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Start Over Author "Locatelli, Marco" Publication Type Academic Journals
572 results on '"Locatelli, Marco"'

13. The “state of the art” of intraoperative neurophysiological monitoring: An Italian neurosurgical survey

Author

Ricciuti, Riccardo Antonio, Mancini, Fabrizio, Guzzi, Giusy, Marruzzo, Daniele, Dario, Alessandro, Della Puppa, Alessandro, Ricci, Alessandro, Barbanera, Andrea, Talacchi, Andrea, Schwarz, Andreas, Germanò, Antonino, Raco, Antonino, Colamaria, Antonio, Santoro, Antonio, Boccaletti, Riccardo, Conti, Carlo, Cenci, Nunzia, Cossandi, Christian, Bernucci, Claudio, Lucantoni, Corrado, Costella, Giovanni Battista, Garbossa, Diego, Zotta, Donato Carlo, De Gonda, Federico, Esposito, Felice, Giordano, Flavio, D'Andrea, Giancarlo, Piatelli, Gianluca, Zona, Gianluigi, Spena, Giannantonio, Tringali, Giovanni, Barbagallo, Giuseppe, Giussani, Carlo, Gladi, Maurizio, Landi, Andrea, Lavano, Angelo, Morabito, Letterio, Mastronardi, Luciano, Locatelli, Marco, D'Agruma, Michele, Lanotte, Michele Maria, Montano, Nicola, Santonocito, Orazio Santo, Pompucci, Angelo, de Falco, Raffaele, Randi, Franco, Bruscella, Sara, Sartori, Ivana, Signorelli, Francesco, Tosatto, Luigino, Trignani, Roberto, Esposito, Vincenzo, Innocenzi, Gualtiero, Paolini, Sergio, Vitiello, Vincenzo, Cavallo, Michele Alessandro, and Sala, Francesco

Published
2024
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15. Relationship between lumbar lordosis, pelvic parameters, PI-LL mismatch and outcome after short fusion surgery for lumbar degenerative disease. Literature review, rational and presentation of public study protocol: RELApSE study (registry for evaluation of lumbar arthrodesis sagittal alignEment)

Author

Tartara, Fulvio, Garbossa, Diego, Armocida, Daniele, Di Perna, Giuseppe, Ajello, Marco, Marengo, Nicola, Bozzaro, Marco, Petrone, Salvatore, Giorgi, Pietro Domenico, Schirò, Giuseppe Rosario, Legrenzi, Simona, Boeris, Davide, Piazzolla, Andrea, Passarelli, Anna Claudia, Longo, Alessandro, Ducati, Alessandro, Penner, Federica, Tancioni, Flavio, Bona, Alberto, Paternò, Giovanni, Tassorelli, Cristina, De Icco, Roberto, Lamaida, Giovanni Andrea, Gallazzi, Enrico, Pilloni, Giulia, Colombo, Elena Virginia, Gaetani, Paolo, Aimar, Enrico, Zoia, Cesare, Stefini, Roberto, Rusconi, Angelo, Querenghi, Amos M., Brembilla, Carlo, Bernucci, Claudio, Fanti, Andrea, Frati, Alessandro, Manelli, Antonio, Muzii, Vitaliano, Sedia, Mattia, Romano, Alberto, Baram, Ali, Figini, Silvia, Ballante, Elena, Gioia, Giuseppe, Locatelli, Marco, Pluderi, Mauro, Morselli, Carlotta, Bassani, Roberto, Costa, Francesco, and Cofano, Fabio

Published
2023
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16. Posterior fossa syndrome in a population of children and young adults with medulloblastoma: a retrospective, multicenter Italian study on incidence and pathophysiology in a histologically homogeneous and consecutive series of 136 patients

