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2,276 results on '"Lv, Xin"'

9. Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung surgery: a protocol for a multicenter, randomized, double-blind, clinical trial

Author

Liao, Dawei, Peng, Ke, Zhang, Yang, Liu, Huayue, Xia, Zhongyuan, Guo, Jian, Wei, Fujiang, Chen, Chen, Lv, Xin, Tong, Jianhua, Li, Xiaoshuang, Qu, Xianfeng, Wang, Xiaobin, Wang, Yingbin, Ou, Shanshan, Liu, Hong, Shan, Xisheng, and Ji, Fuhai

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Pain Research, Lung, Clinical Research, Clinical Trials and Supportive Activities, Chronic Pain, Patient Safety, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, area under the curve, erector spinae plane block, liposomal bupivacaine, postoperative pain, thoracoscopic, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThere is still a controversy about the superiority of liposomal bupivacaine (LB) over traditional local anesthetics in postoperative analgesia after thoracic surgery. This study aims to determine the effect of LB versus bupivacaine hydrochloride (HCl) for preoperative ultrasound-guided erector spinae plane block (ESPB) on postoperative acute and chronic pain in patients undergoing video-assisted thoracoscopic lung surgery.MethodsThis multicenter, randomized, double-blind, controlled trial will include 272 adult patients scheduled for elective video-assisted thoracoscopic lung surgery. Patients will be randomly assigned, 1:1 and stratified by site, to the liposomal bupivacaine (LB) group or the bupivacaine (BUPI) HCl group. All patients will receive ultrasound-guided ESPB with either LB or bupivacaine HCl before surgery and patient-controlled intravenous analgesia (PCIA) as rescue analgesia after surgery. The numeric rating scale (NRS) score will be assessed after surgery. The primary outcome is the area under the curve of pain scores at rest for 0-72 h postoperatively. The secondary outcomes include the total amount of opioid rescue analgesics through 0-72 h postoperatively, time to the first press on the PCIA device as rescue analgesia, the area under the curve of pain scores on activity for 0-72 h postoperatively, NRS scores at rest and on activity at different time points during the 0-72 h postoperative period, Quality of Recovery 15 scores at 72 h after surgery, and NRS scores on activity on postsurgical day 14 and postsurgical 3 months. Adverse events after the surgery are followed up to the postsurgical day 7, including postoperative nausea and vomiting, fever, constipation, dizziness, headache, insomnia, itching, prolonged chest tube leakage, new-onset atrial fibrillation, severe ventricular arrhythmia, deep venous thrombosis, pulmonary embolism, pulmonary atelectasis, cardiac arrest, ileus, urinary retention, chylothorax, pneumothorax, and organ failure. Analyzes will be performed first according to the intention to treat principle and second with the per-protocol analysis.DiscussionWe hypothesize that LB for preoperative ultrasound-guided ESPB would be more effective than bupivacaine HCl in reducing postoperative pain in video-assisted thoracoscopic lung surgery. Our results will contribute to the optimization of postoperative analgesia regimens for patients undergoing video-assisted thoracoscopic lung surgery.Clinical trial registration:http://www.chictr.org.cn, identifier ChiCTR2300074852.

Published
2024

20. Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans

Author

Lv, Yunhui, Li, Kai, Wang, Shuo, Wang, Xiaokang, Yue, Guangxin, Zhang, Yangyang, Lv, Xin, Zhao, Ping, Wang, Shiping, Zhang, Qi, Li, Qiuju, Zhu, Jinyan, Li, Jubo, Peng, Peng, Li, Yue, Luo, Jiafei, Zhang, Xue, Yang, Jianzhong, Zhang, Baojie, Wang, Xuemin, Zhang, Min, Shen, Chen, Wang, Xin, Wang, Miao, Ye, Zhen, and Cui, Yongchun

Published
2024
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