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Objective: The purpose of this study was to analyze the relationship between obesity and clinical outcomes in breast cancer patients by evaluating the mean body mass index (BMI) and overall survival. Material and Methods: The research’s method consisted of a retrospective observational and descriptive study without intervention, carried out in a public oncology service in Brazils Federal District. We selected breast cancer patients with hormonal expression positivity in follow-up from January 2016 to December 2020. Results: 305 female patients were evaluated, aged between 33 and 92 years old (average age of 59). Most patients were over 55 years old (63.3%). The mean weight of the patients was 71.70±9.10 kilograms. Regarding BMI, 38.7% of patients were classified as obese. As for the immunohistochemical classification (IHC), 72.9% of the patients were luminal B. Among the patients in which the initial treatment was registered, 56.1% received hormone therapy, while 43.9% received chemotherapy. The intention to treat in most patients was curative. Most patients had disease staging between II and III. As for the outcome, most patients were still undergoing treatment (83.0%) at the time of data collection. Correlating the IHC classification with patient survival, there was no significant difference between patient’s classified as luminal A and those classified as luminal B (p: 0.342). There was also no significant difference between non-obese and obese patients in the assessment of overall survival and weight (p: 0.917). Conclusion: Despite the high prevalence of obesity in the studied population, the overall survival of this group did not differ from the non-obese group, even in the analyzes by IHC profile.

Objectives: To report real-world data of a cohort of patients treated with immune-checkpoint inhibitors in Brazil, with focus in immune-related adverse events. Material and Methods: In this retrospective study, we analyzed a cohort of patients with metastatic solid tumors treated at an oncology reference center with at least one dose of immune-checkpoint inhibitors (given as monotherapy or in combination with other agents). The safety profile was characterized through the incidence of adverse events, management and hospitalization. Results: We included 185 patients. Immune-related adverse events were observed in 92 of the 185 study patients (49.7%), including 16 patients (8.6%) with such events of grade 3 or 4, and 28 patients (15.1%) requiring systemic corticosteroid therapy. Thyroid disorders (20%), rash (17.8%), pruritus (11.4%) and colitis (11.4%) were the most frequent immune-related adverse events. Five (2.7%) patients discontinued immune-checkpoint inhibitors and 15 (7.0%) were hospitalized due to immune-related adverse events. Development of immune-related adverse events and immune-checkpoint inhibitors used in the firstline setting were associated with prolonged progression-free survival and overall survival in the multivariate analysis. Moreover, age

Resumo Introdução: a análise da validade ética das pesquisas se concretiza nos Comitês de Ética em Pesquisa (CEP) das instituições. Este trabalho pretende apresentar o histórico de organização e funcionamento do CEP na Universidade Federal de Santa Maria, a demanda de análise de projetos, além de divulgar sua importância na nossa universidade. Métodos: foi realizado um levantamento histórico pela análise de arquivos internos e consulta oral a ex-componentes do CEP. Também foi pesquisado o número de projetos submetidos à avaliação pelo CEP desde sua fundação até dezembro de 2009. Resultados: foi possível resgatar e registrar o histórico do CEP e observou-se aumento substancial da demanda de avaliação de projetos. Conclusão: o CEP atualmente pode ser considerado atuante na UFSM e região, orientando e incentivando a prática da ética em pesquisa com seres humanos de forma independente. Palavras-chave: Comitê; ética; pesquisa; histórico; demanda Abstract Introduction: the analysis of the ethical validity of research is materialized in the Ethics Committee (EC) of the institutions. This article aims to briefly present the history of organization and operation of the EC activities in Federal University of Santa Maria (UFSM), to examine trends in demand for project analysis, in addition to disclosing its importance to the institution. Methods: a survey was done by the historical analysis of internal files, in addition to oral consultation to former components of the CEP. We raised the number of projects submitted for review by the CEP since its founding until December 2009.Results: it was possible to raise and register the history of the EC and it was observed a substantial increase in demand for project evaluation. Conclusion: currently the EC can be considered active in UFSM and region, guiding and encouraging the practice of ethics in human research independently. Keywords: Ethics committee; research; history; demand