay, Sheena E, Rangel Junior, João FLB, Rangel Reina, Daniel A, Rangelova, Lalka S, Rarra, Vayia, Rashidi, Mohammad-Mahdi, Rech, Cassiano Ricardo, Redon, Josep, Regecová, Valéria, Renner, Jane DP, Repasy, Judit A, Reuter, Cézane P, Revilla, Luis, Reynolds, Andrew, Rezaei, Negar, Rezaianzadeh, Abbas, Riboli, Elio, Rigo, Fernando, Rigotti, Attilio, Riley, Leanne M, Rinke de Wit, Tobias F, Risérus, Ulf, Ritti-Dias, Raphael M, Roa, Reina G, Roccaldo, Romana, Rodríguez-Artalejo, Fernando, Rodriguez-Perez, María del Cristo, Rodríguez-Villamizar, Laura A, Rodríguez, Andrea Y, Roggenbuck, Ulla, Rohloff, Peter, Rojas-Martinez, Rosalba, Romeo, Elisabetta L, Rosario, Rafaela V, Rosengren, Annika, Rouse, Ian, Rubinstein, Adolfo, Ruiz-Betancourt, Blanca Sandra, Ruiz-Castell, Maria, Ruiz Moreno, Emma, Rusakova, Iuliia A, Rusek, Wojciech, Rust, Petra, Rutkowski, Marcin, Saamel, Marge, Sabbaghi, Hamideh, Sachdev, Harshpal S, Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Saghi, Mohammad Hossien, Saidi, Olfa, Saieva, Calogero, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salazar Martinez, Eduardo, Salkhanova, Akkumis, Salonen, Jukka T, Samoutian, Margarita, Sánchez-Abanto, Jose, Sánchez Rodríguez, Inés, Santos, Diana A, Santos, Ina S, Santos, Maria Paula, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarganas, Giselle, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savin, Stefan, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schienkiewitz, Anja, Schindler, Karin, Schipf, 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- 2024
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7. Optimising antibiotic exposure by customising the duration of treatment for respiratory tract infections based on patient needs in primary care
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Llor, Carl, Frimodt-Møller, Niels, Miravitlles, Marc, Kahlmeter, Gunnar, and Bjerrum, Lars
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- 2024
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8. Colorectal cancer and association with anaerobic bacteraemia: A Danish nationwide population-based cohort study
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Justesen, Ulrik S., Ellebæk, Mark B., Qvist, Niels, Iachina, Maria, Frimodt-Møller, Niels, Søes, Lillian M., Skovgaard, Sissel, Lemming, Lars, Samulioniene, Jurgitta, Andersen, Steen L., Dessau, Ram B., Møller, Jens K., Coia, John E., and Gradel, Kim O.
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- 2024
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9. Impact of a nationwide school policy on body mass index in Danish school children: An interrupted time series analysis
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Pedersen, Natascha H., Grøntved, Anders, Møller, Niels C., Debrabant, Birgit, Larsen, Kristian T., Brønd, Jan C., Troelsen, Jens, Brage, Søren, Hjelmborg, Jacob v B., Wedderkopp, Niels, Christiansen, Lars B., Mortensen, Sofie R., Egebæk, Heidi K., Toftager, Mette, Heidemann, Malene S., and Kristensen, Peter L.