Author

de Laurentis, Camilla, Cristaldi, Paola M. F., Rebora, Paola, Valsecchi, Maria Grazia, Biassoni, Veronica, Schiavello, Elisabetta, Carrabba, Giorgio G., Trezza, Andrea, DiMeco, Francesco, Ferroli, Paolo, Cinalli, Giuseppe, Locatelli, Marco, Cenzato, Marco, Talamonti, Giuseppe, Fontanella, Marco M., Spena, Giannatonio, Stefini, Roberto, Bernucci, Claudio, Bellocchi, Silvio, Locatelli, Davide, Massimino, Maura, and Giussani, Carlo

Published
2022
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17. Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial

Author

Abete Fornara, Giorgia, Agnelli, Nicolò M., Albanese, Alessio, Awad, Issam, Bagnati, Renzo, Balconi, Giovanna, Ballabio, Elena, Beghi, Ettore, Bernasconi, Roberto, Bertani, Giulio A., Besana, Silvia, Blanda, Adriana, Bossi, Chiara, Bresolin, Nereo, Buratti, Maria G., Calabrese, Roberta, Carriero, Maria R., Castori, Marco, Ciceri, Elisa F., Ciurleo, Rossella, Comi, Giacomo P., Contarino, Valeria, Conte, Giorgio, D'Agruma, Leonardo, D'Alessandris, Giorgio Q., de Grazia, Ugo, Di Bonaventura, Rina, d'Orio, Piergiorgio, Farago', Giuseppe, Foresta, Andreana, Fusco, Carmela, Gaudino, Chiara, Lampugnani, Maria G., Lanno, Alessia, Lazzaroni, Francesca, Lee, Cornelia, Locatelli, Marco, Maggioni, Aldo P., Magnusson, Peetra, Malinverno, Matteo, Mangiavacchi, Maurizio, Mangraviti, Antonella, Marino, Silvia, Mazzola, Selene, Nicolis, Enrico B., Novelli, Deborah, Ojeda Fernandez, Maria L., Petracca, Antonio, Pignotti, Fabrizio, Pogliani, Simona, Poloni, Marco, Prelle, Alessandro, Raggi, Pamela, Raucci, Franca, Regna-Gladin, Caroline, Ronchi, Dario, Scelzo, Emma, Seyfried, Salim, Simeone, Anna, Sturiale, Carmelo L., Tassi, Laura, Tettamanti, Mauro, Torri, Valter, Tournier-Lasserve, Elisabeth, Treglia, Rita, Triulzi, Fabio M., Ungaro, Celeste, Ursi, Elison, Valcamonica, Gloria, Vasami', Antonella, Zarino, Barbara, Lanfranconi, Silvia, Scola, Elisa, Meessen, Jennifer M T A, Pallini, Roberto, Bertani, Giulio A, Al-Shahi Salman, Rustam, Dejana, Elisabetta, and Latini, Roberto

Published
2023
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18. A GRASP for a real-world scheduling problem with unrelated parallel print machines and sequence-dependent setup times.

Author

Iori, Manuel, Locatelli, Alberto, and Locatelli, Marco

Subjects
SETUP time, FOOD industry, FOOD packaging, SCHEDULING, MACHINERY, FOOD banks
Abstract

We consider a real-world scheduling problem arising in the colour printing industry. The problem consists in assigning print jobs to a heterogeneous set of flexographic printer machines and finding a processing sequence for the jobs assigned to each machine. The machines are characterised by a limited sequence of colour groups and can equip additional components (e.g. embossing rollers and perforating rolls) to process jobs that require specific treatments. The process to equip a machine with an additional component or to clean a colour group takes a long time, with the effect of significantly raising the setup times. The aim is to minimise a weighted sum of total weighted tardiness and total setup time. The problem derives from the activities of an Italian food packaging company. To solve it, we developed a greedy randomised adaptive search procedure equipped with several local search procedures. The excellent performance of the algorithm is proved by extensive computational experiments on real-world instances, for which it produced good-quality solutions within a limited computing time. The algorithm is currently in use at the company to support their weekly scheduling decisions. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Testing calpain inhibition in tumor endothelial cells: novel targetable biomarkers against glioblastoma malignancy.