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- 2024
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10. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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Slazhnyova, Tatyana, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti YE, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Solovieva, Yuliya V, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Soofi, Sajid, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sossa Jérome, Charles, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spencer, Phoebe R, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Stang, Andreas, Starc, Gregor, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Steinsbekk, Silje, Stergiou, George S, Stessman, Jochanan, Stevanović, Ranko, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sugiyama, Mindy, Suka, Machi, Sulo, Gerhard, Sun, Chien-An, Sun, Liang, Sund, Malin, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Sweis, Nabil William G, Swinburn, Boyd A, Sy, Rody G, Sylva, René Charles, Szponar, Lucjan, Tabone, Lorraine, Tai, E Shyong, Takuro, Furusawa, Tambalis, Konstantinos D, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Tessema, Masresha, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thorand, Barbara, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Tomaszewski, Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid
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- 2024
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11. Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial
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Berg-Hansen, Kristoffer, Gopalasingam, Nigopan, Christensen, Kristian Hylleberg, Ladefoged, Bertil, Andersen, Mads Jønsson, Poulsen, Steen Hvitfeldt, Borlaug, Barry A., Nielsen, Roni, Møller, Niels, and Wiggers, Henrik
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- 2024
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12. Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and β-hydroxybutyrate in healthy young males
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Pedersen, Mette Glavind Bülow, Lauritzen, Esben Stistrup, Svart, Mads Vandsted, Støy, Julie, Søndergaard, Esben, Thomsen, Henrik Holm, Kampmann, Ulla, Bjerre, Mette, Jessen, Niels, Møller, Niels, and Rittig, Nikolaj
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- 2023
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13. Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock: A Randomized, Controlled, Double-Blind Trial
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Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Gopalasingam, Nigopan, Nielsen, Roni, Eiskjær, Hans, Møller, Niels, Birkelund, Thomas, Christensen, Steffen, and Wiggers, Henrik
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- 2023
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14. The Barriers to Rapid Reperfusion in Acute ST-Elevation Myocardial Infarction
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Bartnes, Kristian, Albrigtsen, Hilde, Iversen, Johanne M., Brovold, Henrik, Møller, Niels H., Wembstad, Bjørn, Arstad, Frode, Kristensen, Andreas H., Cortis, Julia, Olsen, Siv J., Nygaard, Ståle N. S., Kindler, Sven G., Moe, Oddgeir, Hansen, Christian, and Mannsverk, Jan T.
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- 2022
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15. High level of colonization with third-generation cephalosporin-resistant Enterobacterales in African community settings, Ghana
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Obeng-Nkrumah, Noah, Hansen, Dennis Schrøder, Awuah-Mensah, Georgina, Blankson, Nana Kweiba, Frimodt-Møller, Niels, Newman, Mercy Jemima, Opintan, Japheth Awuletey, and Krogfelt, Karen Angeliki
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- 2023
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16. The influence of electricity prices on saving electricity in production: Automated multivariate time-series analyses for 99 Danish trades and industries
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Bjerregaard, Casper and Møller, Niels Framroze
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- 2022
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17. A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
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Loft, Anne, Schmidt, Søren Fisker, Caratti, Giorgio, Stifel, Ulrich, Havelund, Jesper, Sekar, Revathi, Kwon, Yun, Sulaj, Alba, Chow, Kan Kau, Alfaro, Ana Jimena, Schwarzmayr, Thomas, Rittig, Nikolaj, Svart, Mads, Tsokanos, Foivos-Filippos, Maida, Adriano, Blutke, Andreas, Feuchtinger, Annette, Møller, Niels, Blüher, Matthias, Nawroth, Peter, Szendrödi, Julia, Færgeman, Nils J., Zeigerer, Anja, Tuckermann, Jan, and Herzig, Stephan
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- 2022
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18. The importance of understanding the infectious microenvironment
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Bjarnsholt, Thomas, Whiteley, Marvin, Rumbaugh, Kendra P, Stewart, Philip S, Jensen, Peter Ø, and Frimodt-Møller, Niels
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- 2022
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19. Novel risk factors associated with common vaginal infections: a nationwide primary health care cohort study
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Jansåker, Filip, Frimodt-Møller, Niels, Li, Xinjun, and Sundquist, Kristina
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- 2022
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20. A 3-Week Ketogenic Diet Increases Skeletal Muscle Insulin Sensitivity in Individuals With Obesity: A Randomized Controlled Crossover Trial.
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Luong, Thien Vinh, Pedersen, Mette Glavind Bülow, Abild, Caroline Bruun, Lauritsen, Katrine Meyer, Kjærulff, Mette Louise Gram, Møller, Niels, Gormsen, Lars Christian, and Søndergaard, Esben
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INSULIN sensitivity ,KETOGENIC diet ,SKELETAL muscle ,TYPE 2 diabetes ,CROSSOVER trials - Abstract
A ketogenic diet (KD) can induce weight loss and improve glycemic regulation, potentially reducing the risk of type 2 diabetes development. To elucidate the underlying mechanisms behind these beneficial effects of a KD, we investigated the impact of a KD on organ-specific insulin sensitivity (IS) in skeletal muscle, liver, and adipose tissue. We hypothesized that a KD would increase IS in skeletal muscle. The study included 11 individuals with obesity who underwent a randomized, crossover trial with two 3-week interventions: 1) a KD and 2) a standard diet. Skeletal muscle IS was quantified as the increase in glucose disposal during a hyperinsulinemic-euglycemic clamp (HEC). Hepatic IS and adipose tissue IS were quantified as the relative suppression of endogenous glucose production (EGP) and the relative suppression of palmitate flux during the HEC. The KD led to a 2.2-kg weight loss and increased insulin-stimulated glucose disposal, whereas the relative suppression of EGP during the HEC was similar. In addition, the KD decreased insulin-mediated suppression of lipolysis. In conclusion, a KD increased skeletal muscle IS in individuals with obesity. Article Highlights: It remains unclear whether the glucose-lowering effect of a ketogenic diet is due to increased glucose disposal in skeletal muscle or due to an increased insulin-mediated suppression of endogenous glucose production. We investigated how the ketogenic diet affects organ-specific insulin sensitivity. A 3-week ketogenic diet increased insulin-mediated glucose disposal with no change in insulin-mediated suppression of endogenous glucose production. In addition, a decreased insulin-mediated suppression of lipolysis was observed. A 3-week ketogenic diet increases skeletal muscle insulin sensitivity in individuals with obesity. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate.
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Ottosen, Rasmus N., Seefeldt, Jacob M., Hansen, Jakob, Nielsen, Roni, Møller, Niels, Johannsen, Mogens, and Poulsen, Thomas B.
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- 2024
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22. Oral lactate slows gastric emptying and suppresses appetite in young males
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Pedersen, Mette Glavind Bülow, Søndergaard, Esben, Nielsen, Camilla Bak, Johannsen, Mogens, Gormsen, Lars Christian, Møller, Niels, Jessen, Niels, and Rittig, Nikolaj
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- 2022
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23. Metformin Lowers Body Weight But Fails to Increase Insulin Sensitivity in Chronic Heart Failure Patients without Diabetes: a Randomized, Double-Blind, Placebo-Controlled Study
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Larsen, Anders Hostrup, Wiggers, Henrik, Dollerup, Ole Lindgård, Jespersen, Nichlas Riise, Hansson, Nils Henrik, Frøkiær, Jørgen, Brøsen, Kim, Nørrelund, Helene, Bøtker, Hans Erik, Møller, Niels, and Jessen, Niels
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- 2021
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24. Identification of prehistoric malting and partial grain germination from starch granules in charred barley grains
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Cordes, Adam, Henriksen, Peter Steen, Hald, Mette Marie, Sørensen, Lasse, Nielsen, Poul Otto, Xu, Jinchuan, Lund, Jørgen, Møller, Niels Algreen, Nielsen, Finn Ole Sonne, Sarauw, Torben, Simonsen, John, Sparrevohn, Lotte Reedtz, Westphal, Jørgen, Blennow, Andreas, and Hebelstrup, Kim Henrik
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- 2021
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25. Abstract 15256: Treatment With Ketone Ester in Patients With Cardiogenic Shock Improves Cardiac Performance
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Berg Hansen, Kristoffer, Christensen, Kristian Hylleberg, Gopalasingam, Nigopan, Nielsen, Roni, Møller, Niels, Birkelund, Thomas, christensen, steffen, and Wiggers, Henrik
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- 2022
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26. The multivariate physical activity signature associated with metabolic health in children and youth: An International Children’s Accelerometry Database (ICAD) analysis
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Aadland, Eivind, Kvalheim, Olav Martin, Hansen, Bjørge Herman, Kriemler, Susi, Ried-Larsen, Mathias, Wedderkopp, Niels, Sardinha, Luis B., Møller, Niels Christian, Hallal, Pedro C., Anderssen, Sigmund A., Northstone, Kate, and Andersen, Lars Bo
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- 2020
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27. Pharmacokinetic and pharmacodynamic evaluation of nitrofurantoin against Escherichia coli in a murine urinary tract infection model.