Author

Guarnaccia, Laura, Navone, Stefania Elena, Begani, Laura, Barilla, Emanuela, Garzia, Emanuele, Campanella, Rolando, Miozzo, Monica, Fontana, Laura, Alotta, Giovanni, Cordiglieri, Chiara, Gaudino, Chiara, Schisano, Luigi, Ampollini, Antonella, Riboni, Laura, Locatelli, Marco, and Marfia, Giovanni

Subjects
CYSTEINE proteinases, GENE expression, PEARSON correlation (Statistics), PROGNOSIS, OVERALL survival, BRAIN tumors
Abstract

Introduction: Glioblastoma IDH-wildtype (GBM) is the most malignant brain tumor in adults, with a poor prognosis of approximately 15 months after diagnosis. Most patients suffer from a recurrence in <1 year, and this renders GBM a life-threatening challenge. Among molecular mechanisms driving GBM aggressiveness, angiogenesis mediated by GBM endothelial cells (GECs) deserves consideration as a therapeutic turning point. In this scenario, calpains, a family of ubiquitously expressed calcium-dependent cysteine proteases, emerged as promising targets to be investigated as a novel therapeutic strategy and prognostic tissue biomarkers. Methods: To explore this hypothesis, GECs were isolated from n=10 GBM biopsies and characterized phenotypically by immunofluorescence. The expression levels of calpains were evaluated by qRT-PCR and Western blot, and their association with patients' prognosis was estimated by Pearson correlation and Kaplan-Meier survival analysis. Calpain targeting efficacy was assessed by a time- and dose-dependent proliferation curve, MTT assay for viability, caspase-3/7 activity, migration and angiogenesis in vitro, and gene and protein expression level modification. Results: Immunofluorescence confirmed the endothelial phenotype of our primary GECs. A significant overexpression was observed for calpain-1/2/3 (CAPN) and calpain-small-subunits-1/2 (CAPNS1), whereas calpastatin gene, the calpain natural inhibitor, was reported to be downregulated. A significant negative correlation was observed between CAPN1/CAPNS1 and patient overall survival. GEC challenging revealed that the inhibition of calpain-1 exerts the strongest proapoptotic efficacy, so GEC mortality reached the 80%, confirmed by the increased activity of caspase-3/7. Functional assays revealed a strong affection of in vitro migration and angiogenesis. Gene and protein expression proved a downregulation of MAPK, VEGF/VEGFRs, and Bcl-2, and an upregulation of caspases and Bax-family mediators. Conclusion: Overall, the differential expression of calpains and their correlation with patient survival suggest a novel promising target pathway, whose blockade showed encouraging results toward precision medicine strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The Protective Role of Cognitive Reserve: A Preliminary Study on Parkinsonian Patients Undergoing Deep Brain Stimulation.

Author

Zirone, Eleonora, Ruggiero, Fabiana, Molisso, Maria Takeko, Ferrucci, Roberta, De Sandi, Angelica, Marfoli, Angelica, Mellace, Denise, Cogiamanian, Filippo, Borellini, Linda, Mailland, Enrico, Pirola, Elena, Ampollini, Antonella, Locatelli, Marco, Barbieri, Sergio, and Mameli, Francesca

Subjects
DEEP brain stimulation, MONTREAL Cognitive Assessment, PARKINSON'S disease, SUBTHALAMIC nucleus, DISEASE risk factors
Abstract