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Maaland, Marit Gaastra, Jakobsen, Lotte, Guardabassi, Luca, and Frimodt‐Møller, Niels
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URINARY tract infections ,ESCHERICHIA coli ,NITROFURANTOIN ,ORAL drug administration ,DOSE fractionation - Abstract
The antimicrobial agent nitrofurantoin is becoming increasingly important for treatment of urinary tract infections (UTIs) due to widespread occurrence of multidrug‐resistant Escherichia coli. Despite many years of use, little data on nitrofurantoin pharmacokinetics (PK) or ‐dynamics (PD) exist. The objective of this study was to (i) evaluate the pharmacokinetics of nitrofurantoin in a mouse model and (ii) use that data to design an in vivo dose fractionation study in an experimental model of UTI with E. coli for determination of the most predictive PK/PD index. Nitrofurantoin concentrations in urine were approximately 100‐fold larger than concentrations in plasma after oral administration of 5, 10, and 20 mg/kg nitrofurantoin. The area under the curve over the minimum inhibitory concentration (AUC/MIC) was weakly correlated to bacterial reduction in urine (r2 = 0.24), while no such correlation was found for the time that nitrofurantoin stayed above the MIC (T > MIC). Increasing size of single‐dose treatment was significantly correlated to eradication of bacteria in the urine, while this was not apparent when the same doses were divided in 2 or 3 doses 8 or 12 h apart. In conclusion, the results indicate that nitrofurantoin activity against E. coli in urine is driven by AUC/MIC. [ABSTRACT FROM AUTHOR]
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- 2024
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28. A snapshot of diversity: Intraclonal variation of Escherichia coli clones as commensals and pathogens
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Stegger, Marc, Leihof, Rikke Fleron, Baig, Sharmin, Sieber, Raphael N., Thingholm, Karen Rønø, Marvig, Rasmus L., Frimodt-Møller, Niels, and Nielsen, Karen Leth
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- 2020
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29. Growth hormone upregulates ANGPTL4 mRNA and suppresses lipoprotein lipase via fatty acids: Randomized experiments in human individuals
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Hjelholt, Astrid Johannesson, Søndergaard, Esben, Pedersen, Steen Bønløkke, Møller, Niels, Jessen, Niels, and Jørgensen, Jens Otto L.
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- 2020
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30. Dementia identified as a risk factor for infection-related hospital contacts in a national, population-based and longitudinal matched-cohort study
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Janbek, Janet, Frimodt-Møller, Niels, Laursen, Thomas Munk, and Waldemar, Gunhild
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- 2021
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31. Developmental Trajectories of Body Mass Index, Waist Circumference, and Aerobic Fitness in Youth: Implications for Physical Activity Guideline Recommendations (CHAMPS Study-DK)
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Hébert, Jeffrey J., Sénéchal, Martin, Fairchild, Timothy, Møller, Niels Christian, Klakk, Heidi, and Wedderkopp, Niels
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- 2020
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32. Vigorous physical activity is important in maintaining a favourable health trajectory in active children: the CHAMPS Study-DK
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Sénéchal, Martin, Hebert, Jeffrey J., Fairchild, Timothy J., Møller, Niels Christian, Klakk, Heidi, and Wedderkopp, Niels
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- 2021
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33. Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans
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Ramshanker, Nilani, Jessen, Niels, Voss, Thomas Schmidt, Pedersen, Steen Bønløkke, Jørgensen, Jens Otto Lunde, Nielsen, Thomas Svava, Frystyk, Jan, and Møller, Niels
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- 2019
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34. Three versus five days of pivmecillinam for community-acquired uncomplicated lower urinary tract infection: A randomised, double-blind, placebo-controlled superiority trial
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Jansåker, Filip, Thønnings, Sara, Hertz, Frederik Boëtius, Kallemose, Thomas, Værnet, Jan, Bjerrum, Lars, Benfield, Thomas, Frimodt-Møller, Niels, and Knudsen, Jenny Dahl
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- 2019
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35. The impact of EU's energy labeling policy: An econometric analysis of increased transparency in the market for cold appliances in Denmark
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Bjerregaard, Casper and Møller, Niels Framroze
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- 2019
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36. Can pecuniary and environmental incentives via SMS messaging make households adjust their electricity demand to a fluctuating production?
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Møller, Niels Framroze, Andersen, Laura Mørch, Hansen, Lars Gårn, and Jensen, Carsten Lynge
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- 2019
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37. Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes.
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Voigt, Jens Hohwü, Lauritsen, Katrine M., Pedersen, Steen Bønløkke, Hansen, Troels K., Møller, Niels, Jessen, Niels, Laurenti, Marcello C., Man, Chiara Dalla, Vella, Adrian, Gormsen, Lars C., and Søndergaard, Esben
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PANCREATIC beta cells ,TYPE 2 diabetes ,BETA functions ,CELL physiology ,GLUCOSE ,POSITRON emission tomography ,FREE fatty acids ,METFORMIN - Abstract
Aims: Sodium glucose co-transporter-2 (SGLT2) inhibition lowers glucose levels independently of insulin, leading to reduced insulin secretion and increased lipolysis, resulting in elevated circulating free fatty acids (FFAs). While SGLT2 inhibition improves tissue insulin sensitivity, the increase in circulating FFAs could reduce insulin sensitivity in skeletal muscle and the liver. We aimed to investigate the effects of SGLT2 inhibition on substrate utilization in skeletal muscle and the liver and to measure beta-cell function and glucose tolerance. Methods: Thirteen metformin-treated individuals with type 2 diabetes were randomized to once-daily empagliflozin 25 mg or placebo for 4 weeks in a crossover design. Skeletal muscle glucose and FFA uptake together with hepatic tissue FFA uptake were measured using [18F]FDG positron emission tomography/computed tomography (PET/CT) and [11C]palmitate PET/CT. Insulin secretion and action were estimated using the oral minimal model. Results: Empagliflozin did not affect glucose (0.73 ± 0.30 vs. 1.16 ± 0.64, µmol/g/min p = 0.11) or FFA (0.60 ± 0.30 vs. 0.56 ± 0.3, µmol/g/min p = 0.54) uptake in skeletal muscle. FFA uptake in the liver (21.2 ± 10.1 vs. 19 ± 8.8, µmol/100 ml/min p = 0.32) was unaffected. Empagliflozin increased total beta-cell responsivity (20 ± 8 vs. 14±9, 10
-9 min-1 , p < 0.01) and glucose effectiveness (2.6 x 10-2 ± 0.3 x 10-2 vs. 2.4 x 10-2 ± 0.3 x 10-2 , dL/kg/min, p = 0.02). Conclusions: Despite improved beta-cell function and glucose tolerance, empagliflozin does not appear to affect skeletal muscle FFA or glucose uptake. [ABSTRACT FROM AUTHOR]- Published
- 2024
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38. Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate.
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Gopalasingam, Nigopan, Moeslund, Niels, Christensen, Kristian Hylleberg, Berg-Hansen, Kristoffer, Seefeldt, Jacob, Homilius, Casper, Nielsen, Erik Nguyen, Dollerup, Mie Ringgaard, Olsen, Aage K. Alstrup, Johannsen, Mogens, Boedtkjer, Ebbe, Møller, Niels, Eiskjær, Hans, Gormsen, Lars Christian, Nielsen, Roni, and Wiggers, Henrik