Background/Objectives: High cognitive reserve (CR) has been shown to have beneficial effects on global cognition, cognitive decline, and risk of dementia in Parkinson's disease (PD). We evaluated the influence of CR on the long-term cognitive outcomes of patients with PD who underwent subthalamic nucleus deep brain stimulation (STN-DBS). Methods: Twenty-five patients with PD underwent neuropsychological screening using the Montreal Cognitive Assessment (MoCA) at baseline, 1 year, and 5 years after bilateral STN-DBS. CR was assessed using the Cognitive Reserve Index questionnaire. According to CR score, patients were assigned to two different groups (LowCR group ≤ 130, HighCR group > 130). Results: Our data showed that patients in the HighCR group obtained a better performance with the MoCA total score at long-term follow-up compared to those in the LowCR group ([mean ± SE] LowCR group: 21.4 ± 1.2 vs. HighCR group: 24.5 ± 1.3, p = 0.05). The cognitive profile of the HighCR group remained unchanged over time. Conversely, the LowCR group had worse global cognition 5 years after surgery (T0: 25.3 ± 0.6 vs. T2: 21.4 ± 1.2, p = 0.02). Cognitive decline was not associated with mood, demographics, or clinical variables. Conclusions: These preliminary findings suggest that higher CR may be protective in PD cognition after STN-DBS. Specifically, a high CR may help cope with long-term decline in the context of surgical treatment. Quantifying a patient's CR could lead to more personalized medical care, tailoring postoperative support and monitoring for those at higher risk of cognitive decline. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Personalized and translational approach for malignant brain tumors in the era of precision medicine: the strategic contribution of an experienced neurosurgery laboratory in a modern neurosurgery and neuro-oncology department

Author

Campanella, Rolando, Guarnaccia, Laura, Caroli, Manuela, Zarino, Barbara, Carrabba, Giorgio, La Verde, Nicla, Gaudino, Chiara, Rampini, Angela, Luzzi, Sabino, Riboni, Laura, Locatelli, Marco, Navone, Stefania Elena, and Marfia, Giovanni

Published
2020
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38. The Novel SSTR3 Agonist ITF2984 Exerts Antimitotic and Proapoptotic Effects in Human Non-Functioning Pituitary Neuroendocrine Tumor (NF-PitNET) Cells.

Author

Di Muro, Genesio, Catalano, Rosa, Treppiedi, Donatella, Barbieri, Anna Maria, Mangili, Federica, Marra, Giusy, Di Bari, Sonia, Esposito, Emanuela, Nozza, Emma, Lania, Andrea G., Ferrante, Emanuele, Locatelli, Marco, Modena, Daniela, Steinkuhler, Christian, Peverelli, Erika, and Mantovani, Giovanna

Subjects
PITUITARY tumors, NEUROENDOCRINE tumors, SOMATOSTATIN receptors, DRUG efficacy, DRUG therapy, CELL proliferation
Abstract

Somatostatin receptor ligands (SRLs) with high affinity for somatostatin receptors 2 and 5 (SSTR2 and SSTR5) are poorly efficacious in NF-PitNETs, expressing high levels of SSTR3. ITF2984 is a pan-SSTR ligand with high affinity for SSTR3, able to induce SSTR3 activation and to exert antitumoral activity in the MENX rat model. The aim of this study was to test ITF2984's antiproliferative and proapoptotic effects in NF-PitNET primary cultured cells derived from surgically removed human tumors and to characterize their SSTR expression profile. We treated cells derived from 23 NF-PitNETs with ITF2984, and a subset of them with octreotide, pasireotide (SRLs with high affinity for SSTR2 or 5, respectively), or cabergoline (DRD2 agonist) and we measured cell proliferation and apoptosis. SSTR3, SSTR2, and SSTR5 expression in tumor tissues was analyzed by qRT-PCR and Western blot. We demonstrated that ITF2984 reduced cell proliferation (−40.8 (17.08)%, p < 0.001 vs. basal, n = 19 NF-PitNETs) and increased cell apoptosis (+41.4 (22.1)%, p < 0.001 vs. basal, n = 17 NF-PitNETs) in all tumors tested, whereas the other drugs were only effective in some tumors. In our model, SSTR3 expression levels did not correlate with ITF2984 antiproliferative nor proapoptotic effects. In conclusion, our data support a possible use of ITF2984 in the pharmacological treatment of NF-PitNET. [ABSTRACT FROM AUTHOR]

Published
2024
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45. An Algorithm with Improved Complexity for Pebble Motion/Multi-Agent Path Finding on Trees.