- Published
- 2024
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- View/download PDF
39. Risk of Major Types of Dementias Following Hospital-Diagnosed Infections and Autoimmune Diseases.
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Janbek, Janet, Laursen, Thomas Munk, Frimodt-Møller, Niels, Magyari, Melinda, Haas, Jürgen G., Lathe, Richard, and Waldemar, Gunhild
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VASCULAR dementia ,ALZHEIMER'S disease ,DEMENTIA ,AUTOIMMUNE diseases ,DISEASE risk factors ,INFECTION ,REPORTING of diseases - Abstract
Background: Population-based studies have shown an increased risk of dementia after infections, but weaker links were reported for autoimmune diseases. Evidence is scarce for whether the links may be modified by the dementia or exposure subtype. Objective: We aimed to investigate the association between infections and/or autoimmune diseases and rates of major types of dementias in the short- and long terms. Methods: Nationwide nested case-control study of dementia cases (65+ years) diagnosed in Denmark 2016–2020 and dementia-free controls. Exposures were hospital-diagnosed infections and autoimmune diseases in the preceding 35 years. Two groups of dementia cases were those diagnosed in memory clinics (MC) and those diagnosed outside memory clinics (non-memory clinic cases, NMC). Results: In total, 26,738 individuals were MC and 12,534 were NMC cases. Following any infection, the incidence rate ratio (IRR) for MC cases was 1.23 (95% CI 1.20–1.27) and 1.70 for NMC cases (1.62–1.76). Long-term increased rates were seen for vascular dementia and NMC cases. IRRs for autoimmune diseases were overall statistically insignificant. Conclusions: Cases with vascular dementia and not Alzheimer's disease, and a subgroup of cases identified with poorer health have increased long-term risk following infections. Autoimmune diseases were not associated with any type of dementia. Notably increased risks (attributed to the short term) and for NMC cases may indicate that immunosenescence rather than de novo infection explains the links. Future focus on such groups and on the role of vascular pathology will explain the infection-dementia links, especially in the long term. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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40. Circulating 3‐hydroxy butyrate predicts mortality in patients with chronic heart failure with reduced ejection fraction.
- Author
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Christensen, Kristian Hylleberg, Nielsen, Roni R., Schou, Morten, Gustafsson, Ida, Jorsal, Anders, Flyvbjerg, Allan, Tarnow, Lise, Bøtker, Hans Erik, Kistorp, Caroline, Johannsen, Mogens, Møller, Niels, and Wiggers, Henrik
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HEART failure patients ,BRAIN natriuretic factor ,LIQUID chromatography-mass spectrometry ,VENTRICULAR ejection fraction ,FATTY acid analysis - Abstract
Aims: In patients with chronic heart failure with reduced ejection fraction (HFrEF), myocardial ketone metabolism is increased and short‐term treatment with the ketone body 3‐hydroxy butyrate (3‐OHB) has beneficial haemodynamic effects. In patients with HFrEF, we investigated whether the level of circulating 3‐OHB predicted all‐cause mortality and sought to identify correlations between patient characteristics and circulating 3‐OHB levels. Methods and results: We conducted a cohort study in 218 patients with HFrEF. Plasma 3‐OHB levels were measured using high‐performance liquid chromatography tandem mass spectrometry. Data on all‐cause mortality were obtained by reviewing the patients' medical records, which are linked to the national 'Central Person Registry' that registers the timing of all deaths in the country. Mean left ventricular ejection fraction was 35 ± 8.6%, mean age was 67 ± 10 years, 54% were New York Heart Association II, and 27% had type 2 diabetes mellitus. Median follow‐up time was 7.3 (interquartile range 6.3–8.4) years. We observed large variations in 3‐OHB levels between patients (median 59 μM, range: 14–694 μM). Patients with 3‐OHB levels above the median displayed a markedly increased risk of death compared with those with low levels {hazard ratio [HR]: 2.1 [95% confidence interval (CI): 1.3–3.5], P = 0.003}. In a multivariate analysis, 3‐OHB predicted mortality independently of known chronic heart failure risk factors [HR: 1.004 (95% CI: 1.001–1.007), P = 0.02] and with a similar statistical strength as N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) [HR: 1.0005 (95% CI: 1.000–1.001), P = 0.02]. For every 100 μmol increase in plasma 3‐OHB, the hazard of death increased by 49%. The following factors significantly predicted 3‐OHB levels in the univariate analysis: free fatty acids (FFAs) [β: 238 (95% CI: 185–292), P < 0.0001], age [β: 2.43 (95% CI: 1.14–3.72), P < 0.0001], plasma insulin {β: −0.28 [95% CI: −0.54–(−0.02)], P = 0.036}, body mass index {β: −3.15 [95% CI: −5.26–(−0.05)], P = 0.046}, diabetes [β: 44.49 (95% CI: 14.84–74.14), P = 0.003], glycosylated haemoglobin [β: 1.92 (95% CI: 0.24–3.59), P = 0.025], New York Heart Association class [β: 26.86 (95% CI: 5.99–47.72), P = 0.012], and NT‐proBNP [β: 0.03 (95% CI: 0.01–0.04), P = 0.001]. In a multivariate analysis, only FFAs predicted 3‐OHB levels [β: 216 (95% CI: 165–268), P > 0.001]. Conclusions: In patients with HFrEF, circulating 3‐OHB was a strong predictor of all‐cause mortality independently of NT‐proBNP. Circulating FFAs were the best predictor of 3‐OHB levels. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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41. Effects of exogenous lactate on lipid, protein, and glucose metabolism--a randomized crossover trial in healthy males.
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Pedersen, Mette G. B., Rittig, Nikolaj, Bangshaab, Maj, Berg-Hansen, Kristoffer, Gopalasingam, Nigopan, Gormsen, Lars C., Søndergaard, Esben, and Møller, Niels
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GLUCOSE metabolism ,INSULIN sensitivity ,CROSSOVER trials ,PROTEIN metabolism ,LIPOLYSIS ,LACTATION ,BLOOD lactate - Abstract
Lactate may inhibit lipolysis and thus enhance insulin sensitivity, but there is a lack of metabolic human studies. This study aimed to determine how hyperlactatemia affects lipolysis, glucose- and protein metabolism, and insulin sensitivity in healthy men. In a single-blind, randomized, crossover design, eight healthy men were studied after an overnight fast on two occasions: 1) during a sodium-lactate infusion (LAC) and 2) during a sodium-matched NaCl infusion (CTR). Both days consisted of a 3-h postabsorptive period followed by a 3-h hyperinsulinemic-euglycemic clamp (HEC). Lipolysis rate, endogenous glucose production (EGP), and delta glucose rate of disappearance (ΔRd
glu ) were evaluated using [9,10-³H]palmitate and [3-³H]glucose tracers. In addition, whole body- and forearm protein metabolism was assessed using [15 N]phenylalanine, [2H4]tyrosine, [15 N]tyrosine, and [13 C] urea tracers. In the postabsorptive period, plasma lactate increased to 2.7 ± 0.5 mmol/L during LAC vs. 0.6 ± 0.3 mmol/L during CTR (P < 0.001). In the postabsorptive period, palmitate flux was 30% lower during LAC compared with CTR (84 ± 32 lmol/min vs. 120 ± 35 lmol/min, P = 0.003). During the HEC, palmitate flux was suppressed similarly during both interventions (P = 0.7). EGP, ΔRdglu , and M value were similar during LAC and CTR. During HEC, LAC increased whole body phenylalanine flux (P = 0.02) and protein synthesis (P = 0.03) compared with CTR; LAC did not affect forearm protein metabolism compared with CTR. Lactate infusion inhibited lipolysis by 30% under postabsorptive conditions but did not affect glucose metabolism or improve insulin sensitivity. In addition, whole body phenylalanine flux was increased. [ABSTRACT FROM AUTHOR]- Published
- 2024
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42. Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
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Heidtmann, Christoffer V., Fejer, Andreas R., Stærk, Kristian, Pedersen, Maria, Asmussen, Marco G., Hertz, Frederik B., Prabhala, Bala K., Frimodt-Møller, Niels, Klitgaard, Janne K., Andersen, Thomas E., Nielsen, Carsten U., and Nielsen, Poul
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- 2024
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43. A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans.