Author

Ardizzoni, Stefano, Saccani, Irene, Consolini, Luca, Locatelli, Marco, and Nebel, Bernhard

Subjects
PEBBLES, GEOMETRIC vertices, DIRECTED graphs, COMPUTER algorithms, PROBLEM solving
Abstract

The pebble motion on trees (PMT) problem consists in finding a feasible sequence of moves that repositions a set of pebbles to assigned target vertices. This problem has been widely studied because, in many cases, the more general Multi-Agent path finding (MAPF) problem on graphs can be reduced to PMT. We propose a simple and easy to implement procedure, which finds solutions of length O(|P|nc + n²), where n is the number of nodes, P is the set of pebbles, and c the maximum length of corridors in the tree. This complexity result is more detailed than the current best known result O(n³), which is equal to our result in the worst case, but does not capture the dependency on c and |P|. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Role of Luteolin as Potential New Therapeutic Option for Patients with Glioblastoma through Regulation of Sphingolipid Rheostat.

Author

Navone, Stefania Elena, Guarnaccia, Laura, Rizzaro, Massimiliano D., Begani, Laura, Barilla, Emanuela, Alotta, Giovanni, Garzia, Emanuele, Caroli, Manuela, Ampollini, Antonella, Violetti, Aniello, Gervasi, Noreen, Campanella, Rolando, Riboni, Laura, Locatelli, Marco, and Marfia, Giovanni

Subjects
GLIOBLASTOMA multiforme, FLAVONOIDS, BRAIN tumors, CELL cycle, CELL survival, METHYLGUANINE, LUTEOLIN
Abstract

Glioblastoma (GBM) is the most aggressive brain tumor, still considered incurable. In this study, conducted on primary GBM stem cells (GSCs), specifically selected as the most therapy-resistant, we examined the efficacy of luteolin, a natural flavonoid, as an anti-tumoral compound. Luteolin is known to impact the sphingolipid rheostat, a pathway regulated by the proliferative sphingosine-1-phosphate (S1P) and the proapoptotic ceramide (Cer), and implicated in numerous oncopromoter biological processes. Here, we report that luteolin is able to inhibit the expression of SphK1/2, the two kinases implicated in S1P formation, and to increase the expression of both SGPL1, the lyase responsible for S1P degradation, and CERS1, the ceramide synthase 1, thus shifting the balance toward the production of ceramide. In addition, luteolin proved to decrease the expression of protumoral signaling as MAPK, RAS/MEK/ERK and PI3K/AKT/mTOR and cyclins involved in cell cycle progression. In parallel, luteolin succeeded in upregulation of proapoptotic mediators as caspases and Bcl-2 family and cell cycle controllers as p53 and p27. Furthermore, luteolin determined the shutdown of autophagy contributing to cell survival. Overall, our data support the use of luteolin as add-on therapy, having demonstrated a good ability in impairing GSC viability and survival and increasing cell sensitivity to TMZ. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Granular cell tumor of the neurohypophysis presenting as a third ventricle mass.

Author

Lopez, Gianluca, Pescia, Carlo, Galli, Carlo, Bramerio, Manuela, Tosoni, Antonella, Nebuloni, Manuela, Ferrara, Mariarosa, Bertani, Giulio, Caschera, Luca, Triulzi, Fabio Maria, Locatelli, Marco, Tabano, Silvia, and Croci, Giorgio Alberto

Subjects
CELL tumors, PITUITARY gland, BENIGN tumors, PITUITARY tumors, GLIOMAS
Abstract

Granular cell tumors of the neurohypophysis (GCT) are rare benign neoplasms belonging, along with pituicytoma and spindle cell oncocytoma, to the family of TTF1‐positive low‐grade neoplasms of the posterior pituitary gland. GCT usually present as a solid sellar mass, slowly growing and causing compressive symptoms over time, occasionally with suprasellar extension. They comprise polygonal monomorphous cells with abundant granular cytoplasm, which is ultrastructurally filled with lysosomes. Here we report the case of a GCT presenting as a third ventricle mass, radiologically mimicking chordoid glioma, with aberrant expression of GFAP and Annexin‐A, which lends itself as an example of an integrated diagnostic approach to sellar/suprasellar and third ventricle masses. [ABSTRACT FROM AUTHOR]

Published
2023
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