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Luong, Thien Vinh, Pedersen, Mette Glavind Bülow, Abild, Caroline Bruun, Cunnane, Stephen C., Croteau, Etienne, Lauritsen, Katrine Meyer, Kjærulff, Mette Louise Gram, Tolbod, Lars Poulsen, Møller, Niels, Søndergaard, Esben, and Gormsen, Lars Christian
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FATTY acid oxidation ,KETOGENIC diet ,OXYGEN consumption ,POSITRON emission tomography ,FREE fatty acids - Abstract
Objective: A ketogenic diet (KD) characterized by very low carbohydrate intake and high fat consumption may simultaneously induce weight loss and be cardioprotective. The "thrifty substrate hypothesis" posits that ketone bodies are more energy efficient compared with other cardiac oxidative substrates such as fatty acids. This work aimed to study whether a KD with presumed increased myocardial ketone body utilization reduces cardiac fatty acid uptake and oxidation, resulting in decreased myocardial oxygen consumption (MVO2). Methods: This randomized controlled crossover trial examined 11 individuals with overweight or obesity on two occasions: (1) after a KD and (2) after a standard diet. Myocardial free fatty acid (FFA) oxidation, uptake, and esterification rate were measured using dynamic [11C]palmitate positron emission tomography (PET)/computed tomography, whereas MVO2 and myocardial external efficiency (MEE) were measured using dynamic [11C]acetate PET. Results: The KD increased plasma β‐hydroxybutyrate, reduced myocardial FFA oxidation (p < 0.01) and uptake (p = 0.03), and increased FFA esterification (p = 0.03). No changes were observed in MVO2 (p = 0.2) or MEE (p = 0.87). Conclusions: A KD significantly reduced myocardial FFA uptake and oxidation, presumably by increasing ketone body oxidation. However, this change in cardiac substrate utilization did not improve MVO2, speaking against the thrifty substrate hypothesis. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
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Frimodt-Møller, Niels, Hansen, Jon U., Plattner, Michel, Huseby, Douglas L., Radmer Almind, Stine, Haldimann, Klara, Gysin, Marina, Petersson, Anna, Ercan, Onur, Ganz, Lea, Hughes, Diarmaid, Vingsbo Lundberg, Carina, and Hobbie, Sven N.
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- 2024
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45. Symptoms of depression in young adulthood is associated with unfavorable clinical- and behavioral cardiovascular disease risk factors
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Klakk, Heidi, Kristensen, Peter Lund, Andersen, Lars Bo, Froberg, Karsten, Møller, Niels Christian, and Grøntved, Anders
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- 2018
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46. Lysyl oxidase and adipose tissue dysfunction
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Pastel, Emilie, Price, Emily, Sjöholm, Kajsa, McCulloch, Laura J., Rittig, Nikolaj, Liversedge, Neil, Knight, Bridget, Møller, Niels, Svensson, Per-Arne, and Kos, Katarina
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- 2018
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47. Antibiotic stewardship: following in the footsteps of Nordic countries?
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Frimodt-Møller, Niels and Hertz, Frederik Boetius
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- 2024
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48. Physical education and leisure-time sport reduce overweight and obesity: a number needed to treat analysis
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Learmonth, Yvonne C., Hebert, Jeffrey J., Fairchild, Timothy J., Møller, Niels Christian, Klakk, Heidi, and Wedderkopp, Niels
- Published
- 2019
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49. Decoding unemployment persistence: an econometric framework for identifying and comparing the sources of persistence with an application to UK macrodata
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Møller, Niels Framroze
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- 2019
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50. Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis
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Voss, Thomas S., Vendelbo, Mikkel H., Kampmann, Ulla, Pedersen, Steen B., Nielsen, Thomas S., Johannsen, Mogens, Svart, Mads V., Jessen, Niels, and Møller, Niels
- Published
- 2019
- Full Text
- View/download PDF
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